LOCUS       NM_001107535            3018 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus tyrosinase (Tyr), mRNA.
ACCESSION   NM_001107535 XM_001060770 XM_238901
VERSION     NM_001107535.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3018)
  AUTHORS   Marubashi S, Shimada H, Fukuda M and Ohbayashi N.
  TITLE     RUTBC1 Functions as a GTPase-activating Protein for Rab32/38 and
            Regulates Melanogenic Enzyme Trafficking in Melanocytes
  JOURNAL   J Biol Chem 291 (3), 1427-1440 (2016)
   PUBMED   26620560
REFERENCE   2  (bases 1 to 3018)
  AUTHORS   Mashimo T, Kaneko T, Sakuma T, Kobayashi J, Kunihiro Y, Voigt B,
            Yamamoto T and Serikawa T.
  TITLE     Efficient gene targeting by TAL effector nucleases coinjected with
            exonucleases in zygotes
  JOURNAL   Sci Rep 3, 1253 (2013)
   PUBMED   23409244
REFERENCE   3  (bases 1 to 3018)
  AUTHORS   Dordic M, Matic IZ, Filipovic-Ljeskovic I, Dzodic R, Sasic M,
            Eric-Nikolic A, Vuletic A, Kolundzija B, Damjanovic A, Grozdanic N,
            Nikolic S, Pralica J, Dobrosavljevic D, Raskovic S, Andrejevic S
            and Juranic Z.
  TITLE     Immunity to melanin and to tyrosinase in melanoma patients, and in
            people with vitiligo
  JOURNAL   BMC Complement Altern Med 12, 109 (2012)
   PUBMED   22834951
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3018)
  AUTHORS   Ko JM, Yang JA, Jeong SY and Kim HJ.
  TITLE     Mutation spectrum of the TYR and SLC45A2 genes in patients with
            oculocutaneous albinism
  JOURNAL   Mol Med Rep 5 (4), 943-948 (2012)
   PUBMED   22294196
REFERENCE   5  (bases 1 to 3018)
  AUTHORS   Ohbayashi N, Maruta Y, Ishida M and Fukuda M.
  TITLE     Melanoregulin regulates retrograde melanosome transport through
            interaction with the RILP-p150Glued complex in melanocytes
  JOURNAL   J Cell Sci 125 (Pt 6), 1508-1518 (2012)
   PUBMED   22275436
REFERENCE   6  (bases 1 to 3018)
  AUTHORS   Tripathi RK, Strunk KM, Giebel LB, Weleber RG and Spritz RA.
  TITLE     Tyrosinase gene mutations in type I (tyrosinase-deficient)
            oculocutaneous albinism define two clusters of missense
            substitutions
  JOURNAL   Am J Med Genet 43 (5), 865-871 (1992)
   PUBMED   1642278
REFERENCE   7  (bases 1 to 3018)
  AUTHORS   Garai J, Tiller AA and Clark JH.
  TITLE     Tyrosinase-like polypeptides in the uterus and in the central
            nervous system of rats
  JOURNAL   Steroids 57 (4), 183-188 (1992)
   PUBMED   1519262
REFERENCE   8  (bases 1 to 3018)
  AUTHORS   Tanaka S, Yamamoto H, Takeuchi S and Takeuchi T.
  TITLE     Melanization in albino mice transformed by introducing cloned mouse
            tyrosinase gene
  JOURNAL   Development 108 (2), 223-227 (1990)
   PUBMED   2112453
REFERENCE   9  (bases 1 to 3018)
  AUTHORS   Kwon BS, Halaban R and Chintamaneni C.
  TITLE     Molecular basis of mouse Himalayan mutation
  JOURNAL   Biochem Biophys Res Commun 161 (1), 252-260 (1989)
   PUBMED   2567165
REFERENCE   10 (bases 1 to 3018)
  AUTHORS   Palmer,L.G. and Civan,M.M.
  TITLE     Intracellular distribution of free potassium in Chironomus salivary
            glands
  JOURNAL   Science 188 (4195), 1321-1322 (1975)
   PUBMED   1145200
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473956.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_238901.4, XM_001060770.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN16418971,
                              SAMN16418986 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3018
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..3018
                     /gene="Tyr"
                     /note="tyrosinase"
                     /db_xref="GeneID:308800"
                     /db_xref="RGD:1589755"
     exon            1..883
                     /gene="Tyr"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..1657
                     /gene="Tyr"
                     /EC_number="1.14.18.1"
                     /codon_start=1
                     /product="tyrosinase precursor"
                     /protein_id="NP_001101005.1"
                     /db_xref="GeneID:308800"
                     /db_xref="RGD:1589755"
                     /translation="MFLAVLYYLLWSFQTSAGHFPRDCASSKNLMAKECCPPWMGDGS
                     PCGHLSGRGSCQDILLSNAPSGPQFPFKGVDDRESWPSVFYNRTCQCSGNFMGFNCGN
                     CKFGFGGPNCTEKRLLIRRNIFDLSASEKNKFFSYLTLAKHTISSVYVIPTGTYGQMN
                     NGSTPMFKDINIYDLFVWMHYYVSRDTLLGGSEIWRDIDFAHEAPGFLPWHRLFLLLW
                     EQEMQELTGDENFTIPYWDWRDAENCDICTDEYLGGRHPENPNLLSPASFFSSWEIIC
                     SRSEEYNSHQVLCDGTPEGPLLRNPGNHDKAKTPRLPSSADVEFCLSLTQYESGSMDR
                     TANFSFRNTLEGFASPLTGIADSSQSSMHNALHIYMNGTMSQVQGSANDPIFLLHHAF
                     VDSIFEQWLRRHRPLLEVYPEANAPIGHNRESYMVPFIPLYRNGDFFISSKDLGYDYS
                     YLQESDPGFYRNYIEPYLEQASRIWPWLLGAALVGAVVATALAGLSSRLCHQKKKQPQ
                     EERQPLLMDKDDYHSLLYQSHL"
     exon            884..1100
                     /gene="Tyr"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1248
                     /gene="Tyr"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1430
                     /gene="Tyr"
                     /inference="alignment:Splign:2.1.0"
     exon            1431..3018
                     /gene="Tyr"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaaaagaag tctgtgacac tcattaactt gtttgagcag atcttgtacg gtctaaaggg
       61 aaaaatgttc ttggctgttt tgtattacct tctgtggagt tttcagacct ctgctggcca
      121 ttttcctcga gactgtgcct cctctaagaa cttgatggca aaagaatgct gcccaccatg
      181 gatgggtgat gggagtccct gcggccacct ttcagggaga ggttcctgcc aggacatcct
      241 tttgtccaat gcaccatctg gacctcagtt ccccttcaaa ggggtggatg accgtgagtc
      301 ctggccctct gtgttttata ataggacctg ccagtgctct ggaaacttca tgggtttcaa
      361 ttgcggaaac tgtaagtttg gatttggggg cccaaattgt acagagaagc gactcttaat
      421 tagacgaaac atttttgatt tgagtgcctc agaaaagaat aagttctttt cttacctcac
      481 tttggcaaaa catactatca gctcagtcta tgtcatcccc acaggcacct atggccaaat
      541 gaacaatggg tcgacaccca tgtttaagga catcaacatc tatgacctct ttgtatggat
      601 gcattactat gtgtcaaggg acacactgct tgggggctct gaaatctgga gggacattga
      661 ttttgctcat gaagcaccag gatttttgcc ttggcacaga ctgttcttgc tattatggga
      721 acaagaaatg caggaactaa ctggggatga gaatttcacc attccatatt gggactggag
      781 agatgcggaa aactgtgaca tttgcacaga tgagtacctg ggaggtcgtc accctgaaaa
      841 tcctaactta ctcagcccag cgtccttctt ctcctcctgg gagatcattt gcagcagatc
      901 agaagagtat aatagccatc aggttttatg tgatggaaca cctgagggac cactattacg
      961 taatcctgga aaccatgaca aagccaaaac ccccaggctc ccatcttcag cagacgtgga
     1021 attttgtttg agtttgaccc agtatgaatc tggatcaatg gatagaactg ccaatttcag
     1081 ctttagaaac acactggaag gatttgccag tccactcaca gggatagcag attcttctca
     1141 aagtagcatg cacaacgctc tgcatatcta tatgaatgga acaatgtcgc aagtacaggg
     1201 atcggccaat gatcccattt ttcttcttca tcatgctttt gtggacagta tttttgaaca
     1261 atggctccga agacaccgcc ctcttttgga agtttaccca gaagccaatg cacctattgg
     1321 ccataacaga gaatcctaca tggttccttt cattccactc tatagaaatg gtgatttctt
     1381 catttcatcc aaggatctgg gatatgacta cagttaccta caagaatcag atccaggctt
     1441 ttaccgaaac tatattgaac cctacttgga acaagctagt cgtatctggc catggcttct
     1501 tggagcagca ctggtgggag ctgttgttgc tacagctcta gctgggctca gcagtaggct
     1561 atgccatcag aagaaaaagc aaccccagga ggaaaggcag cccctcctca tggacaaaga
     1621 tgactaccac agcttgctgt accagagcca tctatgaaaa tcctaggaaa cagagtggga
     1681 ctaaaaggtc tgacctcact ctacctattt gtttgtgttt ctacaatttt aaactaatac
     1741 aaaacataga ccatagctgt ttgtctgact gggttttgct cagacccatg tttttttccc
     1801 acgtcccagt ttctaaggaa agactggtat ttcctaaaaa ataaattgta tctaaataaa
     1861 atttctgtta aaaaatttct cttgggttgg tttttatgaa tgtgttttgg tgatttaaaa
     1921 taaaatcatg tcatttgaaa aaaataaaaa aaaataaaat cacaataaaa ttataaaaag
     1981 tgatgcctat gaacttgagg cacatttttg ttttccttac ttcattgtaa atttccaaga
     2041 aaataaaatt ttgctctctc cctccctctc tctctctctt tctaagtgca tgcatgtgtt
     2101 catgcatgca tgcgtgcttg cgcacgcgcg cgcgcgcgcg cgcgcgcgtg tgtgtgtgtg
     2161 tgtgtgtgtg tgtgtgtgtg tgtgtgtatt tgtgcctctg tgtccatgtt acatgacaat
     2221 tttgaaaatc tcagatagaa atgctcacta atttttgaac tcatttcatt aatgattagg
     2281 agagatgaat aattacaaaa tcagtaacag aggagaacat ctgccagctt tcattagttg
     2341 tcatatttaa gctattttat ctacattcag tgactggtag aaaacaatca ggcaagagat
     2401 ctgaatgttc tgcctaatag aagagtggct tctgggagga gtgaactatt actagagatt
     2461 attacctgaa cattactcat agccagaaaa agaatcaaaa cagatgacta cagtaacatc
     2521 tgaagctttg agtctgcctg actgtgatca gtaatggtca aactcaaggg ccaaaggaat
     2581 agaaacagaa atgtgaaaaa ccgtctgaat cagattctga tgggagaata tcagggccac
     2641 atccagtttc atggtacaat ggtaaactgt tttccccttt atcataatac aacgccctcc
     2701 tttgccactc tgcatgccat catagagtat ttttggtttt tttttttttg tttttttgtt
     2761 tgttttctct agaggctcaa catatctata tgaatagcag tcacaccatc ttttttgatt
     2821 ctatatagtt tcttattatg gcaacaaaat tgtattatgg atatttcaat gtatttgaaa
     2881 gtttcattag attctcatca accttatata ttttagtctt gcttactgtg taaattttat
     2941 aaactgtttc atttttttat gcaattgtcc tgttgctgca tcattttctt aagaaataaa
     3001 taactggcat tctttcct
//
