LOCUS       NM_001012122            2372 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus thymidine phosphorylase (Tymp), mRNA.
ACCESSION   NM_001012122 XM_235562
VERSION     NM_001012122.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2372)
  AUTHORS   Lu,H., Klein,R.S. and Schwartz,E.L.
  TITLE     Antiangiogenic and antitumor activity of
            6-(2-aminoethyl)amino-5-chlorouracil, a novel small-molecule
            inhibitor of thymidine phosphorylase, in combination with the
            vascular endothelial growth factor-trap
  JOURNAL   Clin Cancer Res 15 (16), 5136-5144 (2009)
   PUBMED   19671868
REFERENCE   2  (bases 1 to 2372)
  AUTHORS   Hong,S.P., Shin,S.K., Bang,S., Park,S.W., Chung,J.B., Lee,W.J. and
            Song,S.Y.
  TITLE     Prognostic value of thymidine phosphorylase expression for
            pancreatic cancer
  JOURNAL   Hepatogastroenterology 56 (93), 1178-1182 (2009)
   PUBMED   19760965
REFERENCE   3  (bases 1 to 2372)
  AUTHORS   Harino,Y., Imura,S., Kanemura,H., Morine,Y., Fujii,M., Ikegami,T.,
            Uehara,H. and Shimada,M.
  TITLE     Role of tumor angiogenesis in gallbladder carcinoma: with special
            reference to thymidine phosphorylase
  JOURNAL   Int J Clin Oncol 13 (5), 452-457 (2008)
   PUBMED   18946757
REFERENCE   4  (bases 1 to 2372)
  AUTHORS   Puglisi,F., Cardellino,G.G., Crivellari,D., Di Loreto,C.,
            Magri,M.D., Minisini,A.M., Mansutti,M., Andreetta,C., Russo,S.,
            Lombardi,D., Perin,T., Damante,G. and Veronesi,A.
  TITLE     Thymidine phosphorylase expression is associated with time to
            progression in patients receiving low-dose, docetaxel-modulated
            capecitabine for metastatic breast cancer
  JOURNAL   Ann Oncol 19 (9), 1541-1546 (2008)
   PUBMED   18441329
REFERENCE   5  (bases 1 to 2372)
  AUTHORS   Mazurek,A., Kuc,P., Mazurek-Wadolkowska,E. and Laudanski,T.
  TITLE     A role of thymidine phosphorylase and P53 tissue protein expression
            in biology of endometrial cancer
  JOURNAL   Neoplasma 55 (3), 261-265 (2008)
   PUBMED   18348659
REFERENCE   6  (bases 1 to 2372)
  AUTHORS   Kubiak,R., Miszczak-Zaborska,E., Jesionek-Kupnicka,D. and Greger,J.
  TITLE     The activity of thymidine phosphorylase correlates with tumor size
            and lymph nodes status in breast carcinoma
  JOURNAL   Z Naturforsch C J Biosci 54 (12), 1096-1102 (1999)
   PUBMED   10685502
REFERENCE   7  (bases 1 to 2372)
  AUTHORS   Nishino,I., Spinazzola,A. and Hirano,M.
  TITLE     Thymidine phosphorylase gene mutations in MNGIE, a human
            mitochondrial disorder
  JOURNAL   Science 283 (5402), 689-692 (1999)
   PUBMED   9924029
REFERENCE   8  (bases 1 to 2372)
  AUTHORS   Engels,K., Fox,S.B., Whitehouse,R.M., Gatter,K.C. and Harris,A.L.
  TITLE     Up-regulation of thymidine phosphorylase expression is associated
            with a discrete pattern of angiogenesis in ductal carcinomas in
            situ of the breast
  JOURNAL   J Pathol 182 (4), 414-420 (1997)
   PUBMED   9306962
REFERENCE   9  (bases 1 to 2372)
  AUTHORS   Usuki,K., Saras,J., Waltenberger,J., Miyazono,K., Pierce,G.,
            Thomason,A. and Heldin,C.H.
  TITLE     Platelet-derived endothelial cell growth factor has thymidine
            phosphorylase activity
  JOURNAL   Biochem Biophys Res Commun 184 (3), 1311-1316 (1992)
   PUBMED   1590793
REFERENCE   10 (bases 1 to 2372)
  AUTHORS   Desgranges,C., Razaka,G., Rabaud,M. and Bricaud,H.
  TITLE     Catabolism of thymidine in human blood platelets: purification and
            properties of thymidine phosphorylase
  JOURNAL   Biochim Biophys Acta 654 (2), 211-218 (1981)
   PUBMED   7284378
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Feb 1, 2022 this sequence version replaced NM_001012122.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089830.1, SRR26643286.24201.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-72                JAXUCZ010000007.1  122323450-122323521 c
            73-274              JAXUCZ010000007.1  122323021-122323222 c
            275-477             JAXUCZ010000007.1  122322682-122322884 c
            478-576             JAXUCZ010000007.1  122322141-122322239 c
            577-706             JAXUCZ010000007.1  122321644-122321773 c
            707-825             JAXUCZ010000007.1  122321421-122321539 c
            826-988             JAXUCZ010000007.1  122320907-122321069 c
            989-1219            JAXUCZ010000007.1  122320584-122320814 c
            1220-1360           JAXUCZ010000007.1  122320332-122320472 c
            1361-1539           JAXUCZ010000007.1  122320074-122320252 c
            1540-2372           JAXUCZ010000007.1  122318396-122319228 c
FEATURES             Location/Qualifiers
     source          1..2372
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..2372
                     /gene="Tymp"
                     /gene_synonym="Ecgf1; TP"
                     /note="thymidine phosphorylase"
                     /db_xref="GeneID:315219"
                     /db_xref="RGD:1305756"
     exon            1..72
                     /gene="Tymp"
                     /gene_synonym="Ecgf1; TP"
                     /inference="alignment:Splign:2.1.0"
     exon            73..274
                     /gene="Tymp"
                     /gene_synonym="Ecgf1; TP"
                     /inference="alignment:Splign:2.1.0"
     CDS             82..1512
                     /gene="Tymp"
                     /gene_synonym="Ecgf1; TP"
                     /EC_number="2.4.2.4"
                     /note="tdRPase; endothelial cell growth factor 1
                     (platelet-derived)"
                     /codon_start=1
                     /product="thymidine phosphorylase"
                     /protein_id="NP_001012122.1"
                     /db_xref="GeneID:315219"
                     /db_xref="RGD:1305756"
                     /translation="MAAPGTPPPLAPETAGADSGGGSGEHRQLPELIRLKRNGGHLSE
                     ADIRNFVHALMDGRAQDTQIGAMLMAIRLQGMDLEETSVLTQALAESGQQLEWPKAWH
                     QQLVDKHSTGGVGDKVSLVLAPALAACGCKVPMISGRSLGHTGGTLDKLESIPGFSVT
                     QSPEQMLQILEEVGCCIVGQSEKLVPADGILYAARDVTATVDSVPLITASILSKKAVE
                     GLSTLVVDVKFGGAAVFPDQEKARELAKMLVRVGMGLGLQVAAALTAMDNPLGRNVGH
                     TLEVEEALLCLDGAGPPDLRDLVIRLGGAILWLSGQAETQDQGAARVAAALDDGSALH
                     RFQLMLSAQGVDPGLARALCSGSPTQRRQLLPHARKQEELLSPADGIVECVRALPLAC
                     VLHELGAGRSRAGQPIRPGVGAELLVDVGQWLSRGTPWLRVHLDGPALSSQQRRTLLG
                     ALVLSDRAPFKAPSPFAELVLPPTTP"
     exon            275..477
                     /gene="Tymp"
                     /gene_synonym="Ecgf1; TP"
                     /inference="alignment:Splign:2.1.0"
     exon            478..576
                     /gene="Tymp"
                     /gene_synonym="Ecgf1; TP"
                     /inference="alignment:Splign:2.1.0"
     exon            577..706
                     /gene="Tymp"
                     /gene_synonym="Ecgf1; TP"
                     /inference="alignment:Splign:2.1.0"
     exon            707..825
                     /gene="Tymp"
                     /gene_synonym="Ecgf1; TP"
                     /inference="alignment:Splign:2.1.0"
     exon            826..988
                     /gene="Tymp"
                     /gene_synonym="Ecgf1; TP"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1219
                     /gene="Tymp"
                     /gene_synonym="Ecgf1; TP"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1360
                     /gene="Tymp"
                     /gene_synonym="Ecgf1; TP"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1539
                     /gene="Tymp"
                     /gene_synonym="Ecgf1; TP"
                     /inference="alignment:Splign:2.1.0"
     exon            1540..2372
                     /gene="Tymp"
                     /gene_synonym="Ecgf1; TP"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaactgtctg cacctaactc cacgccgggc tgagggctac caggccggaa cggagccaga
       61 tccagaaaac tggctgcagc aatggcagct ccagggacac cacctccctt ggccccagag
      121 acagctggtg ccgactcggg gggagggagt ggggagcaca ggcagctgcc agagctgatc
      181 cgcctcaagc gaaatggagg gcatctgagc gaagcagata tcagaaactt cgtgcacgcg
      241 ttgatggacg gaagagcaca ggacacacaa atcggggcca tgctgatggc cattcggctg
      301 caaggcatgg acctagagga gacatctgtg ttgactcagg ccctcgcaga gtctgggcag
      361 caactggagt ggcccaaggc ctggcaccag cagcttgtgg acaaacactc cacaggaggt
      421 gtgggcgata aggttagcct ggttctggca cctgccctgg ctgcatgtgg ctgcaaggta
      481 ccaatgatca gcggacgcag tttgggacac acagggggca cgctggataa actggaatct
      541 attcctgggt tcagcgtcac ccagagccca gaacagatgc tgcagatact tgaggaagtc
      601 ggctgctgca ttgttggcca gagtgaaaag ctagttcctg ctgatggaat cctgtatgct
      661 gcacgagatg tgacagctac tgtggacagt gtaccgctca ttacagcgtc aatcctcagt
      721 aagaaagccg tggagggact gtccactctg gtggtagatg ttaagtttgg gggggctgca
      781 gtcttcccag accaggagaa ggcccgagaa ctggcaaaga tgttggttag agtgggaatg
      841 ggtctggggc tgcaggttgc tgcagccctg accgccatgg acaaccctct gggccgcaac
      901 gtgggtcata ccctggaagt ggaagaagcg ttgctttgcc tggatggtgc ggggccgccg
      961 gatctgcggg acctggtcat taggctagga ggcgccattc tttggcttag cggacaggca
     1021 gaaacccaag accagggtgc cgcccgagtg gccgcggcgt tggatgatgg ctctgcgctg
     1081 caccgcttcc agctgatgct ttcggcgcag ggcgtagacc ccggcctagc tagagcattg
     1141 tgctccggaa gccccacgca acgccggcag ttgctgcctc acgcccgaaa gcaagaagag
     1201 ctgctctcac cggcagacgg cattgtggag tgcgtccgag cgctgccgct ggcctgtgta
     1261 ctgcacgagc tcggagccgg acgcagccga gcagggcagc cgatcagacc gggagtgggt
     1321 gccgaactac tggtcgacgt gggccaatgg ttgtcccgcg ggacaccctg gctccgcgtg
     1381 cacctggacg gccccgcgct cagcagtcag cagcgccgca ctcttctggg ggctctcgtg
     1441 ctgtcagatc gagcaccctt caaggcccct tcacccttcg ctgagcttgt cctcccaccg
     1501 accaccccat agccctaaat ctccaaccca tcgctgccag agcttcaggt ccatgatgct
     1561 actggctcta gggcccaaag cttggcccaa gctctctcag ttcaaacccc ttctcaggat
     1621 ctcaaggggt gaaactctgc acataaattc ccggcattgg tcggggcaag gccaaggcca
     1681 acaccaaggc cctgggctaa ggactagact gttgatcact gccctgtttg gggctgggct
     1741 aggctgggcc tggctggccg ctagagctga gaaggaacag tggcgccaac aacagcggac
     1801 agaggccctg cgccaggctg ctgtgggcca gggtgacttc agcctactgg accacaaagg
     1861 ccagcctcga tgcaaagccg acttccgagg ccagtgggtg ctgatgtact ttggttttac
     1921 tcactgccct gatatttgcc ccgatgagct ggaaaagctg gtgcaggtag tgcagaagct
     1981 cgaggcagag cctgagctgc ccctggtgca gcctgtcttc gtcactgtgg acccagaacg
     2041 agatgacgtg gcagccatgg cccgatatgt gcaagaattc cacccaaggc tgctgggtct
     2101 gactggttct acagaacaag tggcccatgc tagtcgcaac taccgtgtat actacagcgc
     2161 tggtcccaag gacgaggacc aggactatat tgtggaccat tccattgcca tctacttgct
     2221 caacccagat ggtctcttca ctgattacta tggtcgtagc aggtcagcag agcagattgt
     2281 agagagtgta cgccggcaca tagctgcctt ccatagcata ctgccctgaa ctgtgtactg
     2341 cctaggccct gtcattaaat ggatgtactt aa
//
