LOCUS       NM_001100579            2640 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus ubiquitin-like modifier activating enzyme 2
            (Uba2), mRNA.
ACCESSION   NM_001100579 XM_001076929 XM_218502
VERSION     NM_001100579.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2640)
  AUTHORS   Jang CY, Shin HS, Kim HD, Kim JW, Choi SY and Kim J.
  TITLE     Ribosomal protein S3 is stabilized by sumoylation
  JOURNAL   Biochem Biophys Res Commun 414 (3), 523-527 (2011)
   PUBMED   21968017
REFERENCE   2  (bases 1 to 2640)
  AUTHORS   Ban R, Nishida T and Urano T.
  TITLE     Mitotic kinase Aurora-B is regulated by SUMO-2/3
            conjugation/deconjugation during mitosis
  JOURNAL   Genes Cells 16 (6), 652-669 (2011)
   PUBMED   21554500
REFERENCE   3  (bases 1 to 2640)
  AUTHORS   Olsen SK, Capili AD, Lu X, Tan DS and Lima CD.
  TITLE     Active site remodelling accompanies thioester bond formation in the
            SUMO E1
  JOURNAL   Nature 463 (7283), 906-912 (2010)
   PUBMED   20164921
REFERENCE   4  (bases 1 to 2640)
  AUTHORS   Gomez-del Arco P, Koipally J and Georgopoulos K.
  TITLE     Ikaros SUMOylation: switching out of repression
  JOURNAL   Mol Cell Biol 25 (7), 2688-2697 (2005)
   PUBMED   15767674
REFERENCE   5  (bases 1 to 2640)
  AUTHORS   Lois LM and Lima CD.
  TITLE     Structures of the SUMO E1 provide mechanistic insights into SUMO
            activation and E2 recruitment to E1
  JOURNAL   EMBO J 24 (3), 439-451 (2005)
   PUBMED   15660128
REFERENCE   6  (bases 1 to 2640)
  AUTHORS   Desterro JM, Rodriguez MS, Kemp GD and Hay RT.
  TITLE     Identification of the enzyme required for activation of the small
            ubiquitin-like protein SUMO-1
  JOURNAL   J Biol Chem 274 (15), 10618-10624 (1999)
   PUBMED   10187858
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC161985.1.
            
            On or before Sep 4, 2008 this sequence version replaced
            XM_218502.4, XM_001076929.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC161985.1, SRR8487231.155042.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2640
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..2640
                     /gene="Uba2"
                     /gene_synonym="Sae2; Uble1b"
                     /note="ubiquitin-like modifier activating enzyme 2"
                     /db_xref="GeneID:308508"
                     /db_xref="RGD:1312023"
     exon            1..206
                     /gene="Uba2"
                     /gene_synonym="Sae2; Uble1b"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..1988
                     /gene="Uba2"
                     /gene_synonym="Sae2; Uble1b"
                     /EC_number="6.3.2.-"
                     /note="ubiquitin-like 1 (sentrin) activating enzyme E1B;
                     SUMO1 activating enzyme subunit 2"
                     /codon_start=1
                     /product="SUMO-activating enzyme subunit 2"
                     /protein_id="NP_001094049.1"
                     /db_xref="GeneID:308508"
                     /db_xref="RGD:1312023"
                     /translation="MSLSRGLPRELAEAVSGGRVLVVGAGGIGCELLKNLVLTGFSHI
                     DLIDLDTIDVSNLNRQFLFQKKHVGRSKAQVAKESVLQFHPQANIEAHHDSIMNPDYN
                     VEFFRQFILVMNALDNRAARNHVNRMCLAADVPLIESGTAGYLGQVTTIKKGVTECYE
                     CHPKPTQRTFPGCTIRNTPSEPIHCIVWAKYLFNQLFGEEDADQEVSPDRADPEAAWE
                     PTEAEARARASNEDGDIKRISTKEWAKSTGYDPVKLFTKLFKDDIRYLLTMDKLWRKR
                     KPPVPLDWAEVQSQGEEANADQQSEPQLGLKDQQVLDVKSYASLFSKSIETLRVRLAE
                     KGDGAELIWDKDDPPAMDFVTSAANLRMHIFSMNMKSRFDIKSMAGNIIPAIATTNAV
                     IAGLIVLEGLKILSGKIDQCRTIFLNKQPNPRKKLLVPCALDPPNTNCYVCASKPEVT
                     VRLNVHKVTVLTLQDKIVKEKFAMVAPDVQIEDGKGTILISSEEGETEANNPKKLSDF
                     GIRNGSRLQADDFLQDYTLLINILHSEDLGKDVEFEVVGDTPEKVGPKQAEDAAKSIA
                     NGSDDGAQPSTSTAQEQDDVLIVDSDEEGPSNSADGSRDDRTRKRKLEENEGASTKKS
                     RLEQVEDQDDVIALD"
     exon            207..290
                     /gene="Uba2"
                     /gene_synonym="Sae2; Uble1b"
                     /inference="alignment:Splign:2.1.0"
     exon            291..361
                     /gene="Uba2"
                     /gene_synonym="Sae2; Uble1b"
                     /inference="alignment:Splign:2.1.0"
     exon            362..426
                     /gene="Uba2"
                     /gene_synonym="Sae2; Uble1b"
                     /inference="alignment:Splign:2.1.0"
     exon            427..527
                     /gene="Uba2"
                     /gene_synonym="Sae2; Uble1b"
                     /inference="alignment:Splign:2.1.0"
     exon            528..649
                     /gene="Uba2"
                     /gene_synonym="Sae2; Uble1b"
                     /inference="alignment:Splign:2.1.0"
     exon            650..717
                     /gene="Uba2"
                     /gene_synonym="Sae2; Uble1b"
                     /inference="alignment:Splign:2.1.0"
     exon            718..839
                     /gene="Uba2"
                     /gene_synonym="Sae2; Uble1b"
                     /inference="alignment:Splign:2.1.0"
     exon            840..939
                     /gene="Uba2"
                     /gene_synonym="Sae2; Uble1b"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1103
                     /gene="Uba2"
                     /gene_synonym="Sae2; Uble1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1197
                     /gene="Uba2"
                     /gene_synonym="Sae2; Uble1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1310
                     /gene="Uba2"
                     /gene_synonym="Sae2; Uble1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1466
                     /gene="Uba2"
                     /gene_synonym="Sae2; Uble1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1467..1563
                     /gene="Uba2"
                     /gene_synonym="Sae2; Uble1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1564..1669
                     /gene="Uba2"
                     /gene_synonym="Sae2; Uble1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1670..1806
                     /gene="Uba2"
                     /gene_synonym="Sae2; Uble1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1807..2613
                     /gene="Uba2"
                     /gene_synonym="Sae2; Uble1b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cacggacttc cggctaccac tctgcttctc ccgcctccga gtgtgcggcg gctcgtggaa
       61 gtcccgccat gtctctgtcg cgggggttac cccgggagct ggccgaggcg gtgtccggcg
      121 gccgggtcct ggtggttggc gcgggtggta tcggctgtga gctacttaag aatctggtgc
      181 tcactggctt ctcccacatc gacctgattg atctggacac tatcgacgtc agcaacctca
      241 acaggcagtt cttgtttcaa aagaaacatg tcggaagatc aaaggctcag gttgccaaag
      301 aaagtgtgct tcagttccac ccccaagcga acattgaggc ccaccatgac agcatcatga
      361 acccagacta taatgtggag ttttttcgac agtttatatt ggttatgaac gcattagata
      421 acagagctgc acgaaaccat gtgaatagga tgtgtctggc agctgacgtg cctctcattg
      481 agagtgggac tgctgggtat cttggacagg tgaccacgat caagaagggt gtgactgagt
      541 gttacgaatg tcatcctaag ccgacccaga gaacgttccc tggctgtacg attcggaaca
      601 caccttcaga acctatccat tgcatcgtat gggccaagta tttgttcaac cagctgtttg
      661 gagaggaaga tgctgatcaa gaagtgtctc ctgacagagc tgaccctgaa gctgcttggg
      721 aaccaacaga ggctgaagcc agagcccgag catccaatga agatggagac attaagcgga
      781 tttccactaa ggaatgggct aagtcaactg gatacgatcc agttaaactt tttaccaagc
      841 tttttaaaga tgatattagg tacctgctga caatggacaa actctggcgc aagaggaaac
      901 ctccagttcc actggactgg gctgaagtgc agagtcaagg agaagaagcc aatgctgatc
      961 aacaaagtga gccccagttg ggtttgaaag accagcaggt tctggatgta aagagctacg
     1021 caagtctgtt ttcaaagagc atcgagaccc tgagagtccg tttagccgag aagggagatg
     1081 gagctgagct catctgggat aaggacgacc cacctgcaat ggattttgtc acgtctgctg
     1141 caaacctcag gatgcacatt ttcagcatga acatgaagag caggtttgat ataaaatcaa
     1201 tggcggggaa catcatccct gctatagcca ccactaatgc agtgatcgcc ggcttgatag
     1261 tgttggaagg attaaagatt ttatctggaa aaatagacca gtgtagaact atatttttga
     1321 ataagcagcc aaacccgaga aagaagctct tggtgccctg tgcactagat cctcccaaca
     1381 ccaactgtta cgtttgtgcc agcaagccag aggtgaccgt gcggctgaat gtccacaaag
     1441 tgactgtcct caccttacag gataagatag tgaaagaaaa gtttgctatg gtggcaccag
     1501 atgtccaaat tgaagatggg aaaggcacaa tcctgatatc ttcagaagag ggagagacag
     1561 aagctaataa ccccaagaag ttgtctgatt ttggaattag aaatggcagc cggcttcaag
     1621 cagacgactt cctgcaggac tacactttgc tgatcaacat tcttcatagc gaggatctag
     1681 gaaaggatgt tgaatttgag gtagttggtg acacccctga aaaagtgggt ccaaaacaag
     1741 ctgaagacgc tgccaaaagc attgccaacg gcagcgatga tggcgcccag ccttccacct
     1801 ccacagcaca agaacaagat gatgtgctca tagttgattc agatgaagaa ggcccttcaa
     1861 atagcgccga cggtagcagg gacgatagga cccgcaagcg gaaactggaa gagaatgagg
     1921 gtgccagtac caagaagtcc cgcttggagc aggtggaaga tcaggatgac gtcatagcat
     1981 tagactgagc aggctcctgc cctggatctg gtcggaaccg gaagttatat cctttgttgc
     2041 agagggtgag cacaggctgc ggtggctttg gtggttctgc ccctgtgaaa gcgttcattt
     2101 gctgagactg ttagagactg ttgctgtgtt gaagtaggaa tagaatttgc gaccctttga
     2161 gcaaagctgg gtggaccagt gatgagctga aagaatgcgg gcgtgcatgt tgccttccct
     2221 gtaaatagcc ttagctatca tttcccagtg gaaaacactg tggggtagga gcgctgcaac
     2281 ctgggtataa atattatgcc tttatttttg gctagagaag agttattttt agcctagatc
     2341 taaccatttt catactctta cctgaaagat tcacagaagt gtcaagtgct atgcattgaa
     2401 acttgttttt taaacgttac ctgacactgt atattaatgt aaaacaatgt taatttactc
     2461 agattttcag tttgtactgc ctggtatgtc tgtgaaagaa gccaattttt gtgtatttgt
     2521 tacagtttca ggttatttat atttgatgtt ttgtaaactc aaacaacaaa tatactgtac
     2581 ttatggacca aataaatgat gtctgcatac ttgaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
