LOCUS       NM_001399579            1467 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus ubiquitin-conjugating enzyme E2E 1 (Ube2e1),
            mRNA.
ACCESSION   NM_001399579 XM_017599838
VERSION     NM_001399579.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1467)
  AUTHORS   Han,X., Gui,B., Xiong,C., Zhao,L., Liang,J., Sun,L., Yang,X.,
            Yu,W., Si,W., Yan,R., Yi,X., Zhang,D., Li,W., Li,L., Yang,J.,
            Wang,Y., Sun,Y.E., Zhang,D., Meng,A. and Shang,Y.
  TITLE     Destabilizing LSD1 by Jade-2 promotes neurogenesis: an antibraking
            system in neural development
  JOURNAL   Mol Cell 55 (3), 482-494 (2014)
   PUBMED   25018020
REFERENCE   2  (bases 1 to 1467)
  AUTHORS   David,Y., Ziv,T., Admon,A. and Navon,A.
  TITLE     The E2 ubiquitin-conjugating enzymes direct polyubiquitination to
            preferred lysines
  JOURNAL   J Biol Chem 285 (12), 8595-8604 (2010)
   PUBMED   20061386
REFERENCE   3  (bases 1 to 1467)
  AUTHORS   Espinosa,A., Oke,V., Elfving,A., Nyberg,F., Covacu,R. and
            Wahren-Herlenius,M.
  TITLE     The autoantigen Ro52 is an E3 ligase resident in the cytoplasm but
            enters the nucleus upon cellular exposure to nitric oxide
  JOURNAL   Exp Cell Res 314 (20), 3605-3613 (2008)
   PUBMED   18845142
REFERENCE   4  (bases 1 to 1467)
  AUTHORS   Nishito,Y., Hasegawa,M., Inohara,N. and Nunez,G.
  TITLE     MEX is a testis-specific E3 ubiquitin ligase that promotes death
            receptor-induced apoptosis
  JOURNAL   Biochem J 396 (3), 411-417 (2006)
   PUBMED   16522193
REFERENCE   5  (bases 1 to 1467)
  AUTHORS   Takeuchi,T., Iwahara,S., Saeki,Y., Sasajima,H. and Yokosawa,H.
  TITLE     Link between the ubiquitin conjugation system and the ISG15
            conjugation system: ISG15 conjugation to the UbcH6 ubiquitin E2
            enzyme
  JOURNAL   J Biochem 138 (6), 711-719 (2005)
   PUBMED   16428300
REFERENCE   6  (bases 1 to 1467)
  AUTHORS   Zhu,B., Zheng,Y., Pham,A.D., Mandal,S.S., Erdjument-Bromage,H.,
            Tempst,P. and Reinberg,D.
  TITLE     Monoubiquitination of human histone H2B: the factors involved and
            their roles in HOX gene regulation
  JOURNAL   Mol Cell 20 (4), 601-611 (2005)
   PUBMED   16307923
REFERENCE   7  (bases 1 to 1467)
  AUTHORS   Hu,Y., Nguyen,T.T., Bui,K.C., Demello,D.E. and Smith,J.B.
  TITLE     A novel inflammation-induced ubiquitin E3 ligase in alveolar type
            II cells
  JOURNAL   Biochem Biophys Res Commun 333 (1), 253-263 (2005)
   PUBMED   15936721
REFERENCE   8  (bases 1 to 1467)
  AUTHORS   Rajendra,R., Malegaonkar,D., Pungaliya,P., Marshall,H., Rasheed,Z.,
            Brownell,J., Liu,L.F., Lutzker,S., Saleem,A. and Rubin,E.H.
  TITLE     Topors functions as an E3 ubiquitin ligase with specific E2 enzymes
            and ubiquitinates p53
  JOURNAL   J Biol Chem 279 (35), 36440-36444 (2004)
   PUBMED   15247280
REFERENCE   9  (bases 1 to 1467)
  AUTHORS   Anan,T., Nagata,Y., Koga,H., Honda,Y., Yabuki,N., Miyamoto,C.,
            Kuwano,A., Matsuda,I., Endo,F., Saya,H. and Nakao,M.
  TITLE     Human ubiquitin-protein ligase Nedd4: expression, subcellular
            localization and selective interaction with ubiquitin-conjugating
            enzymes
  JOURNAL   Genes Cells 3 (11), 751-763 (1998)
   PUBMED   9990509
REFERENCE   10 (bases 1 to 1467)
  AUTHORS   Matuschewski,K., Hauser,H.P., Treier,M. and Jentsch,S.
  TITLE     Identification of a novel family of ubiquitin-conjugating enzymes
            with distinct amino-terminal extensions
  JOURNAL   J Biol Chem 271 (5), 2789-2794 (1996)
   PUBMED   8576256
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On Jan 12, 2022 this sequence version replaced XM_017599838.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079134.1, SRR22399492.136415.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-184               JAXUCZ010000015.1  9870542-9870725
            185-369             JAXUCZ010000015.1  9871264-9871448
            370-420             JAXUCZ010000015.1  9875586-9875636
            421-553             JAXUCZ010000015.1  9921618-9921750
            554-701             JAXUCZ010000015.1  9922395-9922542
            702-1467            JAXUCZ010000015.1  9923429-9924194
FEATURES             Location/Qualifiers
     source          1..1467
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p16"
     gene            1..1467
                     /gene="Ube2e1"
                     /note="ubiquitin-conjugating enzyme E2E 1"
                     /db_xref="GeneID:100366017"
                     /db_xref="RGD:2324438"
     exon            1..184
                     /gene="Ube2e1"
                     /inference="alignment:Splign:2.1.0"
     exon            185..369
                     /gene="Ube2e1"
                     /inference="alignment:Splign:2.1.0"
     CDS             218..799
                     /gene="Ube2e1"
                     /codon_start=1
                     /product="ubiquitin-conjugating enzyme E2 E1"
                     /protein_id="NP_001386508.1"
                     /db_xref="GeneID:100366017"
                     /db_xref="RGD:2324438"
                     /translation="MSDDDSRASTSSSSSSSSNQQTEKEGSTPKKKESKVSMSKNSKL
                     LSTSAKRIQKELADITLDPPPNCSAGPKGDNIYEWRSTILGPPGSVYEGGVFFLDITF
                     TPEYPFKPPKVTFRTRIYHCNINSQGVICLDILKDNWSPALTISKVLLSICSLLTDCN
                     PADPLVGSIATQYMTNRAEHDRMARQWTKRYAT"
     exon            370..420
                     /gene="Ube2e1"
                     /inference="alignment:Splign:2.1.0"
     exon            421..553
                     /gene="Ube2e1"
                     /inference="alignment:Splign:2.1.0"
     exon            554..701
                     /gene="Ube2e1"
                     /inference="alignment:Splign:2.1.0"
     exon            702..1467
                     /gene="Ube2e1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcggggcgg agaggaggag tggcgcggag cgtgtgcggc cggggaagcc attgcctggt
       61 taatagttgc tgttgctgca cttccgcttc tctcccagcg agagcgagac acgagtggcc
      121 aggcccagcc gcagccgcag cagcagccgc ggcggcggca cggagcagcc agacacaaag
      181 agaggggccg ttcgcggggt ggggtggggg gttcgctatg tcggatgacg attcgagggc
      241 cagcaccagc tcttcctcat cttcgtcctc caaccagcag accgagaaag aaggcagcac
      301 ccccaagaag aaggagagta aagtcagcat gagcaaaaac tcgaagctcc tctccaccag
      361 tgccaagagg atccagaagg agctggcaga catcacttta gacccgccgc caaactgcag
      421 tgctggtccc aaaggtgaca acatctatga gtggagatca accattctgg ggcctccagg
      481 gtctgtgtat gaaggtggag tcttcttcct cgacatcact tttacaccag agtatccctt
      541 caagcctcca aaggttacgt ttcgtacaag aatttatcac tgtaatatta atagccaagg
      601 agttatctgc ttggacatat tgaaagacaa ctggagccca gcactaacca tctcgaaagt
      661 cctcctctct atctgctcac tccttacaga ctgcaatcct gccgaccctt tggtgggaag
      721 cattgccact cagtatatga ccaacagagc agagcacgac agaatggcca gacagtggac
      781 caagagatac gctacataaa ctgggttttc acagttctta catgattgtc tgtcacagaa
      841 gagagctgct tatgattttg aaagggtggg ggtgggagtt ggtaaagagt agggtatttc
      901 tataacagat attattcagt cttacttccc aggattttgt tgtaacttaa ggtatcttgc
      961 tacagtagac acagtggtaa tagcgacttt tagagctgtc actttgcaag attagctgac
     1021 ttagtacaac aggaaagaat gcatgtgtag acacttgtgt tccattgatt gtagtctact
     1081 gtactttcaa aaccagtttc aatttgtata ggtcacacac ggccatttat gtaaagtcct
     1141 attttctttt ttaaaaaagt tggaatttgt ttttccttct tagaaggaaa caatggtatt
     1201 taacaagttt gcaaagatga gtttgttacc tcgtatatgt aaaatggaca gctgactaca
     1261 agacaccatg taggaaacca ctagttaatg tattttattt tatatgcaaa ttacttcaag
     1321 agttagatca ggctttgtgg aaagctgtag tgaaatacct taagctgtta agtgtaagtg
     1381 cggagtagga actgctcagt cgattggttg atttagactt cttatgtctg catttgttac
     1441 tgtgctaata aaccatatta agaacaa
//
