LOCUS       NM_001004092             448 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus thioredoxin domain containing 8 (Txndc8), mRNA.
ACCESSION   NM_001004092 XM_342843
VERSION     NM_001004092.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 448)
  AUTHORS   Buckman,C., Ozanon,C., Qiu,J., Sutovsky,M., Carafa,J.A., Rawe,V.Y.,
            Manandhar,G., Miranda-Vizuete,A. and Sutovsky,P.
  TITLE     Semen levels of spermatid-specific thioredoxin-3 correlate with
            pregnancy rates in ART couples
  JOURNAL   PLoS One 8 (5), e61000 (2013)
   PUBMED   23734172
  REMARK    Erratum:[PLoS One. 2013;8(10).
            doi:10.1371/annotation/5ec7a768-7129-460f-9290-57ae5d631dd9]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 448)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   3  (bases 1 to 448)
  AUTHORS   Jimenez,A., Zu,W., Rawe,V.Y., Pelto-Huikko,M., Flickinger,C.J.,
            Sutovsky,P., Gustafsson,J.A., Oko,R. and Miranda-Vizuete,A.
  TITLE     Spermatocyte/spermatid-specific thioredoxin-3, a novel Golgi
            apparatus-associated thioredoxin, is a specific marker of aberrant
            spermatogenesis
  JOURNAL   J Biol Chem 279 (33), 34971-34982 (2004)
   PUBMED   15181017
  REMARK    GeneRIF: SPTRX3 is a novel Golgi apparatus-associated thioredoxin,
            and has a role in aberrant spermatogenesis
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 11, 2021 this sequence version replaced NM_001004092.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY496270.1, SRR26360181.130467.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-47                JAXUCZ010000005.1  77580931-77580977   c
            48-152              JAXUCZ010000005.1  77579048-77579152   c
            153-212             JAXUCZ010000005.1  77568087-77568146   c
            213-278             JAXUCZ010000005.1  77565972-77566037   c
            279-344             JAXUCZ010000005.1  77546265-77546330   c
            345-448             JAXUCZ010000005.1  77544828-77544931   c
FEATURES             Location/Qualifiers
     source          1..448
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q24"
     gene            1..448
                     /gene="Txndc8"
                     /gene_synonym="Sptrx3"
                     /note="thioredoxin domain containing 8"
                     /db_xref="GeneID:362525"
                     /db_xref="RGD:1303121"
     exon            1..47
                     /gene="Txndc8"
                     /gene_synonym="Sptrx3"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..407
                     /gene="Txndc8"
                     /gene_synonym="Sptrx3"
                     /note="spermatocyte/spermatid-specific thioredoxin-3;
                     sptrx-3"
                     /codon_start=1
                     /product="thioredoxin domain-containing protein 8"
                     /protein_id="NP_001004092.1"
                     /db_xref="GeneID:362525"
                     /db_xref="RGD:1303121"
                     /translation="MVQKIKSMREFKELLGAAGNRLVVVEFSAQWCGPCKMIAPAFQA
                     MSLQYRNVMFAQVDVDSSQELTEHCSIQVVPTFQMFKHSRKVTPFSRLKRILCCFRSG
                     PGSKKIFEFQGADIEKLEEKIQELM"
     exon            48..152
                     /gene="Txndc8"
                     /gene_synonym="Sptrx3"
                     /inference="alignment:Splign:2.1.0"
     exon            153..212
                     /gene="Txndc8"
                     /gene_synonym="Sptrx3"
                     /inference="alignment:Splign:2.1.0"
     exon            213..278
                     /gene="Txndc8"
                     /gene_synonym="Sptrx3"
                     /inference="alignment:Splign:2.1.0"
     exon            279..344
                     /gene="Txndc8"
                     /gene_synonym="Sptrx3"
                     /inference="alignment:Splign:2.1.0"
     exon            345..448
                     /gene="Txndc8"
                     /gene_synonym="Sptrx3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagcaagtc ccaggtgata atcatggtgc agaagattaa aagcatgagg gaatttaaag
       61 aattgcttgg cgctgctgga aataggcttg tggtggtaga attttcagca cagtggtgtg
      121 gcccctgcaa aatgattgct cctgctttcc aggcaatgtc tttacaatac cgaaatgtca
      181 tgtttgctca ggtggatgtg gattcatctc aggaattgac tgaacattgt agcatccaag
      241 tagtgcccac attccagatg ttcaagcact cccgaaaggt cactccattc tcaagactca
      301 aaagaatact gtgctgtttc agaagtggac cagggagcaa gaagattttt gaatttcaag
      361 gcgctgatat tgaaaaactg gaagagaaga ttcaagagct aatgtaaact gacacccaaa
      421 tatacctgca accttttcta aagcagca
//
