LOCUS       NM_001191792            2585 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus ubiquitin associated and SH3 domain containing, B
            (Ubash3b), mRNA.
ACCESSION   NM_001191792 XM_236104
VERSION     NM_001191792.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2585)
  AUTHORS   Reppschlager,K., Gosselin,J., Dangelmaier,C.A., Thomas,D.H.,
            Carpino,N., McKenzie,S.E., Kunapuli,S.P. and Tsygankov,A.Y.
  TITLE     TULA-2 Protein Phosphatase Suppresses Activation of Syk through the
            GPVI Platelet Receptor for Collagen by Dephosphorylating Tyr(P)346,
            a Regulatory Site of Syk
  JOURNAL   J Biol Chem 291 (43), 22427-22441 (2016)
   PUBMED   27609517
  REMARK    Erratum:[J Biol Chem. 2017 Mar 10;292(10 ):4360. PMID: 28283589]
REFERENCE   2  (bases 1 to 2585)
  AUTHORS   Back,S.H., Adapala,N.S., Barbe,M.F., Carpino,N.C., Tsygankov,A.Y.
            and Sanjay,A.
  TITLE     TULA-2, a novel histidine phosphatase, regulates bone remodeling by
            modulating osteoclast function
  JOURNAL   Cell Mol Life Sci 70 (7), 1269-1284 (2013)
   PUBMED   23149425
REFERENCE   3  (bases 1 to 2585)
  AUTHORS   Thomas,D.H., Getz,T.M., Newman,T.N., Dangelmaier,C.A., Carpino,N.,
            Kunapuli,S.P., Tsygankov,A.Y. and Daniel,J.L.
  TITLE     A novel histidine tyrosine phosphatase, TULA-2, associates with Syk
            and negatively regulates GPVI signaling in platelets
  JOURNAL   Blood 116 (14), 2570-2578 (2010)
   PUBMED   20585042
REFERENCE   4  (bases 1 to 2585)
  AUTHORS   Peruzzi,G., Molfetta,R., Gasparrini,F., Vian,L., Morrone,S.,
            Piccoli,M., Frati,L., Santoni,A. and Paolini,R.
  TITLE     The adaptor molecule CIN85 regulates Syk tyrosine kinase level by
            activating the ubiquitin-proteasome degradation pathway
  JOURNAL   J Immunol 179 (4), 2089-2096 (2007)
   PUBMED   17675467
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Jul 17, 2010 this sequence version replaced XM_236104.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ223998.1, SRR26643429.29825.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-167               JAXUCZ010000008.1  50428855-50429021   c
            168-221             JAXUCZ010000008.1  50323240-50323293   c
            222-408             JAXUCZ010000008.1  50322363-50322549   c
            409-607             JAXUCZ010000008.1  50319188-50319386   c
            608-777             JAXUCZ010000008.1  50316079-50316248   c
            778-986             JAXUCZ010000008.1  50308924-50309132   c
            987-1119            JAXUCZ010000008.1  50303138-50303270   c
            1120-1240           JAXUCZ010000008.1  50301247-50301367   c
            1241-1363           JAXUCZ010000008.1  50299619-50299741   c
            1364-1456           JAXUCZ010000008.1  50297620-50297712   c
            1457-1601           JAXUCZ010000008.1  50294686-50294830   c
            1602-1708           JAXUCZ010000008.1  50289267-50289373   c
            1709-1818           JAXUCZ010000008.1  50287766-50287875   c
            1819-2585           JAXUCZ010000008.1  50285689-50286455   c
FEATURES             Location/Qualifiers
     source          1..2585
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q22"
     gene            1..2585
                     /gene="Ubash3b"
                     /gene_synonym="RGD1310357; Sts-1; Sts1"
                     /note="ubiquitin associated and SH3 domain containing, B"
                     /db_xref="GeneID:315579"
                     /db_xref="RGD:1310357"
     exon            1..167
                     /gene="Ubash3b"
                     /gene_synonym="RGD1310357; Sts-1; Sts1"
                     /inference="alignment:Splign:2.1.0"
     CDS             40..1956
                     /gene="Ubash3b"
                     /gene_synonym="RGD1310357; Sts-1; Sts1"
                     /EC_number="3.1.3.48"
                     /note="Cbl-interacting protein Sts-1"
                     /codon_start=1
                     /product="ubiquitin-associated and SH3 domain-containing
                     protein B"
                     /protein_id="NP_001178721.1"
                     /db_xref="GeneID:315579"
                     /db_xref="RGD:1310357"
                     /translation="MAAREELYSKVTPRRDRLQRPGTVRHGSALDLLLSMGFPRARAQ
                     KALASTGGRSVQAACDWLFSHVGDPFLDDPLPREYVLYLRPTGPLAQKLSDFWQQSKQ
                     ICGKNKAHNIFPHITLCQFFMCEDSKVDALGEALQTTVSRWRCKFSAPLPLELYTSSN
                     FIGLFVKEDSAEVLKKFAADFAAEAASKTEVHVEPHKKQLHVTLAYHFQASHLPTLEK
                     LAQNIDVKLGCDWVATIFSRDIRFANHETLQVIYPYSPQNDDELELVPGDFIFMSPME
                     QTSTSEGWIYGTSLTTGCSGLLPENYITKADECSTWIFHGSCSILNTVSSSALAFGDG
                     ALERRQYEDQGLGETTPLTIICQPMQPLRVNSQPGPQKRCLFVCRHGERMDVVFGKYW
                     LSQCFDAKGRYIRTNLNMPHSLPQRSGSFRDYEKDAPITVFGCMQARLVGEALLESNT
                     VIDHVYCSPSLRCVQTAHNILKGLQQDNHLKIRVEPGLFEWTKWVAGSTLPAWMPPSE
                     LAAANLSVDTTYRPHIPVSKLVISESYDTYINRSFQVTKEIISECKSKGNNILIVAHA
                     SSLEACTCQLQGLSPQNSKDFVQMVRKIPYLGFCSCEELGETGIWQLTDPPILPLTHG
                     PTGGFNWRETLLQE"
     exon            168..221
                     /gene="Ubash3b"
                     /gene_synonym="RGD1310357; Sts-1; Sts1"
                     /inference="alignment:Splign:2.1.0"
     exon            222..408
                     /gene="Ubash3b"
                     /gene_synonym="RGD1310357; Sts-1; Sts1"
                     /inference="alignment:Splign:2.1.0"
     exon            409..607
                     /gene="Ubash3b"
                     /gene_synonym="RGD1310357; Sts-1; Sts1"
                     /inference="alignment:Splign:2.1.0"
     exon            608..777
                     /gene="Ubash3b"
                     /gene_synonym="RGD1310357; Sts-1; Sts1"
                     /inference="alignment:Splign:2.1.0"
     exon            778..986
                     /gene="Ubash3b"
                     /gene_synonym="RGD1310357; Sts-1; Sts1"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1119
                     /gene="Ubash3b"
                     /gene_synonym="RGD1310357; Sts-1; Sts1"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1240
                     /gene="Ubash3b"
                     /gene_synonym="RGD1310357; Sts-1; Sts1"
                     /inference="alignment:Splign:2.1.0"
     exon            1241..1363
                     /gene="Ubash3b"
                     /gene_synonym="RGD1310357; Sts-1; Sts1"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..1456
                     /gene="Ubash3b"
                     /gene_synonym="RGD1310357; Sts-1; Sts1"
                     /inference="alignment:Splign:2.1.0"
     exon            1457..1601
                     /gene="Ubash3b"
                     /gene_synonym="RGD1310357; Sts-1; Sts1"
                     /inference="alignment:Splign:2.1.0"
     exon            1602..1708
                     /gene="Ubash3b"
                     /gene_synonym="RGD1310357; Sts-1; Sts1"
                     /inference="alignment:Splign:2.1.0"
     exon            1709..1818
                     /gene="Ubash3b"
                     /gene_synonym="RGD1310357; Sts-1; Sts1"
                     /inference="alignment:Splign:2.1.0"
     exon            1819..2585
                     /gene="Ubash3b"
                     /gene_synonym="RGD1310357; Sts-1; Sts1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgagcggt cactcggcat cgcgacccca gccctaggca tggccgcgcg cgaggagctg
       61 tacagcaaag tcaccccgcg tagggaccgc ctgcagcgtc cgggcaccgt caggcatggg
      121 tcggcgctgg acctgctcct gtccatgggc ttcccccgcg cccgcgcaca aaaagctctg
      181 gcatccacgg gaggaagaag cgttcaagca gcatgtgact ggttgttctc ccacgtcggg
      241 gaccccttcc tggatgaccc cctgcctcgg gagtatgttc tctacctccg cccaaccggt
      301 ccattagccc agaagctctc tgacttctgg cagcagtcca agcagatctg tgggaagaac
      361 aaggcccaca acatcttccc ccacatcacc ctctgccagt tcttcatgtg cgaggacagc
      421 aaggtggatg ctctgggaga agccctgcag actactgtca gtcgatggag gtgtaagttc
      481 tcagccccac tacccctgga gctgtacacc tcctccaact tcatcgggct ctttgtgaag
      541 gaagacagcg cagaggtcct caagaagttc gcggctgact tcgccgcaga ggctgcatcc
      601 aaaaccgaag tgcacgtgga gcctcataag aagcagctgc acgtgacact ggcctaccac
      661 ttccaagcca gccacctacc caccctagag aaactcgccc agaacatcga tgtcaagcta
      721 gggtgtgact gggtggccac catattctct cgggatatcc gatttgctaa tcatgagacg
      781 ttacaggtga tctaccccta ttcacctcag aatgatgacg aattggagtt ggtcccaggg
      841 gacttcatct tcatgtctcc tatggaacag accagcacca gtgagggctg gatttatggc
      901 acctcgctga ccactggctg ctctgggctg ctccccgaga actacattac caaggctgat
      961 gagtgtagca cctggatctt ccatggttcc tgttctatct tgaatacggt atcatccagc
     1021 gcactcgcat ttggcgatgg ggcgttagag aggcggcagt atgaggatca aggacttggg
     1081 gagactacac ccctcactat catttgtcag cccatgcagc ccctgagagt caacagccag
     1141 cctgggcccc agaagcgatg cctctttgtc tgtcggcacg gggagaggat ggacgttgtg
     1201 tttgggaagt actggctatc ccaatgtttc gatgccaaag gccgctacat acgcaccaac
     1261 ctgaacatgc ctcacagctt acctcagcgg agcggcagtt tccgggatta cgagaaagat
     1321 gctccaatca ctgtgtttgg gtgtatgcaa gcaagactag tgggtgaagc cttgttagaa
     1381 agtaacaccg tcattgacca cgtttattgc tcaccatccc tacgctgcgt tcagaccgca
     1441 cataatatat tgaaaggttt acaacaagac aatcacttga agattcgggt cgagccaggc
     1501 ctatttgaat ggacaaagtg ggttgctggg agcacattgc cagcatggat gcctccatca
     1561 gagctagcag cagccaacct gagtgttgat acaacctaca gacctcacat tccagtcagc
     1621 aaattggtga tttcggaatc ctatgacacc tacatcaata ggagtttcca ggtgacgaag
     1681 gagataataa gtgaatgcaa aagtaaggga aataacattc tgattgtggc ccacgcatct
     1741 tccctcgaag catgtacctg ccagctccaa ggcctatccc cgcagaactc taaggacttc
     1801 gtgcaaatgg tccggaagat cccatattta ggcttctgtt cctgcgaaga actgggagaa
     1861 accggaatat ggcaactgac agacccaccc atccttcccc ttacccacgg acccactggg
     1921 ggcttcaact ggagagagac ccttctgcaa gaataagctg cctgagggat gggaggaact
     1981 tgcagacgag ccctcaggat gttccttagc agtgggaaag aaagcccacg ctgcattcaa
     2041 agcagacagc tcagaatcat ttagcatatt tcttttcatg cttaggggac agcgagatta
     2101 tgtcaacgag gggaagtcgt gattcagagg gagaattttt aaaaaatcct tctctctgga
     2161 cttgcctagc taacaaggct ttggagaatt gtcttcctga gctgagtacc tgctgctgca
     2221 gaaactacca ccctccttca ggctacgcat ggctaaagag cctcattctt ctcccagaga
     2281 gctgctccca ccctcaaaag gcatgcaagg ggaacgactg tgtctggaat ccaactgggc
     2341 atgggatagc cttttgtgct ctatttgcaa gttaggcaaa gccaccctga ggagtgcatt
     2401 ggtggttgtt aggaaccata cataagaaca gtcctgtgtc agacagcaga ttctcctctc
     2461 ggcagactcc attcattagc gtgccaggca cccacttgag gactcccagc attcaccctg
     2521 gtaccaccac ttgatctcca gagcagcctg gccctttgtg cctctctatc tgtgaaatgt
     2581 ggaga
//
