LOCUS       NM_138895               1166 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus ubiquitin B (Ubb), transcript variant 2, mRNA.
ACCESSION   NM_138895 XM_579661
VERSION     NM_138895.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1166)
  AUTHORS   Kazlauskaite,A., Kondapalli,C., Gourlay,R., Campbell,D.G.,
            Ritorto,M.S., Hofmann,K., Alessi,D.R., Knebel,A., Trost,M. and
            Muqit,M.M.
  TITLE     Parkin is activated by PINK1-dependent phosphorylation of ubiquitin
            at Ser65
  JOURNAL   Biochem J 460 (1), 127-139 (2014)
   PUBMED   24660806
REFERENCE   2  (bases 1 to 1166)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   3  (bases 1 to 1166)
  AUTHORS   Sidoryk-Wegrzynowicz,M., Lee,E.S., Ni,M. and Aschner,M.
  TITLE     Manganese-induced downregulation of astroglial glutamine
            transporter SNAT3 involves ubiquitin-mediated proteolytic system
  JOURNAL   Glia 58 (16), 1905-1912 (2010)
   PUBMED   20737472
  REMARK    GeneRIF: Mn(2+)-induced SNAT3 protein degradation and the
            dysregulation of Gln homeostasis in primary astrocyte cultures
            proceeds through the ubiquitin-mediated proteolytic system
REFERENCE   4  (bases 1 to 1166)
  AUTHORS   Zhang,Y., Xiong,M., Yan,R.Q. and Sun,F.Y.
  TITLE     Mutant ubiquitin-mediated beta-secretase stability via activation
            of caspase-3 is related to beta-amyloid accumulation in ischemic
            striatum in rats
  JOURNAL   J Cereb Blood Flow Metab 30 (3), 566-575 (2010)
   PUBMED   19844237
  REMARK    GeneRIF: We conclude that activation of caspase-3 might be upstream
            of UBB(+1) formation and that excessive UBB(+1) could bind to beta
            secretase
REFERENCE   5  (bases 1 to 1166)
  AUTHORS   Kesimer,M., Scull,M., Brighton,B., DeMaria,G., Burns,K., O'Neal,W.,
            Pickles,R.J. and Sheehan,J.K.
  TITLE     Characterization of exosome-like vesicles released from human
            tracheobronchial ciliated epithelium: a possible role in innate
            defense
  JOURNAL   FASEB J 23 (6), 1858-1868 (2009)
   PUBMED   19190083
REFERENCE   6  (bases 1 to 1166)
  AUTHORS   Florea,L., Di Francesco,V., Miller,J., Turner,R., Yao,A.,
            Harris,M., Walenz,B., Mobarry,C., Merkulov,G.V., Charlab,R.,
            Dew,I., Deng,Z., Istrail,S., Li,P. and Sutton,G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
REFERENCE   7  (bases 1 to 1166)
  AUTHORS   Noga,M., Hayashi,T. and Tanaka,J.
  TITLE     Gene expressions of ubiquitin and hsp70 following focal ischaemia
            in rat brain
  JOURNAL   Neuroreport 8 (5), 1239-1241 (1997)
   PUBMED   9175121
REFERENCE   8  (bases 1 to 1166)
  AUTHORS   Adam,P.J., Weissberg,P.L., Cary,N.R. and Shanahan,C.M.
  TITLE     Polyubiquitin is a new phenotypic marker of contractile vascular
            smooth muscle cells
  JOURNAL   Cardiovasc Res 33 (2), 416-421 (1997)
   PUBMED   9074707
REFERENCE   9  (bases 1 to 1166)
  AUTHORS   Hubbard,M.J. and Carne,A.
  TITLE     Differential feeding-related regulation of ubiquitin and
            calbindin9kDa in rat duodenum
  JOURNAL   Biochim Biophys Acta 1200 (2), 191-196 (1994)
   PUBMED   8031840
REFERENCE   10 (bases 1 to 1166)
  AUTHORS   Hayashi,T., Noga,M. and Matsuda,M.
  TITLE     Nucleotide sequence and expression of the rat polyubiquitin mRNA
  JOURNAL   Biochim Biophys Acta 1218 (2), 232-234 (1994)
   PUBMED   8018730
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Jul 8, 2022 this sequence version replaced NM_138895.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ231801.1, FQ214674.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-93                JAXUCZ010000010.1  47746923-47747015
            94-1166             JAXUCZ010000010.1  47747556-47748628
FEATURES             Location/Qualifiers
     source          1..1166
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q23"
     gene            1..1166
                     /gene="Ubb"
                     /note="ubiquitin B"
                     /db_xref="GeneID:192255"
                     /db_xref="RGD:621562"
     exon            1..93
                     /gene="Ubb"
                     /inference="alignment:Splign:2.1.0"
     exon            94..1166
                     /gene="Ubb"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..1017
                     /gene="Ubb"
                     /note="Polyubiquitin-B"
                     /codon_start=1
                     /product="polyubiquitin-B precursor"
                     /protein_id="NP_620250.3"
                     /db_xref="GeneID:192255"
                     /db_xref="RGD:621562"
                     /translation="MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLI
                     FAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENV
                     KAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTL
                     TGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKEST
                     LHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGK
                     QLEDGRTLSDYNIQKESTLHLVLRLRGGY"
ORIGIN      
        1 cagtgacgag aggctttgtc cggttccgag gtctttctgt gagggtgttt cgacgcgctg
       61 ggcggtttgt tccttcatcg cattcgttaa caggtcaaaa tgcaaatctt cgtgaagacc
      121 ctgaccggca agaccatcac cctagaggtg gagcccagtg acaccatcga gaacgtgaag
      181 gccaagatcc aggataaaga gggcatcccc cctgaccagc agaggctcat ctttgccggc
      241 aagcagctgg aagatggccg caccctctct gactacaaca tccagaaaga gtcaaccctg
      301 cacctggtcc tccgcctgag gggcggcatg cagatcttcg tgaagaccct gaccggcaag
      361 accatcaccc tggaggtgga gcccagtgac accatcgaga acgtgaaggc caagatccag
      421 gataaagagg gcatcccccc tgaccagcag aggctcatct ttgccggcaa gcagctggaa
      481 gatggccgca ccctctctga ttacaacatc cagaaagagt caaccctgca ccttgtcctc
      541 cgcctgaggg gcggcatgca gatcttcgtg aagaccctga ccggcaagac catcacccta
      601 gaggtggagc ccagtgacac catcgagaac gtgaaggcca agatccagga taaagagggc
      661 atcccccctg accagcagag gctcatcttt gccggcaagc agctggaaga tggccgcacc
      721 ctctctgact acaacatcca gaaggagtca accctgcacc tggtcctccg cctgaggggc
      781 ggcatgcaga tcttcgtgaa gaccctgacc ggcaagacca tcaccctgga ggtggagccc
      841 agtgacacca tcgagaacgt gaaggccaag atccaggata aagagggcat cccccctgac
      901 cagcagaggc tcatctttgc cggcaagcag ctggaagatg gccgcaccct ctctgattac
      961 aacatccaga aagagtcaac cctgcacctg gtcctccgcc tgaggggtgg ctattaattc
     1021 ttcagtctgc attcccggcg ggcactgatg gcattactct gcactctagc catttgcccc
     1081 aatttaagtt tagaaattac aagtttcagt aatagctgaa cctctgttaa aaatgttaat
     1141 aaaggttttg ttgcatggta agcata
//
