LOCUS       NM_057205               2189 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus ubiquitin-like modifier activating enzyme 3
            (Uba3), mRNA.
ACCESSION   NM_057205
VERSION     NM_057205.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2189)
  AUTHORS   Ohki,Y., Funatsu,N., Konishi,N. and Chiba,T.
  TITLE     The mechanism of poly-NEDD8 chain formation in vitro
  JOURNAL   Biochem Biophys Res Commun 381 (3), 443-447 (2009)
   PUBMED   19245792
REFERENCE   2  (bases 1 to 2189)
  AUTHORS   Bohnsack,R.N. and Haas,A.L.
  TITLE     Conservation in the mechanism of Nedd8 activation by the human
            AppBp1-Uba3 heterodimer
  JOURNAL   J Biol Chem 278 (29), 26823-26830 (2003)
   PUBMED   12740388
REFERENCE   3  (bases 1 to 2189)
  AUTHORS   Fan,M., Long,X., Bailey,J.A., Reed,C.A., Osborne,E., Gize,E.A.,
            Kirk,E.A., Bigsby,R.M. and Nephew,K.P.
  TITLE     The activating enzyme of NEDD8 inhibits steroid receptor function
  JOURNAL   Mol Endocrinol 16 (2), 315-330 (2002)
   PUBMED   11818503
  REMARK    GeneRIF: activating enzyme of NEDD8 inhibits steroid receptor
            function
REFERENCE   4  (bases 1 to 2189)
  AUTHORS   Tateishi,K., Omata,M., Tanaka,K. and Chiba,T.
  TITLE     The NEDD8 system is essential for cell cycle progression and
            morphogenetic pathway in mice
  JOURNAL   J Cell Biol 155 (4), 571-579 (2001)
   PUBMED   11696557
REFERENCE   5  (bases 1 to 2189)
  AUTHORS   Gong,L. and Yeh,E.T.
  TITLE     Identification of the activating and conjugating enzymes of the
            NEDD8 conjugation pathway
  JOURNAL   J Biol Chem 274 (17), 12036-12042 (1999)
   PUBMED   10207026
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC081743.1.
            
            On Dec 7, 2007 this sequence version replaced NM_057205.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081743.1, AF336829.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..2189
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q34"
     gene            1..2189
                     /gene="Uba3"
                     /gene_synonym="Ube1c"
                     /note="ubiquitin-like modifier activating enzyme 3"
                     /db_xref="GeneID:117553"
                     /db_xref="RGD:621084"
     exon            1..24
                     /gene="Uba3"
                     /gene_synonym="Ube1c"
                     /inference="alignment:Splign:2.1.0"
     CDS             5..1393
                     /gene="Uba3"
                     /gene_synonym="Ube1c"
                     /EC_number="6.2.1.64"
                     /note="NEDD8-activating enzyme E1C; ubiquitin-activating
                     enzyme 3; ubiquitin-activating enzyme E1C (UBA3 homolog,
                     yeast)"
                     /codon_start=1
                     /product="NEDD8-activating enzyme E1 catalytic subunit"
                     /protein_id="NP_476553.1"
                     /db_xref="GeneID:117553"
                     /db_xref="RGD:621084"
                     /translation="MADGEEPEKKRRRIEELLAEKMAVDGGCGDTGDWEGRWNHVKKF
                     LERSGPFTHPDFEPSTESLQFLLDTCKVLVIGAGGLGCELLKNLALSGFRQIHVIDMD
                     TIDVSNLNRQFLFRPKDVGRPKAEVAAEFLNDRVPNCNVVPHFNKIQDFNDTFYRQFH
                     IIVCGLDSIIARRWINGMLISLLNYEDGVLDPSSIVPLIDGGTEGFKGNARVILPGMT
                     ACIECTLELYPPQVNFPMCTIASMPRLPEHCIEYVRMLQWPKEQPFGDGVPLDGDDPE
                     HIQWIFQKSVERASQYNIRGVTYRLTQGVVKRIIPAVASTNAVIAAVCATEVFKIATS
                     AYIPLNNYLVFNDVDGLYTYTFEAERKENCPACSQLPQNIQFSPSAKLQEVLDYLTNS
                     ASLQMKSPAITATLEGKNRTLYLQSVTSIEERTRPNLSKTLKELGLVDGQELAVADVT
                     TPQTVLFKLHFT"
     exon            25..66
                     /gene="Uba3"
                     /gene_synonym="Ube1c"
                     /inference="alignment:Splign:2.1.0"
     exon            67..187
                     /gene="Uba3"
                     /gene_synonym="Ube1c"
                     /inference="alignment:Splign:2.1.0"
     exon            188..268
                     /gene="Uba3"
                     /gene_synonym="Ube1c"
                     /inference="alignment:Splign:2.1.0"
     exon            269..351
                     /gene="Uba3"
                     /gene_synonym="Ube1c"
                     /inference="alignment:Splign:2.1.0"
     exon            352..432
                     /gene="Uba3"
                     /gene_synonym="Ube1c"
                     /inference="alignment:Splign:2.1.0"
     exon            433..476
                     /gene="Uba3"
                     /gene_synonym="Ube1c"
                     /inference="alignment:Splign:2.1.0"
     exon            477..541
                     /gene="Uba3"
                     /gene_synonym="Ube1c"
                     /inference="alignment:Splign:2.1.0"
     exon            542..697
                     /gene="Uba3"
                     /gene_synonym="Ube1c"
                     /inference="alignment:Splign:2.1.0"
     exon            698..800
                     /gene="Uba3"
                     /gene_synonym="Ube1c"
                     /inference="alignment:Splign:2.1.0"
     exon            801..914
                     /gene="Uba3"
                     /gene_synonym="Ube1c"
                     /inference="alignment:Splign:2.1.0"
     exon            915..968
                     /gene="Uba3"
                     /gene_synonym="Ube1c"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1005
                     /gene="Uba3"
                     /gene_synonym="Ube1c"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1087
                     /gene="Uba3"
                     /gene_synonym="Ube1c"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..1188
                     /gene="Uba3"
                     /gene_synonym="Ube1c"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1252
                     /gene="Uba3"
                     /gene_synonym="Ube1c"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..1307
                     /gene="Uba3"
                     /gene_synonym="Ube1c"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..2170
                     /gene="Uba3"
                     /gene_synonym="Ube1c"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caatatggcg gatggcgagg agccggagaa gaaaagaagg agaatagagg agctgctggc
       61 tgagaaaatg gctgttgatg gtgggtgtgg ggacactgga gactgggaag gtcgctggaa
      121 ccatgtaaag aagttcctcg agcggtccgg acccttcaca caccctgatt tcgaaccgag
      181 cactgaatca ctccagttct tgttagatac atgtaaagtt ctagtcattg gagctggtgg
      241 cttaggatgt gagctactga aaaatctggc attgtctggt tttagacaga ttcatgttat
      301 agacatggac actatagatg tttccaattt aaataggcag tttttattta ggcctaaaga
      361 tgttggaaga cccaaggctg aagttgctgc agaattcctg aatgacagag ttcctaactg
      421 caacgtggtc ccacatttca acaagattca agattttaac gacactttct accgacaatt
      481 tcatattatc gtatgtggcc tggactctat catagccagg agatggatca atggaatgct
      541 gatatctctt ctaaattatg aagatggtgt gttggatcca agctccatcg tacctttgat
      601 agatgggggc acagaaggct ttaaagggaa tgcccgagtg attttgcctg gaatgaccgc
      661 ttgtattgag tgcactctgg aactttaccc accacaggtc aatttcccca tgtgtaccat
      721 tgcatctatg cccaggctcc cagagcactg tatcgagtat gtaaggatgt tgcagtggcc
      781 taaagagcag ccttttggag atggggttcc attagacgga gatgaccctg aacatattca
      841 gtggattttc caaaagtctg tagagagagc atcacaatat aatattagag gtgttaccta
      901 cagactcact caaggggtag taaaacgaat cattcccgca gtagcttcta caaatgcagt
      961 cattgcagct gtgtgtgcca ctgaggtttt caagatagct acaagtgcgt acattcccct
     1021 taataattac ttagtattca atgatgtaga tggactgtac acttacacat ttgaagcaga
     1081 gagaaaggag aactgccctg cgtgtagcca gcttcctcaa aacatccagt tctccccatc
     1141 agctaaactg caagaggtgt tagactatct aaccaatagt gcttctctgc aaatgaagtc
     1201 tccagctatt acagccacat tagaggggaa aaacaggaca ctttatttac agtcagtaac
     1261 gtctattgaa gaacgaacga gaccgaatct ttccaaaaca ttaaaagaac tgggactagt
     1321 tgatggacaa gaactggctg ttgctgacgt caccacacca caaactgtac tattcaaact
     1381 tcattttact taaggaaaat aaatctgcac ataatagaat tcatagaaat aatatgcttt
     1441 ataaatgtta tgcaattgaa gagccgggaa gatgaggcag aggggaacac ccaagaaagg
     1501 aaatttaatt gatgtcattt ttagcattag tgtggctaga atttgacttt ttatatatac
     1561 atatatataa aaaatgaatg actctttttt aactttataa gtttctcttg aagactgaac
     1621 ttctgggttg ggctagtaag cattttcatt ttagtaatat tgaaaaccat gcctccagga
     1681 aagattatga acaaatgtcc tgcttcttta aagcaggaca aacactgtct ttttgtgtga
     1741 gtttgttatg gtcaaacaac atattcctca gcttgcattt gagcatccac ctgtatagaa
     1801 atgtattctt gaatggaaat gaggaattat gtcttaagaa cattaaatat ttacaacctg
     1861 acatctagag atatcaaaca taggcaattt cttcattact actcatataa ttgtgactgt
     1921 ccatgtgtgt attaattatt gcagagttta acttgtccat gataatttgt aaacagtatt
     1981 atagagtcat acctgtgcat gaaaatacaa aatattttca tgtatttatt tgcaatgcca
     2041 cagagaccag tatgcacaaa tttaaaccaa gacatggctg ttcaaagaaa ttaatgtttc
     2101 aacagttatc attgatgctt ttgcactatt tattaataaa attgtacatt gtctactttt
     2161 tattgaaaaa aaaaaaaaaa aaaaaaaaa
//
