LOCUS       NM_053299                672 bp    mRNA    linear   ROD 06-OCT-2024
DEFINITION  Rattus norvegicus ubiquitin D (Ubd), mRNA.
ACCESSION   NM_053299
VERSION     NM_053299.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 672)
  AUTHORS   Wan,R., Yuan,P., Guo,L., Shao,J., Liu,X., Lai,W., Kong,Q., Chen,L.,
            Ge,J., Xu,Z., Xie,J., Shen,Y., Hu,J., Zhou,Q., Yu,J., Jiang,Z.,
            Jiang,X. and Hong,K.
  TITLE     Ubiquitin-like protein FAT10 suppresses SIRT1-mediated autophagy to
            protect against ischemic myocardial injury
  JOURNAL   J Mol Cell Cardiol 153, 1-13 (2021)
   PUBMED   33307094
  REMARK    GeneRIF: Ubiquitin-like protein FAT10 suppresses SIRT1-mediated
            autophagy to protect against ischemic myocardial injury.
REFERENCE   2  (bases 1 to 672)
  AUTHORS   Jia,Y., French,B., Tillman,B. and French,S.
  TITLE     Different roles of FAT10, FOXO1, and ADRA2A in hepatocellular
            carcinoma tumorigenesis in patients with alcoholic steatohepatitis
            (ASH) vs non-alcoholic steatohepatitis (NASH)
  JOURNAL   Exp Mol Pathol 105 (1), 144-149 (2018)
   PUBMED   30009772
REFERENCE   3  (bases 1 to 672)
  AUTHORS   Zhou,Q., Peng,X., Liu,X., Chen,L., Xiong,Q., Shen,Y., Xie,J.,
            Xu,Z., Huang,L., Hu,J., Wan,R. and Hong,K.
  TITLE     FAT10 attenuates hypoxia-induced cardiomyocyte apoptosis by
            stabilizing caveolin-3
  JOURNAL   J Mol Cell Cardiol 116, 115-124 (2018)
   PUBMED   29438664
REFERENCE   4  (bases 1 to 672)
  AUTHORS   Cort,L., Habib,M., Eberwine,R.A., Hessner,M.J., Mordes,J.P. and
            Blankenhorn,E.P.
  TITLE     Diubiquitin (Ubd) is a susceptibility gene for virus-triggered
            autoimmune diabetes in rats
  JOURNAL   Genes Immun 15 (3), 168-175 (2014)
   PUBMED   24452267
  REMARK    GeneRIF: These data prove that Ubd is a diabetes susceptibility
            gene, providing insight into the interplay of multiple genes and
            environmental factors in T1D susceptibility.
REFERENCE   5  (bases 1 to 672)
  AUTHORS   Peng,X., Shao,J., Shen,Y., Zhou,Y., Cao,Q., Hu,J., He,W., Yu,X.,
            Liu,X., Marian,A.J. and Hong,K.
  TITLE     FAT10 protects cardiac myocytes against apoptosis
  JOURNAL   J Mol Cell Cardiol 59, 1-10 (2013)
   PUBMED   23416168
  REMARK    GeneRIF: FAT10 protects cardiac myocytes against apoptosis.
REFERENCE   6  (bases 1 to 672)
  AUTHORS   Hurt,P., Walter,L., Sudbrak,R., Klages,S., Muller,I., Shiina,T.,
            Inoko,H., Lehrach,H., Gunther,E., Reinhardt,R. and Himmelbauer,H.
  TITLE     The genomic sequence and comparative analysis of the rat major
            histocompatibility complex
  JOURNAL   Genome Res 14 (4), 631-639 (2004)
   PUBMED   15060004
REFERENCE   7  (bases 1 to 672)
  AUTHORS   Lee,C.G., Ren,J., Cheong,I.S., Ban,K.H., Ooi,L.L., Yong Tan,S.,
            Kan,A., Nuchprayoon,I., Jin,R., Lee,K.H., Choti,M. and Lee,L.A.
  TITLE     Expression of the FAT10 gene is highly upregulated in
            hepatocellular carcinoma and other gastrointestinal and
            gynecological cancers
  JOURNAL   Oncogene 22 (17), 2592-2603 (2003)
   PUBMED   12730673
REFERENCE   8  (bases 1 to 672)
  AUTHORS   Yamashita,S., Wakazono,K., Sugimura,T. and Ushijima,T.
  TITLE     Profiling and selection of genes differentially expressed in the
            pylorus of rat strains with different proliferative responses and
            stomach cancer susceptibility
  JOURNAL   Carcinogenesis 23 (6), 923-928 (2002)
   PUBMED   12082013
REFERENCE   9  (bases 1 to 672)
  AUTHORS   Raasi,S., Schmidtke,G. and Groettrup,M.
  TITLE     The ubiquitin-like protein FAT10 forms covalent conjugates and
            induces apoptosis
  JOURNAL   J Biol Chem 276 (38), 35334-35343 (2001)
   PUBMED   11445583
REFERENCE   10 (bases 1 to 672)
  AUTHORS   Bates,E.E., Ravel,O., Dieu,M.C., Ho,S., Guret,C., Bridon,J.M.,
            Ait-Yahia,S., Briere,F., Caux,C., Banchereau,J. and Lebecque,S.
  TITLE     Identification and analysis of a novel member of the ubiquitin
            family expressed in dendritic cells and mature B cells
  JOURNAL   Eur J Immunol 27 (10), 2471-2477 (1997)
   PUBMED   9368598
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX883052.1.
            
            On Dec 3, 2009 this sequence version replaced NM_053299.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ312394.1, FM052813.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-78                BX883052.1         212907-212984
            79-672              BX883052.1         214265-214858
FEATURES             Location/Qualifiers
     source          1..672
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..672
                     /gene="Ubd"
                     /note="ubiquitin D"
                     /db_xref="GeneID:29168"
                     /db_xref="RGD:69418"
     exon            1..78
                     /gene="Ubd"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..546
                     /gene="Ubd"
                     /note="diubiquitin; ubiquitin-like protein FAT10"
                     /codon_start=1
                     /product="ubiquitin D"
                     /protein_id="NP_445751.2"
                     /db_xref="GeneID:29168"
                     /db_xref="RGD:69418"
                     /translation="MASCVCVVHSEQWPLMTFDTTMSDKVKKINEHIRSQTKVSVQDQ
                     ILLLDSKILKPHRALSSYGIDKENTIHLTLKVVKPSDEELPLSLVESGDEGQRHLLRV
                     RRSSSVAQVKEMIENVTAVPPKKQFVNCNGKRLEDGKIMADYNIKSGSLLFLTAHCIG
                     G"
     exon            79..672
                     /gene="Ubd"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agctactcac atataagcag acatgaggac tcttttctca ctcggcctct gactgcagac
       61 atggcttcct gcgtctgtgt tgtccattcg gagcaatggc cattaatgac ctttgacacc
      121 accatgagtg acaaagtgaa gaaaatcaat gagcatatta ggtcccaaac caaggtctct
      181 gtgcaggacc agatccttct gctagactcc aagatcctca agccccatag agcgttgtca
      241 tcttatggga tcgacaagga aaacactatc cacctcaccc taaaggtggt gaagcccagt
      301 gatgaagagc tgcccttgtc tctggtggag tcgggcgacg aggggcaaag gcacctcctt
      361 cgagttcgaa gatccagctc cgtggcccag gtgaaggaaa tgatcgagaa tgtgactgct
      421 gtgcctccca agaagcagtt cgtgaattgc aatggaaaga ggctggaaga tggaaagatc
      481 atggccgact acaacatcaa gagtggtagt ttgctctttc tcacagcgca ctgcattggg
      541 gggtgactac gggagtgggg tgatgagaag ctcaaaaccg acttccttta atcaattaac
      601 caattgcatc tcttgatgat ataaaaaata atgagaatga aataaagatt tgaagtgggg
      661 tggagtaaaa aa
//
