LOCUS       NM_001106542             763 bp    mRNA    linear   ROD 21-MAR-2023
DEFINITION  Rattus norvegicus ubiquitin-conjugating enzyme E2C (Ube2c), mRNA.
ACCESSION   NM_001106542 XM_001070446 XM_215924
VERSION     NM_001106542.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 763)
  AUTHORS   Tsihlis ND, Oustwani CS, Vavra AK, Jiang Q, Keefer LK and Kibbe MR.
  TITLE     Nitric oxide inhibits vascular smooth muscle cell proliferation and
            neointimal hyperplasia by increasing the ubiquitination and
            degradation of UbcH10
  JOURNAL   Cell Biochem Biophys 60 (1-2), 89-97 (2011)
   PUBMED   21448667
  REMARK    GeneRIF: Data show that changes in Ube2c (UbcH10) levels correlate
            with VSMC proliferation and neointimal hyperplasia, making UbcH10 a
            promising therapeutic target for inhibiting this proliferative
            disease.
REFERENCE   2  (bases 1 to 763)
  AUTHORS   David Y, Ziv T, Admon A and Navon A.
  TITLE     The E2 ubiquitin-conjugating enzymes direct polyubiquitination to
            preferred lysines
  JOURNAL   J Biol Chem 285 (12), 8595-8604 (2010)
   PUBMED   20061386
REFERENCE   3  (bases 1 to 763)
  AUTHORS   Garnett MJ, Mansfeld J, Godwin C, Matsusaka T, Wu J, Russell P,
            Pines J and Venkitaraman AR.
  TITLE     UBE2S elongates ubiquitin chains on APC/C substrates to promote
            mitotic exit
  JOURNAL   Nat Cell Biol 11 (11), 1363-1369 (2009)
   PUBMED   19820702
REFERENCE   4  (bases 1 to 763)
  AUTHORS   Williamson A, Wickliffe KE, Mellone BG, Song L, Karpen GH and Rape
            M.
  TITLE     Identification of a physiological E2 module for the human
            anaphase-promoting complex
  JOURNAL   Proc Natl Acad Sci U S A 106 (43), 18213-18218 (2009)
   PUBMED   19822757
REFERENCE   5  (bases 1 to 763)
  AUTHORS   Jin L, Williamson A, Banerjee S, Philipp I and Rape M.
  TITLE     Mechanism of ubiquitin-chain formation by the human
            anaphase-promoting complex
  JOURNAL   Cell 133 (4), 653-665 (2008)
   PUBMED   18485873
REFERENCE   6  (bases 1 to 763)
  AUTHORS   Fernandes R, Ramalho J and Pereira P.
  TITLE     Oxidative stress upregulates ubiquitin proteasome pathway in
            retinal endothelial cells
  JOURNAL   Mol Vis 12, 1526-1535 (2006)
   PUBMED   17167411
  REMARK    GeneRIF: Oxidative stress upregulated ubiquitin proteasome
            pathway(UPP) and increased turnover of ubiquitin conjugates.
            Upregulation of UPP may account for cell response to stress in
            conditions where oxidative stress is overexpressed.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 763)
  AUTHORS   Kobirumaki F, Miyauchi Y, Fukami K and Tanaka H.
  TITLE     A novel UbcH10-binding protein facilitates the ubiquitinylation of
            cyclin B in vitro
  JOURNAL   J Biochem 137 (2), 133-139 (2005)
   PUBMED   15749827
REFERENCE   8  (bases 1 to 763)
  AUTHORS   Yurchenko V, Xue Z and Sadofsky M.
  TITLE     The RAG1 N-terminal domain is an E3 ubiquitin ligase
  JOURNAL   Genes Dev 17 (5), 581-585 (2003)
   PUBMED   12629039
REFERENCE   9  (bases 1 to 763)
  AUTHORS   Townsley FM, Aristarkhov A, Beck S, Hershko A and Ruderman JV.
  TITLE     Dominant-negative cyclin-selective ubiquitin carrier protein
            E2-C/UbcH10 blocks cells in metaphase
  JOURNAL   Proc Natl Acad Sci U S A 94 (6), 2362-2367 (1997)
   PUBMED   9122200
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474005.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_215924.3, XM_001070446.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ234128.1, FQ222472.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..763
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     gene            1..763
                     /gene="Ube2c"
                     /note="ubiquitin-conjugating enzyme E2C"
                     /db_xref="GeneID:296368"
                     /db_xref="RGD:1305382"
     exon            1..154
                     /gene="Ube2c"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..593
                     /gene="Ube2c"
                     /EC_number="6.3.2.19"
                     /codon_start=1
                     /product="ubiquitin-conjugating enzyme E2 C"
                     /protein_id="NP_001100012.1"
                     /db_xref="GeneID:296368"
                     /db_xref="RGD:1305382"
                     /translation="MASQNRDPAAASVAAVRKGAEPCGGAARGPVGKRLQQELMTLMM
                     SGDKGISAFPESDNLFKWVGTIHGAAGTVYEDLRYKLSLEFPSGYPYNAPTVKFLTPC
                     YHPNVDTQGNICLDILKDKWSALYDVRTILLSIQSLLGEPNIESPLNTHAAELWKNPT
                     AFKKYLQETYSKQVSNQEP"
     exon            155..182
                     /gene="Ube2c"
                     /inference="alignment:Splign:2.1.0"
     exon            183..269
                     /gene="Ube2c"
                     /inference="alignment:Splign:2.1.0"
     exon            270..534
                     /gene="Ube2c"
                     /inference="alignment:Splign:2.1.0"
     exon            535..763
                     /gene="Ube2c"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgcagttgc tctttcctct ccacacgctt gtctccgtgc cagcacctct gggatggcct
       61 cgcagaaccg cgacccagct gcagccagcg ttgccgccgt tcgaaaagga gcagaaccct
      121 gcgggggcgc cgcccggggc cctgtgggca agaggctaca gcaggagctg atgaccctca
      181 tgatgtctgg tgacaaagga atttccgcct tccccgaatc agacaacctg ttcaaatggg
      241 taggaaccat ccatggagcc gccggcactg tatatgaaga cctgaggtat aaactctccc
      301 tagagttccc cagtggctac ccttacaacg cacccacagt gaagttcctc acaccgtgct
      361 accaccccaa cgtggacacc cagggcaaca tctgcctgga catcctcaag gacaagtggt
      421 ctgcactgta tgatgtcagg accatcttgc tctccatcca gagcctgcta ggagaaccca
      481 acatcgagag ccctttgaac acacatgctg cagagctctg gaaaaacccc acagcattta
      541 agaagtacct gcaagaaaca tattcaaagc aggtctccaa ccaagagccc tgacgccagc
      601 tctccagctt tctcttgtgt cgtctctttt cttagatgtc tgtcctttct ccgtggtttc
      661 tgagctgtgc tgttttgttt tatttgtttt tttaaattaa gtctgcttga acccatacaa
      721 tgtatattaa ataaatgcac gttgattgtt tttgtataaa ttg
//
