LOCUS       NM_001014080            3618 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus ubiquitin-like modifier activating enzyme 1
            (Uba1), mRNA.
ACCESSION   NM_001014080 XM_234520
VERSION     NM_001014080.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3618)
  AUTHORS   Qin,Z., Cui,B., Jin,J., Song,M., Zhou,B., Guo,H., Qian,D., He,Y.
            and Huang,L.
  TITLE     The ubiquitin-activating enzyme E1 as a novel therapeutic target
            for the treatment of restenosis
  JOURNAL   Atherosclerosis 247, 142-153 (2016)
   PUBMED   26919560
  REMARK    GeneRIF: UBA1 inhibition effectively suppresses neointimal
            thickening through its anti-proliferative and anti-inflammatory
            effects in carotid artery injury.
REFERENCE   2  (bases 1 to 3618)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (bases 1 to 3618)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 3618)
  AUTHORS   Moudry,P., Lukas,C., Macurek,L., Hanzlikova,H., Hodny,Z., Lukas,J.
            and Bartek,J.
  TITLE     Ubiquitin-activating enzyme UBA1 is required for cellular response
            to DNA damage
  JOURNAL   Cell Cycle 11 (8), 1573-1582 (2012)
   PUBMED   22456334
REFERENCE   5  (bases 1 to 3618)
  AUTHORS   Zhang,L., Fairall,L., Goult,B.T., Calkin,A.C., Hong,C.,
            Millard,C.J., Tontonoz,P. and Schwabe,J.W.
  TITLE     The IDOL-UBE2D complex mediates sterol-dependent degradation of the
            LDL receptor
  JOURNAL   Genes Dev 25 (12), 1262-1274 (2011)
   PUBMED   21685362
REFERENCE   6  (bases 1 to 3618)
  AUTHORS   Chou,A.P., Maidment,N., Klintenberg,R., Casida,J.E., Li,S.,
            Fitzmaurice,A.G., Fernagut,P.O., Mortazavi,F., Chesselet,M.F. and
            Bronstein,J.M.
  TITLE     Ziram causes dopaminergic cell damage by inhibiting E1 ligase of
            the proteasome
  JOURNAL   J Biol Chem 283 (50), 34696-34703 (2008)
   PUBMED   18818210
  REMARK    GeneRIF: E1 ligase of the proteasome is inhibitd by ziram and has a
            role in preventing dopaminergic cell damage
REFERENCE   7  (bases 1 to 3618)
  AUTHORS   Allen,E., Ding,J., Wang,W., Pramanik,S., Chou,J., Yau,V. and
            Yang,Y.
  TITLE     Gigaxonin-controlled degradation of MAP1B light chain is critical
            to neuronal survival
  JOURNAL   Nature 438 (7065), 224-228 (2005)
   PUBMED   16227972
REFERENCE   8  (bases 1 to 3618)
  AUTHORS   Yurchenko,V., Xue,Z. and Sadofsky,M.
  TITLE     The RAG1 N-terminal domain is an E3 ubiquitin ligase
  JOURNAL   Genes Dev 17 (5), 581-585 (2003)
   PUBMED   12629039
REFERENCE   9  (bases 1 to 3618)
  AUTHORS   Imai,N., Kaneda,S., Nagai,Y., Seno,T., Ayusawa,D., Hanaoka,F. and
            Yamao,F.
  TITLE     Cloning and sequence of a functionally active cDNA encoding the
            mouse ubiquitin-activating enzyme E1
  JOURNAL   Gene 118 (2), 279-282 (1992)
   PUBMED   1511901
REFERENCE   10 (bases 1 to 3618)
  AUTHORS   Schwartz,A.L., Trausch,J.S., Ciechanover,A., Slot,J.W. and Geuze,H.
  TITLE     Immunoelectron microscopic localization of the ubiquitin-activating
            enzyme E1 in HepG2 cells
  JOURNAL   Proc Natl Acad Sci U S A 89 (12), 5542-5546 (1992)
   PUBMED   1376922
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC085791.1.
            
            On Apr 1, 2005 this sequence version replaced XM_234520.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085791.1, SRR8487230.120132.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3618
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq11"
     gene            1..3618
                     /gene="Uba1"
                     /gene_synonym="Ube1x"
                     /note="ubiquitin-like modifier activating enzyme 1"
                     /db_xref="GeneID:314432"
                     /db_xref="RGD:1359327"
     exon            1..175
                     /gene="Uba1"
                     /gene_synonym="Ube1x"
                     /inference="alignment:Splign:2.1.0"
     CDS             176..3352
                     /gene="Uba1"
                     /gene_synonym="Ube1x"
                     /EC_number="6.2.1.45"
                     /note="ubiquitin-activating enzyme E1, Chr X"
                     /codon_start=1
                     /product="ubiquitin-like modifier-activating enzyme 1"
                     /protein_id="NP_001014102.1"
                     /db_xref="GeneID:314432"
                     /db_xref="RGD:1359327"
                     /translation="MSSSPLSKKRRVSGPDPKPGSNCSSAQSVLSEVSSVPTNGMAKN
                     GSEADIDESLYSRQLYVLGHEAMKMLQTSSVLVSGLRGLGVEIAKNIILGGVKAVTLH
                     DQGTTQWADLSSQFYLREEDIGKNRAEVSQPRLAELNSYVPVTAYTGPLVEDFLSGFQ
                     VVVLTNSPLEEQLRVGEFCHSRGIKLVVADTRGLFGQLFCDFGEEMVLTDSNGEQPLS
                     AMVSMVTKDNPGVVTCLDEARHGFETGDFVSFSEVQGMVQLNGCQPIEIKVLGPYTFS
                     ICDTSNFSDYIRGGIVSQVKVPKKISFKSLPASLAEPDFVMTDFAKYSRPAQLHIGFQ
                     ALHQFCAQHNRPPRPRNEEDATELVTLAQAVNARSPPAVQQDNVDEDLIRKLAYVAAG
                     DLAPINAFIGGLAAQEVMKACSGKFMPIMQWLYFDALECLPEDKEALTEDKCLPRQNR
                     YDGQVAVFGSDLQEKLGKQKYFLVGAGAIGCELLKNFAMIGLGCGEGGEVVVTDMDTI
                     EKSNLNRQFLFRPWDVTKLKSDTAAAAVRQMNPYIQVTSHQNRVGPDTERIYDDDFFQ
                     NLDGVANALDNVDARMYMDRRCVYYRKPLLESGTLGTKGNVQVVIPFLTESYSSSQDP
                     PEKSIPICTLKNFPNAIEHTLQWARDEFEGLFKQPAENVNQYLTDSKFVERTLRLAGT
                     QPLEVLEAVQRSLVLQRPQTWGDCVTWACHHWHTQYCNNIRQLLHNFPPDQLTSSGAP
                     FWSGPKRCPHPLTFDVNNTLHLDYVMAAANLFAQTYGLTGSQDRAAVASLLQSVQVPE
                     FTPKSGVKIHVSDQELQSANASVDDSRLEELKATLPSPDKLPGFKMYPIDFEKDDDSN
                     FHMDFIVAASNLRAENYDISPADRHKSKLIAGKIIPAIATTTAAVVGLVCLELYKVVQ
                     GHQQLDSYKNGFLNLALPFFGFSEPLAAPRHQYYNQEWTLWDRFEVQGLQPNGEEMTL
                     KQFLDYFKTEHKLEITMLSQGVSMLYSFFMPAAKLKERLDQPMTEIVSRVSKRKLGRH
                     VRALVLELCCNDESGEDVEVPYVRYTIR"
     exon            176..292
                     /gene="Uba1"
                     /gene_synonym="Ube1x"
                     /inference="alignment:Splign:2.1.0"
     exon            293..351
                     /gene="Uba1"
                     /gene_synonym="Ube1x"
                     /inference="alignment:Splign:2.1.0"
     exon            352..520
                     /gene="Uba1"
                     /gene_synonym="Ube1x"
                     /inference="alignment:Splign:2.1.0"
     exon            521..655
                     /gene="Uba1"
                     /gene_synonym="Ube1x"
                     /inference="alignment:Splign:2.1.0"
     exon            656..762
                     /gene="Uba1"
                     /gene_synonym="Ube1x"
                     /inference="alignment:Splign:2.1.0"
     exon            763..853
                     /gene="Uba1"
                     /gene_synonym="Ube1x"
                     /inference="alignment:Splign:2.1.0"
     exon            854..986
                     /gene="Uba1"
                     /gene_synonym="Ube1x"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1084
                     /gene="Uba1"
                     /gene_synonym="Ube1x"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1231
                     /gene="Uba1"
                     /gene_synonym="Ube1x"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1408
                     /gene="Uba1"
                     /gene_synonym="Ube1x"
                     /inference="alignment:Splign:2.1.0"
     exon            1409..1513
                     /gene="Uba1"
                     /gene_synonym="Ube1x"
                     /inference="alignment:Splign:2.1.0"
     exon            1514..1594
                     /gene="Uba1"
                     /gene_synonym="Ube1x"
                     /inference="alignment:Splign:2.1.0"
     exon            1595..1750
                     /gene="Uba1"
                     /gene_synonym="Ube1x"
                     /inference="alignment:Splign:2.1.0"
     exon            1751..1916
                     /gene="Uba1"
                     /gene_synonym="Ube1x"
                     /inference="alignment:Splign:2.1.0"
     exon            1917..2113
                     /gene="Uba1"
                     /gene_synonym="Ube1x"
                     /inference="alignment:Splign:2.1.0"
     exon            2114..2178
                     /gene="Uba1"
                     /gene_synonym="Ube1x"
                     /inference="alignment:Splign:2.1.0"
     exon            2179..2374
                     /gene="Uba1"
                     /gene_synonym="Ube1x"
                     /inference="alignment:Splign:2.1.0"
     exon            2375..2449
                     /gene="Uba1"
                     /gene_synonym="Ube1x"
                     /inference="alignment:Splign:2.1.0"
     exon            2450..2639
                     /gene="Uba1"
                     /gene_synonym="Ube1x"
                     /inference="alignment:Splign:2.1.0"
     exon            2640..2728
                     /gene="Uba1"
                     /gene_synonym="Ube1x"
                     /inference="alignment:Splign:2.1.0"
     exon            2729..2821
                     /gene="Uba1"
                     /gene_synonym="Ube1x"
                     /inference="alignment:Splign:2.1.0"
     exon            2822..3013
                     /gene="Uba1"
                     /gene_synonym="Ube1x"
                     /inference="alignment:Splign:2.1.0"
     exon            3014..3115
                     /gene="Uba1"
                     /gene_synonym="Ube1x"
                     /inference="alignment:Splign:2.1.0"
     exon            3116..3216
                     /gene="Uba1"
                     /gene_synonym="Ube1x"
                     /inference="alignment:Splign:2.1.0"
     exon            3217..3548
                     /gene="Uba1"
                     /gene_synonym="Ube1x"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgaaggaggg tgtcaaggaa gaccacaacc accgcggtcg ggggaggaga aggcgacagt
       61 gatcctagct ggcccaggcg gcagggagga gaaggagaaa gaggagggtg gcggccgagc
      121 ttgacttcgg ctccttgagg agttggcggc ggcacgaccc ggggaaccgg cattgatgtc
      181 cagctcgccg ctgtccaaga aacgtcgcgt gtccgggcct gatccaaagc caggttctaa
      241 ctgctcctct gcacagtcag tgctgtccga agtgtcttca gtgccaacca acggaatggc
      301 gaagaacggc agtgaagcag acatagacga gagcctttac tcccggcagc tgtacgtttt
      361 gggccatgag gcaatgaaaa tgctccagac atccagtgtc ctcgtctcag gcttgcgggg
      421 cttaggtgtc gagattgcta agaacatcat ccttggtggg gtcaaggctg tcaccctaca
      481 tgaccaaggc actacacagt gggctgatct ctcctcccag ttttaccttc gggaggagga
      541 cattggtaaa aatcgagctg aggtatccca gccccgactt gctgaactca acagctatgt
      601 acctgttact gcctacactg ggcctcttgt tgaagacttc cttagtggtt tccaggtggt
      661 ggtccttacc aacagccccc tggaagaaca gcttcgagtg ggtgagttct gtcatagccg
      721 tggcatcaag ctagtggtgg cagatacaag aggcctattt gggcaacttt tctgtgattt
      781 tggagaggaa atggttctca cagattccaa tggggagcag ccactcagtg ctatggtttc
      841 aatggtcacc aaggacaacc ccggtgtggt tacctgcctt gatgaggccc gacatggctt
      901 tgagactggt gacttcgtct cattctcaga agtacagggc atggtccaac tcaatggatg
      961 tcagcccata gagatcaaag tgctgggtcc ttatactttt agtatctgtg acacctccaa
     1021 cttctctgac tacatccgtg gaggcatcgt cagccaggtc aaagtaccta aaaagattag
     1081 ctttaaatcc ttgccagcat cactggcaga gcctgacttt gtgatgactg actttgccaa
     1141 gtattctcgc cctgcccaac tgcacattgg ctttcaagct ctgcaccaat tctgtgctca
     1201 gcacaaccga ccacctcgac cacgaaatga ggaagatgca acagaactgg tgaccctagc
     1261 tcaggctgtg aatgctcggt ccccacctgc agtacaacag gacaacgtgg atgaagacct
     1321 tattcggaag ctagcttatg ttgctgctgg ggacctggca cctataaatg ctttcattgg
     1381 gggcctcgct gcccaggaag tcatgaaggc ctgttctgga aagtttatgc ccatcatgca
     1441 gtggttgtac tttgatgctc ttgaatgtct cccagaggac aaagaggctc tgacagagga
     1501 caagtgcctc ccacgtcaga accgttatga tgggcaggta gctgtatttg gctcagacct
     1561 tcaagagaag ctgggcaagc aaaagtactt cctggtgggt gcaggggcca ttggctgtga
     1621 attgctcaag aactttgcca tgattgggtt aggctgtgga gagggtggag aggtcgtggt
     1681 cacagacatg gacaccattg agaaatcgaa tctgaaccga cagtttcttt tccggccctg
     1741 ggatgtcacg aagttaaagt ctgacacggc cgctgcagct gtgcgacaga tgaatcctta
     1801 catccaggtg acaagccacc agaaccgtgt aggccctgac acggagcgca tctatgatga
     1861 tgattttttc caaaatttgg atggtgtggc caatgcactg gacaatgtag atgcccggat
     1921 gtacatggat cgccgctgtg tgtactatcg gaagccactg ctagagtctg gcacactggg
     1981 cacaaagggc aatgtgcagg tggtgatccc cttcctgaca gaatcataca gctctagcca
     2041 ggacccacca gagaaatcca tccccatttg taccctgaaa aactttccca atgccatcga
     2101 acacactcta cagtgggccc gggatgaatt tgaaggcctt ttcaagcagc cagcagaaaa
     2161 tgttaatcag tacctcacag actccaaatt tgtggagcgg acattgcggc tggcgggtac
     2221 ccagccattg gaggtgctgg aggctgtgca gcgcagcctg gtgctgcagc gaccacagac
     2281 ttggggcgac tgtgtgacct gggcctgcca ccactggcac acccagtact gtaacaacat
     2341 acggcagctg ctgcacaact ttcctcccga ccagctcacc agctcagggg cccctttctg
     2401 gtctggaccc aaacgatgtc cacacccact tacttttgat gttaacaata cattgcatct
     2461 ggattatgtg atggctgctg ccaacctttt tgcccagacc tatgggttga ctggctccca
     2521 agaccgagct gctgtggcct cactcctaca gtcagtacaa gttccagagt tcacccccaa
     2581 gtctggtgtc aagatccatg tttctgacca ggagttgcag agcgccaatg cctctgttga
     2641 tgacagccgt ctcgaggagc tcaaagccac actgccgagc ccagacaagt tacctggatt
     2701 taagatgtac cccattgatt ttgaaaagga cgatgacagc aatttccaca tggatttcat
     2761 tgtggctgca tctaatcttc gggccgaaaa ctatgatatt tcccctgcag accggcacaa
     2821 gagcaagctg atcgcaggga agatcatccc agctatcgcc acaaccacag ctgctgtggt
     2881 tggccttgtg tgtctggaac tctacaaggt agttcagggg caccaacaac ttgattccta
     2941 caaaaatggt ttcctgaatt tggccctgcc cttctttggg ttttcggaac ctcttgctgc
     3001 gcctcgtcac cagtactata atcaagagtg gacattgtgg gatcgctttg aagtacaagg
     3061 gctacagcct aatggtgagg agatgactct caagcagttc cttgattact ttaagacgga
     3121 gcacaaatta gagatcacca tgctgtccca gggtgtgtcc atgctctatt ctttcttcat
     3181 gccagctgct aagctcaagg aacggttgga tcagccgatg acagagattg tgagccgagt
     3241 gtcaaagaga aagctgggcc gccatgtgcg tgcactggtg cttgagctgt gctgcaacga
     3301 tgaaagtggc gaggacgtcg aggtccccta tgtacgatat acaattcgct gatctccatg
     3361 aattccccta agccctagtc cccctacccc ccagatcctt tccagtcctg gtttccattt
     3421 ggcctcaggc agtggtccat ctagccaagc ctggacttcc cttatcaccc agcaacctca
     3481 agatcctctc accactgctt tgtaccttgt ttggaaccta aatcccaata aaaaaaagat
     3541 aacccagaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     3601 aaaaaaaaaa aaaaaaaa
//
