LOCUS       NM_053800                330 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Rattus norvegicus thioredoxin 1 (Txn1), mRNA.
ACCESSION   NM_053800
VERSION     NM_053800.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 330)
  AUTHORS   Jia,J., Liu,H., Sun,L., Xu,Y. and Zeng,X.
  TITLE     Thioredoxin-1 Protects Neurons Through Inhibiting NLRP1-Mediated
            Neuronal Pyroptosis in Models of Alzheimer's Disease
  JOURNAL   Mol Neurobiol 61 (11), 9723-9734 (2024)
   PUBMED   38976128
  REMARK    GeneRIF: Thioredoxin-1 Protects Neurons Through Inhibiting
            NLRP1-Mediated Neuronal Pyroptosis in Models of Alzheimer's
            Disease.
            Erratum:[Mol Neurobiol. 2024 Sep 28. doi:
            10.1007/s12035-024-04523-8.. PMID: 39333348]
REFERENCE   2  (bases 1 to 330)
  AUTHORS   Chen,R., Xie,Q., Xie,L., Huang,J., Hu,L., Lu,H., Shi,P., He,Q.,
            Zhang,Q., Gong,C., Zhang,S., Wang,B., Yang,G. and Yang,Q.
  TITLE     Thioredoxin1 Binding Metastasis-Associated Lung Adenocarcinoma
            Transcript 1 Attenuates Inflammation and Apoptosis after
            Intracerebral Hemorrhage
  JOURNAL   Aging Dis 15 (3), 1384-1397 (2024)
   PUBMED   37196136
  REMARK    GeneRIF: Thioredoxin1 Binding Metastasis-Associated Lung
            Adenocarcinoma Transcript 1 Attenuates Inflammation and Apoptosis
            after Intracerebral Hemorrhage.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 330)
  AUTHORS   Zhu,Y., He,Y.J., Yu,Y., Xu,D., Yuan,S.Y. and Yan,H.
  TITLE     Aldehyde Dehydrogenase 2 Preserves Mitochondrial Function in the
            Ischemic Heart: A Redox-dependent Mechanism for AMPK Activation by
            Thioredoxin-1
  JOURNAL   J Cardiovasc Pharmacol 83 (1), 93-104 (2024)
   PUBMED   37816196
  REMARK    GeneRIF: Aldehyde Dehydrogenase 2 Preserves Mitochondrial Function
            in the Ischemic Heart: A Redox-dependent Mechanism for AMPK
            Activation by Thioredoxin-1.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 330)
  AUTHORS   Jia,J., Zhang,X., Xu,G., Zeng,X. and Li,L.
  TITLE     Thioredoxin-1 inhibits amyloid-beta25-35-induced activation of
            NLRP1/caspase-1/GSDMD pyroptotic pathway in PC12 cells
  JOURNAL   Mol Biol Rep 49 (5), 3445-3452 (2022)
   PUBMED   35072836
  REMARK    GeneRIF: Thioredoxin-1 inhibits amyloid-beta25-35-induced
            activation of NLRP1/caspase-1/GSDMD pyroptotic pathway in PC12
            cells.
REFERENCE   5  (bases 1 to 330)
  AUTHORS   Zhang,X., Deng,R., Zhang,S., Deng,J., Jia,J.J., Sun,B., Zhou,X. and
            Bai,J.
  TITLE     Thioredoxin-1 regulates calcium homeostasis in MPP+ /MPTP-induced
            Parkinson's disease models
  JOURNAL   Eur J Neurosci 54 (3), 4827-4837 (2021)
   PUBMED   34132424
  REMARK    GeneRIF: Thioredoxin-1 regulates calcium homeostasis in MPP(+)
            /MPTP-induced Parkinson's disease models.
REFERENCE   6  (bases 1 to 330)
  AUTHORS   Andersen,J.F., Sanders,D.A., Gasdaska,J.R., Weichsel,A., Powis,G.
            and Montfort,W.R.
  TITLE     Human thioredoxin homodimers: regulation by pH, role of aspartate
            60, and crystal structure of the aspartate 60 --> asparagine mutant
  JOURNAL   Biochemistry 36 (46), 13979-13988 (1997)
   PUBMED   9369469
REFERENCE   7  (bases 1 to 330)
  AUTHORS   Hirota,K., Matsui,M., Iwata,S., Nishiyama,A., Mori,K. and Yodoi,J.
  TITLE     AP-1 transcriptional activity is regulated by a direct association
            between thioredoxin and Ref-1
  JOURNAL   Proc Natl Acad Sci U S A 94 (8), 3633-3638 (1997)
   PUBMED   9108029
REFERENCE   8  (bases 1 to 330)
  AUTHORS   Rubartelli,A., Bajetto,A., Allavena,G., Wollman,E. and Sitia,R.
  TITLE     Secretion of thioredoxin by normal and neoplastic cells through a
            leaderless secretory pathway
  JOURNAL   J Biol Chem 267 (34), 24161-24164 (1992)
   PUBMED   1332947
REFERENCE   9  (bases 1 to 330)
  AUTHORS   Jacquot,J.P., de Lamotte,F., Fontecave,M., Schurmann,P.,
            Decottignies,P., Miginiac-Maslow,M. and Wollman,E.
  TITLE     Human thioredoxin reactivity-structure/function relationship
  JOURNAL   Biochem Biophys Res Commun 173 (3), 1375-1381 (1990)
   PUBMED   2176490
REFERENCE   10 (bases 1 to 330)
  AUTHORS   Tonissen,K.F., Robins,A.J. and Wells,J.R.
  TITLE     Nucleotide sequence of a cDNA encoding rat thioredoxin
  JOURNAL   Nucleic Acids Res 17 (10), 3973 (1989)
   PUBMED   2734107
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF311055.1.
            
            On Jun 10, 2007 this sequence version replaced NM_053800.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF311055.1, BG669245.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132304, SAMEA5756307
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..330
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q24"
     gene            1..330
                     /gene="Txn1"
                     /gene_synonym="Txn"
                     /note="thioredoxin 1"
                     /db_xref="GeneID:116484"
                     /db_xref="RGD:621157"
     CDS             1..318
                     /gene="Txn1"
                     /gene_synonym="Txn"
                     /note="contains a redox-active disulphide
                     (-Cys-Gly-Pro-Cys-) and has multiple biological functions
                     as a hydrogen donor; trx"
                     /codon_start=1
                     /product="thioredoxin"
                     /protein_id="NP_446252.1"
                     /db_xref="GeneID:116484"
                     /db_xref="RGD:621157"
                     /translation="MVKLIESKEAFQEALAAAGDKLVVVDFSATWCGPCKMIKPFFHS
                     LCDKYSNVVFLEVDVDDCQDVAADCEVKCMPTFQFYKKGQKVGEFSGANKEKLEATIT
                     EFA"
     exon            1..24
                     /gene="Txn1"
                     /gene_synonym="Txn"
                     /inference="alignment:Splign:2.1.0"
     exon            25..129
                     /gene="Txn1"
                     /gene_synonym="Txn"
                     /inference="alignment:Splign:2.1.0"
     exon            130..189
                     /gene="Txn1"
                     /gene_synonym="Txn"
                     /inference="alignment:Splign:2.1.0"
     exon            190..255
                     /gene="Txn1"
                     /gene_synonym="Txn"
                     /inference="alignment:Splign:2.1.0"
     exon            256..330
                     /gene="Txn1"
                     /gene_synonym="Txn"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggtgaagc tgatcgagag caaggaagct tttcaggagg ccctggccgc tgcgggagac
       61 aagcttgtgg tagtggactt ctctgccacg tggtgtggac cttgcaaaat gatcaagccc
      121 ttctttcatt ccctctgtga caagtattcc aatgtggtgt tccttgaagt agacgtggat
      181 gactgccagg atgttgctgc agactgtgaa gtcaaatgca tgccgacctt ccagttctat
      241 aaaaagggtc aaaaggttgg ggagttctct ggtgctaaca aggaaaagct cgaagccact
      301 attacggagt ttgcctaatc atgctctgaa
//
