LOCUS       NM_001009669            2350 bp    mRNA    linear   ROD 05-AUG-2024
DEFINITION  Rattus norvegicus ubiquitin-like modifier activating enzyme 5
            (Uba5), mRNA.
ACCESSION   NM_001009669 XM_217245
VERSION     NM_001009669.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2350)
  AUTHORS   Colin,E., Daniel,J., Ziegler,A., Wakim,J., Scrivo,A., Haack,T.B.,
            Khiati,S., Denomme,A.S., Amati-Bonneau,P., Charif,M., Procaccio,V.,
            Reynier,P., Aleck,K.A., Botto,L.D., Herper,C.L., Kaiser,C.S.,
            Nabbout,R., N'Guyen,S., Mora-Lorca,J.A., Assmann,B., Christ,S.,
            Meitinger,T., Strom,T.M., Prokisch,H., Miranda-Vizuete,A.,
            Hoffmann,G.F., Lenaers,G., Bomont,P., Liebau,E. and Bonneau,D.
  CONSRTM   FREX Consortium
  TITLE     Biallelic Variants in UBA5 Reveal that Disruption of the UFM1
            Cascade Can Result in Early-Onset Encephalopathy
  JOURNAL   Am J Hum Genet 99 (3), 695-703 (2016)
   PUBMED   27545681
REFERENCE   2  (bases 1 to 2350)
  AUTHORS   Duan,R., Shi,Y., Yu,L., Zhang,G., Li,J., Lin,Y., Guo,J., Wang,J.,
            Shen,L., Jiang,H., Wang,G. and Tang,B.
  TITLE     UBA5 Mutations Cause a New Form of Autosomal Recessive Cerebellar
            Ataxia
  JOURNAL   PLoS One 11 (2), e0149039 (2016)
   PUBMED   26872069
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2350)
  AUTHORS   Yoo,H.M., Kang,S.H., Kim,J.Y., Lee,J.E., Seong,M.W., Lee,S.W.,
            Ka,S.H., Sou,Y.S., Komatsu,M., Tanaka,K., Lee,S.T., Noh,D.Y.,
            Baek,S.H., Jeon,Y.J. and Chung,C.H.
  TITLE     Modification of ASC1 by UFM1 is crucial for ERalpha transactivation
            and breast cancer development
  JOURNAL   Mol Cell 56 (2), 261-274 (2014)
   PUBMED   25219498
REFERENCE   4  (bases 1 to 2350)
  AUTHORS   Zhang,Y., Zhang,M., Wu,J., Lei,G. and Li,H.
  TITLE     Transcriptional regulation of the Ufm1 conjugation system in
            response to disturbance of the endoplasmic reticulum homeostasis
            and inhibition of vesicle trafficking
  JOURNAL   PLoS One 7 (11), e48587 (2012)
   PUBMED   23152784
REFERENCE   5  (bases 1 to 2350)
  AUTHORS   Tatsumi,K., Sou,Y.S., Tada,N., Nakamura,E., Iemura,S., Natsume,T.,
            Kang,S.H., Chung,C.H., Kasahara,M., Kominami,E., Yamamoto,M.,
            Tanaka,K. and Komatsu,M.
  TITLE     A novel type of E3 ligase for the Ufm1 conjugation system
  JOURNAL   J Biol Chem 285 (8), 5417-5427 (2010)
   PUBMED   20018847
REFERENCE   6  (bases 1 to 2350)
  AUTHORS   Komatsu,M., Chiba,T., Tatsumi,K., Iemura,S., Tanida,I., Okazaki,N.,
            Ueno,T., Kominami,E., Natsume,T. and Tanaka,K.
  TITLE     A novel protein-conjugating system for Ufm1, a ubiquitin-fold
            modifier
  JOURNAL   EMBO J 23 (9), 1977-1986 (2004)
   PUBMED   15071506
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 18, 2021 this sequence version replaced NM_001009669.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC088757.1, SRR22399492.860269.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-349               JAXUCZ010000008.1  113559363-113559711 c
            350-395             JAXUCZ010000008.1  113556885-113556930 c
            396-485             JAXUCZ010000008.1  113556705-113556794 c
            486-595             JAXUCZ010000008.1  113553569-113553678 c
            596-682             JAXUCZ010000008.1  113552423-113552509 c
            683-767             JAXUCZ010000008.1  113551808-113551892 c
            768-872             JAXUCZ010000008.1  113551381-113551485 c
            873-1000            JAXUCZ010000008.1  113551109-113551236 c
            1001-1136           JAXUCZ010000008.1  113547238-113547373 c
            1137-1215           JAXUCZ010000008.1  113546918-113546996 c
            1216-1322           JAXUCZ010000008.1  113546630-113546736 c
            1323-2350           JAXUCZ010000008.1  113544037-113545064 c
FEATURES             Location/Qualifiers
     source          1..2350
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..2350
                     /gene="Uba5"
                     /gene_synonym="Ube1dc1"
                     /note="ubiquitin-like modifier activating enzyme 5"
                     /db_xref="GeneID:300968"
                     /db_xref="RGD:1311702"
     exon            1..349
                     /gene="Uba5"
                     /gene_synonym="Ube1dc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             195..1406
                     /gene="Uba5"
                     /gene_synonym="Ube1dc1"
                     /note="UFM1-activating enzyme; ubiquitin-activating enzyme
                     5; ubiquitin-activating enzyme E1 domain-containing
                     protein 1; ubiquitin-activating enzyme E1-domain
                     containing 1"
                     /codon_start=1
                     /product="ubiquitin-like modifier-activating enzyme 5"
                     /protein_id="NP_001009669.1"
                     /db_xref="GeneID:300968"
                     /db_xref="RGD:1311702"
                     /translation="MAESVERLLQRVEELEQELARERSRRIAGDGHCGRTRIQKMSDE
                     VVDSNPYSRLMALKRMGVVSDYEKIRTYAVAIVGVGGVGSVTAEMLTRCGIGKLLLFD
                     YDKVELANMNRLFFQPYQAGMSKVQAAEHTLRSINPDVLFEVHNYNITTVEHFEHFMN
                     RISNGGLEEGQPVDLVLSCVDNFEARMAINTACNELGQTWMESGVSENAVSGHIQLMV
                     PGESACFACAPPLVVASNIDEKTLKREGVCAASLPTTMGVVAGILVQNVLKFLLKFGT
                     VSFYLGYNAMQDFFPTMFMKPNPQCDDKNCRKQQEEYKKRAPAQPTQETAPQEEEEVV
                     HEDNEWGIELVSEVSEEELKNSSGPVPTLPEGITVAYTVPKKREDSVSEVTVEDSGES
                     LEDLMARMKKM"
     exon            350..395
                     /gene="Uba5"
                     /gene_synonym="Ube1dc1"
                     /inference="alignment:Splign:2.1.0"
     exon            396..485
                     /gene="Uba5"
                     /gene_synonym="Ube1dc1"
                     /inference="alignment:Splign:2.1.0"
     exon            486..595
                     /gene="Uba5"
                     /gene_synonym="Ube1dc1"
                     /inference="alignment:Splign:2.1.0"
     exon            596..682
                     /gene="Uba5"
                     /gene_synonym="Ube1dc1"
                     /inference="alignment:Splign:2.1.0"
     exon            683..767
                     /gene="Uba5"
                     /gene_synonym="Ube1dc1"
                     /inference="alignment:Splign:2.1.0"
     exon            768..872
                     /gene="Uba5"
                     /gene_synonym="Ube1dc1"
                     /inference="alignment:Splign:2.1.0"
     exon            873..1000
                     /gene="Uba5"
                     /gene_synonym="Ube1dc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1136
                     /gene="Uba5"
                     /gene_synonym="Ube1dc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1215
                     /gene="Uba5"
                     /gene_synonym="Ube1dc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..1322
                     /gene="Uba5"
                     /gene_synonym="Ube1dc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..2350
                     /gene="Uba5"
                     /gene_synonym="Ube1dc1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaagtggcg tgcggaagtc cggtgggcat gccggagacg tgtcttactg ggaccattgg
       61 agtcgcttcc ccggtgtagg gatcaggaag gctgtgtcta gtcctcctga acttcgtgag
      121 cccagcagag cagcgtgggg cggcggcgac ggcggcggtc cggcctggga tcgggggcca
      181 ccgggagccc agccatggcc gagtcggtgg agcggctgct gcagcgggtt gaggagctgg
      241 agcaggaact cgcccgggag agaagccggc ggattgcggg ggacggccac tgcggccgga
      301 cccgcatcca gaagatgagc gacgaggtgg tggattccaa tccctacagc cgtctgatgg
      361 cattgaaacg gatgggagtt gtcagtgact atgagaaaat ccgtacctat gctgtagcaa
      421 tagtaggtgt tggtggagtt ggtagtgtga ctgctgaaat gctgacaaga tgtggcattg
      481 gtaagttgct actctttgac tatgacaagg tggagctggc caacatgaat cgacttttct
      541 tccagccgta tcaagcaggg atgagtaagg tccaagcagc agagcacacc ctgaggagca
      601 ttaaccctga tgttctgttt gaagttcaca actataatat caccaccgtg gaacacttcg
      661 aacatttcat gaatagaata agtaatgggg gattagaaga aggacaacct gttgacctag
      721 ttcttagctg tgtggacaac tttgaagctc gaatggcaat aaatacagct tgtaatgaac
      781 ttggtcagac atggatggaa tctggggtca gtgaaaacgc agtttccggg cacatccagc
      841 ttatggtccc tggagagtcg gcttgctttg cgtgcgcacc accacttgta gttgcttcaa
      901 acattgatga aaaaaccctg aaacgagaag gcgtctgcgc ggccagcctc cccaccacca
      961 tgggagtggt tgcagggatc ttggtacaaa atgtattaaa gtttctgtta aaatttggga
     1021 ctgtcagttt ttacctcgga tacaatgcca tgcaggactt cttccctacc atgttcatga
     1081 agccaaaccc tcagtgtgat gacaaaaact gtaggaagca acaagaagaa tacaagaaga
     1141 gggcaccagc gcagcccacg caggagactg cgccccaaga ggaggaagag gtagttcatg
     1201 aggacaacga gtggggtatt gagctggtgt ctgaggtttc agaagaggaa ctgaagaact
     1261 cgtcaggtcc tgttcccacc ttacctgaag gaattacagt ggcatacaca gtcccaaaga
     1321 agagagagga ttctgtttct gaagtaacgg tggaagattc tggtgaaagc ttggaagatc
     1381 tcatggccag gatgaagaag atgtagacag tgggctggca cctgccgtgt ttccttgctt
     1441 gcgctattac tcccttggaa ttaaacagtc agaactaata aaacttagtg ccaccttggt
     1501 tggttcgtga atcatcactg agtcgttacg ctgtatggaa cactagtggt ttcttcgtgc
     1561 ttccctgtac agcctgatca gtaccacaac tacaggaagg agaggagcgg gccatcccat
     1621 tccataactc cctttatgta atcccacgtc tgtggcctga ggctctggac gataaatagc
     1681 acaaatggag gaaggactgt gtaacctgct agctgtggtg acaagtgtct gagtgaatgg
     1741 cttcctacag ttaacccact catagtctga ccaggagtga cttaaaacag cctatagaat
     1801 aaaaacatgc ctcagatgtt tctggatgaa atagaagcag aatgccttca ttggtagtgt
     1861 ataaacccat gggtcgaatc tttagggcaa agcctagata aacgtgagcc gttttcatgc
     1921 agacagaagt acatccagga gacattggtt acagtctaac tttcctcgac caaggagaag
     1981 gcattgctct ctgtagcaga agcgtccaga gtcaccatgt tactggagaa caccgtccat
     2041 actatactat acccatccca gggctcctca atacctgatc tataatactg agatgctagc
     2101 gaggcttgtc aacaacgaac tcagactgcc tctgcagagg tgagcaggta tcaattccct
     2161 gcaagggttc cacttcccaa ctgtgagcac ctcaattgta aacggatgcc ggatgtgaac
     2221 tattggtgtt ttaaccttga agatatggga tgtgtcatta tgaatgtcta aattatatgt
     2281 atcgggaaat gttagcagaa gttaaaagtg ccattctctc ttgtaaaata aagttgtaaa
     2341 gaccaactca
//
