LOCUS       NM_019179               1600 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus thymidylate synthetase (Tyms), mRNA.
ACCESSION   NM_019179
VERSION     NM_019179.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1600)
  AUTHORS   Pellicer,M., Garcia-Gonzalez,X., Garcia,M.I., Robles,L.,
            Gravalos,C., Garcia-Alfonso,P., Pachon,V., Longo,F., Martinez,V.,
            Blanco,C., Iglesias,I., Sanjurjo,M. and Lopez-Fernandez,L.A.
  TITLE     Identification of new SNPs associated with severe toxicity to
            capecitabine
  JOURNAL   Pharmacol Res 120, 133-137 (2017)
   PUBMED   28347776
REFERENCE   2  (bases 1 to 1600)
  AUTHORS   Fraczyk,T., Ruman,T., Wilk,P., Palmowski,P.,
            Rogowska-Wrzesinska,A., Ciesla,J., Zielinski,Z., Niziol,J.,
            Jarmula,A., Maj,P., Golos,B., Winska,P., Ostafil,S.,
            Walajtys-Rode,E., Shugar,D. and Rode,W.
  TITLE     Properties of phosphorylated thymidylate synthase
  JOURNAL   Biochim Biophys Acta 1854 (12), 1922-1934 (2015)
   PUBMED   26315778
REFERENCE   3  (bases 1 to 1600)
  AUTHORS   Joerger,M., Huitema,A.D., Boot,H., Cats,A., Doodeman,V.D.,
            Smits,P.H., Vainchtein,L., Rosing,H., Meijerman,I., Zueger,M.,
            Meulendijks,D., Cerny,T.D., Beijnen,J.H. and Schellens,J.H.
  TITLE     Germline TYMS genotype is highly predictive in patients with
            metastatic gastrointestinal malignancies receiving
            capecitabine-based chemotherapy
  JOURNAL   Cancer Chemother Pharmacol 75 (4), 763-772 (2015)
   PUBMED   25677447
REFERENCE   4  (bases 1 to 1600)
  AUTHORS   Zgheib,N.K., Akra-Ismail,M., Aridi,C., Mahfouz,R., Abboud,M.R.,
            Solh,H. and Muwakkit,S.A.
  TITLE     Genetic polymorphisms in candidate genes predict increased toxicity
            with methotrexate therapy in Lebanese children with acute
            lymphoblastic leukemia
  JOURNAL   Pharmacogenet Genomics 24 (8), 387-396 (2014)
   PUBMED   25007187
REFERENCE   5  (bases 1 to 1600)
  AUTHORS   Jekic,B., Lukovic,L., Bunjevacki,V., Milic,V., Novakovic,I.,
            Damnjanovic,T., Milasin,J., Popovic,B., Maksimovic,N., Damjanov,N.,
            Radunovic,G., Kovacevic,L. and Krajinovic,M.
  TITLE     Association of the TYMS 3G/3G genotype with poor response and GGH
            354GG genotype with the bone marrow toxicity of the methotrexate in
            RA patients
  JOURNAL   Eur J Clin Pharmacol 69 (3), 377-383 (2013)
   PUBMED   22763757
REFERENCE   6  (bases 1 to 1600)
  AUTHORS   Chu,E., Koeller,D.M., Casey,J.L., Drake,J.C., Chabner,B.A.,
            Elwood,P.C., Zinn,S. and Allegra,C.J.
  TITLE     Autoregulation of human thymidylate synthase messenger RNA
            translation by thymidylate synthase
  JOURNAL   Proc Natl Acad Sci U S A 88 (20), 8977-8981 (1991)
   PUBMED   1924359
REFERENCE   7  (bases 1 to 1600)
  AUTHORS   Tsukamoto,I. and Kojo,S.
  TITLE     The effects of fluorouracil on thymidylate synthase and thymidine
            kinase in regenerating rat liver after partial hepatectomy
  JOURNAL   Biochim Biophys Acta 1074 (1), 52-55 (1991)
   PUBMED   2043679
REFERENCE   8  (bases 1 to 1600)
  AUTHORS   Tsukamoto,I. and Kojo,S.
  TITLE     Effect of glucocorticoid on liver regeneration after partial
            hepatectomy in the rat
  JOURNAL   Gut 30 (3), 387-390 (1989)
   PUBMED   2707640
REFERENCE   9  (bases 1 to 1600)
  AUTHORS   Peterson,A.M.
  TITLE     Differentiation associated changes in thymidylate synthetase and
            thymidine kinase activities in intestinal cells
  JOURNAL   Cell Differ 5 (1), 37-43 (1976)
   PUBMED   1260861
REFERENCE   10 (bases 1 to 1600)
  AUTHORS   Langenbach.
  TITLE     Thymidylate synthetase of in vitro chemically and virally
            transformed rat cells
  JOURNAL   Biochim Biophys Acta 422 (2), 295-301 (1976)
   PUBMED   1247599
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Nov 27, 2020 this sequence version replaced NM_019179.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L12138.1, BC126093.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN12840107,
                                           SAMN12840111 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-187               JAXUCZ010000009.1  120775897-120776083 c
            188-261             JAXUCZ010000009.1  120774372-120774445 c
            262-436             JAXUCZ010000009.1  120772797-120772971 c
            437-538             JAXUCZ010000009.1  120766809-120766910 c
            539-714             JAXUCZ010000009.1  120766024-120766199 c
            715-786             JAXUCZ010000009.1  120765037-120765108 c
            787-1600            JAXUCZ010000009.1  120763382-120764195 c
FEATURES             Location/Qualifiers
     source          1..1600
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q38"
     gene            1..1600
                     /gene="Tyms"
                     /note="thymidylate synthetase"
                     /db_xref="GeneID:29261"
                     /db_xref="RGD:3921"
     CDS             1..924
                     /gene="Tyms"
                     /EC_number="2.1.1.45"
                     /note="TS; TSase"
                     /codon_start=1
                     /product="thymidylate synthase"
                     /protein_id="NP_062052.1"
                     /db_xref="GeneID:29261"
                     /db_xref="RGD:3921"
                     /translation="MLVEGSELQSGAQQPRTEAPQHGELQYLRQVEHIMRCGFKKEDR
                     TGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVRI
                     WDANGSRDFLDSLGFSARQEGDLGPVYGFQWRHFGADYKDMDSDYSGQGVDQLQKVID
                     TIKTNPDDRRIIMCAWNPKDLPLMALPPCHALCQFYVVNGELSCQLYQRSGDMGLGVP
                     FNIASYALLTYMIAHITGLQPGDFVHTLGDAHIYLNHIEPLKIQLQREPRPFPKLRIL
                     RKVETIDDFKVEDFQIEGYNPHPTIKMEMAV"
     exon            1..187
                     /gene="Tyms"
                     /inference="alignment:Splign:2.1.0"
     exon            188..261
                     /gene="Tyms"
                     /inference="alignment:Splign:2.1.0"
     exon            262..436
                     /gene="Tyms"
                     /inference="alignment:Splign:2.1.0"
     exon            437..538
                     /gene="Tyms"
                     /inference="alignment:Splign:2.1.0"
     exon            539..714
                     /gene="Tyms"
                     /inference="alignment:Splign:2.1.0"
     exon            715..786
                     /gene="Tyms"
                     /inference="alignment:Splign:2.1.0"
     exon            787..1600
                     /gene="Tyms"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgctggttg aaggctctga gctgcagtcc ggtgctcaac agccacgcac ggaagccccg
       61 cagcatggag aactccagta cctgaggcag gtggagcaca ttatgcgctg cggcttcaag
      121 aaggaggacc gcacgggcac tggcaccctg tcggtgttcg gcatgcaggc acggtacagc
      181 ctgagagatg aatttcctct gctcacaacc aaacgagtat tctggaaggg tgttttggag
      241 gagttgttgt ggtttattaa gggctccaca aatgctaaag aactgtcctc caagggagtg
      301 agaatttggg atgccaatgg gtcccgagac tttttggaca gcttgggatt ctctgcccga
      361 caggaaggag acctgggccc agtttatgga ttccagtgga gacattttgg agcagactac
      421 aaagatatgg attcagatta ctcgggtcaa ggagtagacc agctgcaaaa agtgattgac
      481 accatcaaaa ccaaccccga tgacagaaga atcatcatgt gtgcctggaa cccaaaagat
      541 cttcccctga tggcactgcc tccttgccat gccctctgtc aattttatgt ggtgaatggg
      601 gagctgtctt gccagcttta ccagcggtca ggagatatgg gtctgggtgt gcccttcaac
      661 attgccagct atgctctgct gacctacatg attgcacata tcacgggcct gcagccgggt
      721 gattttgtcc atactttggg agatgcacac atttatctga atcatattga gccactgaaa
      781 attcagctac agcgagaacc aagacctttc ccaaagctca gaatcctccg aaaagttgag
      841 acaatcgatg atttcaaagt tgaagacttt cagattgaag ggtataatcc acatccaacg
      901 attaaaatgg aaatggctgt ttagtgcttt cagtgatgct gtgaatatca tcagttttta
      961 ctgaaggaaa aattgacagt gatctgtctg taatgatcac cagcatctaa agtgtcccag
     1021 acactgagaa actgcctttc ctttagtatt tactgaaggt atgtataaag ctgagactat
     1081 atacttggca aaaccccagg catttatgta tatctaaaag gtggtgaaat tcagagtata
     1141 ttgtatataa acttgaaata tgttattgtt catttctaaa cattttatat gctatatagt
     1201 aatagttttg catttgtcgg tttcttaaag acttttagtt tttgtgtggg cattataagt
     1261 cagagagctc agtttgaggt tagtgacagg ctcaatttct gcctagaaaa ttgactgacc
     1321 taaaaaccct aagccttcat tagctcatat atatctcagg ctggcctcaa aacactcgga
     1381 agctgagggt aaattgggct tataaaaaca aagccctatt cacattaggt gacttgctat
     1441 atagcacgag cttccttagc ccgctacctc tgaggtggtc ggttttaggt ggtgtagtgc
     1501 cttttgattt actttttatc ttccttggat ccctttggct tgaccttgtc ttatatagaa
     1561 gaaacttaat aaaatgtttg tcatatgtat gaaaaaggaa
//
