LOCUS       NM_001100840            1386 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus thioredoxin domain containing 12 (Txndc12), mRNA.
ACCESSION   NM_001100840 XM_001067457 XM_216482
VERSION     NM_001100840.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1386)
  AUTHORS   Jeong,W., Lee,D.Y., Park,S. and Rhee,S.G.
  TITLE     ERp16, an endoplasmic reticulum-resident thiol-disulfide
            oxidoreductase: biochemical properties and role in apoptosis
            induced by endoplasmic reticulum stress
  JOURNAL   J Biol Chem 283 (37), 25557-25566 (2008)
   PUBMED   18628206
  REMARK    GeneRIF: ERp16 mediates disulfide bond formation in the ER and
            plays an important role in cellular defense against prolonged ER
            stress
REFERENCE   2  (bases 1 to 1386)
  AUTHORS   Knoblach,B., Keller,B.O., Groenendyk,J., Aldred,S., Zheng,J.,
            Lemire,B.D., Li,L. and Michalak,M.
  TITLE     ERp19 and ERp46, new members of the thioredoxin family of
            endoplasmic reticulum proteins
  JOURNAL   Mol Cell Proteomics 2 (10), 1104-1119 (2003)
   PUBMED   12930873
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CV117277.1 and BC100255.1.
            
            On or before Oct 24, 2008 this sequence version replaced
            XM_001067457.1, XM_216482.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC100255.1, DY320949.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132263, SAMD00132264
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-58                CV117277.1         238-295
            59-1386             BC100255.1         1-1328
FEATURES             Location/Qualifiers
     source          1..1386
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q34"
     gene            1..1386
                     /gene="Txndc12"
                     /gene_synonym="RGD1305960"
                     /note="thioredoxin domain containing 12"
                     /db_xref="GeneID:298370"
                     /db_xref="RGD:1305960"
     exon            1..238
                     /gene="Txndc12"
                     /gene_synonym="RGD1305960"
                     /inference="alignment:Splign:2.1.0"
     CDS             148..660
                     /gene="Txndc12"
                     /gene_synonym="RGD1305960"
                     /EC_number="1.8.4.2"
                     /note="thioredoxin domain-containing protein 12;
                     thioredoxin domain containing 12 (endoplasmic reticulum)"
                     /codon_start=1
                     /product="thioredoxin domain-containing protein 12
                     precursor"
                     /protein_id="NP_001094310.1"
                     /db_xref="GeneID:298370"
                     /db_xref="RGD:1305960"
                     /translation="MSLRFGATCLLSFSFLLLITSSDGRTGLGKGFGDHIHWRTLEDG
                     KKEAAASGLPLMVIIHKSWCGACKALKPKFAESTEISELSHNFVMVNLEDEEEPRDED
                     FSPDGGYIPRILFLDPSGKVRPEIINESGNPSYKYFYVSAEQVVQGMKEAQVRLTGDA
                     FREKHFQDEL"
     exon            239..299
                     /gene="Txndc12"
                     /gene_synonym="RGD1305960"
                     /inference="alignment:Splign:2.1.0"
     exon            300..352
                     /gene="Txndc12"
                     /gene_synonym="RGD1305960"
                     /inference="alignment:Splign:2.1.0"
     exon            353..426
                     /gene="Txndc12"
                     /gene_synonym="RGD1305960"
                     /inference="alignment:Splign:2.1.0"
     exon            427..496
                     /gene="Txndc12"
                     /gene_synonym="RGD1305960"
                     /inference="alignment:Splign:2.1.0"
     exon            497..580
                     /gene="Txndc12"
                     /gene_synonym="RGD1305960"
                     /inference="alignment:Splign:2.1.0"
     exon            581..1315
                     /gene="Txndc12"
                     /gene_synonym="RGD1305960"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acatcacttc cttcggtgtt tggagaggaa aaaaatctgg gaatccgagg ggttgggctg
       61 agcggcgata agagggcaca ggggagcttc tcctggaaat cctgtgttcc cgcaatccgg
      121 tggctctgtg caactacccc agtggagatg tcgcttcgtt tcggggccac ctgtttgctg
      181 agcttcagtt tcctgctcct catcacttct tcagacggac gcactgggct tggaaagggt
      241 tttggagatc atattcactg gaggactcta gaagatggga agaaagaagc agctgcaagt
      301 ggcttgccgc tgatggtgat catccacaag tcttggtgtg gagcctgcaa agctttaaaa
      361 cccaaatttg cagaatctac agaaatttca gaactgtccc ataatttcgt tatggtaaat
      421 ctggaggatg aagaggaacc cagggatgaa gacttcagtc ctgatggggg ttatattccg
      481 cgcatccttt tcttggatcc cagtggcaag gtgcgccctg aaatcatcaa tgagagtgga
      541 aaccccagct acaagtattt ctacgtcagt gctgagcaag ttgttcaagg gatgaaggaa
      601 gcacaggtga ggctgactgg tgatgccttc agagagaaac attttcagga tgaattgtga
      661 tacgaatgag tattctgaaa gaaaagctgc agggagagaa tacggaagaa tcacccagaa
      721 taattaaacc accggaaacc atgcttctac ctacaccgga aggagctctt actgggacag
      781 gcctgctgac agaagctggt ctgtgcaccc agcatcctgg ccgactgact ctcatctgct
      841 ccctctccta aatatccatt cctctgaatg taaagaatga aactatttaa tacgaaactt
      901 gagccacttg gagatttgct ccacgtcagt atttgaatct tcatccattt cctcccactt
      961 cctcaagctg aagtgaaaca aaccgaagta tcttttgtat agtgtacaaa gtgcgggagg
     1021 tccttatcag attttaaaga aggcttggta ctactcctgg acttcctgaa tccctgcacc
     1081 cttccttctt tgctcaggca tccctgtttg cacggatgtg cgtcaagaat ggctgtgtgc
     1141 tgaggctcag ccccaactgg aagcatgttt tccctgttgt tagagaaact caagcctgca
     1201 aaccctacat gaagccattt tgtcaattca ccaactgtat ttttgtactg gggttaaaac
     1261 aaacacaaga gataaaatat gtttcactaa gctttattaa aacttgaaat ggaaaaaaaa
     1321 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1381 aaaaaa
//
