LOCUS       NM_001309168             734 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus thioredoxin-like 4A (Txnl4a), mRNA.
ACCESSION   NM_001309168 XM_006254960
VERSION     NM_001309168.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 734)
  AUTHORS   Goos,J.A.C., Swagemakers,S.M.A., Twigg,S.R.F., van Dooren,M.F.,
            Hoogeboom,A.J.M., Beetz,C., Gunther,S., Magielsen,F.J.,
            Ockeloen,C.W., A Ramos-Arroyo,M., Pfundt,R., Yntema,H.G., van der
            Spek,P.J., Stanier,P., Wieczorek,D., Wilkie,A.O.M., van den
            Ouweland,A.M.W., Mathijssen,I.M.J. and Hurst,J.A.
  TITLE     Identification of causative variants in TXNL4A in Burn-McKeown
            syndrome and isolated choanal atresia
  JOURNAL   Eur J Hum Genet 25 (10), 1126-1133 (2017)
   PUBMED   28905882
REFERENCE   2  (bases 1 to 734)
  AUTHORS   Bertram,K., Agafonov,D.E., Dybkov,O., Haselbach,D., Leelaram,M.N.,
            Will,C.L., Urlaub,H., Kastner,B., Luhrmann,R. and Stark,H.
  TITLE     Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for
            Activation
  JOURNAL   Cell 170 (4), 701-713 (2017)
   PUBMED   28781166
REFERENCE   3  (bases 1 to 734)
  AUTHORS   Agafonov,D.E., Kastner,B., Dybkov,O., Hofele,R.V., Liu,W.T.,
            Urlaub,H., Luhrmann,R. and Stark,H.
  TITLE     Molecular architecture of the human U4/U6.U5 tri-snRNP
  JOURNAL   Science 351 (6280), 1416-1420 (2016)
   PUBMED   26912367
REFERENCE   4  (bases 1 to 734)
  AUTHORS   Wieczorek,D., Newman,W.G., Wieland,T., Berulava,T., Kaffe,M.,
            Falkenstein,D., Beetz,C., Graf,E., Schwarzmayr,T., Douzgou,S.,
            Clayton-Smith,J., Daly,S.B., Williams,S.G., Bhaskar,S.S.,
            Urquhart,J.E., Anderson,B., O'Sullivan,J., Boute,O., Gundlach,J.,
            Czeschik,J.C., van Essen,A.J., Hazan,F., Park,S., Hing,A.,
            Kuechler,A., Lohmann,D.R., Ludwig,K.U., Mangold,E., Steenpass,L.,
            Zeschnigk,M., Lemke,J.R., Lourenco,C.M., Hehr,U., Prott,E.C.,
            Waldenberger,M., Bohmer,A.C., Horsthemke,B., O'Keefe,R.T.,
            Meitinger,T., Burn,J., Ludecke,H.J. and Strom,T.M.
  TITLE     Compound heterozygosity of low-frequency promoter deletions and
            rare loss-of-function mutations in TXNL4A causes Burn-McKeown
            syndrome
  JOURNAL   Am J Hum Genet 95 (6), 698-707 (2014)
   PUBMED   25434003
REFERENCE   5  (bases 1 to 734)
  AUTHORS   Pessa,H.K., Will,C.L., Meng,X., Schneider,C., Watkins,N.J.,
            Perala,N., Nymark,M., Turunen,J.J., Luhrmann,R. and Frilander,M.J.
  TITLE     Minor spliceosome components are predominantly localized in the
            nucleus
  JOURNAL   Proc Natl Acad Sci U S A 105 (25), 8655-8660 (2008)
   PUBMED   18559850
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1 and FM059279.1.
            
            On Apr 15, 2016 this sequence version replaced XM_006254960.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CK845114.1, FM059279.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-58                JAXUCZ010000018.1  75934085-75934142
            59-644              FM059279.1         1-586
            645-734             JAXUCZ010000018.1  75949784-75949873
FEATURES             Location/Qualifiers
     source          1..734
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.3"
     gene            1..734
                     /gene="Txnl4a"
                     /gene_synonym="Txnl4"
                     /note="thioredoxin-like 4A"
                     /db_xref="GeneID:100911462"
                     /db_xref="RGD:6492735"
     exon            1..90
                     /gene="Txnl4a"
                     /gene_synonym="Txnl4"
                     /inference="alignment:Splign:2.1.0"
     exon            91..280
                     /gene="Txnl4a"
                     /gene_synonym="Txnl4"
                     /inference="alignment:Splign:2.1.0"
     CDS             128..556
                     /gene="Txnl4a"
                     /gene_synonym="Txnl4"
                     /note="thioredoxin-like protein 4A-like"
                     /codon_start=1
                     /product="thioredoxin-like protein 4A"
                     /protein_id="NP_001296097.1"
                     /db_xref="GeneID:100911462"
                     /db_xref="RGD:6492735"
                     /translation="MSYMLPHLHNGWQVDQAILSEEDRVVVIRFGHDWDPTCMKMDEV
                     LYSIAEKVKNFAVIYLVDITEVPDFNKMYELYDPCTVMFFFRNKHIMIDLGTGNNNKI
                     NWAMEDKQEMVDIIETVYRGARKGRGLVVSPKDYSTKYRY"
     exon            281..384
                     /gene="Txnl4a"
                     /gene_synonym="Txnl4"
                     /inference="alignment:Splign:2.1.0"
     exon            385..734
                     /gene="Txnl4a"
                     /gene_synonym="Txnl4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaaaaagcgt cagcgcgtga gggcgcggga ggcgctggcg ctggtgctgg gtggaggacc
       61 cggcggtcgg gccgcgtggg ctcacacgag gtagttcgcg gcgtccggcc gcgcaagcgc
      121 gttcaagatg tcgtacatgc ttccgcatct gcacaatggc tggcaggtag accaggccat
      181 tctttcggag gaggaccgcg tggtcgtcat tcgcttcgga cacgactggg accccacttg
      241 catgaagatg gacgaggttc tgtacagcat tgccgaaaag gttaaaaatt ttgcagttat
      301 ttatcttgtg gatattacag aagtacctga cttcaacaag atgtatgagc tctatgaccc
      361 atgcacggtc atgttcttct tcagaaacaa acacatcatg attgatttgg gcactggtaa
      421 caataacaag atcaactggg ccatggaaga caagcaggaa atggttgaca tcatagagac
      481 cgtgtaccgt ggcgcccgca aaggccgagg cctggtggtg tcgcccaagg actattccac
      541 aaagtacaga tactgagcac tgactcaggc tgtgcacagg acactgggag cctcttctgg
      601 ctagacagac tctgctctca tagcctcggg aaagggcctg cagcagaaca tggccttagg
      661 gctggaggag ccttgagatg agttacaggg gccttaacta cctgaagcaa ataaacgtga
      721 aggaacagta ggaa
//
