LOCUS       NM_001106006            4971 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus ubiquitin-conjugating enzyme E2K (Ube2k), mRNA.
ACCESSION   NM_001106006 XM_001071289 XM_214043
VERSION     NM_001106006.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4971)
  AUTHORS   Park ES, Elangovan M, Kim YJ and Yoo YJ.
  TITLE     UbcD4, an ortholog of E2-25K/Ube2K, is essential for activation of
            the immune deficiency pathway in Drosophila
  JOURNAL   Biochem Biophys Res Commun 469 (4), 891-896 (2016)
   PUBMED   26707646
REFERENCE   2  (bases 1 to 4971)
  AUTHORS   Rajsbaum R, Versteeg GA, Schmid S, Maestre AM, Belicha-Villanueva
            A, Martinez-Romero C, Patel JR, Morrison J, Pisanelli G, Miorin L,
            Laurent-Rolle M, Moulton HM, Stein DA, Fernandez-Sesma A, tenOever
            BR and Garcia-Sastre A.
  TITLE     Unanchored K48-linked polyubiquitin synthesized by the E3-ubiquitin
            ligase TRIM6 stimulates the interferon-IKKepsilon kinase-mediated
            antiviral response
  JOURNAL   Immunity 40 (6), 880-895 (2014)
   PUBMED   24882218
REFERENCE   3  (bases 1 to 4971)
  AUTHORS   David Y, Ziv T, Admon A and Navon A.
  TITLE     The E2 ubiquitin-conjugating enzymes direct polyubiquitination to
            preferred lysines
  JOURNAL   J Biol Chem 285 (12), 8595-8604 (2010)
   PUBMED   20061386
REFERENCE   4  (bases 1 to 4971)
  AUTHORS   Rock JR and Harfe BD.
  TITLE     Expression of TMEM16 paralogs during murine embryogenesis
  JOURNAL   Dev Dyn 237 (9), 2566-2574 (2008)
   PUBMED   18729231
REFERENCE   5  (bases 1 to 4971)
  AUTHORS   Song S, Lee H, Kam TI, Tai ML, Lee JY, Noh JY, Shim SM, Seo SJ,
            Kong YY, Nakagawa T, Chung CW, Choi DY, Oubrahim H and Jung YK.
  TITLE     E2-25K/Hip-2 regulates caspase-12 in ER stress-mediated Abeta
            neurotoxicity
  JOURNAL   J Cell Biol 182 (4), 675-684 (2008)
   PUBMED   18710920
REFERENCE   6  (bases 1 to 4971)
  AUTHORS   Wassler MJ, Shur BD, Zhou W and Geng YJ.
  TITLE     Characterization of a novel ubiquitin-conjugating enzyme that
            regulates beta1,4-galactosyltransferase-1 in embryonic stem cells
  JOURNAL   Stem Cells 26 (8), 2006-2018 (2008)
   PUBMED   18511602
REFERENCE   7  (bases 1 to 4971)
  AUTHORS   Nathan JA, Sengupta S, Wood SA, Admon A, Markson G, Sanderson C and
            Lehner PJ.
  TITLE     The ubiquitin E3 ligase MARCH7 is differentially regulated by the
            deubiquitylating enzymes USP7 and USP9X
  JOURNAL   Traffic 9 (7), 1130-1145 (2008)
   PUBMED   18410486
REFERENCE   8  (bases 1 to 4971)
  AUTHORS   Christensen DE, Brzovic PS and Klevit RE.
  TITLE     E2-BRCA1 RING interactions dictate synthesis of mono- or specific
            polyubiquitin chain linkages
  JOURNAL   Nat Struct Mol Biol 14 (10), 941-948 (2007)
   PUBMED   17873885
REFERENCE   9  (bases 1 to 4971)
  AUTHORS   Yamada M, Ohnishi J, Ohkawara B, Iemura S, Satoh K, Hyodo-Miura J,
            Kawachi K, Natsume T and Shibuya H.
  TITLE     NARF, an nemo-like kinase (NLK)-associated ring finger protein
            regulates the ubiquitylation and degradation of T cell
            factor/lymphoid enhancer factor (TCF/LEF)
  JOURNAL   J Biol Chem 281 (30), 20749-20760 (2006)
   PUBMED   16714285
REFERENCE   10 (bases 1 to 4971)
  AUTHORS   Navarro-Lerida I, Martinez Moreno M, Roncal F, Gavilanes F, Albar
            JP and Rodriguez-Crespo I.
  TITLE     Proteomic identification of brain proteins that interact with
            dynein light chain LC8
  JOURNAL   Proteomics 4 (2), 339-346 (2004)
   PUBMED   14760703
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473981.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_214043.4, XM_001071289.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ226880.1, FQ234076.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4971
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p11"
     gene            1..4971
                     /gene="Ube2k"
                     /gene_synonym="E2-25k; Hip2; Hypg; Lig"
                     /note="ubiquitin-conjugating enzyme E2K"
                     /db_xref="GeneID:289623"
                     /db_xref="RGD:1311626"
     exon            1..275
                     /gene="Ube2k"
                     /gene_synonym="E2-25k; Hip2; Hypg; Lig"
                     /inference="alignment:Splign:2.1.0"
     CDS             213..815
                     /gene="Ube2k"
                     /gene_synonym="E2-25k; Hip2; Hypg; Lig"
                     /EC_number="6.3.2.19"
                     /note="ubiquitin-conjugating enzyme E2-25K; huntingtin
                     interacting protein 2; ubiquitin-conjugating enzyme E2K
                     (UBC1 homolog, yeast)"
                     /codon_start=1
                     /product="ubiquitin-conjugating enzyme E2 K"
                     /protein_id="NP_001099476.1"
                     /db_xref="GeneID:289623"
                     /db_xref="RGD:1311626"
                     /translation="MANIAVQRIKREFKEVLKSEETSKNQIKVDLVDENFTELRGEIA
                     GPPDTPYEGGRYQLEIKIPETYPFNPPKVRFITKIWHPNISSVTGAICLDILKDQWAA
                     AMTLRTVLLSLQALLAAAEPDDPQDAVVANQYKQNPEMFKQTARLWAHVYAGAPVSSP
                     EYTKKIENLCAMGFDRNAVIVALSSKSWDVETATELLLSN"
     exon            276..369
                     /gene="Ube2k"
                     /gene_synonym="E2-25k; Hip2; Hypg; Lig"
                     /inference="alignment:Splign:2.1.0"
     exon            370..428
                     /gene="Ube2k"
                     /gene_synonym="E2-25k; Hip2; Hypg; Lig"
                     /inference="alignment:Splign:2.1.0"
     exon            429..511
                     /gene="Ube2k"
                     /gene_synonym="E2-25k; Hip2; Hypg; Lig"
                     /inference="alignment:Splign:2.1.0"
     exon            512..611
                     /gene="Ube2k"
                     /gene_synonym="E2-25k; Hip2; Hypg; Lig"
                     /inference="alignment:Splign:2.1.0"
     exon            612..740
                     /gene="Ube2k"
                     /gene_synonym="E2-25k; Hip2; Hypg; Lig"
                     /inference="alignment:Splign:2.1.0"
     exon            741..4971
                     /gene="Ube2k"
                     /gene_synonym="E2-25k; Hip2; Hypg; Lig"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgcatgcgc ggacccggcg ccattttggt ggccgggcgc ggaggtgatt ctacactgag
       61 ggggaacgcg acggcaaggg tggcagtggc agcgttcgtg tgctcgggtc tgaatcactg
      121 agggaggagg cggtggagga agaggtggca gcggtggcgg tggtcgtagc ggtggcggag
      181 gaggcgggta cgaatcagct gcgggcagag acatggccaa catcgcggtg cagcgaatca
      241 agcgggagtt caaggaggtg ctgaagagcg aggagacgag caaaaatcaa attaaagtag
      301 atcttgtaga tgagaatttt acagaattaa gaggagaaat agcaggacct ccagacacac
      361 cgtatgaagg tggaagatat caactagaga taaaaatacc agaaacatat ccatttaacc
      421 cccctaaggt ccggtttatc actaaaatat ggcaccctaa tattagttcc gtcacagggg
      481 ctatttgttt ggatatcctg aaagatcaat gggcagcagc aatgactctg cgcacagtat
      541 tattgtcatt gcaagcactg ctggccgctg cagaaccaga tgacccccaa gatgcagtag
      601 tagcaaatca gtacaaacaa aatcctgaaa tgttcaagca gacagctcga ctttgggcac
      661 acgtgtatgc tggagcacca gtgtctagtc cagaatacac caaaaaaata gaaaacctct
      721 gtgctatggg ttttgatagg aacgcagtaa tagtggcctt gtcttcaaaa tcatgggatg
      781 tagagactgc aacagaactg cttctgagta actgaggcac aggagctgcc agccacgctc
      841 gccccttcct gaggagcgtc cacacctgtc atttttagga ttctgcataa atttctttta
      901 aactggcatt cttgcctaat gatgttacct aggcaccatt ggagactgca aaaaaaaaaa
      961 aaaaaattac ctgctctgta aataaagcta attaaacgtc tgtgtaaatt taaaaaggga
     1021 aaatacttta atttttttct tggtagtgta aaaatccttt gagctaagct aaaaccatgg
     1081 gaaaacatgc tactttagtg tttagcagtg tgacagacta gtgagtttgc ttcagggttc
     1141 tgttgagtaa ctaggataac actcgagtgt tggccctacc ttgtggagta gcatcacagt
     1201 ccctcaagcc tgaacatgga tcctctgtgc ctgtgactta cttgcatgct tgacctctta
     1261 gaacgggtag ctgaaagacc acccttttaa gcgttaggac atttttgaat tatgagattt
     1321 atcctgattt aaagatggtg acctaatcag agctttttcg tccctgtgga ctggtgggga
     1381 ctgtcttttt tccttgtcac catccagagt ggagagtctc atggtcagtt tcttttgtgt
     1441 ttggtgggaa acgtgctgag gaacagtgtc ccgtgttcca cttttagctc ataggtttgg
     1501 aatgttttgt ccaagctctt cactttgtaa gtaggaatgt aacaaaggag ctgccaattt
     1561 catttctctt ataaaaggag aaaatacttg atgttgcagt atttccagat ttaataaaag
     1621 gacactgctt agtttttcag tgattttgac attaagtttt aaaatgataa agtctttgga
     1681 aacttgaagg gtgcagcacc tgtcccctcg tgctcagcct gagttgggcg tgacagtttt
     1741 ctttgtcaga cacttgagtt actgcactcc ccatgttgac acacgaaagc tgtggtgtct
     1801 cgctgtacat accagatgca cataggaaca ggggtgtgct ctaaatctag ctttttatga
     1861 tgtttctgat aatgtgagaa ttgaaacttt accttttctt gtacatagac ttcctgtcct
     1921 tagtaactgt cgtatctcat tctaagttcc aaagcttgaa aattaatagt tttgcaaatt
     1981 ggttttgcaa actcagatac ttaatttaac catctttatt aaggttcaag tgaatttatg
     2041 taggcagttg ttacatagga gatataatta aagattttga gaaccaatgc ataaattaca
     2101 gaaatgtaat ggaatcagac tgagttaaag taaggctgta tgtatattga aagtcatatt
     2161 ctaaaaggtt tgtttctcga agagttgatt gatcttatag tcatgaagta tttcaaaaat
     2221 actttctgaa cctattaact cagcataact tcatttgact tttaataatc tcgatactac
     2281 aagcaataaa tgagccatca atacattaca ttacagatgt gaaggttctt ccagcagctc
     2341 ataaggcttt cccagtcaac agtgacttgg gctcgctgcc ctgcactaag ctcaggctgc
     2401 tgctccccat gtctgtgatg cacacattcc cgcccgcggc agctacatcc ttattgctgt
     2461 aggtcatttt ataaagatgc caaaggagac aaggttttct ttattttcaa tagctgggac
     2521 tttgtctttt tctttatctt ctcagataag ctggaaatgt cagaaattct ggaccgttga
     2581 cctccgttgt cagttaggac tgtttaatgg agggtggtaa cattgatatt taggtatgga
     2641 aatgcataca tcttccttgc attcctctct gcctgcattg tcagggcgta gtgtctgggt
     2701 agacgtcaag cagcaccact ttgtcttgga ggcagctgtt tctacttatt gtcttttttt
     2761 tttttttttt tggttctttt ttttcggagc tggggactga acccagggcc ttgcgcttcc
     2821 taggtaagcg ctctaccact gagctaaatc cccagaccct ttgtttttta ttttatattt
     2881 tttgcatatt ggtttcagac agcttccatg tgtgcatata acatggtgtc atagatttta
     2941 catgattatg ctatcatctc tgtgacccta gaacttgggt gtgagaacca tgaactcaag
     3001 gctgtccagg tttcatacac caggctgctt gggggttttc ttcatttaat atgatcatag
     3061 accttctgtg ggacttcctc actgttctcc tggtggtctt tttattcttt tatttcccat
     3121 cttgtaggtt tagttcatct taaagcagag gcttaggctt ctatcctggt tttacataca
     3181 tttaggaaaa ctactcaaaa tctagatcta gtaaaacttg ccccgatgga aattattttt
     3241 gtaaatttca tttgagagtt tatcatctta gtgagtcctg aaaaggttct gtcttggtct
     3301 aggcgtggtg gcgcctttac tcccatgctc tggaaaggga aaggcaggca gcttctgtga
     3361 gacacctcgt gggaggtgtg tgtccagtct taacccctac tccacagtct tagtgaaatc
     3421 ccagttagga ttccttggta ctcgctggtc ctctgacatg cttttacata atccagcctt
     3481 tttttcctga gcctatgcct gacttttagt ataaaacttt gagcatgttg ggaactttga
     3541 attcaaaaaa catgtaagtg tttggaatca aatattttgc ctttgagaag tgtaacttac
     3601 ctatcaaatg agattaaaac attttttgaa atttttttat atttctgatt gttgatggca
     3661 tttaacacta tgcaaaaact caagtatctg cagaaaacag ttgacagcgg gcttcgctcc
     3721 cactgtagaa cacagcgtgt tatatatcac tggtgaggct gttgaccaag ttgacaaatg
     3781 tggaagccgg gttgtgagcg taggcctcac acagctttta aaactgcagg agagttacgg
     3841 ttttgcagtc tagtgtagca gcacagaagt gaagtttcgg tagggtacgg gcttaatgcg
     3901 aatttgggaa tcagcagtgg agtcaggtat actgtacata gatggattcc atgtgtagat
     3961 gggaaaagga aggtatctgt tcatactgag ctttatttca tgactgataa aactgttctg
     4021 tattaattac tttttctagt tccaaggagt tgatctttca agtcacattt tcatctttca
     4081 gaatctggtt taagtcagcg tgtgcccatc agcctgttgg tgtcactgag gaacagcctt
     4141 ttctcgaaca gtgtctacgg ttctgatgca cagatacact gtttgcagtg ttgcaatgca
     4201 gagaacaaac tgcagcttac attggtgcgg gtgagggtgg gggttgttgg cgtttccctt
     4261 acctatcttg ctactgcttt ctcagactgc cagaacccct gcctgcaggc gtcactggaa
     4321 ggtgtcccga ttgtgttgtc tgtggcatgg ttactcccac cacgctgctg tttgtcctca
     4381 ggtgtggcac aggtctcttt ggttctaggc aagtggatca agtcactgca ctgtgctttc
     4441 actgatcgtg tctgcttacc gtcacctact tatacaggca tcataaaagc tagacaattt
     4501 ctttggggga aaagagactt atttaatgta atttaaagag ttttccaata aaaaatggaa
     4561 tattattaaa tatctatttt tagctttcag cctttgatgg tgctttgtcg tgctttgctg
     4621 gaagctactg acgttatagg gatttccatt aacctcactt tggaagagcc ttgcttgtta
     4681 gcttctttag gtctctgaac agtttgttag tgatggtaaa ttctgtagga gggtctattc
     4741 tgagccatta acttcttgta aggggaaaac gggctggtta ccagaaacac tgctgaagca
     4801 gggcggctgt gggtggaggg tcgggcgtct gtcttgagaa ttaaaaacta cgaaacactt
     4861 ttgtatacaa atttttaaaa aaaaataaac acatttttaa agatgttgaa ctttccccct
     4921 tattgggaat tcttaaaaat aaatgcatgc acattccccc ccgccccccg t
//
