LOCUS       NM_001024255            2308 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus TXK tyrosine kinase (Txk), mRNA.
ACCESSION   NM_001024255 XM_223365
VERSION     NM_001024255.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2308)
  AUTHORS   Felices M and Berg LJ.
  TITLE     The Tec kinases Itk and Rlk regulate NKT cell maturation, cytokine
            production, and survival
  JOURNAL   J Immunol 180 (5), 3007-3018 (2008)
   PUBMED   18292523
REFERENCE   2  (bases 1 to 2308)
  AUTHORS   Maruyama T, Nara K, Yoshikawa H and Suzuki N.
  TITLE     Txk, a member of the non-receptor tyrosine kinase of the Tec
            family, forms a complex with poly(ADP-ribose) polymerase 1 and
            elongation factor 1alpha and regulates interferon-gamma gene
            transcription in Th1 cells
  JOURNAL   Clin Exp Immunol 147 (1), 164-175 (2007)
   PUBMED   17177976
REFERENCE   3  (bases 1 to 2308)
  AUTHORS   Kashiwakura J, Suzuki N, Takeno M, Itoh S, Oku T, Sakane T, Nakajin
            S and Toyoshima S.
  TITLE     Evidence of autophosphorylation in Txk: Y91 is an
            autophosphorylation site
  JOURNAL   Biol Pharm Bull 25 (6), 718-721 (2002)
   PUBMED   12081135
REFERENCE   4  (bases 1 to 2308)
  AUTHORS   Takeba Y, Nagafuchi H, Takeno M, Kashiwakura J and Suzuki N.
  TITLE     Txk, a member of nonreceptor tyrosine kinase of Tec family, acts as
            a Th1 cell-specific transcription factor and regulates IFN-gamma
            gene transcription
  JOURNAL   J Immunol 168 (5), 2365-2370 (2002)
   PUBMED   11859127
REFERENCE   5  (bases 1 to 2308)
  AUTHORS   Kashiwakura J, Suzuki N, Nagafuchi H, Takeno M, Takeba Y, Shimoyama
            Y and Sakane T.
  TITLE     Txk, a nonreceptor tyrosine kinase of the Tec family, is expressed
            in T helper type 1 cells and regulates interferon gamma production
            in human T lymphocytes
  JOURNAL   J Exp Med 190 (8), 1147-1154 (1999)
   PUBMED   10523612
REFERENCE   6  (bases 1 to 2308)
  AUTHORS   Schaeffer EM, Debnath J, Yap G, McVicar D, Liao XC, Littman DR,
            Sher A, Varmus HE, Lenardo MJ and Schwartzberg PL.
  TITLE     Requirement for Tec kinases Rlk and Itk in T cell receptor
            signaling and immunity
  JOURNAL   Science 284 (5414), 638-641 (1999)
   PUBMED   10213685
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC095847.1.
            
            On May 27, 2005 this sequence version replaced XM_223365.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC095847.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMN11044071
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2308
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p11"
     gene            1..2308
                     /gene="Txk"
                     /note="TXK tyrosine kinase"
                     /db_xref="GeneID:305311"
                     /db_xref="RGD:1306481"
     exon            1..62
                     /gene="Txk"
                     /inference="alignment:Splign:2.1.0"
     exon            63..237
                     /gene="Txk"
                     /inference="alignment:Splign:2.1.0"
     CDS             167..1747
                     /gene="Txk"
                     /EC_number="2.7.10.1"
                     /codon_start=1
                     /product="tyrosine-protein kinase TXK"
                     /protein_id="NP_001019426.1"
                     /db_xref="GeneID:305311"
                     /db_xref="RGD:1306481"
                     /translation="MISFSDSTFQSILCCCCCCSVQGRRVTTRISLSREEELSEKHSQ
                     RQRQWFSKLMGKSQSSRGGVQPSKRRPLPPLPQEFTEERIRVKALYDFLPREPCNLAL
                     KRAEEYLILERCDPHWWRARDRLGNEGLIPSNYVTENRLTNLETYEWYHKNITRDQTE
                     RLLRQEAKEGAFIVRDSRHLGSYTISVFTRARRHTQSSIKHYQIKKNDSGQWYVTERH
                     LFPSVPELIQYHQYNAAGLMSRLRYPVGLLGSCLPATSGFSYEKWEIDPSELTFVKEI
                     GSGQFGVVYLGEWRARIRVAIKAINEGSMSEEDFIEEAKVMMKLSHSRLVQLYGVCIQ
                     QKPLYIVTEFMENGCLLDYLRERKGKLPKALLLSMCQDICEGMAYLEKSCYIHRDLAA
                     RNCLVSSACVVKISDFGMARYVLDDEYISSSGAKFPVKWSPPEVFHFNKYSSKSDVWS
                     FGVLMWEVFTEGKMPFENKSNLQVVEAISKGFRLYRPHLAPMSIYGVMYSCWHESPKG
                     RPTFAELLQVLAEIAETW"
     exon            238..340
                     /gene="Txk"
                     /inference="alignment:Splign:2.1.0"
     exon            341..543
                     /gene="Txk"
                     /inference="alignment:Splign:2.1.0"
     exon            544..609
                     /gene="Txk"
                     /inference="alignment:Splign:2.1.0"
     exon            610..664
                     /gene="Txk"
                     /inference="alignment:Splign:2.1.0"
     exon            665..744
                     /gene="Txk"
                     /inference="alignment:Splign:2.1.0"
     exon            745..872
                     /gene="Txk"
                     /inference="alignment:Splign:2.1.0"
     exon            873..947
                     /gene="Txk"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1119
                     /gene="Txk"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1336
                     /gene="Txk"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..1401
                     /gene="Txk"
                     /inference="alignment:Splign:2.1.0"
     exon            1402..1520
                     /gene="Txk"
                     /inference="alignment:Splign:2.1.0"
     exon            1521..1678
                     /gene="Txk"
                     /inference="alignment:Splign:2.1.0"
     exon            1679..2281
                     /gene="Txk"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgaagaac caaggcttct gtgtgtgccc agccaacagg gtagccatga tcctgtcctc
       61 ttatggtggt gatgttccca agcctctgac catgtgttgt tccctgttct cgtcgggagc
      121 atagccagag tcgtccacac agtgtcatgg cctcccgact gcgacaatga tctccttttc
      181 agacagcacc ttccagtcta tcctctgttg ctgctgttgc tgctcagtgc aggggagacg
      241 agtgacaaca cggatcagcc taagcagaga ggaagaactc tcagaaaagc attcccagcg
      301 tcagaggcag tggttctcca aactgatggg caaaagtcaa tccagcagag gtggggtgca
      361 accctcaaag cgtaggccac tgcctcccct cccgcaggag tttacagaag agagaatccg
      421 ggtcaaggct ctttatgact tcctgcctcg ggagccctgt aatttggcac tgaagagagc
      481 agaggaatat ctgatattgg agaggtgtga ccctcactgg tggagggcca gagaccgcct
      541 cgggaatgaa ggcttaatcc caagcaacta tgtgacagaa aacagactca ccaatttaga
      601 aacatatgaa tggtatcata agaacatcac tagagaccag acggaacgcc tgttgaggca
      661 ggaggctaaa gaaggtgcat ttatcgtgag agattcgaga catttggggt cttacacaat
      721 ctctgtgttt acaagagcta gaaggcatac acagtcttca ataaaacatt atcagattaa
      781 aaagaatgac tcaggacaat ggtacgtcac cgaaagacac ctctttccct cggttcccga
      841 gttgatccag tatcaccagt acaatgcagc tggtctcatg tcccgtctcc gctatcctgt
      901 tgggctcctg ggcagctgtt taccagccac atctggtttt agctatgaaa agtgggaaat
      961 agatccgtct gagttgactt ttgtcaagga gatcggaagt ggtcagtttg gggtagtcta
     1021 cttaggagag tggagagcac gtatccgggt cgccatcaag gccatcaatg aaggctccat
     1081 gtctgaagaa gatttcattg aggaagccaa ggtgatgatg aagctgtcac actcgaggtt
     1141 agttcaactt tatggggtgt gcatacagca gaagcccctc tacatagtga cggagttcat
     1201 ggaaaatggc tgcctgctcg actatctcag ggagagaaaa ggcaagcttc cgaaggcatt
     1261 gcttttgagc atgtgccagg acatatgtga agggatggcg tacctggaga agagctgcta
     1321 tatccacagg gatctggctg ccaggaactg tttggtcagt tctgcctgcg tagtaaagat
     1381 ctcggacttt gggatggcga ggtacgtttt ggacgatgaa tatatcagtt cttctggagc
     1441 taagttccca gtcaagtggt ccccacctga agtttttcat ttcaacaagt acagtagcaa
     1501 gtctgacgtc tggtcattcg gagttttaat gtgggaagtt tttacagaag gaaaaatgcc
     1561 ctttgagaat aagtccaatt tgcaagtggt ggaagccatt tctaaaggtt tccggctcta
     1621 tcgtcctcac ctggccccca tgtccatata cggagttatg tacagttgct ggcatgagag
     1681 ccctaaaggc cgtccgacat ttgctgagtt gcttcaggtt ctcgcagaga tcgcggaaac
     1741 ctggtgatct aaaacggaac accagcccac agggtcatct tgtaaaactg tcacaaggtg
     1801 gaatcatggg catcactgct ggggagtatc tccacgaggg ttgttgactc ttggtaaagg
     1861 agcaagggtc actggcttgt cacactgatt tcaatgcaaa atgctctgat ggtagtcttt
     1921 gtactgccgt gagagagact tctgaactgc actcctctca cacactccac ttcagccttc
     1981 cagatggctt gctcatgata ggtaccctca cgacccttag agtgacacag acccctgatt
     2041 cttcataagg ctaaggcgac ttctttcttg ggcactgaca tttctgtttg gagtggtcca
     2101 tgcagagagg gggaaaaata ggttctgcca actcatggag taaagaaacc ttcccaacag
     2161 tttcatgttt gggcctgtat aaatgtttat agaaaacata gctttggaaa cctatgtgaa
     2221 cattctggaa atgtctttta taatcttgcc gtatgttatt taataaactc ttttgattat
     2281 taaaaaaaaa aaaaaaaaaa aaaaaaaa
//
