LOCUS       NM_001399781            3043 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus ubiquitin C (Ubc), transcript variant 1, mRNA.
ACCESSION   NM_001399781 XM_039089711
VERSION     NM_001399781.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3043)
  AUTHORS   Beeken,M., Lindenmeyer,M.T., Blattner,S.M., Radon,V., Oh,J.,
            Meyer,T.N., Hildebrand,D., Schluter,H., Reinicke,A.T., Knop,J.H.,
            Vivekanandan-Giri,A., Munster,S., Sachs,M., Wiech,T., Pennathur,S.,
            Cohen,C.D., Kretzler,M., Stahl,R.A. and Meyer-Schwesinger,C.
  TITLE     Alterations in the ubiquitin proteasome system in persistent but
            not reversible proteinuric diseases
  JOURNAL   J Am Soc Nephrol 25 (11), 2511-2525 (2014)
   PUBMED   24722446
  REMARK    GeneRIF: This study identifies altered proteolysis as a feature of
            persistent podocyte injury. In the future, specific UPS proteins
            may serve as new biomarkers or therapeutic targets in persistent
            nephrotic syndrome.
REFERENCE   2  (bases 1 to 3043)
  AUTHORS   Joshi,S.K., Kim,H.T., Feeley,B.T. and Liu,X.
  TITLE     Differential ubiquitin-proteasome and autophagy signaling following
            rotator cuff tears and suprascapular nerve injury
  JOURNAL   J Orthop Res 32 (1), 138-144 (2014)
   PUBMED   24018537
  REMARK    GeneRIF: While the ubiquitin-proteasome pathway was a major
            contributor to the atrophy seen following suprascapular nerve
            denervation, autophagy was a major contributor following tendon
            transection.
REFERENCE   3  (bases 1 to 3043)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   4  (bases 1 to 3043)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   5  (bases 1 to 3043)
  AUTHORS   Ralat,L.A., Kalas,V., Zheng,Z., Goldman,R.D., Sosnick,T.R. and
            Tang,W.J.
  TITLE     Ubiquitin is a novel substrate for human insulin-degrading enzyme
  JOURNAL   J Mol Biol 406 (3), 454-466 (2011)
   PUBMED   21185309
REFERENCE   6  (bases 1 to 3043)
  AUTHORS   Werner,H.B., Kuhlmann,K., Shen,S., Uecker,M., Schardt,A.,
            Dimova,K., Orfaniotou,F., Dhaunchak,A., Brinkmann,B.G., Mobius,W.,
            Guarente,L., Casaccia-Bonnefil,P., Jahn,O. and Nave,K.A.
  TITLE     Proteolipid protein is required for transport of sirtuin 2 into CNS
            myelin
  JOURNAL   J Neurosci 27 (29), 7717-7730 (2007)
   PUBMED   17634366
REFERENCE   7  (bases 1 to 3043)
  AUTHORS   Palmer,D.J., Kelly,V.C., Smit,A.M., Kuy,S., Knight,C.G. and
            Cooper,G.J.
  TITLE     Human colostrum: identification of minor proteins in the aqueous
            phase by proteomics
  JOURNAL   Proteomics 6 (7), 2208-2216 (2006)
   PUBMED   16502470
REFERENCE   8  (bases 1 to 3043)
  AUTHORS   Marinovic,A.C., Zheng,B., Mitch,W.E. and Price,S.R.
  TITLE     Ubiquitin (UbC) expression in muscle cells is increased by
            glucocorticoids through a mechanism involving Sp1 and MEK1
  JOURNAL   J Biol Chem 277 (19), 16673-16681 (2002)
   PUBMED   11872750
REFERENCE   9  (bases 1 to 3043)
  AUTHORS   Adam,P.J., Weissberg,P.L., Cary,N.R. and Shanahan,C.M.
  TITLE     Polyubiquitin is a new phenotypic marker of contractile vascular
            smooth muscle cells
  JOURNAL   Cardiovasc Res 33 (2), 416-421 (1997)
   PUBMED   9074707
REFERENCE   10 (bases 1 to 3043)
  AUTHORS   Hayashi,T., Noga,M. and Matsuda,M.
  TITLE     Nucleotide sequence and expression of the rat polyubiquitin mRNA
  JOURNAL   Biochim Biophys Acta 1218 (2), 232-234 (1994)
   PUBMED   8018730
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Jan 14, 2022 this sequence version replaced XM_039089711.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062397.1, SRR26643295.45119.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                JAXUCZ010000012.1  36900500-36900566
            68-3043             JAXUCZ010000012.1  36902300-36905275
FEATURES             Location/Qualifiers
     source          1..3043
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q15"
     gene            1..3043
                     /gene="Ubc"
                     /note="ubiquitin C"
                     /db_xref="GeneID:50522"
                     /db_xref="RGD:621244"
     exon            1..67
                     /gene="Ubc"
                     /inference="alignment:Splign:2.1.0"
     exon            68..3043
                     /gene="Ubc"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..2959
                     /gene="Ubc"
                     /note="isoform 1 is encoded by transcript variant 1;
                     polyubiquitin-C"
                     /codon_start=1
                     /product="polyubiquitin-C isoform 1"
                     /protein_id="NP_001386710.1"
                     /db_xref="GeneID:50522"
                     /db_xref="RGD:621244"
                     /translation="MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLI
                     FAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENV
                     KAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTL
                     TGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKEST
                     LHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGK
                     QLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKI
                     QDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKT
                     ITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLV
                     LRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLED
                     GRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKE
                     GIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLE
                     VEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLR
                     GGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTL
                     SDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPP
                     DQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPS
                     DTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQ
                     IFVKTLTGKTITLDVEPSVNTKKVKQEDTRTFLTTVSRKSPSCACSWV"
ORIGIN      
        1 agctagttcc gtggagaccg ccagttccgt ctctactctt ttgtgaggac tgcagccaac
       61 accgctgaca atgcagatct ttgtgaaaac cttaactggt aagaccatca ccctggaggt
      121 cgagcccagt gacaccattg aaaatgtcaa ggcaaagatc caggacaagg agggcatccc
      181 ccctgaccag cagaggctga tctttgcagg caagcagctg gaagatggcc gcaccctgtc
      241 agactacaac atccagaagg agtccacctt gcacctggtc cttcgcctca gagggggcat
      301 gcagatcttt gtgaagaccc tgacaggcaa gaccatcacc ctggaggtcg agcccagtga
      361 caccattgaa aatgtcaagg caaagatcca ggacaaggag ggcatccccc ctgaccagca
      421 gaggctgatc tttgcaggca agcagctgga agatggccgc accctgtcag actacaacat
      481 ccagaaggag tccaccctgc acctggtcct tcgcctcaga gggggcatgc agatctttgt
      541 gaagaccctg acaggcaaga ccatcaccct ggaggtcgag cccagtgaca ccattgaaaa
      601 tgtcaaggca aagatccagg acaaggaggg catcccccct gaccagcaga ggctgatctt
      661 tgcaggcaag cagctggaag atggccgcac cctgtcagat tacaacatcc agaaggagtc
      721 caccctgcac ctggtccttc gcctcagagg gggcatgcag atctttgtga agaccctgac
      781 aggcaagacc atcaccctgg aggtcgagcc cagtgacacc attgaaaatg tcaaggcaaa
      841 gatccaggac aaggagggca tcccccctga ccagcagagg ctgatctttg caggcaagca
      901 gctggaagat ggccgcaccc tgtcagacta caacatccag aaggagtcca ccttgcacct
      961 ggtccttcgc ctcagagggg gcatgcagat ctttgtgaag accctgacag gcaagaccat
     1021 caccctggag gtcgagccca gtgacaccat tgaaaatgtc aaggcaaaga tccaggacaa
     1081 ggagggcatc ccccctgacc agcagaggct gatctttgca ggcaagcagc tggaagatgg
     1141 ccgcaccctg tcagactaca acatccagaa ggagtccacc ttgcacctgg tccttcgcct
     1201 cagagggggc atgcagatct ttgtgaagac cctgacaggc aagaccatca ccctggaggt
     1261 cgagcccagt gacaccattg aaaatgtcaa ggcaaagatc caggacaagg agggcatccc
     1321 ccctgaccag cagaggctga tctttgcagg caagcagctg gaagatggcc gcaccctgtc
     1381 agattacaac atccagaagg agtccaccct gcacctggtc cttcgcctca gagggggcat
     1441 gcagatcttt gtgaagaccc tgacaggcaa gaccatcacc ctggaggtcg agcccagtga
     1501 caccattgaa aatgtcaagg caaagatcca ggacaaggag ggcatccccc ctgaccagca
     1561 gaggctgatc tttgcaggca agcagctgga agatggccgc accctgtcag actacaacat
     1621 ccagaaggag tccaccctgc acctggtcct tcgcctcaga gggggcatgc agatctttgt
     1681 gaagaccctg acaggcaaga ccatcaccct ggaggtcgag cccagtgaca ccattgaaaa
     1741 tgtcaaggca aagatccagg acaaggaggg catcccccct gaccagcaga ggctgatctt
     1801 tgcaggcaag cagctggaag atggccgcac cctgtctgac tacaacatcc agaaggagtc
     1861 caccctgcac ctggtcctgc gcctcagagg gggcatgcag atctttgtga agaccctgac
     1921 aggcaagacc atcaccctgg aggtcgagcc cagtgacacc attgaaaatg tcaaggcaaa
     1981 gatccaggac aaggagggca tcccccctga ccagcagagg ctgatctttg caggcaagca
     2041 gctggaagat ggccgcaccc tgtcagacta caacatccag aaggagtcca ccttgcacct
     2101 ggtccttcgc ctcagagggg gcatgcagat ctttgtgaag accctgacag gcaagaccat
     2161 caccctggag gtcgagccca gtgacaccat tgaaaatgtc aaggcaaaga tccaggacaa
     2221 ggagggcatc ccccctgacc agcagaggct gatctttgca ggcaagcagc tggaagatgg
     2281 ccgcaccctg tctgactaca acatccagaa ggagtccacc ctgcacctgg tcctgcgcct
     2341 cagagggggc atgcagatct ttgtgaagac cctgacaggc aagaccatca ccctggaggt
     2401 cgagcccagt gacaccattg aaaatgtcaa ggcaaagatc caggacaagg agggcatccc
     2461 ccctgaccag cagaggctga tctttgcagg caagcagctg gaagatggcc gcaccctgtc
     2521 agactacaac atccagaagg agtccaccct gcacctggtc cttcgcctca gagggggcat
     2581 gcagatcttt gtgaagaccc tgacaggcaa gaccatcacc ctggaggtcg agcccagtga
     2641 caccattgaa aatgtcaagg caaagatcca ggacaaggag ggcatccccc ctgaccagca
     2701 gaggctgatc tttgcaggca agcagctgga agatggccgc accctgtcag actacaacat
     2761 ccagaaggag tccaccctgc acctggtcct gcgcctcaga gggggcatgc agatctttgt
     2821 gaagaccctg acaggcaaga ccatcactct ggatgtcgag cccagtgtta acaccaagaa
     2881 ggtcaaacag gaagatactc gtacctttct caccacagta tctagaaaga gcccttcttg
     2941 tgcttgttct tgggtttgat ggggaggtgt cttagttttc cctatctttt aagctgttaa
     3001 caagtttcat tgcactttga ataaagttct tgcattccca aaa
//
