LOCUS       NM_017092               3726 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Rattus norvegicus TYRO3 protein tyrosine kinase (Tyro3), mRNA.
ACCESSION   NM_017092
VERSION     NM_017092.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3726)
  AUTHORS   Powell,N.A., Kohrt,J.T., Filipski,K.J., Kaufman,M., Sheehan,D.,
            Edmunds,J.E., Delaney,A., Wang,Y., Bourbonais,F., Lee,D.Y.,
            Schwende,F., Sun,F., McConnell,P., Catana,C., Chen,H., Ohren,J. and
            Perrin,L.A.
  TITLE     Novel and selective spiroindoline-based inhibitors of Sky kinase
  JOURNAL   Bioorg Med Chem Lett 22 (1), 190-193 (2012)
   PUBMED   22119469
  REMARK    GeneRIF: analysis of novel and selective spiroindoline-based
            inhibitors of Sky kinase
REFERENCE   2  (bases 1 to 3726)
  AUTHORS   Brown,J.E., Krodel,M., Pazos,M., Lai,C. and Prieto,A.L.
  TITLE     Cross-phosphorylation, signaling and proliferative functions of the
            Tyro3 and Axl receptors in Rat2 cells
  JOURNAL   PLoS One 7 (5), e36800 (2012)
   PUBMED   22606290
  REMARK    GeneRIF: Overexpression of Tyro3 in the Rat2 cell line that
            expresses Axl, but not Mer or Tyro3, resulted in a 5 fold increase
            in cell proliferation.
REFERENCE   3  (bases 1 to 3726)
  AUTHORS   Wang,Q., Lu,Q.J., Xiao,B., Zheng,Y. and Wang,X.M.
  TITLE     Expressions of Axl and Tyro-3 receptors are under regulation of
            nerve growth factor and are involved in differentiation of PC12
            cells
  JOURNAL   Neurosci Bull 27 (1), 15-22 (2011)
   PUBMED   21270900
  REMARK    GeneRIF: nerve growth factor affected intracellular localization of
            full-length Axl-eGFP and Tyro-3-eCFP in PC12 cells
REFERENCE   4  (bases 1 to 3726)
  AUTHORS   Zhong,Z., Wang,Y., Guo,H., Sagare,A., Fernandez,J.A., Bell,R.D.,
            Barrett,T.M., Griffin,J.H., Freeman,R.S. and Zlokovic,B.V.
  TITLE     Protein S protects neurons from excitotoxic injury by activating
            the TAM receptor Tyro3-phosphatidylinositol 3-kinase-Akt pathway
            through its sex hormone-binding globulin-like region
  JOURNAL   J Neurosci 30 (46), 15521-15534 (2010)
   PUBMED   21084607
  REMARK    Erratum:[J Neurosci. 2024 Apr 10;44(15):e0435242024. doi:
            10.1523/JNEUROSCI.0435-24.2024.. PMID: 38561230]
REFERENCE   5  (bases 1 to 3726)
  AUTHORS   Cosemans,J.M., Van Kruchten,R., Olieslagers,S., Schurgers,L.J.,
            Verheyen,F.K., Munnix,I.C., Waltenberger,J., Angelillo-Scherrer,A.,
            Hoylaerts,M.F., Carmeliet,P. and Heemskerk,J.W.
  TITLE     Potentiating role of Gas6 and Tyro3, Axl and Mer (TAM) receptors in
            human and murine platelet activation and thrombus stabilization
  JOURNAL   J Thromb Haemost 8 (8), 1797-1808 (2010)
   PUBMED   20546121
REFERENCE   6  (bases 1 to 3726)
  AUTHORS   Broberger,C., Johansen,J., Schalling,M. and Hokfelt,T.
  TITLE     Hypothalamic neurohistochemistry of the murine anorexia (anx/anx)
            mutation: altered processing of neuropeptide Y in the arcuate
            nucleus
  JOURNAL   J Comp Neurol 387 (1), 124-135 (1997)
   PUBMED   9331176
REFERENCE   7  (bases 1 to 3726)
  AUTHORS   Kajii,Y., Ninomiya,D., Kato,M., Mizuguchi,M., Saji,M.,
            Katsumoto,T., Ohno,K., Takashima,S. and Onodera,K.
  TITLE     A tyrosine kinase-like molecule is localized in the nuclear
            membrane of neurons: hippocampal behavior under stress
  JOURNAL   Biol Cell 88 (1-2), 45-54 (1996)
   PUBMED   9175267
REFERENCE   8  (bases 1 to 3726)
  AUTHORS   Ohashi,K., Honda,S., Ichinomiya,N., Nakamura,T. and Mizuno,K.
  TITLE     Molecular cloning and in situ localization in the brain of rat sky
            receptor tyrosine kinase
  JOURNAL   J Biochem 117 (6), 1267-1275 (1995)
   PUBMED   7490270
REFERENCE   9  (bases 1 to 3726)
  AUTHORS   Toshima,J., Ohashi,K., Iwashita,S. and Mizuno,K.
  TITLE     Autophosphorylation activity and association with Src family kinase
            of Sky receptor tyrosine kinase
  JOURNAL   Biochem Biophys Res Commun 209 (2), 656-663 (1995)
   PUBMED   7537495
REFERENCE   10 (bases 1 to 3726)
  AUTHORS   Mark,M.R., Scadden,D.T., Wang,Z., Gu,Q., Goddard,A. and
            Godowski,P.J.
  TITLE     rse, a novel receptor-type tyrosine kinase with homology to
            Axl/Ufo, is expressed at high levels in the brain
  JOURNAL   J Biol Chem 269 (14), 10720-10728 (1994)
   PUBMED   7511603
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from D37880.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D37880.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132263, SAMD00132272
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3726
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q35"
     gene            1..3726
                     /gene="Tyro3"
                     /gene_synonym="Brt"
                     /note="TYRO3 protein tyrosine kinase"
                     /db_xref="GeneID:25232"
                     /db_xref="RGD:3923"
     exon            1..119
                     /gene="Tyro3"
                     /gene_synonym="Brt"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..2668
                     /gene="Tyro3"
                     /gene_synonym="Brt"
                     /EC_number="2.7.10.1"
                     /note="tyrosine-protein kinase receptor TYRO3;
                     tyrosine-protein kinase SKY; TYRO3 protein tyrosine kinase
                     3; Bruton agammaglobulinemia tyrosine kinase"
                     /codon_start=1
                     /product="tyrosine-protein kinase receptor TYRO3
                     precursor"
                     /protein_id="NP_058788.1"
                     /db_xref="GeneID:25232"
                     /db_xref="RGD:3923"
                     /translation="MALRRSMGRPGLRPLLLAGLASLLLPGSAAAGLKLMGAPVKMTV
                     SQGQPVKLNCSVEGMDDPDIHWMKDGAVVQNASQVSISISEQNWIGLLSLKSAERSDA
                     GLYWCQVKDGEETKISQSVWLTVEGVPFFTVEPKDLAVPPNVPFQLSCEAVGPPEPVT
                     IFWWRGPTKVGGPASSPSVLNVTGVTQRTEFSCEAHNIKGLATSRPAIIRLQAPPAAP
                     FNITVTTISSSNASVAWVPGADGLALLHSCTVQVAHAPGEWEALAVVVPVPPFTCLLR
                     NLAPATNYSLRVRCANALGPSPYGDWVPFQTKGLAPARAPQNFHAIRTDSGLILEWEE
                     VIPEDPGEGPLGPYKLSWVQENGTQDELMVEGTTANLTDWDPQKDLVLRVCASNAIGD
                     GPWSQPLVVSSHDHAGRQGPPHSRTSWVPVVLGVLTALITAAALALILLRKRRKETRF
                     GQAFDSVMARGEPAVHFRAARSFNRERPERIEATLDSLGISDELKEKLEDVLIPEQQF
                     TLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFD
                     HPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLVR
                     FMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCAS
                     KLPVKWLALESLADNLYTVHSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLISGNR
                     LKQPPECMEEVYDLMYQCWSADPKQRPSFTCLRMELENILGHLSVLSTSQDPLYINIE
                     RAGQPAENGSPELPCGEQSSSEAGDGSGMGAIGGIPSDCRYIFSPGGLAESPGQLEQQ
                     PESPLNENQRLLLLQQGLLPHSSC"
     exon            120..303
                     /gene="Tyro3"
                     /gene_synonym="Brt"
                     /inference="alignment:Splign:2.1.0"
     exon            304..404
                     /gene="Tyro3"
                     /gene_synonym="Brt"
                     /inference="alignment:Splign:2.1.0"
     exon            405..575
                     /gene="Tyro3"
                     /gene_synonym="Brt"
                     /inference="alignment:Splign:2.1.0"
     exon            576..662
                     /gene="Tyro3"
                     /gene_synonym="Brt"
                     /inference="alignment:Splign:2.1.0"
     exon            663..778
                     /gene="Tyro3"
                     /gene_synonym="Brt"
                     /inference="alignment:Splign:2.1.0"
     exon            779..956
                     /gene="Tyro3"
                     /gene_synonym="Brt"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1102
                     /gene="Tyro3"
                     /gene_synonym="Brt"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1247
                     /gene="Tyro3"
                     /gene_synonym="Brt"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..1377
                     /gene="Tyro3"
                     /gene_synonym="Brt"
                     /inference="alignment:Splign:2.1.0"
     exon            1378..1478
                     /gene="Tyro3"
                     /gene_synonym="Brt"
                     /inference="alignment:Splign:2.1.0"
     exon            1479..1574
                     /gene="Tyro3"
                     /gene_synonym="Brt"
                     /inference="alignment:Splign:2.1.0"
     exon            1575..1655
                     /gene="Tyro3"
                     /gene_synonym="Brt"
                     /inference="alignment:Splign:2.1.0"
     exon            1656..1748
                     /gene="Tyro3"
                     /gene_synonym="Brt"
                     /inference="alignment:Splign:2.1.0"
     exon            1749..1870
                     /gene="Tyro3"
                     /gene_synonym="Brt"
                     /inference="alignment:Splign:2.1.0"
     exon            1871..1980
                     /gene="Tyro3"
                     /gene_synonym="Brt"
                     /inference="alignment:Splign:2.1.0"
     exon            1981..2140
                     /gene="Tyro3"
                     /gene_synonym="Brt"
                     /inference="alignment:Splign:2.1.0"
     exon            2141..2277
                     /gene="Tyro3"
                     /gene_synonym="Brt"
                     /inference="alignment:Splign:2.1.0"
     exon            2278..3726
                     /gene="Tyro3"
                     /gene_synonym="Brt"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccggcatggt gcggcgtcgc cgccgatggc gctgaggcgg agcatggggc ggccggggct
       61 ccggccgctg ctgctggcgg ggctggcctc tctgctgctc ccagggtccg cggccgcagg
      121 cctgaagctc atgggagccc cagtgaagat gacagtgtct caggggcagc cagtgaagct
      181 taactgcagt gtggaaggga tggatgaccc tgacatacac tggatgaagg atggcgctgt
      241 ggtccagaat gcaagccagg tgtccatctc aataagcgaa cagaactgga ttggcttact
      301 cagcctaaag tcagcggagc ggtctgatgc cggcctgtac tggtgccagg tgaaggatgg
      361 ggaggaaacc aagatctctc agtcagtatg gctcactgtt gaaggtgtgc cattcttcac
      421 ggtggaacca aaagatctgg cggtgccacc caatgtccct tttcaactgt cttgtgaggc
      481 tgtgggtcca ccagaacccg taaccatttt ctggtggaga ggacccacta aggttggggg
      541 acctgcttcc tctccctctg ttttaaatgt aacaggagtg acccagcgca cagagttttc
      601 ttgtgaagct cataacataa aaggcctggc cacttcccga ccagccatta ttcgccttca
      661 agcaccgcct gcagctcctt tcaacatcac agtaacaacg atctccagca gcaacgctag
      721 tgtggcctgg gtgccgggtg ctgatggctt agctctgctg cactcctgta ctgtacaggt
      781 ggcacatgcc ccaggagaat gggaggccct tgctgtcgtg gttcccgtgc caccctttac
      841 ttgcttgctt cggaacttgg cccctgccac caactacagc cttagggttc gctgtgccaa
      901 cgccttgggc ccttctccct atggcgactg ggtgcccttt cagacaaagg gcctagcgcc
      961 agccagagcc cctcagaatt tccacgccat tcgtactgac tcaggcctta tcctggaatg
     1021 ggaagaagtg attcctgagg accctgggga aggccccctg ggaccttata agctgtcctg
     1081 ggtccaagaa aatggaaccc aggatgagct gatggtggaa ggaactacgg ccaatctgac
     1141 tgactgggat ccccagaagg acctggtttt gcgtgtgtgt gcctccaatg caattggtga
     1201 tgggccctgg agtcaaccac tggtggtgtc ttctcatgac catgcaggga ggcagggccc
     1261 tcctcacagc cgtacatcct gggtgcctgt ggtcctgggt gtgctcaccg ccctgatcac
     1321 agctgctgcc ttggccctca tcctgcttcg gaagagacgc aaggagacgc ggttcgggca
     1381 agcctttgac agtgtcatgg cccgagggga gccagctgta cacttccggg cagcccggtc
     1441 tttcaatcga gaaaggcctg aacgcattga agctacattg gatagcctgg gcatcagcga
     1501 tgaattgaag gagaagctgg aggacgtcct catcccagag cagcagttca ccctcggccg
     1561 gatgttgggc aaaggagagt ttggatcagt gcgggaagcc cagctgaagc aggaagatgg
     1621 ctcctttgtg aaagtggcag tgaagatgct gaaagctgac atcattgcct caagcgacat
     1681 agaagagttc ctgagagaag cagcttgcat gaaggagttt gaccatccac acgtggccaa
     1741 gcttgttgga gtgagcctcc ggagcagggc taaaggtcgt ctccccattc ccatggtcat
     1801 cctgcccttc atgaagcacg gagacttgca tgcctttctg ctcgcctccc gaattgggga
     1861 gaaccctttt aacctgcccc tccagaccct cgtccggttc atggtggaca ttgcctgtgg
     1921 catggagtac ctgagctccc ggaacttcat ccaccgagac ctagcagctc ggaattgcat
     1981 gctggcagag gacatgacag tgtgtgtggc tgactttgga ctctcccgga aaatttatag
     2041 cggggactat tatcgtcagg gctgtgcctc caaactgcct gtcaagtggc tggccctgga
     2101 gagcttggct gacaacttgt atactgtaca cagcgatgtg tgggccttcg gggtgaccat
     2161 gtgggagatc atgactcgtg ggcagacgcc atatgctggc atcgaaaatg ctgagattta
     2221 caactacctc atcagcggga accgcctgaa gcagcctccg gagtgcatgg aggaagtgta
     2281 tgatctcatg taccagtgct ggagtgccga cccaaagcag cgcccaagct tcacatgcct
     2341 gcgaatggaa ctggagaaca ttctgggcca cctatctgtt ctgtccacca gccaggaccc
     2401 cttgtacatc aacattgaga gagctgggca gcctgctgag aatggcagtc ccgagctgcc
     2461 ctgtggagag cagtctagca gcgaggcggg ggatggcagt ggcatggggg caataggtgg
     2521 catccccagt gactgtcggt acatcttcag ccctggaggg ttggccgagt caccagggca
     2581 gctggagcag cagccagaaa gccccctcaa cgagaaccag aggcttttgt tgttgcagca
     2641 agggctactg cctcacagta gctgttaacc tgcaggcaga ggacagctgg ggccccctgg
     2701 ctctgccggc cattgcgctg gcttactagg ccccgtctga tcacagccca ggcagcaagg
     2761 tatggaggct cctgtggtag tcctcccaag ctgtgctggg acctggactg accaaattgc
     2821 ccaatcccag ttcttcctgc agccgctctg gccagcctgg catcagttca ggccttggct
     2881 tagaggaggt gagccagatc tggttgcctg aatgcaggca gctggcagga ggggagggtg
     2941 gctgtgtttc catgggtacc atgggtgtgg atggcagtaa gggagggtag cagcagccct
     3001 gtgggcccct accctcctgg ctgagctgct cctactttag tgcatgcttg gagccgcctg
     3061 cagcctggag ctcagcactg cccaccacac ctgagtttaa atgccaggtt tgcccctcta
     3121 cgtcacaaag agatgtcctt gtattgttcc cttttaggtg acgattagga agggattggc
     3181 acacttaggt ccttaagccc catgacagga aatggtggga tattctcagg tccgaatcct
     3241 catcaccttc ctgattcccc accctgccat ggcctggaac tgactgggtg gctgagggat
     3301 gcacgaggac aaagactacc gagatccgac tcctaaaggc agggtctgag tctgccagat
     3361 ggagggggtg ctaagaggtt ggcccaggag tcaggcattt caggacccct ctaagcttct
     3421 acagtctgtc tgagcatgct accaagcccc caaacatccc agaactaaca ggcagttttg
     3481 tctgagccca gcccttccac atggtgaccc ttaggtctac catcctctct gaatggatat
     3541 cacttgtccc aagtcttaag agagagatac acctgatggc tgatgtgggt aagaaaagtt
     3601 cctggaacca gggctggggt ctaggcaccg cactgcaaac ctcctggaat gcagaggcag
     3661 gctcttgggc tgttaggaac atttccaagc tattaagttg ctgtttcaaa acaataaaat
     3721 tgaaac
//
