LOCUS       NM_001170473            1492 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus tRNA-yW synthesizing protein 5 (Tyw5), transcript
            variant 1, mRNA.
ACCESSION   NM_001170473 XM_001067847 XM_217397
VERSION     NM_001170473.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1492)
  AUTHORS   Kato M, Araiso Y, Noma A, Nagao A, Suzuki T, Ishitani R and Nureki
            O.
  TITLE     Crystal structure of a novel JmjC-domain-containing protein, TYW5,
            involved in tRNA modification
  JOURNAL   Nucleic Acids Res 39 (4), 1576-1585 (2011)
   PUBMED   20972222
REFERENCE   2  (bases 1 to 1492)
  AUTHORS   Noma A, Ishitani R, Kato M, Nagao A, Nureki O and Suzuki T.
  TITLE     Expanding role of the jumonji C domain as an RNA hydroxylase
  JOURNAL   J Biol Chem 285 (45), 34503-34507 (2010)
   PUBMED   20739293
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC158619.1, FM112098.1 and CK845177.1.
            
            On or before Dec 20, 2009 this sequence version replaced
            XM_217397.4, XM_001067847.1.
            
            Transcript Variant: This variant (1) represents the protein-coding
            transcript.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-488               BC158619.1         1-488
            489-751             FM112098.1         204-466
            752-1285            BC158619.1         733-1266
            1286-1492           CK845177.1         1-207               c
FEATURES             Location/Qualifiers
     source          1..1492
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q31"
     gene            1..1492
                     /gene="Tyw5"
                     /gene_synonym="C2orf60; RGD1311269"
                     /note="tRNA-yW synthesizing protein 5"
                     /db_xref="GeneID:301419"
                     /db_xref="RGD:1311269"
     exon            1..352
                     /gene="Tyw5"
                     /gene_synonym="C2orf60; RGD1311269"
                     /inference="alignment:Splign:2.1.0"
     CDS             275..1222
                     /gene="Tyw5"
                     /gene_synonym="C2orf60; RGD1311269"
                     /EC_number="1.14.11.42"
                     /codon_start=1
                     /product="tRNA wybutosine-synthesizing protein 5"
                     /protein_id="NP_001163944.1"
                     /db_xref="GeneID:301419"
                     /db_xref="RGD:1311269"
                     /translation="MAEQRLPVPRLRGVSREQFMEHLYPQRKPLVLEGLDLGSCTSKW
                     TVDYLSQVGGTKEVKIHVAAVAQMDFISKNFVYRTLPFNKLVQRAAEETHKEFFISQD
                     ERYYLRSLGEDPRKDIADIRQQFPSLGEDITFPMFFREEQFFSSVFRISSPGLQLWTH
                     YDVMDNFLIQVTGKKRITLFSPRDAQYLYLSGSKSEVLNIDSPDLDKYPLFPKARRYE
                     CSLEAGDVLFIPALWFHNVVSEEFGVGVNVFLKHLPSECYDTTDTYGNKDPVAASRAM
                     QILDRALKTLAELPEEYRDFYARQMVLRIQDKAYSKNSE"
     exon            353..507
                     /gene="Tyw5"
                     /gene_synonym="C2orf60; RGD1311269"
                     /inference="alignment:Splign:2.1.0"
     exon            508..577
                     /gene="Tyw5"
                     /gene_synonym="C2orf60; RGD1311269"
                     /inference="alignment:Splign:2.1.0"
     exon            578..622
                     /gene="Tyw5"
                     /gene_synonym="C2orf60; RGD1311269"
                     /inference="alignment:Splign:2.1.0"
     exon            623..760
                     /gene="Tyw5"
                     /gene_synonym="C2orf60; RGD1311269"
                     /inference="alignment:Splign:2.1.0"
     exon            761..848
                     /gene="Tyw5"
                     /gene_synonym="C2orf60; RGD1311269"
                     /inference="alignment:Splign:2.1.0"
     exon            849..965
                     /gene="Tyw5"
                     /gene_synonym="C2orf60; RGD1311269"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1478
                     /gene="Tyw5"
                     /gene_synonym="C2orf60; RGD1311269"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1225..1230
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tyw5"
                     /gene_synonym="C2orf60; RGD1311269"
     regulatory      1252..1257
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tyw5"
                     /gene_synonym="C2orf60; RGD1311269"
     polyA_site      1285
                     /gene="Tyw5"
                     /gene_synonym="C2orf60; RGD1311269"
     regulatory      1428..1433
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tyw5"
                     /gene_synonym="C2orf60; RGD1311269"
     regulatory      1444..1449
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tyw5"
                     /gene_synonym="C2orf60; RGD1311269"
     polyA_site      1478
                     /gene="Tyw5"
                     /gene_synonym="C2orf60; RGD1311269"
ORIGIN      
        1 caggccggag ggaaacctgt tcgccgttgt tggagaagtg gagccaaggc cgcctagctg
       61 ctgccacctc tggtgagtcc tcccatctcc actgtgttcg cactcaatcc aggccgaggc
      121 ccttgggctc cccgccgctc gcttcgaacc agccgccctc tggggtcagt caccttcgcg
      181 gaccttttct tccgaggtgg tgtttacggg gagaaatcac gcgtggacga actcgtccaa
      241 attccgagac ctgggaaaac tagcctgagc caccatggcc gaacagcgtc ttccggtacc
      301 ccggcttcgg ggcgtctcgc gggagcagtt catggagcat ctttacccgc agagaaagcc
      361 tcttgtgttg gaaggactcg acttaggatc ttgcacaagc aaatggacag tggattacct
      421 gagtcaagtc ggagggacga aagaggtgaa gattcacgtc gctgcagtcg cgcagatgga
      481 cttcattagt aagaactttg tctatagaac tttacctttt aacaagctgg tccagagagc
      541 ggccgaagaa acacataaag agttcttcat ttcacaggat gagagatact acttacggtc
      601 acttggagaa gacccgagga aggatattgc agacatcagg cagcagtttc cgtcattagg
      661 agaagatatt acctttccaa tgttcttcag agaggaacag ttcttttcca gtgtttttcg
      721 aattagctca cctggattgc agctctggac tcactatgat gtaatggata actttttaat
      781 acaagtgaca ggaaagaagc gaattacact gttcagtcct cgggatgcac aatatttata
      841 tttatcaggt tctaaatcag aagtgctgaa tatcgacagc ccagacctgg ataaataccc
      901 actctttcct aaggcaagga ggtatgaatg ttcccttgaa gctggtgatg tcctgttcat
      961 tcctgcttta tggttccata atgtagtttc tgaagagttt ggagtggggg tgaatgtctt
     1021 cctgaagcac cttccatcgg aatgctatga cacaacagac acctatggca acaaagatcc
     1081 tgtggcagca tccagagcca tgcagatctt ggacagagct ttgaaaacac tggctgagtt
     1141 accagaggaa tacagggact tctatgcgcg ccaaatggtc ttacgtattc aagacaaagc
     1201 ctacagcaag aactctgagt gaaaaataaa ctaaatgtag caaaatttaa aaataaaaag
     1261 cagctcaagt atttgaaaac tataacaaaa tataaaattt aaagatactt tttaaaatag
     1321 gaaagagaag gctgagattt atagtataaa aggaatgtac atctgatttc tacgtggtat
     1381 attgaaaatg cttagcagga ctattcttta gctctaagat ataaataaat aaaattcaga
     1441 gttaataaaa ctaatctatt gagtcacact acataaaaaa aaaaaaaaaa aa
//
