LOCUS       NM_001195564            4422 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus uveal autoantigen with coiled-coil domains and
            ankyrin repeats (Uaca), mRNA.
ACCESSION   NM_001195564 XR_085898 XR_086324
VERSION     NM_001195564.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4422)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   2  (bases 1 to 4422)
  AUTHORS   Sakai,T., Liu,L., Teng,X., Mukai-Sakai,R., Shimada,H., Kaji,R.,
            Mitani,T., Matsumoto,M., Toida,K., Ishimura,K., Shishido,Y.,
            Mak,T.W. and Fukui,K.
  TITLE     Nucling recruits Apaf-1/pro-caspase-9 complex for the induction of
            stress-induced apoptosis
  JOURNAL   J Biol Chem 279 (39), 41131-41140 (2004)
   PUBMED   15271982
REFERENCE   3  (bases 1 to 4422)
  AUTHORS   Liu,L., Sakai,T., Sano,N. and Fukui,K.
  TITLE     Nucling mediates apoptosis by inhibiting expression of galectin-3
            through interference with nuclear factor kappaB signalling
  JOURNAL   Biochem J 380 (Pt 1), 31-41 (2004)
   PUBMED   14961764
REFERENCE   4  (bases 1 to 4422)
  AUTHORS   Sakai,T., Liu,L., Shishido,Y. and Fukui,K.
  TITLE     Identification of a novel, embryonal carcinoma cell-associated
            molecule, nucling, that is up-regulated during cardiac muscle
            differentiation
  JOURNAL   J Biochem 133 (4), 429-436 (2003)
   PUBMED   12761289
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On or before Sep 17, 2010 this sequence version replaced
            XR_086324.1, XR_085898.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA5760383, SAMEA5760386
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-147               JAXUCZ010000008.1  70155114-70155260
            148-281             JAXUCZ010000008.1  70204900-70205033
            282-370             JAXUCZ010000008.1  70210078-70210166
            371-435             JAXUCZ010000008.1  70212130-70212194
            436-493             JAXUCZ010000008.1  70212953-70213010
            494-564             JAXUCZ010000008.1  70213675-70213745
            565-671             JAXUCZ010000008.1  70213842-70213948
            672-859             JAXUCZ010000008.1  70217442-70217629
            860-897             JAXUCZ010000008.1  70219540-70219577
            898-966             JAXUCZ010000008.1  70222526-70222594
            967-1074            JAXUCZ010000008.1  70224441-70224548
            1075-1107           JAXUCZ010000008.1  70226208-70226240
            1108-1206           JAXUCZ010000008.1  70226400-70226498
            1207-1243           JAXUCZ010000008.1  70229256-70229292
            1244-1296           JAXUCZ010000008.1  70230359-70230411
            1297-4005           JAXUCZ010000008.1  70232461-70235169
            4006-4158           JAXUCZ010000008.1  70236631-70236783
            4159-4224           JAXUCZ010000008.1  70239873-70239938
            4225-4422           JAXUCZ010000008.1  70243219-70243416
FEATURES             Location/Qualifiers
     source          1..4422
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..4422
                     /gene="Uaca"
                     /gene_synonym="RGD1560011"
                     /note="uveal autoantigen with coiled-coil domains and
                     ankyrin repeats"
                     /db_xref="GeneID:315732"
                     /db_xref="RGD:1560011"
     exon            1..147
                     /gene="Uaca"
                     /gene_synonym="RGD1560011"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..4296
                     /gene="Uaca"
                     /gene_synonym="RGD1560011"
                     /codon_start=1
                     /product="uveal autoantigen with coiled-coil domains and
                     ankyrin repeats"
                     /protein_id="NP_001182493.1"
                     /db_xref="GeneID:315732"
                     /db_xref="RGD:1560011"
                     /translation="MKSLKSRLWRQDAPGPTSPTSPTAVTSSLSAEWNKYDDRLMKAA
                     ERGDVEKVSSILAKKGVHPGKLDVEGRSAFHVVAAKGNLECLNAILTHGIDVATRDSA
                     GRNALHLAAKYGHALCLQKLLQYNCPTEHVDLQGRTALHDAAMADCPSSIQLLCDHGA
                     SVNAKDIDGRTPLVLATQMCRPTICQLLIDRGADVNSRDKQNRTALMLGCEYGCRDAV
                     EVLVRNGADLTLLDALGHDSSYYARIGDNLDILNLLKTASESTSKGGRRELWRKGPPL
                     QQRNLSHTQDEGNVKSNQREHHSFQDLEMENEDLKEKLRKIQQEQRILLDKVNGLQLQ
                     LNEEVMVADDLESEREKLKSLLAAKEKQHEESLRTIEALKNRFKYFESDHPGPGSYSS
                     NRKEDMLHKQGQMYTADSQCTSPGVPPHMQSRSMLRPLELSLPSQTSYSENEILKKEL
                     EAMRTFCDSAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQK
                     RMYESEGKVKQMQTHFLALKEHLTNEAATGSHRVIEELREQLKDMKGKYEGASAEVGK
                     LRNQIKQSEMLVEGFKRDESRLVEENKRLQKECSTCEIDRERRGRRVTELEGQLKELG
                     AKLALSVPTETFESMKSSLSNDISEKAKRLAEVGRDYESSQGEIRQLKRDLESVRAQH
                     IRPEEHEQLRSRLEQKSGELGKKVTELTLKNQTLQKEVEKLYADNKLLNQQVHSLTVE
                     MKTRYVPLRVSEEMKKAHDVNVEDLNKKLSDATQRYAEKKLEAERLLAENDKLTKNVS
                     RLEAVFVAPEKHEKELMGLKSNIAELKMQLCELNKKCGEGQEKIRALMSENTSLKKTL
                     SSQYVPAKTHEEVKASLSSTLEKTNRALLDSKKRLDDTSQEFSKLREENEVLRRNLEN
                     VQNQMKADYVSLEEHSRKMNMANQSLKEAQDAHTALLADYRQGQEEIVTLHAEIKAQK
                     KELDTIQECIKLKYAPLSRMEECERKFKATEKALKEQLSEQTHKGQVRDEEVKKGKQE
                     NERLRKDLAALQKELKDRNVLVEEAREAERALSRKTEELGKQLKELSQKYSDVKSERE
                     KLVEEKAKQTSEILAAQNLLQKQPVPLEQVEALKTSLNGTIEHLKEELRSKERCLERE
                     QQAVSQLQQLLENQKSSSVTLADHLQLKEALEKEVGIMKASLREKEEESQKKTKEVSK
                     LQTEVQNTKQALKNLETREVVDMSKYKATKNDLETQISNLNDKLASLNRKYDQVCEEK
                     VSAKDEKELLHLNIEQEIRDQKERCDKSLTTIMELQQRIQESAKQIEAKDNKITELLN
                     DVERLKQALNGLSQLTYSSGGPTKRQSQLVDTLQQRVRDLQQQLADADRQHQEVIAIY
                     RTHLLSAAQGHMDEDVQAALLQIIQMRQGLVC"
     exon            148..281
                     /gene="Uaca"
                     /gene_synonym="RGD1560011"
                     /inference="alignment:Splign:2.1.0"
     exon            282..370
                     /gene="Uaca"
                     /gene_synonym="RGD1560011"
                     /inference="alignment:Splign:2.1.0"
     exon            371..435
                     /gene="Uaca"
                     /gene_synonym="RGD1560011"
                     /inference="alignment:Splign:2.1.0"
     exon            436..493
                     /gene="Uaca"
                     /gene_synonym="RGD1560011"
                     /inference="alignment:Splign:2.1.0"
     exon            494..564
                     /gene="Uaca"
                     /gene_synonym="RGD1560011"
                     /inference="alignment:Splign:2.1.0"
     exon            565..671
                     /gene="Uaca"
                     /gene_synonym="RGD1560011"
                     /inference="alignment:Splign:2.1.0"
     exon            672..859
                     /gene="Uaca"
                     /gene_synonym="RGD1560011"
                     /inference="alignment:Splign:2.1.0"
     exon            860..897
                     /gene="Uaca"
                     /gene_synonym="RGD1560011"
                     /inference="alignment:Splign:2.1.0"
     exon            898..966
                     /gene="Uaca"
                     /gene_synonym="RGD1560011"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1074
                     /gene="Uaca"
                     /gene_synonym="RGD1560011"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1107
                     /gene="Uaca"
                     /gene_synonym="RGD1560011"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1206
                     /gene="Uaca"
                     /gene_synonym="RGD1560011"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1243
                     /gene="Uaca"
                     /gene_synonym="RGD1560011"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1296
                     /gene="Uaca"
                     /gene_synonym="RGD1560011"
                     /inference="alignment:Splign:2.1.0"
     exon            1297..4005
                     /gene="Uaca"
                     /gene_synonym="RGD1560011"
                     /inference="alignment:Splign:2.1.0"
     exon            4006..4158
                     /gene="Uaca"
                     /gene_synonym="RGD1560011"
                     /inference="alignment:Splign:2.1.0"
     exon            4159..4224
                     /gene="Uaca"
                     /gene_synonym="RGD1560011"
                     /inference="alignment:Splign:2.1.0"
     exon            4225..4422
                     /gene="Uaca"
                     /gene_synonym="RGD1560011"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctccggctct tgccctcgca gcccgcaacc tggtggggac ccggaccctt cagagccgcg
       61 gccatgaaga gcctcaagtc ccggctgtgg aggcaggacg cgcccggtcc cacgtcaccc
      121 acatctccca ccgcggtgac cagttcgctt tcagcagagt ggaataaata cgatgaccgg
      181 ctgatgaagg ctgctgaaag gggggatgtg gagaaagtat cctctatcct tgccaaaaag
      241 ggcgtccatc caggcaagct ggatgtggaa ggcagatcgg ccttccacgt cgtggcagcc
      301 aaagggaatc tggagtgtct gaacgccatt cttactcatg gcattgatgt tgcaaccagg
      361 gacagtgcag ggaggaatgc gcttcacctg gcagctaagt acggacacgc gttgtgccta
      421 cagaaacttc tacagtacaa ctgtcccact gagcatgtgg accttcaggg aagaaccgcc
      481 ctacacgacg cagcaatggc ggactgtcct tccagcatcc agctgctttg tgaccatggg
      541 gcctccgtga atgccaaaga tatagacggg cggacaccac ttgttctggc gactcagatg
      601 tgcaggccga caatttgtca gttgctgata gacagagggg cggatgtcaa ttccagagac
      661 aaacaaaaca ggacagccct catgctgggc tgtgagtacg gttgcagaga cgctgtagaa
      721 gtcctcgtga gaaatggggc cgacttgacc ttgctggatg cccttggcca tgacagttct
      781 tactacgcga gaattggtga caatctggac atcctgaacc tgctgaagac agcgtcagaa
      841 agcaccagca aaggtggcag gagagaactt tggaggaaag gaccgccttt gcaacagcgg
      901 aatttgtcac acactcaaga tgaaggaaat gtgaagtcaa atcagagaga acaccacagc
      961 tttcaggatc tagagatgga aaatgaagat ttgaaagaga agttgaggaa gattcagcaa
     1021 gagcaaagaa tactcctgga taaagtcaac ggcttacagt tacagctgaa tgaggaagtc
     1081 atggttgcag atgatctgga aagcgagaga gaaaagctga agtccctttt ggcagctaaa
     1141 gaaaagcagc acgaagaaag cttacgaacc atcgaggccc tgaaaaacag atttaaatat
     1201 tttgagagtg atcatccagg acccggaagt tactcgagta accgaaaaga agacatgctt
     1261 cataaacaag gtcaaatgta cacggcagat tcacagtgta catcaccggg cgtacccccc
     1321 catatgcaga gtaggtctat gttaaggcct ctggagttgt ctttaccaag tcagacctca
     1381 tactctgaaa atgagatttt aaagaaagag ttggaagcta tgcgaacttt ctgtgactcg
     1441 gcgaaacagg accgactgaa gctccaaaac gagttggcgc acaaggttgc ggagtgcaaa
     1501 gccttggctc tggagtgcga gagagtcaag gaggactcag acgagcagat caagcagctg
     1561 gaagatgccc tcaaagatgt gcagaagagg atgtatgagt cggaaggcaa agtcaagcaa
     1621 atgcagaccc acttcctggc cctcaaagag cacctgacca atgaagcagc cacggggagc
     1681 caccgcgtca tcgaggagct gagggagcag ctgaaagaca tgaaagggaa atatgaaggc
     1741 gcttcagcag aagtgggcaa gctgaggaac caaatcaaac agagcgagat gctggtagaa
     1801 gggttcaaga gggacgagag caggctggtg gaagagaata agagattgca gaaggaatgc
     1861 agcacgtgtg aaatagatcg ggagaggagg gggcggaggg tcacggagct ggagggccag
     1921 ctcaaagagc tgggggctaa gctggccctt tccgtgccca cagagacatt tgaaagcatg
     1981 aagagctcgt tatccaatga catcagtgag aaagcgaaaa ggctagcgga ggtggggcgg
     2041 gactatgaaa gctctcaggg ggagattcga cagctgaaga gggatctgga gagcgttagg
     2101 gcccagcaca tcagaccgga ggagcatgag cagctcagga gcaggttgga gcagaagtcg
     2161 ggagagctgg ggaagaaagt gacagagcta accctgaaaa accagacact ccagaaagaa
     2221 gtggaaaaac tctacgcaga caacaaactc ctcaaccagc aggtgcacag cctcacggtg
     2281 gagatgaaaa ctcgctatgt gcctttgagg gtcagcgagg agatgaagaa ggcgcatgat
     2341 gtgaatgtgg aggatttgaa taagaagctt tcggatgcaa cacagagata cgcagagaag
     2401 aagctagaag cagagagact gctggcagag aacgataagt tgaccaagaa cgtcagccgc
     2461 ctggaagctg tgtttgtagc tcccgagaaa catgaaaagg agctaatggg tctgaaatcc
     2521 aatatcgctg aactaaaaat gcagctgtgt gagcttaata aaaaatgtgg tgagggtcag
     2581 gagaaaatac gtgcgcttat gtctgaaaac accagcttga aaaagactct gagtagccag
     2641 tacgtgcctg ccaaaaccca cgaggaggtg aaggcctccc tgagcagcac tttggagaaa
     2701 accaacagag ctttattgga ctcgaagaaa aggcttgacg acacgagcca ggaattttca
     2761 aaactaaggg aggagaatga agtgttgagg aggaacctgg agaacgttca gaatcagatg
     2821 aaggctgact acgtgagcct ggaggaacac tcgagaaaga tgaacatggc gaaccagagc
     2881 ctgaaggagg cgcaggatgc ccacactgcc ctcctggctg actaccgcca gggccaggag
     2941 gagatcgtca cgctgcacgc agaaattaag gcccagaaaa aggagctcga caccatccaa
     3001 gaatgcatca agctaaaata tgctcccctc tcccgaatgg aagagtgtga acgcaagttc
     3061 aaggctacag agaaagcact gaaggagcag ttatcagagc agacacacaa gggccaggtg
     3121 agggacgaag aggtcaagaa gggcaagcaa gagaatgaga ggctgaggaa ggatctcgcc
     3181 gcccttcaga aggagctgaa ggataggaat gttctggtgg aagaggccag ggaggcagaa
     3241 agagcactga gcaggaagac agaagaactc ggcaaacagc tgaaggaact gtcccagaag
     3301 tacagcgatg tgaagagcga gagagagaag ctggtggaag aaaaggccaa gcagacttcc
     3361 gagatccttg cagcccaaaa tcttctgcaa aaacagccag tcccactgga gcaggtggag
     3421 gctctcaaaa catctctcaa cggcacaatc gagcacctaa aggaggagct gaggagtaag
     3481 gagaggtgtc tggagagaga gcagcaggcg gtgagccaac ttcagcagct gctggagaat
     3541 cagaagagct cctccgtgac cctggcggat cacctgcagc taaaggaagc cttggagaaa
     3601 gaggttggga tcatgaaagc cagcctgaga gagaaggaag aggaaagcca gaagaaaacc
     3661 aaagaagtct ccaaactcca gaccgaggtc cagaacacca agcaggcgct gaagaactta
     3721 gagaccagag aggtcgtcga catgtcaaaa tacaaagcca ccaagaatga tttggagacc
     3781 cagatttcca acttaaatga caaactggcc agtctgaaca ggaagtacga ccaagtgtgt
     3841 gaggagaagg tctctgccaa ggacgagaag gagctgctgc atcttaacat cgagcaggag
     3901 atcagggacc agaaggagcg gtgtgacaag tccctgacaa ccatcatgga gctgcagcag
     3961 aggatacagg agtccgccaa gcagatcgaa gcaaaggaca ataagataac tgaacttctg
     4021 aatgatgtcg aaagactaaa gcaggcgctc aatggccttt cccagctcac ctacagcagc
     4081 ggcggcccca ccaagcggca gagccagcta gtggacaccc tgcagcagcg agtgagggat
     4141 ctgcagcagc agctggctga tgctgacaga cagcaccagg aagtgatcgc tatctaccgg
     4201 acacacctcc tcagtgccgc acagggtcac atggatgaag atgtgcaggc agccttgctg
     4261 cagatcatac agatgcgaca aggcctcgtg tgctagcgtc agctgacttg gaacctgcgc
     4321 tgctggtgct atgcattctg ggtgcaactc tgtggctctt ctgggcctta ctctgatagt
     4381 atcagtaaaa taaactatat tttgttccgt tgttgaattt ta
//
