LOCUS       NM_013050               1071 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus ubiquitin-conjugating enzyme E2I (Ube2i), mRNA.
ACCESSION   NM_013050
VERSION     NM_013050.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1071)
  AUTHORS   Tang,B., Hu,Y., Wang,Z., Cheng,C., Wang,P., Liang,L., Xiong,H.,
            Luo,C., Xu,C., Chen,Q. and Wang,Q.K.
  TITLE     UBC9 regulates cardiac sodium channel Nav1.5 ubiquitination,
            degradation and sodium current density
  JOURNAL   J Mol Cell Cardiol 129, 79-91 (2019)
   PUBMED   30772377
  REMARK    GeneRIF: UBC9 regulates Nav1.5 expression levels in a
            SUMOylation-independent manner.
REFERENCE   2  (bases 1 to 1071)
  AUTHORS   Sin,Y., Tanaka,K. and Saijo,M.
  TITLE     The C-terminal Region and SUMOylation of Cockayne Syndrome Group B
            Protein Play Critical Roles in Transcription-coupled Nucleotide
            Excision Repair
  JOURNAL   J Biol Chem 291 (3), 1387-1397 (2016)
   PUBMED   26620705
REFERENCE   3  (bases 1 to 1071)
  AUTHORS   Baumgarten,A., Bang,C., Tschirner,A., Engelmann,A., Adams,V., von
            Haehling,S., Doehner,W., Pregla,R., Anker,M.S., Blecharz,K.,
            Meyer,R., Hetzer,R., Anker,S.D., Thum,T. and Springer,J.
  TITLE     TWIST1 regulates the activity of ubiquitin proteasome system via
            the miR-199/214 cluster in human end-stage dilated cardiomyopathy
  JOURNAL   Int J Cardiol 168 (2), 1447-1452 (2013)
   PUBMED   23360823
REFERENCE   4  (bases 1 to 1071)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   5  (bases 1 to 1071)
  AUTHORS   Jang,C.Y., Shin,H.S., Kim,H.D., Kim,J.W., Choi,S.Y. and Kim,J.
  TITLE     Ribosomal protein S3 is stabilized by sumoylation
  JOURNAL   Biochem Biophys Res Commun 414 (3), 523-527 (2011)
   PUBMED   21968017
REFERENCE   6  (bases 1 to 1071)
  AUTHORS   Duprez,E., Saurin,A.J., Desterro,J.M., Lallemand-Breitenbach,V.,
            Howe,K., Boddy,M.N., Solomon,E., de The,H., Hay,R.T. and
            Freemont,P.S.
  TITLE     SUMO-1 modification of the acute promyelocytic leukaemia protein
            PML: implications for nuclear localisation
  JOURNAL   J Cell Sci 112 (Pt 3), 381-393 (1999)
   PUBMED   9885291
REFERENCE   7  (bases 1 to 1071)
  AUTHORS   Lee,G.W., Melchior,F., Matunis,M.J., Mahajan,R., Tian,Q. and
            Anderson,P.
  TITLE     Modification of Ran GTPase-activating protein by the small
            ubiquitin-related modifier SUMO-1 requires Ubc9, an E2-type
            ubiquitin-conjugating enzyme homologue
  JOURNAL   J Biol Chem 273 (11), 6503-6507 (1998)
   PUBMED   9497385
REFERENCE   8  (bases 1 to 1071)
  AUTHORS   Loveys,D.A., Streiff,M.B., Schaefer,T.S. and Kato,G.J.
  TITLE     The mUBC9 murine ubiquitin conjugating enzyme interacts with the
            E2A transcription factors
  JOURNAL   Gene 201 (1-2), 169-177 (1997)
   PUBMED   9409784
REFERENCE   9  (bases 1 to 1071)
  AUTHORS   Tashiro,K., Pando,M.P., Kanegae,Y., Wamsley,P.M., Inoue,S. and
            Verma,I.M.
  TITLE     Direct involvement of the ubiquitin-conjugating enzyme Ubc9/Hus5 in
            the degradation of IkappaBalpha
  JOURNAL   Proc Natl Acad Sci U S A 94 (15), 7862-7867 (1997)
   PUBMED   9223278
REFERENCE   10 (bases 1 to 1071)
  AUTHORS   Kho,C.J., Huggins,G.S., Endege,W.O., Hsieh,C.M., Lee,M.E. and
            Haber,E.
  TITLE     Degradation of E2A proteins through a ubiquitin-conjugating enzyme,
            UbcE2A
  JOURNAL   J Biol Chem 272 (6), 3845-3851 (1997)
   PUBMED   9013644
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            [WARNING] On Apr 2, 2024 this sequence was replaced by NM_013050.3.
            
            On Nov 26, 2020 this sequence version replaced NM_013050.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC086592.1, U54632.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760475 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-68                JAXUCZ010000010.1  14798187-14798254   c
            69-145              JAXUCZ010000010.1  14793721-14793797   c
            146-229             JAXUCZ010000010.1  14793510-14793593   c
            230-302             JAXUCZ010000010.1  14792607-14792679   c
            303-412             JAXUCZ010000010.1  14788634-14788743   c
            413-492             JAXUCZ010000010.1  14786392-14786471   c
            493-1071            JAXUCZ010000010.1  14783651-14784229   c
FEATURES             Location/Qualifiers
     source          1..1071
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q12"
     gene            1..1071
                     /gene="Ube2i"
                     /gene_synonym="Ubc9; UbcE2A"
                     /note="ubiquitin-conjugating enzyme E2I"
                     /db_xref="GeneID:25573"
                     /db_xref="RGD:3926"
     exon            1..68
                     /gene="Ube2i"
                     /gene_synonym="Ubc9; UbcE2A"
                     /inference="alignment:Splign:2.1.0"
     exon            69..145
                     /gene="Ube2i"
                     /gene_synonym="Ubc9; UbcE2A"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..556
                     /gene="Ube2i"
                     /gene_synonym="Ubc9; UbcE2A"
                     /EC_number="6.3.2.19"
                     /note="SUMO-protein ligase; RING-type E3 SUMO transferase
                     UBC9; ubiquitin-protein ligase I; ubiquitin carrier
                     protein 9; ubiquitin carrier protein I;
                     ubiquitin-conjugating enzyme UbcE2A; Ubiquitin conjugating
                     enzyme E2I (homologous to yeast UBC9);
                     ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)"
                     /codon_start=1
                     /product="SUMO-conjugating enzyme UBC9"
                     /protein_id="NP_037182.1"
                     /db_xref="GeneID:25573"
                     /db_xref="RGD:3926"
                     /translation="MSGIALSRLAQERKAWRKDHPFGFVAVPTKNPDGTMNLMNWECA
                     IPGKKGTPWEGGLFKLRMLFKDDYPSSPPKCKFEPPLFHPNVYPSGTVCLSILEEDKD
                     WRPAITIKQILLGIQELLNEPNIQDPAQAEAYTIYCQNRVEYEKRVRAQAKKFAPS"
     exon            146..229
                     /gene="Ube2i"
                     /gene_synonym="Ubc9; UbcE2A"
                     /inference="alignment:Splign:2.1.0"
     exon            230..302
                     /gene="Ube2i"
                     /gene_synonym="Ubc9; UbcE2A"
                     /inference="alignment:Splign:2.1.0"
     exon            303..412
                     /gene="Ube2i"
                     /gene_synonym="Ubc9; UbcE2A"
                     /inference="alignment:Splign:2.1.0"
     exon            413..492
                     /gene="Ube2i"
                     /gene_synonym="Ubc9; UbcE2A"
                     /inference="alignment:Splign:2.1.0"
     exon            493..1071
                     /gene="Ube2i"
                     /gene_synonym="Ubc9; UbcE2A"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggaagtccc gagacaaagg agcgccgccg cctctgccgc cgcgacggtc cgggccgcgg
       61 tcgcccaggg actttgaata tgtcggggat tgccctcagc cgacttgcgc aggagaggaa
      121 agcctggagg aaggaccacc cttttggctt tgtggctgtc ccaacaaaga accctgatgg
      181 cacgatgaac ctgatgaact gggagtgtgc tatccctgga aagaagggga ctccgtggga
      241 aggaggcttg ttcaagctac ggatgctttt caaagatgac tatccgtcct caccaccaaa
      301 atgtaaattt gagccaccac tgtttcatcc aaacgtgtat ccttctggca cagtgtgcct
      361 gtccatcctg gaggaagaca aggactggcg gccagctatt acgatcaaac agatcttatt
      421 aggaatacaa gaacttctaa atgaaccaaa tattcaagac ccagctcaag cagaggccta
      481 tacaatttac tgccaaaaca gagtggaata tgagaaaagg gttcgagcac aagcgaagaa
      541 gtttgccccc tcataagcag cggcccgggc tccatgacga ggaagggatt ggcttggcaa
      601 gaacttgttt acaacctttt gcagatctaa gtcgctccgt acagttacta gtagcctggg
      661 agggttgagc gggcgccatt ttccatttcc gccactggca tattcagtct tttgtatttt
      721 tgattattga gtaaaacttg cttttatttt aatattgatg tcagtatttc aactgctgta
      781 aaatgataaa cttttgtact tggtaagccc ctaggagcta gtttcttctc gtcgcgctcg
      841 gatgcaggca tgcttcccac tgttcagagc tctggcctcc agctggctgt atgacagaac
      901 cacactgtcc ctccttcctt ccctaccctc gtccttctca gaaacctggg ctgttgctta
      961 tgagcctcag atccaaagtt ggccagcatc tccattctgc accacttcct ttgtgtttat
     1021 atggcgtttt gtctgtgttg ctgtttagag taaataaact gtttatataa a
//
