LOCUS       NM_001106664            2685 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus tyrosinase-related protein 1 (Tyrp1), mRNA.
ACCESSION   NM_001106664 XM_001059355 XM_001059411 XM_001059470 XM_238398
VERSION     NM_001106664.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2685)
  AUTHORS   Gao,Y., Liu,L., Zhang,Z., Qin,C., Yang,B. and Ke,Y.
  TITLE     TYRP1 Protects Against the Apoptosis and Oxidative Stress of
            Retinal Ganglion Cells by Binding to PMEL
  JOURNAL   Ocul Immunol Inflamm 31 (5), 1024-1034 (2023)
   PUBMED   35708352
  REMARK    GeneRIF: TYRP1 Protects Against the Apoptosis and Oxidative Stress
            of Retinal Ganglion Cells by Binding to PMEL.
REFERENCE   2  (bases 1 to 2685)
  AUTHORS   Tyrrell,B.J., Woodham,E.F., Spence,H.J., Strathdee,D., Insall,R.H.
            and Machesky,L.M.
  TITLE     Loss of strumpellin in the melanocytic lineage impairs the WASH
            Complex but does not affect coat colour
  JOURNAL   Pigment Cell Melanoma Res 29 (5), 559-571 (2016)
   PUBMED   27390154
REFERENCE   3  (bases 1 to 2685)
  AUTHORS   Marubashi,S., Shimada,H., Fukuda,M. and Ohbayashi,N.
  TITLE     RUTBC1 Functions as a GTPase-activating Protein for Rab32/38 and
            Regulates Melanogenic Enzyme Trafficking in Melanocytes
  JOURNAL   J Biol Chem 291 (3), 1427-1440 (2016)
   PUBMED   26620560
REFERENCE   4  (bases 1 to 2685)
  AUTHORS   Ohbayashi,N., Maruta,Y., Ishida,M. and Fukuda,M.
  TITLE     Melanoregulin regulates retrograde melanosome transport through
            interaction with the RILP-p150Glued complex in melanocytes
  JOURNAL   J Cell Sci 125 (Pt 6), 1508-1518 (2012)
   PUBMED   22275436
REFERENCE   5  (bases 1 to 2685)
  AUTHORS   Yamada,M., Sakai,K., Hayashi,M., Hozumi,Y., Abe,Y., Kawaguchi,M.,
            Ihn,H. and Suzuki,T.
  TITLE     Oculocutaneous albinism type 3: a Japanese girl with novel
            mutations in TYRP1 gene
  JOURNAL   J Dermatol Sci 64 (3), 217-222 (2011)
   PUBMED   21996312
REFERENCE   6  (bases 1 to 2685)
  AUTHORS   Jimenez-Cervantes,C., Martinez-Esparza,M., Solano,F., Lozano,J.A.
            and Garcia-Borron,J.C.
  TITLE     Molecular interactions within the melanogenic complex: formation of
            heterodimers of tyrosinase and TRP1 from B16 mouse melanoma
  JOURNAL   Biochem Biophys Res Commun 253 (3), 761-767 (1998)
   PUBMED   9918801
REFERENCE   7  (bases 1 to 2685)
  AUTHORS   Hirobe,T., Wakamatsu,K. and Ito,S.
  TITLE     Effects of genic substitution at the agouti, brown, albino, dilute,
            and pink-eyed dilution loci on the proliferation and
            differentiation of mouse epidermal melanocytes in serum-free
            culture
  JOURNAL   Eur J Cell Biol 75 (2), 184-191 (1998)
   PUBMED   9548375
REFERENCE   8  (bases 1 to 2685)
  AUTHORS   Boissy,R.E., Zhao,H., Oetting,W.S., Austin,L.M., Wildenberg,S.C.,
            Boissy,Y.L., Zhao,Y., Sturm,R.A., Hearing,V.J., King,R.A. and
            Nordlund,J.J.
  TITLE     Mutation in and lack of expression of tyrosinase-related protein-1
            (TRP-1) in melanocytes from an individual with brown oculocutaneous
            albinism: a new subtype of albinism classified as 'OCA3'
  JOURNAL   Am J Hum Genet 58 (6), 1145-1156 (1996)
   PUBMED   8651291
REFERENCE   9  (bases 1 to 2685)
  AUTHORS   Ozeki,H., Ito,S., Wakamatsu,K. and Hirobe,T.
  TITLE     Chemical characterization of hair melanins in various coat-color
            mutants of mice
  JOURNAL   J Invest Dermatol 105 (3), 361-366 (1995)
   PUBMED   7665913
REFERENCE   10 (bases 1 to 2685)
  AUTHORS   Moore,K.J., Swing,D.A., Copeland,N.G. and Jenkins,N.A.
  TITLE     Interaction of the murine dilute suppressor gene (dsu) with
            fourteen coat color mutations
  JOURNAL   Genetics 125 (2), 421-430 (1990)
   PUBMED   2379821
  REMARK    Erratum:[Genetics 1990 Sep;126(1):285]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473978.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001059355.1, XM_001059411.1, XM_001059470.1, XM_238398.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN12840117,
                              SAMN12840121 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2685
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q31"
     gene            1..2685
                     /gene="Tyrp1"
                     /note="tyrosinase-related protein 1"
                     /db_xref="GeneID:298182"
                     /db_xref="RGD:1593266"
     exon            1..163
                     /gene="Tyrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            164..630
                     /gene="Tyrp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             246..1859
                     /gene="Tyrp1"
                     /EC_number="1.14.18.-"
                     /note="tyrosine phosphatase 1, same as B (Brown);
                     5,6-dihydroxyindole-2-carboxylic acid oxidase"
                     /codon_start=1
                     /product="5,6-dihydroxyindole-2-carboxylic acid oxidase
                     precursor"
                     /protein_id="NP_001100134.1"
                     /db_xref="GeneID:298182"
                     /db_xref="RGD:1593266"
                     /translation="MKSYNVLLLASLFLSLMLLCPVWAQFPRECANIEALRSGVCCPD
                     LFPSSGPGTDPCGSSSGRGRCVAVTADSRPHSRHYPHDGRDDREGWPLRFFNRTCQCN
                     GNFSGHNCGACRPGWRGAACNQKILTVRRNLLDLSTEEKSHFVRALDMAKRTTHPQFV
                     IATRRSEDMLGPDGSTPQFENISIYNYFVWTHYYSVKKTFLGAGQESFGDVDFSHEGP
                     AFLTWHRYHLLQLERDIQEMLQEPSFSLPYWNFATGKNICDICTDDLMGSRSNFDSTL
                     ISPNSVFSQWRVVCESLEEYDTLGTLCNSTEGGPIRRNPAGNVGRPAVQRLPAPQDVT
                     RCLEVRVFDTPPFYSNSTNSFRNTVEGYSDPTGKYDPAVRSLHNLAHLFLNGTGGQTH
                     LSPNDPIFVLLHTFTDAVFDEWLRRYNADISTFPLENAPIGHNRQYNMVPFWPPVTNT
                     EMFVTAPDNLGYAYELQWPGQEFTVSEIITIAVIAGLLLVAAIFGSASCLIRSRSTKN
                     EANQPLLTDHYQRYAEEYEELPNPNQTMV"
     exon            631..953
                     /gene="Tyrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1158
                     /gene="Tyrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1326
                     /gene="Tyrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1327..1506
                     /gene="Tyrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..1653
                     /gene="Tyrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1654..2685
                     /gene="Tyrp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaagagagga ccagcccctg ccagcgtgag tgatctggct tgggatttgc tgtctggcag
       61 aaaaccacat gcaattaaca gctggcatca ggggaaaagc ggacatccaa cactagctct
      121 gaaggagatc agccgagaaa ccttccagga gttcatggta ctgctgtatt ttcatctcag
      181 tacccctctt ctccagcaaa gagcagcata ctagacctgt gtcctgcact cttgattcta
      241 caggaatgaa atcttacaac gtcctcctcc tagcctctct cttcctttcc ctgatgctgc
      301 tttgtcctgt ctgggctcag tttccacgag aatgcgccaa tattgaggct ctgagaagtg
      361 gggtgtgttg cccagacctg tttccttcct ctggaccagg gactgacccc tgtggctcat
      421 catcaggaag gggcaggtgt gtggctgtga ccgcagactc ccgaccccac agccgccatt
      481 atccccatga tggtagagat gaccgggaag gctggcctct gaggttcttc aataggacat
      541 gtcagtgcaa tggtaatttc tcaggacaca actgtggggc ttgtcgtcct gggtggagag
      601 gagctgcatg caaccagaaa attctcacag tcaggagaaa tcttcttgac ttaagtacag
      661 aagaaaaaag ccacttcgtc agggccttgg atatggcgaa gcgcacaact caccctcaat
      721 ttgtcattgc cacaaggagg tcagaagaca tgctgggacc agatggcagc acaccacaat
      781 ttgagaacat ttccatttac aactactttg tttggacaca ctattattca gtcaaaaaaa
      841 ccttccttgg ggcaggacag gagagctttg gcgatgtgga tttctctcac gaaggaccag
      901 ctttcctcac atggcacagg taccatctgc tgcagctgga gcgagacatt caggagatgc
      961 tgcaggagcc ttctttctcc cttccttact ggaattttgc aactgggaaa aacatctgtg
     1021 atatctgcac tgatgacttg atgggatcca gaagcaactt cgattctact cttataagcc
     1081 ccaactctgt cttttcacaa tggagagtgg tctgtgaatc cttagaagag tacgataccc
     1141 tgggaacact ttgcaacagc actgagggtg gtccaatcag gagaaaccca gccggaaatg
     1201 tagggagacc agcagtacag cgtcttcctg cgccacagga tgttactcga tgcctggagg
     1261 ttcgtgtgtt tgacacgcct cctttttatt ccaattctac aaacagtttt cgaaacacag
     1321 tggaaggtta cagcgatccc acggggaaat atgaccctgc tgttcgaagc cttcataacc
     1381 tggcccacct cttcctgaat gggacaggag gacaaaccca tctgtctccc aatgatccta
     1441 tttttgtcct cctgcatact ttcactgatg cagtctttga tgaatggcta aggagataca
     1501 atgccgatat ttctaccttc ccattggaaa atgctcctat tggacataac aggcaatata
     1561 acatggtacc attctggcct ccagttacca acacagaaat gtttgttact gctccagaca
     1621 acctgggata tgcttatgaa cttcaatggc caggtcagga atttactgta tctgaaatca
     1681 ttaccattgc tgtaatagct gggctgttac ttgtagctgc catttttggg agtgcttctt
     1741 gtctgatccg ctctagaagc accaagaatg aagccaacca gcctctcctc accgatcact
     1801 accaacgcta tgctgaggaa tatgaagaac tcccaaatcc taatcaaacc atggtctgac
     1861 acctgcctgc ctggcctctc atgcaacagg ttgggaagca acctgattga aacacagccg
     1921 tcaaccgcgt ttccttttgc taccttcttt tctttttact atagatgtgg tttggaatta
     1981 aagcatcgct ttccttttca gagatgcaga ttcacaatct tttcaatggg ttttaattat
     2041 tagttctatt gaagatgaca tattgtacca gcctcatgat atccgagagg gtaacgtgat
     2101 tctttgtgct atgctgtgaa gaagtgatgc tttgtgtaca caggaaaata agtggtgtaa
     2161 aatctacact tcaaatatat gattggccaa tcttatagag tgaacatggg attgcattgc
     2221 cattgctgct actaatcaaa agatttaaaa gcagccaggt tgactggtta aaataaatta
     2281 cataacacta tgaaccaata gaaccctgat tatctttctg aaactggtct cattattttg
     2341 ctgtcagtat attatttggc cttaggtgca agaccacaac aaagtcacag tccttgtcac
     2401 actttgtaaa gatgaaagct tcgtttactg gaacacagct gctactctat atttgctact
     2461 gtgttcccag ctcagttctc tggatgggaa actgcccctg ccacagttca cctcctaatt
     2521 ctaatgtctt agaggcctac aaggaaggta taattcagag gacacagtgt tctgtgcatc
     2581 ttatcaaacg ttgtgtttca ttattattat aacagcatta tttcaccact tatcagccgt
     2641 ctgtgtattt caaaataaat ataataaaat cttgtttcat tggtc
//
