LOCUS       NM_001399786            2135 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus ubiquitin C (Ubc), transcript variant 7, mRNA.
ACCESSION   NM_001399786
VERSION     NM_001399786.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2135)
  AUTHORS   Beeken,M., Lindenmeyer,M.T., Blattner,S.M., Radon,V., Oh,J.,
            Meyer,T.N., Hildebrand,D., Schluter,H., Reinicke,A.T., Knop,J.H.,
            Vivekanandan-Giri,A., Munster,S., Sachs,M., Wiech,T., Pennathur,S.,
            Cohen,C.D., Kretzler,M., Stahl,R.A. and Meyer-Schwesinger,C.
  TITLE     Alterations in the ubiquitin proteasome system in persistent but
            not reversible proteinuric diseases
  JOURNAL   J Am Soc Nephrol 25 (11), 2511-2525 (2014)
   PUBMED   24722446
  REMARK    GeneRIF: This study identifies altered proteolysis as a feature of
            persistent podocyte injury. In the future, specific UPS proteins
            may serve as new biomarkers or therapeutic targets in persistent
            nephrotic syndrome.
REFERENCE   2  (bases 1 to 2135)
  AUTHORS   Joshi,S.K., Kim,H.T., Feeley,B.T. and Liu,X.
  TITLE     Differential ubiquitin-proteasome and autophagy signaling following
            rotator cuff tears and suprascapular nerve injury
  JOURNAL   J Orthop Res 32 (1), 138-144 (2014)
   PUBMED   24018537
  REMARK    GeneRIF: While the ubiquitin-proteasome pathway was a major
            contributor to the atrophy seen following suprascapular nerve
            denervation, autophagy was a major contributor following tendon
            transection.
REFERENCE   3  (bases 1 to 2135)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   4  (bases 1 to 2135)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   5  (bases 1 to 2135)
  AUTHORS   Ralat,L.A., Kalas,V., Zheng,Z., Goldman,R.D., Sosnick,T.R. and
            Tang,W.J.
  TITLE     Ubiquitin is a novel substrate for human insulin-degrading enzyme
  JOURNAL   J Mol Biol 406 (3), 454-466 (2011)
   PUBMED   21185309
REFERENCE   6  (bases 1 to 2135)
  AUTHORS   Werner,H.B., Kuhlmann,K., Shen,S., Uecker,M., Schardt,A.,
            Dimova,K., Orfaniotou,F., Dhaunchak,A., Brinkmann,B.G., Mobius,W.,
            Guarente,L., Casaccia-Bonnefil,P., Jahn,O. and Nave,K.A.
  TITLE     Proteolipid protein is required for transport of sirtuin 2 into CNS
            myelin
  JOURNAL   J Neurosci 27 (29), 7717-7730 (2007)
   PUBMED   17634366
REFERENCE   7  (bases 1 to 2135)
  AUTHORS   Palmer,D.J., Kelly,V.C., Smit,A.M., Kuy,S., Knight,C.G. and
            Cooper,G.J.
  TITLE     Human colostrum: identification of minor proteins in the aqueous
            phase by proteomics
  JOURNAL   Proteomics 6 (7), 2208-2216 (2006)
   PUBMED   16502470
REFERENCE   8  (bases 1 to 2135)
  AUTHORS   Marinovic,A.C., Zheng,B., Mitch,W.E. and Price,S.R.
  TITLE     Ubiquitin (UbC) expression in muscle cells is increased by
            glucocorticoids through a mechanism involving Sp1 and MEK1
  JOURNAL   J Biol Chem 277 (19), 16673-16681 (2002)
   PUBMED   11872750
REFERENCE   9  (bases 1 to 2135)
  AUTHORS   Adam,P.J., Weissberg,P.L., Cary,N.R. and Shanahan,C.M.
  TITLE     Polyubiquitin is a new phenotypic marker of contractile vascular
            smooth muscle cells
  JOURNAL   Cardiovasc Res 33 (2), 416-421 (1997)
   PUBMED   9074707
REFERENCE   10 (bases 1 to 2135)
  AUTHORS   Hayashi,T., Noga,M. and Matsuda,M.
  TITLE     Nucleotide sequence and expression of the rat polyubiquitin mRNA
  JOURNAL   Biochim Biophys Acta 1218 (2), 232-234 (1994)
   PUBMED   8018730
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22399484.6052.1,
                                           SRR22399484.524475.1 [ECO:0000332]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                JAXUCZ010000012.1  36900500-36900566
            68-2135             JAXUCZ010000012.1  36903208-36905275
FEATURES             Location/Qualifiers
     source          1..2135
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q15"
     gene            1..2135
                     /gene="Ubc"
                     /note="ubiquitin C"
                     /db_xref="GeneID:50522"
                     /db_xref="RGD:621244"
     exon            1..67
                     /gene="Ubc"
                     /inference="alignment:Splign:2.1.0"
     exon            68..2135
                     /gene="Ubc"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..2051
                     /gene="Ubc"
                     /note="isoform 6 is encoded by transcript variant 7;
                     polyubiquitin-C"
                     /codon_start=1
                     /product="polyubiquitin-C isoform 6"
                     /protein_id="NP_001386715.1"
                     /db_xref="GeneID:50522"
                     /db_xref="RGD:621244"
                     /translation="MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLI
                     FAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENV
                     KAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTL
                     TGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKEST
                     LHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGK
                     QLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKI
                     QDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKT
                     ITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLV
                     LRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLED
                     GRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKE
                     GIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLD
                     VEPSVNTKKVKQEDTRTFLTTVSRKSPSCACSWV"
ORIGIN      
        1 agctagttcc gtggagaccg ccagttccgt ctctactctt ttgtgaggac tgcagccaac
       61 accgctgagg gggcatgcag atctttgtga agaccctgac aggcaagacc atcaccctgg
      121 aggtcgagcc cagtgacacc attgaaaatg tcaaggcaaa gatccaggac aaggagggca
      181 tcccccctga ccagcagagg ctgatctttg caggcaagca gctggaagat ggccgcaccc
      241 tgtcagacta caacatccag aaggagtcca ccttgcacct ggtccttcgc ctcagagggg
      301 gcatgcagat ctttgtgaag accctgacag gcaagaccat caccctggag gtcgagccca
      361 gtgacaccat tgaaaatgtc aaggcaaaga tccaggacaa ggagggcatc ccccctgacc
      421 agcagaggct gatctttgca ggcaagcagc tggaagatgg ccgcaccctg tcagattaca
      481 acatccagaa ggagtccacc ctgcacctgg tccttcgcct cagagggggc atgcagatct
      541 ttgtgaagac cctgacaggc aagaccatca ccctggaggt cgagcccagt gacaccattg
      601 aaaatgtcaa ggcaaagatc caggacaagg agggcatccc ccctgaccag cagaggctga
      661 tctttgcagg caagcagctg gaagatggcc gcaccctgtc agactacaac atccagaagg
      721 agtccaccct gcacctggtc cttcgcctca gagggggcat gcagatcttt gtgaagaccc
      781 tgacaggcaa gaccatcacc ctggaggtcg agcccagtga caccattgaa aatgtcaagg
      841 caaagatcca ggacaaggag ggcatccccc ctgaccagca gaggctgatc tttgcaggca
      901 agcagctgga agatggccgc accctgtctg actacaacat ccagaaggag tccaccctgc
      961 acctggtcct gcgcctcaga gggggcatgc agatctttgt gaagaccctg acaggcaaga
     1021 ccatcaccct ggaggtcgag cccagtgaca ccattgaaaa tgtcaaggca aagatccagg
     1081 acaaggaggg catcccccct gaccagcaga ggctgatctt tgcaggcaag cagctggaag
     1141 atggccgcac cctgtcagac tacaacatcc agaaggagtc caccttgcac ctggtccttc
     1201 gcctcagagg gggcatgcag atctttgtga agaccctgac aggcaagacc atcaccctgg
     1261 aggtcgagcc cagtgacacc attgaaaatg tcaaggcaaa gatccaggac aaggagggca
     1321 tcccccctga ccagcagagg ctgatctttg caggcaagca gctggaagat ggccgcaccc
     1381 tgtctgacta caacatccag aaggagtcca ccctgcacct ggtcctgcgc ctcagagggg
     1441 gcatgcagat ctttgtgaag accctgacag gcaagaccat caccctggag gtcgagccca
     1501 gtgacaccat tgaaaatgtc aaggcaaaga tccaggacaa ggagggcatc ccccctgacc
     1561 agcagaggct gatctttgca ggcaagcagc tggaagatgg ccgcaccctg tcagactaca
     1621 acatccagaa ggagtccacc ctgcacctgg tccttcgcct cagagggggc atgcagatct
     1681 ttgtgaagac cctgacaggc aagaccatca ccctggaggt cgagcccagt gacaccattg
     1741 aaaatgtcaa ggcaaagatc caggacaagg agggcatccc ccctgaccag cagaggctga
     1801 tctttgcagg caagcagctg gaagatggcc gcaccctgtc agactacaac atccagaagg
     1861 agtccaccct gcacctggtc ctgcgcctca gagggggcat gcagatcttt gtgaagaccc
     1921 tgacaggcaa gaccatcact ctggatgtcg agcccagtgt taacaccaag aaggtcaaac
     1981 aggaagatac tcgtaccttt ctcaccacag tatctagaaa gagcccttct tgtgcttgtt
     2041 cttgggtttg atggggaggt gtcttagttt tccctatctt ttaagctgtt aacaagtttc
     2101 attgcacttt gaataaagtt cttgcattcc caaaa
//
