LOCUS       NM_001257347            4535 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus tyrosine kinase 2 (Tyk2), mRNA.
ACCESSION   NM_001257347 XM_002726995 XM_002729874
VERSION     NM_001257347.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4535)
  AUTHORS   Li,H., Spagnol,G., Zheng,L., Stauch,K.L. and Sorgen,P.L.
  TITLE     Regulation of Connexin43 Function and Expression by Tyrosine Kinase
            2
  JOURNAL   J Biol Chem 291 (30), 15867-15880 (2016)
   PUBMED   27235399
  REMARK    GeneRIF: These findings indicate that, like Src, Tyk2 can also
            inhibit gap junction communication by phosphorylating Cx43.
REFERENCE   2  (bases 1 to 4535)
  AUTHORS   Jones,S.A., Scheller,J. and Rose-John,S.
  TITLE     Therapeutic strategies for the clinical blockade of IL-6/gp130
            signaling
  JOURNAL   J Clin Invest 121 (9), 3375-3383 (2011)
   PUBMED   21881215
  REMARK    Review article
REFERENCE   3  (bases 1 to 4535)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   4  (bases 1 to 4535)
  AUTHORS   Sabat,R., Grutz,G., Warszawska,K., Kirsch,S., Witte,E., Wolk,K. and
            Geginat,J.
  TITLE     Biology of interleukin-10
  JOURNAL   Cytokine Growth Factor Rev 21 (5), 331-344 (2010)
   PUBMED   21115385
  REMARK    Review article
REFERENCE   5  (bases 1 to 4535)
  AUTHORS   Yu,Y., Kranzler,H.R., Panhuysen,C., Weiss,R.D., Poling,J.,
            Farrer,L.A. and Gelernter,J.
  TITLE     Substance dependence low-density whole genome association study in
            two distinct American populations
  JOURNAL   Hum Genet 123 (5), 495-506 (2008)
   PUBMED   18438686
REFERENCE   6  (bases 1 to 4535)
  AUTHORS   Kisseleva,T., Bhattacharya,S., Braunstein,J. and Schindler,C.W.
  TITLE     Signaling through the JAK/STAT pathway, recent advances and future
            challenges
  JOURNAL   Gene 285 (1-2), 1-24 (2002)
   PUBMED   12039028
  REMARK    Review article
REFERENCE   7  (bases 1 to 4535)
  AUTHORS   Hellgren,G., Jansson,J.O., Carlsson,L.M. and Carlsson,B.
  TITLE     The growth hormone receptor associates with Jak1, Jak2 and Tyk2 in
            human liver
  JOURNAL   Growth Horm IGF Res 9 (3), 212-218 (1999)
   PUBMED   10502458
REFERENCE   8  (bases 1 to 4535)
  AUTHORS   Pan,J., Fukuda,K., Kodama,H., Makino,S., Takahashi,T., Sano,M.,
            Hori,S. and Ogawa,S.
  TITLE     Role of angiotensin II in activation of the JAK/STAT pathway
            induced by acute pressure overload in the rat heart
  JOURNAL   Circ Res 81 (4), 611-617 (1997)
   PUBMED   9314843
REFERENCE   9  (bases 1 to 4535)
  AUTHORS   Muller,M., Briscoe,J., Laxton,C., Guschin,D., Ziemiecki,A.,
            Silvennoinen,O., Harpur,A.G., Barbieri,G., Witthuhn,B.A.,
            Schindler,C. et al.
  TITLE     The protein tyrosine kinase JAK1 complements defects in
            interferon-alpha/beta and -gamma signal transduction
  JOURNAL   Nature 366 (6451), 129-135 (1993)
   PUBMED   8232552
REFERENCE   10 (bases 1 to 4535)
  AUTHORS   Velazquez,L., Fellous,M., Stark,G.R. and Pellegrini,S.
  TITLE     A protein tyrosine kinase in the interferon alpha/beta signaling
            pathway
  JOURNAL   Cell 70 (2), 313-322 (1992)
   PUBMED   1386289
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On or before Apr 1, 2012 this sequence version replaced
            XM_002729874.1, XM_002726995.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.32641.1,
                                           SRR26643288.32864.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-208               JAXUCZ010000008.1  27938946-27939153   c
            209-332             JAXUCZ010000008.1  27936440-27936563   c
            333-480             JAXUCZ010000008.1  27936058-27936205   c
            481-644             JAXUCZ010000008.1  27935555-27935718   c
            645-1011            JAXUCZ010000008.1  27933241-27933607   c
            1012-1212           JAXUCZ010000008.1  27932403-27932603   c
            1213-1370           JAXUCZ010000008.1  27932159-27932316   c
            1371-1479           JAXUCZ010000008.1  27929291-27929399   c
            1480-1675           JAXUCZ010000008.1  27929001-27929196   c
            1676-1779           JAXUCZ010000008.1  27928810-27928913   c
            1780-1956           JAXUCZ010000008.1  27928536-27928712   c
            1957-2044           JAXUCZ010000008.1  27928356-27928443   c
            2045-2172           JAXUCZ010000008.1  27927470-27927597   c
            2173-2308           JAXUCZ010000008.1  27925779-27925914   c
            2309-2463           JAXUCZ010000008.1  27925539-27925693   c
            2464-2614           JAXUCZ010000008.1  27924979-27925129   c
            2615-2712           JAXUCZ010000008.1  27924667-27924764   c
            2713-2905           JAXUCZ010000008.1  27923822-27924014   c
            2906-3024           JAXUCZ010000008.1  27923318-27923436   c
            3025-3197           JAXUCZ010000008.1  27922325-27922497   c
            3198-3315           JAXUCZ010000008.1  27921914-27922031   c
            3316-3426           JAXUCZ010000008.1  27919239-27919349   c
            3427-4535           JAXUCZ010000008.1  27918054-27919162   c
FEATURES             Location/Qualifiers
     source          1..4535
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q13"
     gene            1..4535
                     /gene="Tyk2"
                     /note="tyrosine kinase 2"
                     /db_xref="GeneID:100361294"
                     /db_xref="RGD:2320469"
     CDS             1..3561
                     /gene="Tyk2"
                     /EC_number="2.7.10.2"
                     /codon_start=1
                     /product="non-receptor tyrosine-protein kinase TYK2"
                     /protein_id="NP_001244276.1"
                     /db_xref="GeneID:100361294"
                     /db_xref="RGD:2320469"
                     /translation="MVTSMPLCGRRAASEDSKADGTEAQPLVPTGRLMVLLHWPGPEG
                     GEPWVTFSQPSLTAEEMCIHIAHKVGITPPCLNLFALYDAQAKVWLPPNHVLDTSQDA
                     TLRLYFRMRFYFRNWHGMNPQEPAVYRCGFPGAETSSDHAEQGVQLLDSASFEYLFEQ
                     GKHEFMNDVVSLRDLSSEEEIHHFKNESLGMAFLHLCHLALNRGVPLEEMAREISFKN
                     CIPHSFRQHIRQHNVLTRLRLRRVFRRFLQAFQPGHLSQQVVMVKYLATLERLAPRFG
                     SEHIPVCHLEVLAQPERDPCYIQNSGQTTGDPGPELASGPATHEVLVTGTGGIQWRPL
                     QTQDSERGHSRGNPQGSQSGKKPKAPESGEHLAGSPQEPPWTYFCDFQDISHVVLKER
                     RVHIHLQDNKCLLLCLCSQAEALSFVALVDGYFRLTADSSHYLCHEVAPPRLVTSIQN
                     GIHGPLMDPFVQAKLWPEDGLYLIQWSTSHLHRLILTVAHRNPASRNGPRGLRLRKFP
                     ITQQPGAFVLDGWGRSFDSLGDLRQALQGCSLRAGDDCFPLHHCCLPRPREISNLVIM
                     RGSRAHTRPLNLSQLSFHRVHQDEITQLSHLGQGTRTNVYEGLLSVGGPNEGKVDSGC
                     PSGPDRGSGQQLRVVLKVLDPSHHDIALAFYETASLMSQVSHMHLAFLHGVCVRGSEN
                     IIVAEFVEHGPLDVWLRRQRGRVPMPWKMVVAQQLASALSYLEDKNLVHGNVCGRNIL
                     LARLGLEEGTNPFIKLSDPGVGQGALSREERVERIPWTAPECLSGGANSLGTATDMWG
                     FGATLLEICFDGEAPLQGRGPSEKERFYTKKHQLPEPSCPELATLTRQCLSYEPAQRP
                     SFRTILRDLTRLQPQNLVGTSTVNSDSPASDPTVFHKRYLKRIRDLGEGHFGKVSLYC
                     YDPNNDGTGEMVAVKALKEGCGPQLRSGWQREIEILRTLYHEHIVKYKGCCEDQGEKS
                     VQLVMEYVPLGSLRDYLPRHSVGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLL
                     DNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKECKFYYASDVWSFGV
                     TLYELLTYCDSSQSPPTKFIELIGVTQGQMTVLRLTELLERGERLPRPDRCPCEIYHL
                     MKNCWESEASFRPTFQNLVPILKTAQEKYQGQVPSVFSVC"
     exon            1..208
                     /gene="Tyk2"
                     /inference="alignment:Splign:2.1.0"
     exon            209..332
                     /gene="Tyk2"
                     /inference="alignment:Splign:2.1.0"
     exon            333..480
                     /gene="Tyk2"
                     /inference="alignment:Splign:2.1.0"
     exon            481..644
                     /gene="Tyk2"
                     /inference="alignment:Splign:2.1.0"
     exon            645..1011
                     /gene="Tyk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1212
                     /gene="Tyk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..1370
                     /gene="Tyk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1479
                     /gene="Tyk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1480..1675
                     /gene="Tyk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1676..1779
                     /gene="Tyk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1780..1956
                     /gene="Tyk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1957..2044
                     /gene="Tyk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2045..2172
                     /gene="Tyk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2173..2308
                     /gene="Tyk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2309..2463
                     /gene="Tyk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2464..2614
                     /gene="Tyk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2615..2712
                     /gene="Tyk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2713..2905
                     /gene="Tyk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2906..3024
                     /gene="Tyk2"
                     /inference="alignment:Splign:2.1.0"
     exon            3025..3197
                     /gene="Tyk2"
                     /inference="alignment:Splign:2.1.0"
     exon            3198..3315
                     /gene="Tyk2"
                     /inference="alignment:Splign:2.1.0"
     exon            3316..3426
                     /gene="Tyk2"
                     /inference="alignment:Splign:2.1.0"
     exon            3427..4535
                     /gene="Tyk2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggtgacaa gcatgcctct gtgtgggcgg agagccgcct cggaagacag caaggcagat
       61 ggcacagaag ctcagcccct ggtgcccaca ggacggttga tggtgctgct gcactggccc
      121 gggcctgagg gcggggagcc ctgggtcacc ttcagccagc catctctgac tgcagaggag
      181 atgtgcatcc acatcgcaca caaagtcggc atcactccac cctgcctgaa tctcttcgca
      241 ctctacgatg cacaggccaa ggtctggctg cccccaaacc acgttctgga cacatcccaa
      301 gacgcaaccc tgaggctcta ttttcgaatg aggttttact tccggaactg gcatggcatg
      361 aatccccaag agcctgctgt ataccgatgt ggtttcccag gggcagagac ttcctcagac
      421 catgcagagc aaggtgtaca gctcttggac tctgcctcat ttgaatacct ttttgagcag
      481 ggaaaacatg aattcatgaa cgatgtggta tctctgcggg acctgtctag cgaggaagag
      541 atccaccact ttaagaatga gagcctgggc atggcctttc tgcacctctg ccatcttgct
      601 ctcaaccgtg gcgtccccct ggaggagatg gccagagaga tcagcttcaa gaactgtatc
      661 cctcactcct tccgtcagca catccgccag cacaatgtgc ttacgcgcct gcgtctccgc
      721 agagtcttcc gccgcttcct gcaggccttc cagcctggcc acctctccca acaggttgtg
      781 atggttaagt acttggccac cctggagcgg ctggctcctc gttttggctc agagcacata
      841 cctgtgtgtc atctggaagt tctggcccag cctgagaggg acccctgcta catccagaac
      901 agtgggcaga ccactgggga cccaggccca gagctggctt ctgggccagc cacccatgag
      961 gtactggtga caggcaccgg aggtatccag tggcgtccac tacagaccca ggactctgag
     1021 agaggtcaca gcagagggaa tccccaaggc agccagtctg ggaagaaacc caaggcccct
     1081 gagtctggag agcacctggc agggagtccc caggaaccac cttggaccta cttctgtgac
     1141 ttccaggaca tttcccatgt ggtactaaag gagcgtcgag tgcacatcca ccttcaagac
     1201 aacaagtgct tgttgctgtg cctctgctcc caggccgagg ccctgtcctt tgtggccctg
     1261 gtcgatggct atttccgctt gactgctgac tccagccact acctgtgcca tgaggtagca
     1321 cccccgaggc tggtgactag catccagaat ggcatccacg ggcccctgat ggacccattt
     1381 gtacaggcta agctgtggcc agaggatggc ctctacctga tccagtggag caccagccac
     1441 ctgcaccgac tgatcctcac cgtagcccat cgaaacccgg cttccagaaa cggccctagg
     1501 ggcctacgcc tccgaaagtt ccccatcacc cagcagcctg gagcctttgt gcttgatggt
     1561 tggggccgct cctttgacag cttgggggac cttcggcagg ccttgcaggg ctgctcattg
     1621 cgagctggtg atgactgttt cccgttgcac cactgctgcc tgccccgacc aagagaaatc
     1681 tccaaccttg tcatcatgcg ggggtctagg gcccacaccc ggccactcaa cctcagtcag
     1741 cttagcttcc acagggttca ccaggatgaa atcacccagc tgtcccactt gggccaaggc
     1801 acaaggacca atgtgtatga gggcctgcta agtgtgggag gccccaatga gggcaaagtg
     1861 gacagtggat gcccctctgg gcctgatagg ggcagtgggc agcagcttcg agtggtgctc
     1921 aaagtcctcg accctagtca ccatgatatc gccttggcct tctatgagac tgccagcctc
     1981 atgagccagg tgtcacacat gcacctggct ttcctgcatg gtgtctgcgt gcgtggctca
     2041 gagaatatca ttgtagcgga attcgtagag cacggtcccc tggatgtgtg gttacggaga
     2101 cagagaggcc gagtgcccat gccctggaag atggtcgtgg ctcagcagct ggccagcgcc
     2161 ctgagctacc tggaggacaa gaatctggtt cacgggaacg tatgtggccg gaacatcctg
     2221 ctggcccgcc tggggctgga ggagggtacc aaccccttca tcaagctcag tgaccctggc
     2281 gtgggccaag gcgccctctc cagggaagag cgggtggagc gaatcccctg gacagctccg
     2341 gagtgcctgt ccggaggggc caacagcttg ggcactgcca cggacatgtg gggctttggt
     2401 gccaccctcc ttgagatctg ttttgatgga gaggcacctc tgcagggccg tggtccctcc
     2461 gagaaagaac ggttctacac aaagaaacat cagctgccag agccctcatg cccggagctg
     2521 gccacactca cccgtcagtg cctgagctat gaacccgcac agaggccatc gttccgcacc
     2581 attttgcggg acctcacaag actgcagcca cagaatctag tgggaacttc gactgtgaac
     2641 tcggactcac cagcatcgga ccccaccgtt tttcacaagc gttacttgaa aaggatccgg
     2701 gatttgggtg agggtcactt tggcaaggtc agcctgtact gctatgaccc gaacaatgac
     2761 ggcactggcg agatggtggc tgtgaaagcc ctgaaggagg gatgtggtcc ccagctccgc
     2821 tcaggctggc agcgggagat cgaaatcctt cggacgctgt accacgagca cattgtcaag
     2881 tacaaaggct gctgtgaaga ccaaggggag aagtctgtac agctggtcat ggaatacgtc
     2941 cctctgggca gcctccgaga ctacctgcca aggcacagcg tggggctggc tcagctcctg
     3001 ttgtttgccc agcagatctg cgagggcatg gcttacctgc acgctcagca ctacattcac
     3061 cgagacctcg ctgcgcgaaa cgtgctgctg gacaacgacc ggctggtcaa gattggagac
     3121 tttggcctag ccaaggctgt acctgaaggc cacgagtact accgagtgcg cgaggacggg
     3181 gacagcccag tattctggta tgccccagaa tgcctaaagg agtgcaagtt ttactatgca
     3241 tctgatgtct ggtccttcgg ggtgaccctt tatgagctgt tgacatactg tgactctagc
     3301 cagagtcccc ccacgaaatt catcgagctc atcggcgtaa cccagggcca gatgactgtg
     3361 ctgaggctca cagagctgct ggagcgaggg gagaggctgc cgcggcctga cagatgtccc
     3421 tgtgagatct atcacctcat gaagaactgc tgggagtcag aggcctcctt ccggcccacg
     3481 ttccagaatc ttgtgcccat ccttaagaca gcacaggaga agtaccaagg ccaggtgcct
     3541 tcagtgttca gcgtgtgctg agagtcaagg gcatcgggga acagccccac aaaggcctcc
     3601 acacactcta tcccttactc tgcctgaaac cccacctgtg aactaagttt ccttccttgg
     3661 ccctgagcct ggctatgacc tgaacagacc ctggatgttc aacagggata actgggagtc
     3721 ctgggtcttt tcacagttga gacctactgt cttcattagc tgggaagaag ctgtttgctt
     3781 tgctggaggc ctgagggttt cgggggtcca tcttcaggaa ggtagcctat cgagctgtgc
     3841 aagcagaatg agacttcaaa agaagctgtg atacttctga tcacccctaa accagcagcc
     3901 aagctgcagt gtgacctgga gagcctgtgc ttagcatggg tccctagctg gctaagccac
     3961 caactagatc agttcctggt atacagaagg cactcagtag ctgcttgtta gaagctgggg
     4021 agatggcttg gtcagtgagg ggcattcaaa agtgcttgcc ttgcaagtaa gcacaaggcc
     4081 gtgagttcaa ttcccagaac ccacgttagc tctgtgtggt aggacatgct tgttgtccca
     4141 gtgctgggga aatggagaca ggcagccttg tggacctcac tgtcaagaag cctagtccat
     4201 tcagtggtgc tcaggccaaa aagcaaaaca aaatggtgga gcagtgcttc aggaagaata
     4261 cccagagttg tcctctgacc tctgtacaaa catgtgcata cacacctgca catacatatg
     4321 cattcacaca ggaaggccat ttgtcacata tgtaggactg ccaattttac cctttccttc
     4381 ctgtgtaacc tcaggaaaat gtcttgacct ctctgggctc atctcagcca tggggatggt
     4441 cagcctttct acctcataga gctgatgatg ggttccattt aaactgctta ggagagacac
     4501 agatgagtgt ttaataaagt ttatgtttat tgcta
//
