LOCUS       NM_031237               1531 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus ubiquitin-conjugating enzyme E2D 3 (Ube2d3),
            mRNA.
ACCESSION   NM_031237
VERSION     NM_031237.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1531)
  AUTHORS   Wang,X., Yang,P., Jiang,Y., Xu,Y., Wang,N., Rao,P., Yang,L., Sun,L.
            and Lu,D.
  TITLE     UBE2D3 contributes to myocardial ischemia-reperfusion injury by
            regulating autophagy in dependence of p62/SQSTM1
  JOURNAL   Cell Signal 87, 110118 (2021)
   PUBMED   34391873
  REMARK    GeneRIF: UBE2D3 contributes to myocardial ischemia-reperfusion
            injury by regulating autophagy in dependence of p62/SQSTM1.
REFERENCE   2  (bases 1 to 1531)
  AUTHORS   Hasson,S.A., Kane,L.A., Yamano,K., Huang,C.H., Sliter,D.A.,
            Buehler,E., Wang,C., Heman-Ackah,S.M., Hessa,T., Guha,R.,
            Martin,S.E. and Youle,R.J.
  TITLE     High-content genome-wide RNAi screens identify regulators of parkin
            upstream of mitophagy
  JOURNAL   Nature 504 (7479), 291-295 (2013)
   PUBMED   24270810
REFERENCE   3  (bases 1 to 1531)
  AUTHORS   Tokumoto,M., Lee,J.Y., Fujiwara,Y., Uchiyama,M. and Satoh,M.
  TITLE     Inorganic arsenic induces apoptosis through downregulation of Ube2d
            genes and p53 accumulation in rat proximal tubular cells
  JOURNAL   J Toxicol Sci 38 (6), 815-820 (2013)
   PUBMED   24212999
REFERENCE   4  (bases 1 to 1531)
  AUTHORS   Zhang,L., Fairall,L., Goult,B.T., Calkin,A.C., Hong,C.,
            Millard,C.J., Tontonoz,P. and Schwabe,J.W.
  TITLE     The IDOL-UBE2D complex mediates sterol-dependent degradation of the
            LDL receptor
  JOURNAL   Genes Dev 25 (12), 1262-1274 (2011)
   PUBMED   21685362
REFERENCE   5  (bases 1 to 1531)
  AUTHORS   Wenzel,D.M., Lissounov,A., Brzovic,P.S. and Klevit,R.E.
  TITLE     UBCH7 reactivity profile reveals parkin and HHARI to be RING/HECT
            hybrids
  JOURNAL   Nature 474 (7349), 105-108 (2011)
   PUBMED   21532592
REFERENCE   6  (bases 1 to 1531)
  AUTHORS   Qiu,X.B., Markant,S.L., Yuan,J. and Goldberg,A.L.
  TITLE     Nrdp1-mediated degradation of the gigantic IAP, BRUCE, is a novel
            pathway for triggering apoptosis
  JOURNAL   EMBO J 23 (4), 800-810 (2004)
   PUBMED   14765125
REFERENCE   7  (bases 1 to 1531)
  AUTHORS   Lopez Salon,M., Morelli,L., Castano,E.M., Soto,E.F. and
            Pasquini,J.M.
  TITLE     Defective ubiquitination of cerebral proteins in Alzheimer's
            disease
  JOURNAL   J Neurosci Res 62 (2), 302-310 (2000)
   PUBMED   11020223
REFERENCE   8  (bases 1 to 1531)
  AUTHORS   Ohta,T., Michel,J.J., Schottelius,A.J. and Xiong,Y.
  TITLE     ROC1, a homolog of APC11, represents a family of cullin partners
            with an associated ubiquitin ligase activity
  JOURNAL   Mol Cell 3 (4), 535-541 (1999)
   PUBMED   10230407
REFERENCE   9  (bases 1 to 1531)
  AUTHORS   Anan,T., Nagata,Y., Koga,H., Honda,Y., Yabuki,N., Miyamoto,C.,
            Kuwano,A., Matsuda,I., Endo,F., Saya,H. and Nakao,M.
  TITLE     Human ubiquitin-protein ligase Nedd4: expression, subcellular
            localization and selective interaction with ubiquitin-conjugating
            enzymes
  JOURNAL   Genes Cells 3 (11), 751-763 (1998)
   PUBMED   9990509
REFERENCE   10 (bases 1 to 1531)
  AUTHORS   Wing,S.S. and Jain,P.
  TITLE     Molecular cloning, expression and characterization of a ubiquitin
            conjugation enzyme (E2(17)kB) highly expressed in rat testis
  JOURNAL   Biochem J 305 (Pt 1) (Pt 1), 125-132 (1995)
   PUBMED   7826319
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB006852.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB006852.1, CF110851.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1531
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q43"
     gene            1..1531
                     /gene="Ube2d3"
                     /note="ubiquitin-conjugating enzyme E2D 3"
                     /db_xref="GeneID:81920"
                     /db_xref="RGD:619912"
     exon            1..297
                     /gene="Ube2d3"
                     /inference="alignment:Splign:2.1.0"
     CDS             274..717
                     /gene="Ube2d3"
                     /EC_number="2.3.2.23"
                     /EC_number="2.3.2.24"
                     /note="PAPase; E2(17)KB 3; phosphoarginine phosphatase;
                     ubiquitin-protein ligase D3; ubiquitin carrier protein D3;
                     ubiquitin-conjugating enzyme E2-17 kDa 3;
                     ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog,
                     yeast); ubiquitin-conjugating enzyme E2(17)KB 3;
                     ubiquitin-conjugating enzyme E2D 3 (homologous to yeast
                     UBC4/5); E2 ubiquitin-conjugating enzyme D3;
                     (E3-independent) E2 ubiquitin-conjugating enzyme D3"
                     /codon_start=1
                     /product="ubiquitin-conjugating enzyme E2 D3"
                     /protein_id="NP_112516.1"
                     /db_xref="GeneID:81920"
                     /db_xref="RGD:619912"
                     /translation="MALKRINKELSDLARDPPAQCSAGPVGDDMFHWQATIMGPNDSP
                     YQGGVFFLTIHFPTDYPFKPPKVAFTTRIYHPNINSNGSICLDILRSQWSPALTISKV
                     LLSICSLLCDPNPDDPLVPEIARIYKTDRDKYNRISREWTQKYAM"
     exon            298..361
                     /gene="Ube2d3"
                     /inference="alignment:Splign:2.1.0"
     exon            362..393
                     /gene="Ube2d3"
                     /inference="alignment:Splign:2.1.0"
     exon            394..471
                     /gene="Ube2d3"
                     /inference="alignment:Splign:2.1.0"
     exon            472..577
                     /gene="Ube2d3"
                     /inference="alignment:Splign:2.1.0"
     exon            578..671
                     /gene="Ube2d3"
                     /inference="alignment:Splign:2.1.0"
     exon            672..1531
                     /gene="Ube2d3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctctgggcga agcgcggata taagtagctg gtggctctgc caccccaccc tgcccggatc
       61 gcgacggttt tcagggttct ggaatcagca gggttcctct gaggccttgg cgagtggctg
      121 atctgctccg tttttgcaaa aggcgcctgt gtctggcaga gccggtgtga gaagaagaga
      181 gaatccttcc ccgccgccgg gataatcaag agttttggcc ggacctttga gtacacatcg
      241 ggatagtgag aagcccggcg aaaagcacag actatggcgc tgaaacggat taataaggaa
      301 cttagtgatt tggcccgtga ccctccagca caatgttctg caggtccagt tggagatgac
      361 atgtttcatt ggcaagccac aattatggga cctaatgaca gcccatatca aggtggtgta
      421 ttctttttga caattcattt tcctacagac taccccttca aaccacctaa ggttgcattt
      481 acaacaagaa tttatcatcc aaatattaac agtaatggca gcatttgtct tgatattcta
      541 agatcacagt ggtctcctgc tttaactatt tctaaagttc ttttatccat ttgttcactg
      601 ctatgtgatc caaacccaga tgacccccta gtgccagaga ttgcacggat ctataaaaca
      661 gacagagaca agtacaacag aatatctcgg gaatggactc agaagtatgc catgtgatgc
      721 taccttaaag tcagaataac ctgcattata gctggaataa actttaaatt actgttcctt
      781 ttttgatttt cttatccggc tgctccccta tcagacctca tcttttttaa ttttattttt
      841 tgtttccctc cctccattca ttcacatgct catctgagaa gacctaagtt cttccagctt
      901 tggacaataa ctgcttttag aaactgtaaa gtagttacaa gagaacagtt gcccaagatt
      961 cagaaatttt tttaaaactg gagcatgtgt attatgtggc caatgtcttc actctaactt
     1021 ggttatgaga ctaaaccaat cctcactgct ctaacatgct gaagaagcca tctgaggggg
     1081 agggggatgg atgctgagct gtcacatcaa aggaaacagc attattccag cagcatccat
     1141 tcttgtctaa accttccact gttagagatt tgaggttaca tgatatactt tatgctcata
     1201 actgatgtgg ctggagaatt ggtattgaat tatagcatca gcagaacaga aaatgtgatg
     1261 tattttatgc atgtcaataa aggaatgacc tgttcttgtt ctacagagaa tggaaattgg
     1321 aagtcaaaca ccctttgtat tccaaaatag ggtctcaaaa cattttgtaa ttttcattta
     1381 aattgttagg cttggagcta ttagttaatc tatcttccaa tactgtttaa tatagcactg
     1441 aataaatgat gcgagttgtc aatggatgag tgatcaacta atagctctcc tagtaattga
     1501 tttatttttc ttcaataaag ttgcataaac c
//
