LOCUS       NM_001013933            1737 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus ubiquitin-conjugating enzyme E2A (Ube2a), mRNA.
ACCESSION   NM_001013933 XM_216466
VERSION     NM_001013933.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1737)
  AUTHORS   Cui,W., Dai,X., Marcho,C., Han,Z., Zhang,K., Tremblay,K.D. and
            Mager,J.
  TITLE     Towards Functional Annotation of the Preimplantation Transcriptome:
            An RNAi Screen in Mammalian Embryos
  JOURNAL   Sci Rep 6, 37396 (2016)
   PUBMED   27869233
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1737)
  AUTHORS   Zeman,M.K., Lin,J.R., Freire,R. and Cimprich,K.A.
  TITLE     DNA damage-specific deubiquitination regulates Rad18 functions to
            suppress mutagenesis
  JOURNAL   J Cell Biol 206 (2), 183-197 (2014)
   PUBMED   25023518
REFERENCE   3  (bases 1 to 1737)
  AUTHORS   David,Y., Ziv,T., Admon,A. and Navon,A.
  TITLE     The E2 ubiquitin-conjugating enzymes direct polyubiquitination to
            preferred lysines
  JOURNAL   J Biol Chem 285 (12), 8595-8604 (2010)
   PUBMED   20061386
REFERENCE   4  (bases 1 to 1737)
  AUTHORS   Kim,J., Guermah,M., McGinty,R.K., Lee,J.S., Tang,Z., Milne,T.A.,
            Shilatifard,A., Muir,T.W. and Roeder,R.G.
  TITLE     RAD6-Mediated transcription-coupled H2B ubiquitylation directly
            stimulates H3K4 methylation in human cells
  JOURNAL   Cell 137 (3), 459-471 (2009)
   PUBMED   19410543
REFERENCE   5  (bases 1 to 1737)
  AUTHORS   Tasaki,T., Sohr,R., Xia,Z., Hellweg,R., Hortnagl,H., Varshavsky,A.
            and Kwon,Y.T.
  TITLE     Biochemical and genetic studies of UBR3, a ubiquitin ligase with a
            function in olfactory and other sensory systems
  JOURNAL   J Biol Chem 282 (25), 18510-18520 (2007)
   PUBMED   17462990
REFERENCE   6  (bases 1 to 1737)
  AUTHORS   Roest,H.P., Baarends,W.M., de Wit,J., van Klaveren,J.W.,
            Wassenaar,E., Hoogerbrugge,J.W., van Cappellen,W.A.,
            Hoeijmakers,J.H. and Grootegoed,J.A.
  TITLE     The ubiquitin-conjugating DNA repair enzyme HR6A is a maternal
            factor essential for early embryonic development in mice
  JOURNAL   Mol Cell Biol 24 (12), 5485-5495 (2004)
   PUBMED   15169909
REFERENCE   7  (bases 1 to 1737)
  AUTHORS   Sarcevic,B., Mawson,A., Baker,R.T. and Sutherland,R.L.
  TITLE     Regulation of the ubiquitin-conjugating enzyme hHR6A by
            CDK-mediated phosphorylation
  JOURNAL   EMBO J 21 (8), 2009-2018 (2002)
   PUBMED   11953320
REFERENCE   8  (bases 1 to 1737)
  AUTHORS   Xin,H., Lin,W., Sumanasekera,W., Zhang,Y., Wu,X. and Wang,Z.
  TITLE     The human RAD18 gene product interacts with HHR6A and HHR6B
  JOURNAL   Nucleic Acids Res 28 (14), 2847-2854 (2000)
   PUBMED   10908344
REFERENCE   9  (bases 1 to 1737)
  AUTHORS   Koken,M.H., Smit,E.M., Jaspers-Dekker,I., Oostra,B.A.,
            Hagemeijer,A., Bootsma,D. and Hoeijmakers,J.H.
  TITLE     Localization of two human homologs, HHR6A and HHR6B, of the yeast
            DNA repair gene RAD6 to chromosomes Xq24-q25 and 5q23-q31
  JOURNAL   Genomics 12 (3), 447-453 (1992)
   PUBMED   1559696
REFERENCE   10 (bases 1 to 1737)
  AUTHORS   Koken,M.H., Reynolds,P., Jaspers-Dekker,I., Prakash,L., Prakash,S.,
            Bootsma,D. and Hoeijmakers,J.H.
  TITLE     Structural and functional conservation of two human homologs of the
            yeast DNA repair gene RAD6
  JOURNAL   Proc Natl Acad Sci U S A 88 (20), 8865-8869 (1991)
   PUBMED   1717990
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079353.1.
            
            [WARNING] On Oct 16, 2024 this sequence was replaced by
            NM_001013933.2.
            
            On Apr 20, 2005 this sequence version replaced XM_216466.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079353.1, CK481496.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132291, SAMD00132294
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1737
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq34"
     gene            1..1737
                     /gene="Ube2a"
                     /note="ubiquitin-conjugating enzyme E2A"
                     /db_xref="GeneID:298317"
                     /db_xref="RGD:1359534"
     exon            1..182
                     /gene="Ube2a"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..627
                     /gene="Ube2a"
                     /EC_number="6.3.2.19"
                     /note="ubiquitin-conjugating enzyme E2A (RAD6 homolog)"
                     /codon_start=1
                     /product="ubiquitin-conjugating enzyme E2 A"
                     /protein_id="NP_001013955.1"
                     /db_xref="GeneID:298317"
                     /db_xref="RGD:1359534"
                     /translation="MSTPARRRLMRDFKRLQEDPPAGVSGAPSENNIMVWNAVIFGPE
                     GTPFEDGTHVETTGQLGTFKLTIEFTEEYPNKPPTVRFVSKMFHPNVYADGSICLDIL
                     QNRWSPTYDVSSILTSIQSLLDEPNPNSPANSQAAQLYQENKREYEKRVSAIVEQSWR
                     DC"
     exon            183..263
                     /gene="Ube2a"
                     /inference="alignment:Splign:2.1.0"
     exon            264..289
                     /gene="Ube2a"
                     /inference="alignment:Splign:2.1.0"
     exon            290..319
                     /gene="Ube2a"
                     /inference="alignment:Splign:2.1.0"
     exon            320..409
                     /gene="Ube2a"
                     /inference="alignment:Splign:2.1.0"
     exon            410..498
                     /gene="Ube2a"
                     /inference="alignment:Splign:2.1.0"
     exon            499..1710
                     /gene="Ube2a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttagccggc gccagaccga ccctcggctt cggagaggta gtgctgttcc tctcggtgct
       61 ccctcggctt cggcttcctc cgcttcctca gggaccgcgg accctggtat atgccctacc
      121 tctgaccctg ctaaagccat gtcgaccccg gcccggcgcc gcctcatgag ggacttcaag
      181 aggttacaag aggatcctcc ggctggagtg agtggagccc cgtcggagaa caacataatg
      241 gtttggaacg cggtcatttt tgggcccgaa gggaccccat ttgaggatgg tacacatgtg
      301 gaaaccacag gacaacttgg aacatttaaa cttacaattg aattcactga agaatatcca
      361 aataaaccac ctactgttag atttgtgtct aagatgttcc accctaacgt ctatgcagat
      421 ggtagtatat gtctggatat acttcagaac cgttggagtc caacctatga tgtgtcttcc
      481 attttaacat ccatacagtc tctattggat gaacctaatc ccaatagtcc agcaaacagc
      541 caggctgccc agctgtacca ggagaacaag cgggaatatg aaaagcgtgt ttctgcaata
      601 gtagaacaaa gctggcgtga ctgttgactc agggtagagc agaagaggct ggccataaga
      661 aaaatgtata ttgatgcatt tatcacctta ttcctaattc attacattta ctttattaaa
      721 aacaaaatag ctgttgtgct gtttctgtct tcccttggca agtttttctt cccctttctg
      781 tcctcctgtg gagcatcaga gatactattt gaaatccaat gtactgtacc tgggttactt
      841 gcaaacatta caactgcata cgtccctttg tcgtatctca tctccagcct caaagcggtt
      901 atcaggttac tgtacttttt atactaagct tttaagaaga taaaatgtta cgtatagtct
      961 ggtgaccagg atgttatttg taacaaaatg attgctgctg tgtttcatcc tgaccagtcc
     1021 ttcccttgtg tttgatttgg caaagaatgt agttagaata tgacctaaag aaaacaggaa
     1081 tgtatccata taaacacaat ttgaaagggg aaggaaagct gaaaaatcct atactcattt
     1141 gtaggcaata tgaattacaa gatggtactt actggtagca aggagactgc taaagaccca
     1201 gctaacaaac tgaagcaatt ttaataactg acacagtcca ctttttgcaa gatattcata
     1261 gtgtaagctc gttatgtttc agaatcctgg ccttcagagt tttttgcttt ttataaagag
     1321 gtgtgagaac aggactagac tctttttttt ttagttagga aaaactgaag atcctctatt
     1381 ctcttaaagg agcaatgttg ccctaaataa actttccttt ttatgattca aggaagggag
     1441 catatcttgc aaacttttcc cattcagatc cagagttaat gctgcatgct ttcagtgttt
     1501 tgagaacctt ctaatgccca tatctgcagt ttttctttgg atatttacac ttttaaatat
     1561 acagtatggg gcaaggcttg taaatgtttt gtctaatata ttttaattgt taatctatta
     1621 tgcatttata gcacttctaa ctttgcacaa gtaacccatg taaaaactgt acattttcaa
     1681 aagttgtaaa taaaaaaaat aaccttaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa
//
