LOCUS       NM_001108932            2313 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus trypsin like peroxisomal matrix peptidase 1
            (Tysnd1), mRNA.
ACCESSION   NM_001108932 XM_001056113 XM_345106
VERSION     NM_001108932.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2313)
  AUTHORS   Mizuno Y, Ninomiya Y, Nakachi Y, Iseki M, Iwasa H, Akita M, Tsukui
            T, Shimozawa N, Ito C, Toshimori K, Nishimukai M, Hara H, Maeba R,
            Okazaki T, Alodaib AN, Al Amoudi M, Jacob M, Alkuraya FS, Horai Y,
            Watanabe M, Motegi H, Wakana S, Noda T, Kurochkin IV, Mizuno Y,
            Schonbach C and Okazaki Y.
  TITLE     Tysnd1 deficiency in mice interferes with the peroxisomal
            localization of PTS2 enzymes, causing lipid metabolic abnormalities
            and male infertility
  JOURNAL   PLoS Genet 9 (2), e1003286 (2013)
   PUBMED   23459139
REFERENCE   2  (bases 1 to 2313)
  AUTHORS   Okumoto K, Kametani Y and Fujiki Y.
  TITLE     Two proteases, trypsin domain-containing 1 (Tysnd1) and peroxisomal
            lon protease (PsLon), cooperatively regulate fatty acid
            beta-oxidation in peroxisomal matrix
  JOURNAL   J Biol Chem 286 (52), 44367-44379 (2011)
   PUBMED   22002062
REFERENCE   3  (bases 1 to 2313)
  AUTHORS   Ghosh D, Lippert D, Krokhin O, Cortens JP and Wilkins JA.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   4  (bases 1 to 2313)
  AUTHORS   Kurochkin IV, Mizuno Y, Konagaya A, Sakaki Y, Schonbach C and
            Okazaki Y.
  TITLE     Novel peroxisomal protease Tysnd1 processes PTS1- and
            PTS2-containing enzymes involved in beta-oxidation of fatty acids
  JOURNAL   EMBO J 26 (3), 835-845 (2007)
   PUBMED   17255948
  REMARK    GeneRIF: Tysnd1-mediated processing of the peroxisomal enzymes
            promotes their assembly into a supramolecular complex to enhance
            the rate of beta-oxidation.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474016.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_345106.2, XM_001056113.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC160877.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2313
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20q11"
     gene            1..2313
                     /gene="Tysnd1"
                     /note="trypsin like peroxisomal matrix peptidase 1"
                     /db_xref="GeneID:365571"
                     /db_xref="RGD:1307354"
     exon            1..1227
                     /gene="Tysnd1"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..1762
                     /gene="Tysnd1"
                     /note="trypsin domain containing 1"
                     /codon_start=1
                     /product="peroxisomal leader peptide-processing protease"
                     /protein_id="NP_001102402.1"
                     /db_xref="GeneID:365571"
                     /db_xref="RGD:1307354"
                     /translation="MGRQWGPSLRVAEQAGCVVSASRAGQPDAGSWSCSGVILSRSPG
                     LVLCHGGIFTPFLRTGSAALTQTGAAFLPGDSCSDDLRLHVQWGPTAASPAGRADQEL
                     PGLCTPQCASLGLEPGAPSRARARPLQPPRPAQLLLLLSCPAFRSHFARLFGAEAADQ
                     WHFVSSAPDDAVSEEEEEDQLRALGWFALLRVQRGAAAEERRGPAVTVAPLGAVAKGA
                     PLLACGSPFGAFCPDIFLNTLSRGVLSNAAGPLLLTDARCLPGTEGGGVFAARPAGAL
                     VALVAAPLCWKAREWVGLTLLCAAAPLLQVARSALSRLHPDSTSLSALLPPEVGAPRG
                     LSLRDLGSSWAAAAVLVECGAVWGSGVAVAPRLVVTCRHVAPRETARVLVHSATPRNV
                     AIWGRVVFATQETSPYDIAVVSLEEELNGVPVPVPAEHFHEGEPVSVVGFGVFGQACG
                     PSVTSGILSAVVHVDDAPVMLQTTCAVHGGSSGGPLFSTRSGDLLGIVASNTRDNNTG
                     ATYPHLNFSIPITVLQPALKQYSQTGDLCGLRELDHTTEPVRVVWRLQRPLPEAPRSK
                     L"
     exon            1228..1358
                     /gene="Tysnd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1359..1544
                     /gene="Tysnd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1545..2313
                     /gene="Tysnd1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagagtttgc gccagtcgcc ctgaggtgac agccattgtg cgacgtcttg gagaagccat
       61 gggacggcaa tggggaccgt ctttgagagt ggcagagcag gcgggttgcg tagtgagcgc
      121 ctcgcgagca ggacagcccg atgcgggctc gtggagctgc agcggggtga tcctgagccg
      181 cagcccaggc ctggtgctgt gccacggggg cattttcacc cccttcctca gaactggtag
      241 cgcggctttg acccaaacgg gagccgcctt cctaccgggc gacagttgca gcgatgacct
      301 gcgcctccac gtgcagtggg gacccacggc tgccagcccc gccggccgcg cggaccagga
      361 acttccaggg ctgtgcacgc ctcagtgcgc aagcctgggc ctcgaacccg gtgccccgag
      421 ccgggcccgc gcgcggcctc tgcagcctcc gcggccggcg cagctgctgt tgctgctcag
      481 ctgcccggcc ttccgctcgc acttcgcgcg gctcttcggg gccgaagcgg cggatcaatg
      541 gcacttcgtg agctcggcgc ccgacgacgc ggtgtcagag gaggaggagg aggatcagct
      601 gcgcgcgctc ggctggttcg ccctcctgcg ggtgcagcgg ggcgcggcgg ccgaggagag
      661 gcgcgggccg gcggtgaccg tggcaccgct cggggccgtg gccaagggcg caccgctgct
      721 ggcttgtggc tctccgttcg gtgccttctg cccggacatc ttcctcaaca cgctgagccg
      781 gggcgtgctc agcaacgcgg ccggtccgct gttgctcacc gacgcgcgct gcctgccggg
      841 cacagaaggc ggcggagtgt tcgcggcccg acctgcgggc gcgctggtgg ctctggtggc
      901 cgcgcctcta tgctggaagg cccgcgagtg ggtgggcctc acgttgctgt gcgccgctgc
      961 ccctctgctt caggttgctc gctcggctct ctctcgcctg catccggact ccacctctct
     1021 gtccgcgctg ctgccacccg aagtgggcgc gccaaggggc ctgtccctac gagatctcgg
     1081 atcctcgtgg gcagccgcgg cggtgctggt ggagtgtggt gccgtgtggg gctccggagt
     1141 ggctgtggcg cctcgcctgg tggtgacctg ccgtcatgtg gcaccccggg aaacagccag
     1201 ggtcttggta cactcagcta cacccaggaa tgtggcaatc tggggacgag tggtatttgc
     1261 cactcaggag acctctccat atgacatagc ggtggtgagc ctggaagagg aactgaatgg
     1321 tgtccccgtg cctgtcccag ctgagcactt ccatgaaggc gagcctgtca gcgtggtggg
     1381 ctttggcgtg tttggccagg cctgcgggcc ctcagtgacc tcaggcatcc tgtcggccgt
     1441 ggtgcatgtg gatgatgccc cagtgatgct acagaccacc tgtgccgtgc atggcggctc
     1501 tagcggagga cctctcttct ctacacgctc gggggacctc ttgggcattg ttgctagcaa
     1561 cactcgggac aacaacacgg gggccaccta cccacacctg aacttcagca tccccatcac
     1621 cgtgctccag ccggccctga agcagtacag tcagactggt gacctgtgtg gcctcagaga
     1681 gctggaccac accactgagc ctgtcagggt cgtgtggcgg ctgcagcggc ccctgccgga
     1741 agccccccgg agcaagctct gagactgtgc ctccctggaa gaaagtagac cactctatgc
     1801 catgggaagt gtgttggtgt ggcagctgtg acatctaagt catctgccgg gacagcccaa
     1861 gccccctcct cgtcttcacc tacatgagca aacttctgtg caactgtggg tccctgatca
     1921 actttggggt gctttcttga gcctatccca tcgtttccca gaattagact cagcaatgcc
     1981 gtcgtccttc tgggggttct atcctttggg taggtaccgg tttggcattt ctgtgcctca
     2041 taacccctgg ctacccaaaa tggttacact acagccaagg gctcttgcct ggtactctgt
     2101 actcagagaa ctctgcgtgg aagcccagag tcctagtggt cagtaacagg agtgttttcc
     2161 cgttgccata gtgatatgta ggcaaatccc tgagagccac ctgggcctta actctgacac
     2221 agtgccttcg tttttgagcc tgggacttgg cgacctgtag gtggtgtgtg cagtcagagc
     2281 tagggaataa acaatttgaa tggcctcact tct
//
