LOCUS       NM_031001               1499 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus ubiquitin-conjugating enzyme E2D 2B (Ube2d2b),
            mRNA.
ACCESSION   NM_031001
VERSION     NM_031001.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1499)
  AUTHORS   Tokumoto,M., Lee,J.Y., Fujiwara,Y., Uchiyama,M. and Satoh,M.
  TITLE     Inorganic arsenic induces apoptosis through downregulation of Ube2d
            genes and p53 accumulation in rat proximal tubular cells
  JOURNAL   J Toxicol Sci 38 (6), 815-820 (2013)
   PUBMED   24212999
REFERENCE   2  (bases 1 to 1499)
  AUTHORS   Zhang,L., Fairall,L., Goult,B.T., Calkin,A.C., Hong,C.,
            Millard,C.J., Tontonoz,P. and Schwabe,J.W.
  TITLE     The IDOL-UBE2D complex mediates sterol-dependent degradation of the
            LDL receptor
  JOURNAL   Genes Dev 25 (12), 1262-1274 (2011)
   PUBMED   21685362
REFERENCE   3  (bases 1 to 1499)
  AUTHORS   Tokumoto,M., Fujiwara,Y., Shimada,A., Hasegawa,T., Seko,Y.,
            Nagase,H. and Satoh,M.
  TITLE     Cadmium toxicity is caused by accumulation of p53 through the
            down-regulation of Ube2d family genes in vitro and in vivo
  JOURNAL   J Toxicol Sci 36 (2), 191-200 (2011)
   PUBMED   21467746
REFERENCE   4  (bases 1 to 1499)
  AUTHORS   David,Y., Ziv,T., Admon,A. and Navon,A.
  TITLE     The E2 ubiquitin-conjugating enzymes direct polyubiquitination to
            preferred lysines
  JOURNAL   J Biol Chem 285 (12), 8595-8604 (2010)
   PUBMED   20061386
REFERENCE   5  (bases 1 to 1499)
  AUTHORS   Lopez Salon,M., Morelli,L., Castano,E.M., Soto,E.F. and
            Pasquini,J.M.
  TITLE     Defective ubiquitination of cerebral proteins in Alzheimer's
            disease
  JOURNAL   J Neurosci Res 62 (2), 302-310 (2000)
   PUBMED   11020223
REFERENCE   6  (bases 1 to 1499)
  AUTHORS   Wing,S.S., Bedard,N., Morales,C., Hingamp,P. and Trasler,J.
  TITLE     A novel rat homolog of the Saccharomyces cerevisiae
            ubiquitin-conjugating enzymes UBC4 and UBC5 with distinct
            biochemical features is induced during spermatogenesis
  JOURNAL   Mol Cell Biol 16 (8), 4064-4072 (1996)
   PUBMED   8754804
REFERENCE   7  (bases 1 to 1499)
  AUTHORS   Wing,S.S. and Jain,P.
  TITLE     Molecular cloning, expression and characterization of a ubiquitin
            conjugation enzyme (E2(17)kB) highly expressed in rat testis
  JOURNAL   Biochem J 305 (Pt 1) (Pt 1), 125-132 (1995)
   PUBMED   7826319
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC078808.1.
            
            On Aug 8, 2004 this sequence version replaced NM_031001.1.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC078808.1, U56407.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1499
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     gene            1..1499
                     /gene="Ube2d2b"
                     /gene_synonym="RGD69425; Ube2d2; Ube2d4"
                     /note="ubiquitin-conjugating enzyme E2D 2B"
                     /db_xref="GeneID:79435"
                     /db_xref="RGD:69425"
     exon            1..1475
                     /gene="Ube2d2b"
                     /gene_synonym="RGD69425; Ube2d2; Ube2d4"
                     /inference="alignment:Splign:2.1.0"
     CDS             186..629
                     /gene="Ube2d2b"
                     /gene_synonym="RGD69425; Ube2d2; Ube2d4"
                     /EC_number="2.3.2.23"
                     /note="ubiquitin-conjugating enzyme E2D 2; E2(17)KB 2B;
                     ubiquitin-protein ligase D2B; ubiquitin carrier protein
                     D2B; ubiquitin-conjugating enzyme E2-17 kDa 2B;
                     ubiquitin-conjugating enzyme E2(17)KB 2B; E2
                     ubiquitin-conjugating enzyme D2B; ubiquitin-conjugating
                     enzyme E2D 4 (putative)"
                     /codon_start=1
                     /product="ubiquitin-conjugating enzyme E2 D2B"
                     /protein_id="NP_112263.1"
                     /db_xref="GeneID:79435"
                     /db_xref="RGD:69425"
                     /translation="MALKRIHKELNDLAQDPPAQCSAGPVGEDMFHWQATIMGPNDSP
                     YQGGAFFLTIDFPTEYPFKPPKVEFTTRIYHPNVNSNGSICLDILRSQWSPALTISKV
                     LLSISSLLCDPNPDDPLVPEIAQIYKTDRDKYNRTAREWTQKYAM"
ORIGIN      
        1 ggcagatagt gtccacggtg gctggcccgg aagctgagtg ggcctcggcc ctcagcgtat
       61 tctgccaggg ccaggccaga actgcctgcc tcctcttctg cggctgatcc aaaaccaaca
      121 aggcagccac aggccgtcgg tgcctgccgc cttccaccag gggcccgcca agacaacctt
      181 ccaccatggc tttgaagaga atccacaagg aactgaacga cctggcgcag gatcccccag
      241 cacagtgttc agcaggtcct gtcggggaag atatgttcca ttggcaagct acaatcatgg
      301 ggccaaatga cagtccctac cagggtggag catttttctt gacaattgat ttcccaacag
      361 agtacccctt caaaccacct aaggttgaat ttacaacaag aatttatcat ccaaatgtta
      421 acagtaatgg cagcatttgt cttgatattc ttcggtcaca gtggtctcca gcactaacta
      481 tttcaaaagt acttttgtcc atcagttctc tgttgtgtga tcccaatccc gatgatccct
      541 tagtgcctga gattgctcag atctacaaaa cagatagaga caagtacaac agaacagctc
      601 gggaatggac tcagaagtat gccatgtgac taaagagatt attggatcct ctgcgaataa
      661 aagctagggg aactctgaaa gagaaagtcc ttttgattcc cacttgactg tttgctgtga
      721 acccacgatg taccggcctc gtcctccctg gtgcacggtc ttcatctgat acagtactgt
      781 tgcatgttgc acgcaccaaa aatactgtgt ttctgtacca acactgtctc ctagcagacg
      841 agccttctcc aggcataacc taggtgtgag attaaaagtt ttccttattg acttaaatct
      901 ggataacaag gtgtgagtga gggtggtggg tacaagatac tgctcagaag gggtaaaggt
      961 ccccaaccta taagacaatg agatggcttt tcagtggaag ccatttacag ctaaatgttt
     1021 aaatgaatga aaagctaggt gaagaacatg aatgttcctg tactcatttt attccaaaag
     1081 acctagagct taaatgaaca ttaaaaccaa ccagactaag ccaacccacc tcctgtattt
     1141 taaagtctaa ttggtcaaca aaaatagatc ggcactatcg gtccataaag tgtgcctggc
     1201 tttgttccca aatcctttat acacggatga ctcaacctat tttctttcac actttctctc
     1261 catattcttt ggtttacttg cggtttctca gttgattcat cactaatagc tcttattttt
     1321 attatattaa ctgcttaatc tatttggatg taaaggtaga cattcaactt gatgaaaaaa
     1381 gcttgtgtat agagacctaa ttgctcctct ggagcttgta cagtcaagaa tgatgcatct
     1441 gtgtaataaa ccaattattc tagccattac ataaaaaaaa aaaaaaaaaa aaaaaaaaa
//
