LOCUS       NM_053331               1142 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus thioredoxin 2 (Txn2), mRNA; nuclear gene for
            mitochondrial product.
ACCESSION   NM_053331
VERSION     NM_053331.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1142)
  AUTHORS   Hu,C., Zhang,H., Qiao,Z., Wang,Y., Zhang,P. and Yang,D.
  TITLE     Loss of thioredoxin 2 alters mitochondrial respiratory function and
            induces cardiomyocyte hypertrophy
  JOURNAL   Exp Cell Res 372 (1), 61-72 (2018)
   PUBMED   30236513
  REMARK    GeneRIF: Loss of TXN2 alters mitochondrial respiratory function and
            induces cardiomyocyte hypertrophy.
REFERENCE   2  (bases 1 to 1142)
  AUTHORS   Bauza-Thorbrugge,M., M Galmes-Pascual,B., Sbert-Roig,M., J
            Garcia-Palmer,F., Gianotti,M., M Proenza,A. and Llado,I.
  TITLE     Antioxidant peroxiredoxin 3 expression is regulated by
            17beta-estradiol in rat white adipose tissue
  JOURNAL   J Steroid Biochem Mol Biol 172, 9-19 (2017)
   PUBMED   28529127
  REMARK    GeneRIF: Estradiol-17beta upregulation of both PRX3 and TRX2 in the
            white adipose tissue, but not in the brown adipose tissue could
            play a key role in the sex dimorphism reported in the antioxidant
            defense of the white adipose tissue in order to alleviate the
            detrimental effect of the oxidative stress.
REFERENCE   3  (bases 1 to 1142)
  AUTHORS   Folda,A., Citta,A., Scalcon,V., Cali,T., Zonta,F., Scutari,G.,
            Bindoli,A. and Rigobello,M.P.
  TITLE     Mitochondrial Thioredoxin System as a Modulator of Cyclophilin D
            Redox State
  JOURNAL   Sci Rep 6, 23071 (2016)
   PUBMED   26975474
  REMARK    GeneRIF: Data show that the redox state of cyclophilin D was
            stimulated by thioredoxin 1 and 2 and peroxiredoxin 3 in heart
            mitochondria.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1142)
  AUTHORS   Sun,H.Y., Hu,Y.J., Zhao,X.Y., Zhong,Y., Zeng,L.L., Chen,X.B.,
            Yuan,J., Wu,J., Sun,Y., Kong,W. and Kong,W.J.
  TITLE     Age-related changes in mitochondrial antioxidant enzyme Trx2 and
            TXNIP-Trx2-ASK1 signal pathways in the auditory cortex of a mimetic
            aging rat model: changes to Trx2 in the auditory cortex
  JOURNAL   FEBS J 282 (14), 2758-2774 (2015)
   PUBMED   25996168
  REMARK    GeneRIF: Age-related changes in Trx2 and the TXNIP-Trx2-ASK1 signal
            pathway in the auditory cortex
REFERENCE   5  (bases 1 to 1142)
  AUTHORS   Sun,N., Hao,J.R., Li,X.Y., Yin,X.H., Zong,Y.Y., Zhang,G.Y. and
            Gao,C.
  TITLE     GluR6-FasL-Trx2 mediates denitrosylation and activation of
            procaspase-3 in cerebral ischemia/reperfusion in rats
  JOURNAL   Cell Death Dis 4 (8), e771 (2013)
   PUBMED   23949220
  REMARK    GeneRIF: Cerebral ischemia/reperfusion mediates procaspase-3
            denitrosylation and activation through GluR6-FasL-Trx2 pathway,
            which leads to neuronal apoptosis and cell death.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1142)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   7  (bases 1 to 1142)
  AUTHORS   Samoilov,M.O., Rybnikova,E.A., Tjulkova,E.I., Spyrou,G. and
            Pelto-Huikko,M.
  TITLE     The mitochondrial antioxidants thioredoxin-2 and Mn-superoxide
            dismutase are involved in the mechanisms of brain hypoxic tolerance
  JOURNAL   Dokl Biol Sci 387, 498-500 (2002)
   PUBMED   12577622
  REMARK    GeneRIF: TRx2 has a role scavenging reactive oxygen species in
            mitochondria and is involved in regulating apoptotic cascades
REFERENCE   8  (bases 1 to 1142)
  AUTHORS   Chen,Y., Cai,J., Murphy,T.J. and Jones,D.P.
  TITLE     Overexpressed human mitochondrial thioredoxin confers resistance to
            oxidant-induced apoptosis in human osteosarcoma cells
  JOURNAL   J Biol Chem 277 (36), 33242-33248 (2002)
   PUBMED   12032145
REFERENCE   9  (bases 1 to 1142)
  AUTHORS   Rybnikova,E., Damdimopoulos,A.E., Gustafsson,J.A., Spyrou,G. and
            Pelto-Huikko,M.
  TITLE     Expression of novel antioxidant thioredoxin-2 in the rat brain
  JOURNAL   Eur J Neurosci 12 (5), 1669-1678 (2000)
   PUBMED   10792444
REFERENCE   10 (bases 1 to 1142)
  AUTHORS   Spyrou,G., Enmark,E., Miranda-Vizuete,A. and Gustafsson,J.
  TITLE     Cloning and expression of a novel mammalian thioredoxin
  JOURNAL   J Biol Chem 272 (5), 2936-2941 (1997)
   PUBMED   9006939
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC081760.1.
            
            On Jun 10, 2007 this sequence version replaced NM_053331.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081760.1, FQ217268.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132297, SAMD00132304
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1142
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..1142
                     /gene="Txn2"
                     /note="thioredoxin 2"
                     /db_xref="GeneID:79462"
                     /db_xref="RGD:71040"
     exon            1..61
                     /gene="Txn2"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..562
                     /gene="Txn2"
                     /note="thioredoxin, mitochondrial; MTRX; mt-Trx"
                     /codon_start=1
                     /product="thioredoxin, mitochondrial precursor"
                     /protein_id="NP_445783.1"
                     /db_xref="GeneID:79462"
                     /db_xref="RGD:71040"
                     /translation="MAQRLLLRRFLTSVISRKPPQGVWASLTSTSLQTPPYNAGGLTG
                     TPSPARTFHTTRVCSTTFNVQDGPDFQDRVVNSETPVVVDFHAQWCGPCKILGPRLEK
                     MVAKQHGKVVMAKVDIDDHTDLAIEYEVSAVPTVLAIKNGDVVDKFVGIKDEDQLEAF
                     LKKLIG"
     exon            62..324
                     /gene="Txn2"
                     /inference="alignment:Splign:2.1.0"
     exon            325..448
                     /gene="Txn2"
                     /inference="alignment:Splign:2.1.0"
     exon            449..1101
                     /gene="Txn2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagtgccct tgacgggcag gccggctggg ctctgcatcc ctctgctcac actgccggga
       61 gatggctcag cggcttctcc tgaggaggtt cctgacctca gtcatctcca ggaagcctcc
      121 tcaaggtgtg tgggcttccc tcacctctac gagcctgcag acccctccgt acaatgctgg
      181 tggtctaact ggaacaccca gccctgcccg gacatttcac accaccagag tctgttcaac
      241 aacctttaac gtccaggatg gacctgactt tcaagacaga gttgtcaaca gtgagacacc
      301 agttgtcgtg gactttcatg cacagtggtg tggcccctgc aagatcctag gacctcggtt
      361 agagaagatg gtagccaaac agcacgggaa ggtggtgatg gccaaagtgg acattgacga
      421 tcacacagac cttgccattg agtacgaggt gtctgctgtg cctaccgtgc tggccatcaa
      481 gaacggggac gtggtggaca agtttgtggg gatcaaggac gaagaccagc tggaagcctt
      541 cctgaagaag ctaattggct gacaagcagg gaagaggcca gactgccctt gcctgctgga
      601 aacccatttg gggaggaacc tagtagaact cccagccctc agctgtcatc cttcgtgccc
      661 tgcccccgtt ttgtccttgt gggtcttgcc tttgggcagc agacttccaa acctagaagc
      721 caccagcact tcagagccag ccctcagcca ggatggccag gagaggggca atgctgccga
      781 tggtgtggag gaggggcatc ctgagcacct cctactgtgt gctcctcctg tgcacctact
      841 gtgtgcttct tctagggctt gttgctattc ccctagatgc tagacaaagc ctgggccagc
      901 ctgtagtcac cgcccaggca atggcccagt cctcgtctct gaggtcctct gatctgaagc
      961 ctcagcccca cacacacaca tttgcctctg gtgtatttcc tctcctgcct ctgcttgaaa
     1021 aggaaacaag aagctgaaca agtgagagta atggataatt ctctcatctt ttgtaggtct
     1081 gtaataaaga actttatgtg aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1141 aa
//
