LOCUS       NM_001393920            3253 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus ubiquitin-like modifier activating enzyme 7
            (Uba7), mRNA.
ACCESSION   NM_001393920 XM_039081229
VERSION     NM_001393920.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3253)
  AUTHORS   Giannakopoulos,N.V., Arutyunova,E., Lai,C., Lenschow,D.J.,
            Haas,A.L. and Virgin,H.W.
  TITLE     ISG15 Arg151 and the ISG15-conjugating enzyme UbE1L are important
            for innate immune control of Sindbis virus
  JOURNAL   J Virol 83 (4), 1602-1610 (2009)
   PUBMED   19073728
REFERENCE   2  (bases 1 to 3253)
  AUTHORS   Durfee,L.A., Kelley,M.L. and Huibregtse,J.M.
  TITLE     The basis for selective E1-E2 interactions in the ISG15 conjugation
            system
  JOURNAL   J Biol Chem 283 (35), 23895-23902 (2008)
   PUBMED   18583345
REFERENCE   3  (bases 1 to 3253)
  AUTHORS   Kim,K.I., Yan,M., Malakhova,O., Luo,J.K., Shen,M.F., Zou,W., de la
            Torre,J.C. and Zhang,D.E.
  TITLE     Ube1L and protein ISGylation are not essential for alpha/beta
            interferon signaling
  JOURNAL   Mol Cell Biol 26 (2), 472-479 (2006)
   PUBMED   16382139
REFERENCE   4  (bases 1 to 3253)
  AUTHORS   Takeuchi,T., Iwahara,S., Saeki,Y., Sasajima,H. and Yokosawa,H.
  TITLE     Link between the ubiquitin conjugation system and the ISG15
            conjugation system: ISG15 conjugation to the UbcH6 ubiquitin E2
            enzyme
  JOURNAL   J Biochem 138 (6), 711-719 (2005)
   PUBMED   16428300
REFERENCE   5  (bases 1 to 3253)
  AUTHORS   Giannakopoulos,N.V., Luo,J.K., Papov,V., Zou,W., Lenschow,D.J.,
            Jacobs,B.S., Borden,E.C., Li,J., Virgin,H.W. and Zhang,D.E.
  TITLE     Proteomic identification of proteins conjugated to ISG15 in mouse
            and human cells
  JOURNAL   Biochem Biophys Res Commun 336 (2), 496-506 (2005)
   PUBMED   16139798
REFERENCE   6  (bases 1 to 3253)
  AUTHORS   Kim,K.I., Giannakopoulos,N.V., Virgin,H.W. and Zhang,D.E.
  TITLE     Interferon-inducible ubiquitin E2, Ubc8, is a conjugating enzyme
            for protein ISGylation
  JOURNAL   Mol Cell Biol 24 (21), 9592-9600 (2004)
   PUBMED   15485925
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 23, 2021 this sequence version replaced XM_039081229.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760400,
                              SAMEA5760476 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-200               JAXUCZ010000008.1  117543902-117544101
            201-369             JAXUCZ010000008.1  117544186-117544354
            370-504             JAXUCZ010000008.1  117544443-117544577
            505-611             JAXUCZ010000008.1  117544681-117544787
            612-702             JAXUCZ010000008.1  117545095-117545185
            703-838             JAXUCZ010000008.1  117545289-117545424
            839-936             JAXUCZ010000008.1  117545518-117545615
            937-1083            JAXUCZ010000008.1  117545705-117545851
            1084-1254           JAXUCZ010000008.1  117546209-117546379
            1255-1362           JAXUCZ010000008.1  117546566-117546673
            1363-1443           JAXUCZ010000008.1  117546808-117546888
            1444-1602           JAXUCZ010000008.1  117546965-117547123
            1603-1768           JAXUCZ010000008.1  117547205-117547370
            1769-1965           JAXUCZ010000008.1  117547449-117547645
            1966-2030           JAXUCZ010000008.1  117547752-117547816
            2031-2217           JAXUCZ010000008.1  117547898-117548084
            2218-2292           JAXUCZ010000008.1  117548156-117548230
            2293-2452           JAXUCZ010000008.1  117548434-117548593
            2453-2535           JAXUCZ010000008.1  117549421-117549503
            2536-2628           JAXUCZ010000008.1  117549755-117549847
            2629-2820           JAXUCZ010000008.1  117549941-117550132
            2821-2913           JAXUCZ010000008.1  117551757-117551849
            2914-3014           JAXUCZ010000008.1  117551923-117552023
            3015-3253           JAXUCZ010000008.1  117552471-117552709
FEATURES             Location/Qualifiers
     source          1..3253
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..3253
                     /gene="Uba7"
                     /gene_synonym="Ube1l"
                     /note="ubiquitin-like modifier activating enzyme 7"
                     /db_xref="GeneID:301000"
                     /db_xref="RGD:1308323"
     exon            1..200
                     /gene="Uba7"
                     /gene_synonym="Ube1l"
                     /inference="alignment:Splign:2.1.0"
     CDS             172..3144
                     /gene="Uba7"
                     /gene_synonym="Ube1l"
                     /codon_start=1
                     /product="ubiquitin-like modifier-activating enzyme 7"
                     /protein_id="NP_001380849.1"
                     /db_xref="GeneID:301000"
                     /db_xref="RGD:1308323"
                     /translation="MDEELYSRQLYVLGLPAMQRIREAKVLLCGLQGLGAEVAKNLVL
                     MGVGSLTLHDPHPTCWADLAAQFFLSEESLGRSRAEASQPQLAQLNEAVQISVHRGDI
                     TEDLVRGFQVVVLTDSKLEDQLNMGALCHKNRVYFLMAETRGLVGRLFCDFGEDFTVV
                     DPTEVEPTSAAIQDISQGSPGIVTLRGGSKRPSFYDGDLVMFSDIEGMVELNSHSPQP
                     VRVQKDGSLEIGDTTTFSRYLRGGVVTEVKRPKTVKHKPLDIALLQPCMVVQNTQEIQ
                     RAHCLHQTFHALHKFQQLHGRLPKPWDPDDAETVVWLAQDLEPLKGAKEESLDEALLR
                     TIALSSAGSLSPMAAILGGVAAQEVLKAVSGKFMPLDQWLYFDALECLPEDETLLPSP
                     EDCHPRNCRYDGQIAVFGTGFQEKLSYKHYLLQVGAGAIGCEMLKGFALVGLGVRDNG
                     GVTIADMDHVERSNLSRQFLFRPKDTGRPKAEVAAEAAHRLNPDLQVTSHTCPLDPTT
                     EDIYDDDFFSRVDGVVAALDSFQARHYVAARCTHYLKPLLEAGTQGTRGSASVFVPYV
                     TEVYKGPTSAEEAPYPVCTLRHFPSTVEHSLQWAQDEFEGLFRLSAETINDYQQTCTS
                     SLLGTDGTGILALLQQVMGVLRTRPQTWQDCVVWALGHWQLCFRDNIVELLRKFPSDK
                     VLEDGTLFWSGSKKCPHPLQFDPNQDTHFLYVLAAANLYARMHGLPGSQSQTALRELL
                     TLTLLQEPDSMPQNLFSAEFGQEQLKELQETLDDWNKGPPLKPVLFGKDDSSNFHEDF
                     VVAATDLRCQNYGILPVNRARIKQTIGRIIPAIATSTAVVAGLLGLELYKVVSGPRPL
                     GTFRHSYLHLAENHFIRSAPSAPAMQSFHHLEWTCWHRLTVPAGQPERTLESLLAHLQ
                     EEHGLTVRMLLHDQALLYSSGWPFEKQAQHLGLRVTELVQQVTGQKPKPGLRVLVFEL
                     SCEGEDDEMAFPPLHYEL"
     exon            201..369
                     /gene="Uba7"
                     /gene_synonym="Ube1l"
                     /inference="alignment:Splign:2.1.0"
     exon            370..504
                     /gene="Uba7"
                     /gene_synonym="Ube1l"
                     /inference="alignment:Splign:2.1.0"
     exon            505..611
                     /gene="Uba7"
                     /gene_synonym="Ube1l"
                     /inference="alignment:Splign:2.1.0"
     exon            612..702
                     /gene="Uba7"
                     /gene_synonym="Ube1l"
                     /inference="alignment:Splign:2.1.0"
     exon            703..838
                     /gene="Uba7"
                     /gene_synonym="Ube1l"
                     /inference="alignment:Splign:2.1.0"
     exon            839..936
                     /gene="Uba7"
                     /gene_synonym="Ube1l"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1083
                     /gene="Uba7"
                     /gene_synonym="Ube1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1254
                     /gene="Uba7"
                     /gene_synonym="Ube1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1255..1362
                     /gene="Uba7"
                     /gene_synonym="Ube1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1443
                     /gene="Uba7"
                     /gene_synonym="Ube1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1602
                     /gene="Uba7"
                     /gene_synonym="Ube1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1603..1768
                     /gene="Uba7"
                     /gene_synonym="Ube1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1769..1965
                     /gene="Uba7"
                     /gene_synonym="Ube1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1966..2030
                     /gene="Uba7"
                     /gene_synonym="Ube1l"
                     /inference="alignment:Splign:2.1.0"
     exon            2031..2217
                     /gene="Uba7"
                     /gene_synonym="Ube1l"
                     /inference="alignment:Splign:2.1.0"
     exon            2218..2292
                     /gene="Uba7"
                     /gene_synonym="Ube1l"
                     /inference="alignment:Splign:2.1.0"
     exon            2293..2452
                     /gene="Uba7"
                     /gene_synonym="Ube1l"
                     /inference="alignment:Splign:2.1.0"
     exon            2453..2535
                     /gene="Uba7"
                     /gene_synonym="Ube1l"
                     /inference="alignment:Splign:2.1.0"
     exon            2536..2628
                     /gene="Uba7"
                     /gene_synonym="Ube1l"
                     /inference="alignment:Splign:2.1.0"
     exon            2629..2820
                     /gene="Uba7"
                     /gene_synonym="Ube1l"
                     /inference="alignment:Splign:2.1.0"
     exon            2821..2913
                     /gene="Uba7"
                     /gene_synonym="Ube1l"
                     /inference="alignment:Splign:2.1.0"
     exon            2914..3014
                     /gene="Uba7"
                     /gene_synonym="Ube1l"
                     /inference="alignment:Splign:2.1.0"
     exon            3015..3253
                     /gene="Uba7"
                     /gene_synonym="Ube1l"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcattcattg gaaggaccag gaaccaactc tgtctagttt cacttttggt ttcctgaaat
       61 tacagaggag ccagaaagag agctgtaacc agcagcaccc agcagctcca agccctgttt
      121 cccttgctct tctgtgggca ctgcagcttc ttctccagcc cacgactgag aatggatgaa
      181 gagctgtact cgaggcagct gtatgtactg ggcttgcctg ctatgcagag gatccgggaa
      241 gccaaagtct tgctgtgtgg cctgcagggc ctgggagctg aggtggccaa gaacctggtc
      301 cttatgggtg tgggcagcct caccctgcat gatccccatc ccacctgctg ggctgacttg
      361 gctgctcagt ttttcctctc agaagagagc ttgggaagga gcagggctga ggcctctcaa
      421 ccacaattgg cccagcttaa tgaagctgtc cagatctccg tccacagagg cgacatcact
      481 gaggacctag tgcggggttt tcaggtagtg gtgctgactg actccaagct agaggaccag
      541 ctgaatatgg gagccttgtg ccataagaat agagtctact tcctcatggc tgaaacccgg
      601 ggccttgtgg ggcggttatt ctgtgatttt ggtgaggact tcactgttgt ggaccctaca
      661 gaggtggagc ccacgtcagc tgccatccag gacatctctc agggctcccc cggcattgtc
      721 actctgagag gaggcagcaa aagaccttcc ttttatgatg gggacttggt gatgttctca
      781 gacattgaag gcatggttga actcaacagt cattctccac agcctgtccg tgtgcagaaa
      841 gatggatcct tggagattgg agatacaaca actttctccc gttacttgag gggtggggtt
      901 gtcactgaag tcaagagacc caagactgtg aagcataagc ccctggacat agctctgctc
      961 cagccctgca tggtggtcca gaatactcag gaaatacaac gcgctcactg cctacaccag
     1021 accttccatg cactgcacaa gttccagcaa cttcatggcc ggctacccaa gccctgggat
     1081 cctgatgacg cagagaccgt ggtgtggctg gcccaggacc tagagccact aaaaggggca
     1141 aaagaagagt cgctggatga ggctctactc cggacaattg ccctgagtag tgctggtagc
     1201 ttaagtccca tggcagccat tctgggagga gtggctgccc aggaagtcct gaaggcagtc
     1261 tccgggaagt tcatgcccct ggaccagtgg ctgtactttg atgcccttga atgtcttcca
     1321 gaagatgaga cgctcctgcc cagtcctgag gactgtcatc caagaaactg ccgatacgac
     1381 gggcaaattg ctgtgttcgg gactggtttt caggagaaac tgagctacaa acactacctc
     1441 ttgcaggtag gtgctggtgc cattggctgt gagatgctca aaggttttgc cctagtgggc
     1501 ctgggagtta gggataatgg cggtgtgaca attgctgaca tggaccacgt agaacgctcc
     1561 aacctcagcc ggcagttcct cttcaggccc aaggacactg ggaggcccaa ggcagaggtg
     1621 gctgcagagg cagcccatcg cctaaaccca gacctgcaag tgacttcaca tacctgccct
     1681 ctggatccca ccacagagga catctatgac gacgacttct tctccagggt ggacggcgtt
     1741 gttgctgctt tggacagttt ccaggcccgg cactatgttg ctgctcgatg cacccactat
     1801 ttgaaaccac tgctggaggc aggcacccag ggaacccggg ggagtgcttc agtgtttgtg
     1861 ccatatgtga cagaagtcta caaaggtcct acctcagccg aggaagctcc ctaccctgtg
     1921 tgcaccctgc ggcattttcc cagcactgtg gagcacagcc tgcagtgggc ccaggacgaa
     1981 tttgaggggc tcttcagact atccgcagag accatcaacg actaccaaca gacatgcact
     2041 tcctccctgt tgggcaccga tgggactgga atattggcct tactgcagca agtgatgggc
     2101 gtcctaagaa ctcggccaca gacctggcaa gactgtgtgg tgtgggctct tggccactgg
     2161 caactgtgct tccgtgataa catcgtggag ctgctgagaa aattcccatc tgataaagtg
     2221 cttgaggacg gaactctgtt ctggtcagga tccaaaaagt gcccacatcc cttgcaattt
     2281 gatcccaacc aagacacgca tttcctctat gtactggcag ctgccaacct gtatgcacgg
     2341 atgcatgggc tgccgggctc acaaagtcag actgcactca gggaactgct gacactgaca
     2401 ctgctgcagg agcctgattc catgccccag aacctcttct ctgctgagtt tggccaggaa
     2461 cagttgaagg aactgcagga aaccctggat gactggaaca aggggcctcc actgaagcct
     2521 gtgctgtttg ggaaggatga cagcagcaac ttccacgagg actttgtagt agcagcgaca
     2581 gacctgcgct gtcagaacta tgggatcctg ccagttaacc gtgctcggat caagcaaacc
     2641 atcggccgga ttatcccagc cattgccacc agtacagcag ttgtggcggg cttactgggc
     2701 ctggagctgt ataaggtggt aagtgggcca cggccccttg gcacctttcg gcacagctac
     2761 ctgcacctgg ctgaaaacca cttcatacgc tcagcacctt ctgccccggc catgcagtcg
     2821 ttccatcacc tggaatggac ctgttggcac cgcctgacgg tgcctgctgg gcagcctgag
     2881 aggacactgg aatccctgct ggcccatctc caggaagagc atggactgac ggtgaggatg
     2941 ctgctgcatg accaggctct gctctattct tcaggatggc catttgaaaa gcaggctcag
     3001 cacttgggcc tcagggtgac agaactagtt cagcaggtga ccggccagaa acccaagcct
     3061 gggctgagag ttctggtgtt tgagctgagc tgtgagggtg aggatgacga aatggccttc
     3121 ccacctctgc attatgagct gtgatgaggt ggccaccacg ccaccacttg gccatcacga
     3181 actctgcata caattcctgc atcttcagcc cacagcggat acttcaacaa taaaagcttg
     3241 ttgaaggaag gca
//
