LOCUS       NM_212525                545 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus transmembrane immune signaling adaptor Tyrobp
            (Tyrobp), mRNA.
ACCESSION   NM_212525 XM_341823
VERSION     NM_212525.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 545)
  AUTHORS   Zhou,X., Song,H., He,J., Han,W. and Li,Q.
  TITLE     Deciphering microglial activation and neuronal apoptosis
            post-traumatic brain injury: The role of TYROBP in inflammation
            regulation networks
  JOURNAL   Mol Med Rep 29 (6) (2024)
   PUBMED   38639190
  REMARK    GeneRIF: Deciphering microglial activation and neuronal apoptosis
            post-traumatic brain injury: The role of TYROBP in inflammation
            regulation networks.
REFERENCE   2  (bases 1 to 545)
  AUTHORS   Zhao,Y., Wu,X., Li,X., Jiang,L.L., Gui,X., Liu,Y., Sun,Y., Zhu,B.,
            Pina-Crespo,J.C., Zhang,M., Zhang,N., Chen,X., Bu,G., An,Z.,
            Huang,T.Y. and Xu,H.
  TITLE     TREM2 Is a Receptor for beta-Amyloid that Mediates Microglial
            Function
  JOURNAL   Neuron 97 (5), 1023-1031 (2018)
   PUBMED   29518356
REFERENCE   3  (bases 1 to 545)
  AUTHORS   Fan,D., He,X., Bian,Y., Guo,Q., Zheng,K., Zhao,Y., Lu,C., Liu,B.,
            Xu,X., Zhang,G. and Lu,A.
  TITLE     Triptolide Modulates TREM-1 Signal Pathway to Inhibit the
            Inflammatory Response in Rheumatoid Arthritis
  JOURNAL   Int J Mol Sci 17 (4), 498 (2016)
   PUBMED   27049384
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 545)
  AUTHORS   Zhong,L., Chen,X.F., Zhang,Z.L., Wang,Z., Shi,X.Z., Xu,K.,
            Zhang,Y.W., Xu,H. and Bu,G.
  TITLE     DAP12 Stabilizes the C-terminal Fragment of the Triggering Receptor
            Expressed on Myeloid Cells-2 (TREM2) and Protects against
            LPS-induced Pro-inflammatory Response
  JOURNAL   J Biol Chem 290 (25), 15866-15877 (2015)
   PUBMED   25957402
REFERENCE   5  (bases 1 to 545)
  AUTHORS   Kobayashi,M., Konishi,H., Takai,T. and Kiyama,H.
  TITLE     A DAP12-dependent signal promotes pro-inflammatory polarization in
            microglia following nerve injury and exacerbates degeneration of
            injured neurons
  JOURNAL   Glia 63 (6), 1073-1082 (2015)
   PUBMED   25690660
REFERENCE   6  (bases 1 to 545)
  AUTHORS   Naper,C., Hayashi,S., Kveberg,L., Niemi,E.C., Lanier,L.L.,
            Vaage,J.T. and Ryan,J.C.
  TITLE     Ly-49s3 is a promiscuous activating rat NK cell receptor for
            nonclassical MHC class I-encoded target ligands
  JOURNAL   J Immunol 169 (1), 22-30 (2002)
   PUBMED   12077224
REFERENCE   7  (bases 1 to 545)
  AUTHORS   Bouchon,A., Hernandez-Munain,C., Cella,M. and Colonna,M.
  TITLE     A DAP12-mediated pathway regulates expression of CC chemokine
            receptor 7 and maturation of human dendritic cells
  JOURNAL   J Exp Med 194 (8), 1111-1122 (2001)
   PUBMED   11602640
REFERENCE   8  (bases 1 to 545)
  AUTHORS   Dietrich,J., Cella,M., Seiffert,M., Buhring,H.J. and Colonna,M.
  TITLE     Cutting edge: signal-regulatory protein beta 1 is a
            DAP12-associated activating receptor expressed in myeloid cells
  JOURNAL   J Immunol 164 (1), 9-12 (2000)
   PUBMED   10604985
REFERENCE   9  (bases 1 to 545)
  AUTHORS   Tomasello,E., Olcese,L., Vely,F., Geourgeon,C., Blery,M.,
            Moqrich,A., Gautheret,D., Djabali,M., Mattei,M.G. and Vivier,E.
  TITLE     Gene structure, expression pattern, and biological activity of
            mouse killer cell activating receptor-associated protein
            (KARAP)/DAP-12
  JOURNAL   J Biol Chem 273 (51), 34115-34119 (1998)
   PUBMED   9852069
REFERENCE   10 (bases 1 to 545)
  AUTHORS   Smith,K.M., Wu,J., Bakker,A.B., Phillips,J.H. and Lanier,L.L.
  TITLE     Ly-49D and Ly-49H associate with mouse DAP12 and form activating
            receptors
  JOURNAL   J Immunol 161 (1), 7-10 (1998)
   PUBMED   9647200
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY247021.1.
            
            On Aug 30, 2004 this sequence version replaced XM_341823.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY247021.1, FQ211365.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..545
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="F344"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..545
                     /gene="Tyrobp"
                     /gene_synonym="Karap"
                     /note="transmembrane immune signaling adaptor Tyrobp"
                     /db_xref="GeneID:361537"
                     /db_xref="RGD:1303081"
     exon            1..70
                     /gene="Tyrobp"
                     /gene_synonym="Karap"
                     /inference="alignment:Splign:2.1.0"
     CDS             10..354
                     /gene="Tyrobp"
                     /gene_synonym="Karap"
                     /note="TYRO protein tyrosine kinase-binding protein;
                     DNAX-activation protein 12; killer cell activating
                     receptor-associated protein; DAP12; Tyro protein tyrosine
                     kinase binding protein"
                     /codon_start=1
                     /product="TYRO protein tyrosine kinase-binding protein
                     precursor"
                     /protein_id="NP_997690.1"
                     /db_xref="GeneID:361537"
                     /db_xref="RGD:1303081"
                     /translation="MGAPEPSWCFLFLPVLLTVGGLSPVQAQSDNYPGCECSSVSPGV
                     LAGIVLGDLVLTLLIALAVYSLGRLVSRGRGTADGTRKQHMAETESPYQELQGQRPEV
                     YSDLNTQRQYYR"
     exon            71..97
                     /gene="Tyrobp"
                     /gene_synonym="Karap"
                     /inference="alignment:Splign:2.1.0"
     exon            98..244
                     /gene="Tyrobp"
                     /gene_synonym="Karap"
                     /inference="alignment:Splign:2.1.0"
     exon            245..288
                     /gene="Tyrobp"
                     /gene_synonym="Karap"
                     /inference="alignment:Splign:2.1.0"
     exon            289..528
                     /gene="Tyrobp"
                     /gene_synonym="Karap"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctggccacca tgggggcccc agagccctcc tggtgctttc tgttccttcc tgtcctcctg
       61 actgtgggag gattaagtcc cgtacaggcc cagagtgaca attacccagg atgcgaatgt
      121 tcctctgtga gcccgggtgt actggctggg attgtgctgg gcgacttggt gctgactctg
      181 ctcatcgccc tggcggtgta ctctctgggc cgcctggtct ctcgaggccg agggactgca
      241 gacgggaccc ggaaacagca catggctgag actgagtcac cttatcagga gcttcagggt
      301 cagaggccag aagtatacag tgacctcaac acacagaggc agtattacag atgaacccac
      361 cctatgccca ccaacaacct gatgcccgga tccactcatt ccagacgctt actcaacaaa
      421 ccctccctgg gatcaggact cccgctggaa taaatatcca cagagtgccc tctgggagat
      481 atctgacctt gtaccgtttc tgtccccaaa taaaagacga agcaaaaaaa aaaaaaaaaa
      541 aaaaa
//
