LOCUS       NM_001146004            1807 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus thioredoxin domain containing 2 (Txndc2),
            transcript variant 1, mRNA.
ACCESSION   NM_001146004
VERSION     NM_001146004.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1807)
  AUTHORS   Smith,T.B., Baker,M.A., Connaughton,H.S., Habenicht,U. and
            Aitken,R.J.
  TITLE     Functional deletion of Txndc2 and Txndc3 increases the
            susceptibility of spermatozoa to age-related oxidative stress
  JOURNAL   Free Radic Biol Med 65, 872-881 (2013)
   PUBMED   23707457
REFERENCE   2  (bases 1 to 1807)
  AUTHORS   Yu,Y., Oko,R. and Miranda-Vizuete,A.
  TITLE     Developmental expression of spermatid-specific thioredoxin-1
            protein: transient association to the longitudinal columns of the
            fibrous sheath during sperm tail formation
  JOURNAL   Biol Reprod 67 (5), 1546-1554 (2002)
   PUBMED   12390887
REFERENCE   3  (bases 1 to 1807)
  AUTHORS   Jimenez,A., Oko,R., Gustafsson,J.A., Spyrou,G., Pelto-Huikko,M. and
            Miranda-Vizuete,A.
  TITLE     Cloning, expression and characterization of mouse spermatid
            specific thioredoxin-1 gene and protein
  JOURNAL   Mol Hum Reprod 8 (8), 710-718 (2002)
   PUBMED   12149401
REFERENCE   4  (bases 1 to 1807)
  AUTHORS   Miranda-Vizuete,A., Ljung,J., Damdimopoulos,A.E., Gustafsson,J.A.,
            Oko,R., Pelto-Huikko,M. and Spyrou,G.
  TITLE     Characterization of Sptrx, a novel member of the thioredoxin family
            specifically expressed in human spermatozoa
  JOURNAL   J Biol Chem 276 (34), 31567-31574 (2001)
   PUBMED   11399755
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC079238.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079238.1, CK600803.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760434 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1807              BC079238.1         1-1807
FEATURES             Location/Qualifiers
     source          1..1807
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q37"
     gene            1..1807
                     /gene="Txndc2"
                     /note="thioredoxin domain containing 2"
                     /db_xref="GeneID:316777"
                     /db_xref="RGD:1359251"
     exon            1..238
                     /gene="Txndc2"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..1761
                     /gene="Txndc2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     thioredoxin domain-containing protein 2; sptrx-1;
                     spermatid-specific thioredoxin-1; thioredoxin domain
                     containing 2 (spermatozoa)"
                     /codon_start=1
                     /product="thioredoxin domain-containing protein 2 isoform
                     1"
                     /protein_id="NP_001139476.1"
                     /db_xref="GeneID:316777"
                     /db_xref="RGD:1359251"
                     /translation="MFKKNQKLSKDKGLEVNSVQAGAPEESDVKLNNGGKANERGSNE
                     FLDTAQSKEKVIASVVGNMLHMSTEESEPPQQVSSTSMFSENTIYPKHEGSPKSSTKN
                     TQLKQEDISKTSSYSKQTNSSNIPKSLAITTYPKQGSTLKPAANGTHDREAEKPKSSE
                     DLIQSKKGDIFKPSEDSIQSKKGDMPKSSEDPIQSKKDDTAKSLEDTIQSKNGDMPKS
                     SEDPIQSKKDDTARSLEDSIQSKKGDMPKSSDTIQSKESETPKFLQDTIQSKGGKINK
                     QVKDSMKSKESKIRKPLKDSIQSKENKIPKSSQDSAQPKEGKIHKPLKDSLPSKEGDI
                     SKPSEDTIQAKEEITVSPEDTIQAKEEITMSPEDTIQAKEEITVSPEDTIQAKEEITV
                     SPEDTMQSKEEITVSPEDTVQSQEGDIKSSEDVQPSENEIFPFEAEIETLEEGMVRVI
                     KDKEEFEEVLKDAGEKLVAVDFSAPWCGPCRKMRPHFHSLSLKHEDVIFLEVDTEDCE
                     QLVQDCEVFHLPTFQFYKNEEKVGEFSGALVEKLEKSIAELK"
     exon            239..1786
                     /gene="Txndc2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctccccgaag gtcgctgttg ggggtactgg ttaggaacgt cagctgtgga gtgctgcctg
       61 aacattaagt agttagtgta ttttgttctt agtttggcca tagaggaaat gtttaagaag
      121 aaccaaaagc tgagtaagga caaggggttg gaggtgaaca gcgtccaagc aggagcccct
      181 gaagagtcag atgtgaaact taacaatgga ggaaaagcaa atgaaagggg tagcaatgag
      241 ttcttggata cagcccagtc caaagaaaaa gtcattgctt ccgtggtcgg caacatgctt
      301 catatgtcca cagaagagtc tgagccccca cagcaggtta gtagcacctc catgttctca
      361 gaaaacacca tctatcccaa acacgaaggg agccccaagt cctcaacaaa aaacactcag
      421 ctgaaacagg aagacatttc taaaacctca agctactcca agcagaccaa ctctagcaac
      481 atccccaagt ccttggcaat aaccacctat cccaaacagg ggagcactct caagcctgca
      541 gcaaatggta cccatgacag ggaggctgaa aagcccaagt cctcagaaga cctcatccaa
      601 tccaagaaag gggacatatt caagccttca gaagactcca tccaatccaa gaaaggggac
      661 atgcccaagt cctcagaaga ccccatccaa tccaaaaagg atgacacggc caagtcttta
      721 gaagatacca tccaatccaa gaatggggac atgcccaagt cctcagaaga ccccatccaa
      781 tccaaaaagg atgacacggc caggtcttta gaagattcca tccaatccaa gaaaggggac
      841 atgcccaagt cctcagacac cattcaatcc aaggaaagcg aaacacccaa gttcttgcag
      901 gacaccatcc aatccaaggg aggtaaaatc aacaaacaag tgaaagacag catgaagtcc
      961 aaggagagta aaattcgcaa gcccttgaaa gacagcatcc agtccaagga gaacaaaatc
     1021 cccaagtcct cacaggactc cgcccagcct aaggagggta aaatccacaa gcccttaaaa
     1081 gacagcctcc catccaagga gggagatatc tctaagccct cagaagacac catccaggcc
     1141 aaggaagaaa tcaccgtgtc cccagaagac accatccagg ccaaggaaga aatcaccatg
     1201 tccccagaag acaccatcca ggccaaggaa gaaatcaccg tgtccccaga agacaccatc
     1261 caggccaagg aagaaatcac cgtgtcccca gaagacacca tgcagtctaa ggaagaaatc
     1321 accgtgtccc cagaagacac agtccagtcc caggaaggtg acatcaagtc ttcagaagac
     1381 gtgcagccct cggagaacga aatcttccct tttgaagcag aaatagagac cctggaggaa
     1441 ggcatggtga gagtgatcaa agacaaagaa gagtttgagg aggtgctcaa agatgctgga
     1501 gagaagctgg tagctgtaga tttctcagcc ccttggtgtg gcccttgcag aaagatgagg
     1561 ccacacttcc attccctgtc tttgaagcat gaagatgtga tattcttgga ggtggatact
     1621 gaggactgtg aacagctggt gcaagactgt gaggtcttcc acctcccgac tttccagttt
     1681 tataaaaacg aagaaaaggt gggtgaattt tcgggtgccc ttgtggaaaa acttgaaaag
     1741 agcattgcag aattaaagtg atcatatgtt ctgagaacac tgtaaaaaaa aaaaaaaaaa
     1801 aaaaaaa
//
