LOCUS       NM_001008767            2745 bp    mRNA    linear   ROD 09-JUL-2024
DEFINITION  Rattus norvegicus thioredoxin interacting protein (Txnip), mRNA.
ACCESSION   NM_001008767 XM_342299
VERSION     NM_001008767.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2745)
  AUTHORS   Zhao,Y., Chen,Y., Liu,Z., Zhou,L., Huang,J., Luo,X., Luo,Y., Li,J.,
            Lin,Y., Lai,J. and Liu,J.
  TITLE     TXNIP knockdown protects rats against bupivacaine-induced spinal
            neurotoxicity via the inhibition of oxidative stress and apoptosis
  JOURNAL   Free Radic Biol Med 219, 1-16 (2024)
   PUBMED   38614227
  REMARK    GeneRIF: TXNIP knockdown protects rats against bupivacaine-induced
            spinal neurotoxicity via the inhibition of oxidative stress and
            apoptosis.
REFERENCE   2  (bases 1 to 2745)
  AUTHORS   Sui,J., Dai,F., Shi,J. and Zhou,C.
  TITLE     Ubiquitin-specific peptidase 25 exacerbated osteoarthritis
            progression through facilitating TXNIP ubiquitination and NLRP3
            inflammasome activation
  JOURNAL   J Orthop Surg Res 18 (1), 762 (2023)
   PUBMED   37814350
  REMARK    GeneRIF: Ubiquitin-specific peptidase 25 exacerbated osteoarthritis
            progression through facilitating TXNIP ubiquitination and NLRP3
            inflammasome activation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2745)
  AUTHORS   Fei,J., Wang,H., Han,J., Zhang,X., Ma,H., Qin,X., Yu,C. and
            Jiang,J.
  TITLE     TXNIP activates NLRP3/IL-1beta and participate in inflammatory
            response and oxidative stress to promote deep venous thrombosis
  JOURNAL   Exp Biol Med (Maywood) 248 (18), 1588-1597 (2023)
   PUBMED   37749991
  REMARK    GeneRIF: TXNIP activates NLRP3/IL-1beta and participate in
            inflammatory response and oxidative stress to promote deep venous
            thrombosis.
REFERENCE   4  (bases 1 to 2745)
  AUTHORS   Li,S., Ouyang,G., Yuan,L., Wu,X. and Zhang,L.
  TITLE     SRY-box transcription factor 9 modulates Muller cell gliosis in
            diabetic retinopathy by upregulating TXNIP transcription
  JOURNAL   Exp Anim 72 (3), 302-313 (2023)
   PUBMED   36642539
  REMARK    GeneRIF: SRY-box transcription factor 9 modulates Muller cell
            gliosis in diabetic retinopathy by upregulating TXNIP
            transcription.
REFERENCE   5  (bases 1 to 2745)
  AUTHORS   Song,M.Y., Yi,F., Xiao,H., Yin,J., Huang,Q., Xia,J., Yin,X.M.,
            Wen,Y.B., Zhang,L., Liu,Y.H., Xiao,B. and Gu,W.P.
  TITLE     Energy restriction induced SIRT6 inhibits microglia activation and
            promotes angiogenesis in cerebral ischemia via transcriptional
            inhibition of TXNIP
  JOURNAL   Cell Death Dis 13 (5), 449 (2022)
   PUBMED   35562171
  REMARK    GeneRIF: Energy restriction induced SIRT6 inhibits microglia
            activation and promotes angiogenesis in cerebral ischemia via
            transcriptional inhibition of TXNIP.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2745)
  AUTHORS   Hirota,T., Okano,T., Kokame,K., Shirotani-Ikejima,H., Miyata,T. and
            Fukada,Y.
  TITLE     Glucose down-regulates Per1 and Per2 mRNA levels and induces
            circadian gene expression in cultured Rat-1 fibroblasts
  JOURNAL   J Biol Chem 277 (46), 44244-44251 (2002)
   PUBMED   12213820
REFERENCE   7  (bases 1 to 2745)
  AUTHORS   Wang,Y., De Keulenaer,G.W. and Lee,R.T.
  TITLE     Vitamin D(3)-up-regulated protein-1 is a stress-responsive gene
            that regulates cardiomyocyte viability through interaction with
            thioredoxin
  JOURNAL   J Biol Chem 277 (29), 26496-26500 (2002)
   PUBMED   12011048
  REMARK    GeneRIF: vitamin D(3)-up-regulated protein-1/thioredoxin axis has
            an important role in the preservation of cellular viability
REFERENCE   8  (bases 1 to 2745)
  AUTHORS   Saitoh,T., Tanaka,S. and Koike,T.
  TITLE     Rapid induction and Ca(2+) influx-mediated suppression of vitamin
            D3 up-regulated protein 1 (VDUP1) mRNA in cerebellar granule
            neurons undergoing apoptosis
  JOURNAL   J Neurochem 78 (6), 1267-1276 (2001)
   PUBMED   11579135
REFERENCE   9  (bases 1 to 2745)
  AUTHORS   Junn,E., Han,S.H., Im,J.Y., Yang,Y., Cho,E.W., Um,H.D., Kim,D.K.,
            Lee,K.W., Han,P.L., Rhee,S.G. and Choi,I.
  TITLE     Vitamin D3 up-regulated protein 1 mediates oxidative stress via
            suppressing the thioredoxin function
  JOURNAL   J Immunol 164 (12), 6287-6295 (2000)
   PUBMED   10843682
REFERENCE   10 (bases 1 to 2745)
  AUTHORS   Young,L.H., Yang,X. and Voigt,J.M.
  TITLE     Alteration of gene expression in rat mammary tumors induced by
            N-methyl-N-nitrosourea
  JOURNAL   Mol Carcinog 15 (4), 251-260 (1996)
   PUBMED   8634083
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001008767.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC088411.1, SRR26643293.13398.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-440               JAXUCZ010000002.1  186781933-186782372
            441-513             JAXUCZ010000002.1  186782760-186782832
            514-661             JAXUCZ010000002.1  186782938-186783085
            662-764             JAXUCZ010000002.1  186783198-186783300
            765-1021            JAXUCZ010000002.1  186783433-186783689
            1022-1178           JAXUCZ010000002.1  186783784-186783940
            1179-1330           JAXUCZ010000002.1  186784049-186784200
            1331-2745           JAXUCZ010000002.1  186784322-186785736
FEATURES             Location/Qualifiers
     source          1..2745
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..2745
                     /gene="Txnip"
                     /gene_synonym="Vdup1"
                     /note="thioredoxin interacting protein"
                     /db_xref="GeneID:117514"
                     /db_xref="RGD:620886"
     exon            1..440
                     /gene="Txnip"
                     /gene_synonym="Vdup1"
                     /inference="alignment:Splign:2.1.0"
     CDS             191..1375
                     /gene="Txnip"
                     /gene_synonym="Vdup1"
                     /note="vitamin D3 up-regulated protein 1; upregulated by
                     1,25-dihydroxyvitamin D-3"
                     /codon_start=1
                     /product="thioredoxin-interacting protein"
                     /protein_id="NP_001008767.1"
                     /db_xref="GeneID:117514"
                     /db_xref="RGD:620886"
                     /translation="MVMFKKIKSFEVVFNDPEKVYGSGEKVAGRVTVEVCEVTRVKAV
                     RILACGVAKVLWMQGSQQCKQTLDYLRYEDTLLLEDQPTGENEMVIMRPGNKYEYKFG
                     FELPQGPLGTSFKGKYGCVDYWVKAFLDRPSQPTQEAKKNFEVMDLVDVNTPDLMAPV
                     SAKKEKKVSCMFIPDGRVSVSARIDRKGFCEGDDISIHADFENTCSRIVVPKAAIVAR
                     HTYLANGQTKVLTQKLSSVRGNHIISGTCASWRGKSLRVQKIRPSILGCNILRVEYSL
                     LIYVSVPGSKKVILDLPLVIGSRSGLSSRTSSMASRTSSEMSWIDLNIPDTPEAPPCY
                     MDVIPEDHRLESPTTPLLDDVDDSQDSPIFMYAPEFQFMPPPTYTEVDPCVLNNNNNN
                     VQ"
     exon            441..513
                     /gene="Txnip"
                     /gene_synonym="Vdup1"
                     /inference="alignment:Splign:2.1.0"
     exon            514..661
                     /gene="Txnip"
                     /gene_synonym="Vdup1"
                     /inference="alignment:Splign:2.1.0"
     exon            662..764
                     /gene="Txnip"
                     /gene_synonym="Vdup1"
                     /inference="alignment:Splign:2.1.0"
     exon            765..1021
                     /gene="Txnip"
                     /gene_synonym="Vdup1"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1178
                     /gene="Txnip"
                     /gene_synonym="Vdup1"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..1330
                     /gene="Txnip"
                     /gene_synonym="Vdup1"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..2745
                     /gene="Txnip"
                     /gene_synonym="Vdup1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcacaacca gctggttgaa actttcaggc accttttaga gaagttgtta aggttttgtt
       61 tgaggctttc tttgggtttt taagccctct ctgcctcacg gagagactta agttcttagt
      121 ttgctgagaa ggattctgaa gagtttttcc tctccggctt ccgtttttct tgaacccact
      181 cggctcaatc atggtgatgt tcaagaagat caagtctttt gaggtggtct tcaacgaccc
      241 tgagaaggtg tatggcagcg gggagaaggt ggccggccgg gtgacagtgg aagtgtgtga
      301 agttacccga gtcaaagccg tcaggatcct ggcttgcggt gtggccaagg tcctgtggat
      361 gcaagggtct cagcagtgca aacagacctt ggactacttg cgctatgaag acacccttct
      421 cctagaagac cagcctacag gtgagaacga gatggtgatc atgagaccag gaaacaaata
      481 tgagtacaag ttcggctttg agcttcctca agggcccctg ggaacatcct tcaaagggaa
      541 atatggctgt gtagactact gggtgaaggc ttttctcgat cgtcccagcc agccaactca
      601 agaggcaaag aaaaactttg aagtgatgga tctagtggac gtcaatactc ctgacttaat
      661 ggcaccagtg tctgccaaaa aggagaagaa agtttcctgc atgttcattc ctgatggacg
      721 cgtgtcagtc tccgctcgaa tcgacagaaa aggattctgt gaaggtgatg acatttccat
      781 ccacgctgac tttgagaaca catgttcccg aatcgtggtc cccaaagcag ctattgtggc
      841 ccggcacact taccttgcca atggccagac caaagtgctc actcagaagc tgtcctcagt
      901 cagaggcaat cacattatct cagggacttg cgcatcatgg cgtggcaaga gtctccgagt
      961 gcagaagatc agaccgtcca ttctgggctg caacatcctc agagttgaat actccttgct
     1021 gatctatgtt agtgtccctg gctccaagaa agtcatcctc gatctgcccc tagtgattgg
     1081 cagcaggtcg ggcctaagca gccggacatc cagcatggct agccggacaa gctctgaaat
     1141 gagctggata gacctaaaca tcccagacac cccagaagct ccaccttgct atatggacgt
     1201 gattcctgaa gatcacagac tggagagccc caccaccccc ctgctagatg atgtggatga
     1261 ttctcaagac agccctatct ttatgtacgc ccccgagttc cagttcatgc ctccgcccac
     1321 ttacactgag gtggatccct gcgtccttaa caacaacaac aacaacgtgc agtgagcctt
     1381 cagggacgac tcatctgtac tactcaacgc tttctgcctc tctgcttgaa ctccaatgtt
     1441 tcagagactc agtctctcca gtggggagtg ggtacacccc cgcctctgac tccacagatg
     1501 ggtggcaatc agtaggcaag tctccagcct caaggggtgc agaccagtgc ccgcaccgtg
     1561 atataggagt gtttgctggg tgaatgtcgg aacgctcaaa acattcagac ctggcccact
     1621 ttcccagatg ttggaaatga agaagttgtt atttttttga gtcggggtct aagtgacctt
     1681 caggcatggt ctttccaagg tgttttgttt tgaagggaat taaaagaaca gaccatgaac
     1741 ttctgtgcca tggggcaaca gagccaatgt cacatactag aaaaagagaa atcatggcca
     1801 atattttgaa agcgaggagt gtttttgttt tttaaaatca gtgttccctt tttatatctt
     1861 tacaaagaaa aaagaccttc cacggctggt gaccgtgcag cctgtgaagt acgggcagct
     1921 gctccaagtt gactaaccgt gggagcggta gtggccgcac acaccagcag ccaggtgcac
     1981 tgcgttctct tgcaatcgga tgggagaacc cgttatttcc gtgtgactcc ttagaattga
     2041 ttctaaggtg atgttcttgg cactttagct tgtcaatttt tagtctgggt tatagatgga
     2101 ggctcttaag ggttaagccc agtgacaggg aaaaggagtt attactttgg gagggtgggg
     2161 gtagggcctc tatcccagaa ctccatagac caggctggcc tcaaagatcc acctgcctct
     2221 ccttcctaac tgctgagatt aaaggcccag cttggttatt acttttggag gctttccccc
     2281 aacacacaga cttctgtgat tctgacacta ctcctatgaa gggttgctgc tgacagctgg
     2341 accctggtga cactcttaca ttgagatgcc ctaacactga tggaggcaca gtgagaactg
     2401 caggtttcca tggaagctcc cagacccatt tcctgtccag tgttaggaga aagttctgct
     2461 ctcgccgtgg cctctagcac tccaaaactt actccgcctt agcactttgt tccgtgtcct
     2521 gtgtcagagc tccaagctcc actctaagca ctccacccga gaactgtgca gccagaaagt
     2581 gtgagctgat ggaggtgtcg tctttgttgt ttttgtattt tgtgtatctt tttgtatgat
     2641 taaaaactat attttgtact taaccaaata tattttcacc ccaaagtggg gctatccttt
     2701 gtaaaaaaaa aaaaaaatca aaataaagtt ttttaatggc aaaaa
//
