LOCUS       NP_001386508             193 aa            linear   ROD 31-MAR-2024
DEFINITION  ubiquitin-conjugating enzyme E2 E1 [Rattus norvegicus].
ACCESSION   NP_001386508 XP_017455327
VERSION     NP_001386508.1
DBSOURCE    REFSEQ: accession NM_001399579.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 193)
  AUTHORS   Han,X., Gui,B., Xiong,C., Zhao,L., Liang,J., Sun,L., Yang,X.,
            Yu,W., Si,W., Yan,R., Yi,X., Zhang,D., Li,W., Li,L., Yang,J.,
            Wang,Y., Sun,Y.E., Zhang,D., Meng,A. and Shang,Y.
  TITLE     Destabilizing LSD1 by Jade-2 promotes neurogenesis: an antibraking
            system in neural development
  JOURNAL   Mol Cell 55 (3), 482-494 (2014)
   PUBMED   25018020
REFERENCE   2  (residues 1 to 193)
  AUTHORS   David,Y., Ziv,T., Admon,A. and Navon,A.
  TITLE     The E2 ubiquitin-conjugating enzymes direct polyubiquitination to
            preferred lysines
  JOURNAL   J Biol Chem 285 (12), 8595-8604 (2010)
   PUBMED   20061386
REFERENCE   3  (residues 1 to 193)
  AUTHORS   Espinosa,A., Oke,V., Elfving,A., Nyberg,F., Covacu,R. and
            Wahren-Herlenius,M.
  TITLE     The autoantigen Ro52 is an E3 ligase resident in the cytoplasm but
            enters the nucleus upon cellular exposure to nitric oxide
  JOURNAL   Exp Cell Res 314 (20), 3605-3613 (2008)
   PUBMED   18845142
REFERENCE   4  (residues 1 to 193)
  AUTHORS   Nishito,Y., Hasegawa,M., Inohara,N. and Nunez,G.
  TITLE     MEX is a testis-specific E3 ubiquitin ligase that promotes death
            receptor-induced apoptosis
  JOURNAL   Biochem J 396 (3), 411-417 (2006)
   PUBMED   16522193
REFERENCE   5  (residues 1 to 193)
  AUTHORS   Takeuchi,T., Iwahara,S., Saeki,Y., Sasajima,H. and Yokosawa,H.
  TITLE     Link between the ubiquitin conjugation system and the ISG15
            conjugation system: ISG15 conjugation to the UbcH6 ubiquitin E2
            enzyme
  JOURNAL   J Biochem 138 (6), 711-719 (2005)
   PUBMED   16428300
REFERENCE   6  (residues 1 to 193)
  AUTHORS   Zhu,B., Zheng,Y., Pham,A.D., Mandal,S.S., Erdjument-Bromage,H.,
            Tempst,P. and Reinberg,D.
  TITLE     Monoubiquitination of human histone H2B: the factors involved and
            their roles in HOX gene regulation
  JOURNAL   Mol Cell 20 (4), 601-611 (2005)
   PUBMED   16307923
REFERENCE   7  (residues 1 to 193)
  AUTHORS   Hu,Y., Nguyen,T.T., Bui,K.C., Demello,D.E. and Smith,J.B.
  TITLE     A novel inflammation-induced ubiquitin E3 ligase in alveolar type
            II cells
  JOURNAL   Biochem Biophys Res Commun 333 (1), 253-263 (2005)
   PUBMED   15936721
REFERENCE   8  (residues 1 to 193)
  AUTHORS   Rajendra,R., Malegaonkar,D., Pungaliya,P., Marshall,H., Rasheed,Z.,
            Brownell,J., Liu,L.F., Lutzker,S., Saleem,A. and Rubin,E.H.
  TITLE     Topors functions as an E3 ubiquitin ligase with specific E2 enzymes
            and ubiquitinates p53
  JOURNAL   J Biol Chem 279 (35), 36440-36444 (2004)
   PUBMED   15247280
REFERENCE   9  (residues 1 to 193)
  AUTHORS   Anan,T., Nagata,Y., Koga,H., Honda,Y., Yabuki,N., Miyamoto,C.,
            Kuwano,A., Matsuda,I., Endo,F., Saya,H. and Nakao,M.
  TITLE     Human ubiquitin-protein ligase Nedd4: expression, subcellular
            localization and selective interaction with ubiquitin-conjugating
            enzymes
  JOURNAL   Genes Cells 3 (11), 751-763 (1998)
   PUBMED   9990509
REFERENCE   10 (residues 1 to 193)
  AUTHORS   Matuschewski,K., Hauser,H.P., Treier,M. and Jentsch,S.
  TITLE     Identification of a novel family of ubiquitin-conjugating enzymes
            with distinct amino-terminal extensions
  JOURNAL   J Biol Chem 271 (5), 2789-2794 (1996)
   PUBMED   8576256
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On Jan 12, 2022 this sequence version replaced XP_017455327.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079134.1, SRR22399492.136415.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..193
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p16"
     Protein         1..193
                     /product="ubiquitin-conjugating enzyme E2 E1"
                     /calculated_mol_wt=21202
     Region          50..190
                     /region_name="UBCc_UBE2E"
                     /note="Ubiquitin-conjugating enzyme E2, catalytic (UBCc)
                     domain of ubiquitin conjugating enzyme E2 E1-E3 and
                     related proteins; cd23793"
                     /db_xref="CDD:467413"
     CDS             1..193
                     /gene="Ube2e1"
                     /coded_by="NM_001399579.1:218..799"
                     /db_xref="GeneID:100366017"
                     /db_xref="RGD:2324438"
ORIGIN      
        1 msdddsrast ssssssssnq qtekegstpk kkeskvsmsk nskllstsak riqkeladit
       61 ldpppncsag pkgdniyewr stilgppgsv yeggvffldi tftpeypfkp pkvtfrtriy
      121 hcninsqgvi cldilkdnws paltiskvll sicslltdcn padplvgsia tqymtnraeh
      181 drmarqwtkr yat
//
