LOCUS       NM_001412824            4031 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus twisted gastrulation BMP signaling modulator 1
            (Twsg1), transcript variant 2, mRNA.
ACCESSION   NM_001412824 XM_039083934
VERSION     NM_001412824.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4031)
  AUTHORS   Tzachanis,D., Li,L., Lafuente,E.M., Berezovskaya,A., Freeman,G.J.
            and Boussiotis,V.A.
  TITLE     Twisted gastrulation (Tsg) is regulated by Tob and enhances
            TGF-beta signaling in activated T lymphocytes
  JOURNAL   Blood 109 (7), 2944-2952 (2007)
   PUBMED   17164348
REFERENCE   2  (bases 1 to 4031)
  AUTHORS   Melnick,M., Petryk,A., Abichaker,G., Witcher,D., Person,A.D. and
            Jaskoll,T.
  TITLE     Embryonic salivary gland dysmorphogenesis in Twisted gastrulation
            deficient mice
  JOURNAL   Arch Oral Biol 51 (5), 433-438 (2006)
   PUBMED   16289463
REFERENCE   3  (bases 1 to 4031)
  AUTHORS   Zakin,L., Reversade,B., Kuroda,H., Lyons,K.M. and De Robertis,E.M.
  TITLE     Sirenomelia in Bmp7 and Tsg compound mutant mice: requirement for
            Bmp signaling in the development of ventral posterior mesoderm
  JOURNAL   Development 132 (10), 2489-2499 (2005)
   PUBMED   15843411
REFERENCE   4  (bases 1 to 4031)
  AUTHORS   Petryk,A., Shimmi,O., Jia,X., Carlson,A.E., Tervonen,L.,
            Jarcho,M.P., O'connor,M.B. and Gopalakrishnan,R.
  TITLE     Twisted gastrulation and chordin inhibit differentiation and
            mineralization in MC3T3-E1 osteoblast-like cells
  JOURNAL   Bone 36 (4), 617-626 (2005)
   PUBMED   15780974
REFERENCE   5  (bases 1 to 4031)
  AUTHORS   Petryk,A., Anderson,R.M., Jarcho,M.P., Leaf,I., Carlson,C.S.,
            Klingensmith,J., Shawlot,W. and O'Connor,M.B.
  TITLE     The mammalian twisted gastrulation gene functions in foregut and
            craniofacial development
  JOURNAL   Dev Biol 267 (2), 374-386 (2004)
   PUBMED   15013800
REFERENCE   6  (bases 1 to 4031)
  AUTHORS   Zakin,L. and De Robertis,E.M.
  TITLE     Inactivation of mouse Twisted gastrulation reveals its role in
            promoting Bmp4 activity during forebrain development
  JOURNAL   Development 131 (2), 413-424 (2004)
   PUBMED   14681194
REFERENCE   7  (bases 1 to 4031)
  AUTHORS   Nosaka,T., Morita,S., Kitamura,H., Nakajima,H., Shibata,F.,
            Morikawa,Y., Kataoka,Y., Ebihara,Y., Kawashima,T., Itoh,T.,
            Ozaki,K., Senba,E., Tsuji,K., Makishima,F., Yoshida,N. and
            Kitamura,T.
  TITLE     Mammalian twisted gastrulation is essential for
            skeleto-lymphogenesis
  JOURNAL   Mol Cell Biol 23 (8), 2969-2980 (2003)
   PUBMED   12665593
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Oct 19, 2022 this sequence version replaced XM_039083934.1.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR26643299.40853.1, SRR26643296.25089.1
                                    [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMEA5760383,
                                    SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-73                JAXUCZ010000009.1  113014243-113014315 c
            74-128              JAXUCZ010000009.1  113012645-113012699 c
            129-285             JAXUCZ010000009.1  113011897-113012053 c
            286-385             JAXUCZ010000009.1  112999485-112999584 c
            386-652             JAXUCZ010000009.1  112984306-112984572 c
            653-4031            JAXUCZ010000009.1  112979972-112983350 c
FEATURES             Location/Qualifiers
     source          1..4031
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q37"
     gene            1..4031
                     /gene="Twsg1"
                     /note="twisted gastrulation BMP signaling modulator 1"
                     /db_xref="GeneID:363294"
                     /db_xref="RGD:1311215"
     exon            1..73
                     /gene="Twsg1"
                     /inference="alignment:Splign:2.1.0"
     exon            74..128
                     /gene="Twsg1"
                     /inference="alignment:Splign:2.1.0"
     exon            129..285
                     /gene="Twsg1"
                     /inference="alignment:Splign:2.1.0"
     CDS             166..834
                     /gene="Twsg1"
                     /note="twisted gastrulation homolog 1; twisted
                     gastrulation protein homolog 1"
                     /codon_start=1
                     /product="twisted gastrulation protein homolog 1
                     precursor"
                     /protein_id="NP_001399753.1"
                     /db_xref="GeneID:363294"
                     /db_xref="RGD:1311215"
                     /translation="MNSHHVVLTLASLMFLMCLPVSQSCNKALCASDVSKCLIQELCQ
                     CRPGEGNCPCCKECMLCLGALWDECCDCVGMCNPRNYSDTPPTSKSTVEELHEPIPSL
                     FRALTEGDTQLNWNIVSFPVAEELTHHENLVSFLETVNQPHHQNVSVPSNNVHAPFPS
                     DKEHMCTVVYFDDCMSIHQCKISCESMGASKYRWFHNACCECVGPECIDYGSKTVKCM
                     NCMF"
     exon            286..385
                     /gene="Twsg1"
                     /inference="alignment:Splign:2.1.0"
     exon            386..652
                     /gene="Twsg1"
                     /inference="alignment:Splign:2.1.0"
     exon            653..4031
                     /gene="Twsg1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgtgtgtcg gcggcgccgg ggttcgcggg agctgcttga aggctcggcc gccgggagga
       61 ggccgcggcc acggtgcccc aggaagtcat aggattccac tcccctccca ctggagataa
      121 agtgacagct tcttggaagc tacggagtga cttccttaaa gaatcatgaa ttcacaccat
      181 gttgtgctaa ctctagcctc cctgatgttc ctgatgtgcc tccctgtgtc acagagctgt
      241 aacaaagcac tctgtgccag cgatgtgagc aagtgcctca ttcaggagct gtgccagtgc
      301 cggcctgggg aaggaaactg cccctgctgt aaggagtgca tgctgtgcct cggggccctg
      361 tgggatgagt gttgcgattg tgtcggtatg tgcaaccctc ggaattacag cgacacacct
      421 cccacttcaa agagcacagt ggaggagctg catgagccca tcccctccct gttcagggcc
      481 ctgacagagg gcgacaccca gctgaactgg aacatcgtgt cctttccggt ggcagaggag
      541 ctgacacacc acgaaaatct cgtctccttt ctagaaaccg tgaaccagcc acatcaccaa
      601 aatgtgtctg ttcccagcaa caatgttcac gccccttttc ccagcgacaa agagcacatg
      661 tgcactgtgg tgtactttga tgactgcatg tccatacacc agtgtaagat ctcctgtgag
      721 tccatgggag cgtccaaata ccgctggttt cacaacgcct gctgcgagtg cgtcggcccg
      781 gagtgcatcg actatggcag caagactgtc aagtgcatga actgcatgtt ttaaagagga
      841 aaagaaatgc acataagcag gtcagttacc aggaggactg cagactactc agtaagccat
      901 ggagtgcaga actcttgaga ctagcatgct aggagtgtgt tagactgtat cattgtgact
      961 gtgctttgta tgtttaatgc cttagcattt gtctgccatt ggattcagta gaactttagt
     1021 cacgtgagaa tcgcgttcag aggagtcctg aaaagatgtg acgacgtctg acaggagggg
     1081 ctgccttctt ccagcttccc aaaggctttt ggttttgagc gtgatagccc aagcctgatg
     1141 catgcatgtg gctctcacct gccagttcta ggatgacagg tagtcgcacc tgtctcgatt
     1201 gtgccttgac tggctcatcg ggtttacatg agtaaacatt gccatctata actctaacag
     1261 ctcacattca aactgtttta cactggcttc agaaagtaaa cgtttactgt atttcaccac
     1321 agaagggttt acctagggcc agcaagctgg ctcaggggat gaacgtgctt gctaccaagc
     1381 ctgaccactg agtctgatcc ccagagccca cattgtggaa ggaaagaacc agctcctgta
     1441 agttgtcctc tgacctccat gcatgtacag tgcatgcata caggtatgca tgtgcgtgca
     1501 cacataaata actacatggt taaaaaatgt aaacctctta caaggtgaaa tctaaatcca
     1561 ccgtgtagtg ctcacgccga cagtgacttt gacagtgtcc gccgaagtgc tgatgcagtg
     1621 gtgtacagag tcaccaccat tcatcagagt ggcagacttg cctctgccga gaactgcatg
     1681 gcacggcttt gaaacggcat caaatgcact gtgaggacct ggatggagaa gtagccaggg
     1741 aagagcagcg gggctgcaga tgaagccaca tgaggaggct ccatgtagag ccccaggtag
     1801 cagccgtctg tccctcttca ggtgcacagc atggctgaat gtgaggctgg caggagagcg
     1861 tctggctcag cagcacaaac cagccagggt ctccagcatg cgtgagaagg gagaggcttg
     1921 aagaaagatt tgcagacatg gtcagagaag ggcaaaaatg ttgggaactc ctagtagggt
     1981 ccaccttaaa gctatgaata gtcactggtt ttgtcacttt gtagcactgc atttgtttct
     2041 ggatatctga atctaaataa gcatcatatt tcaaggagct atatttctga aattacaggg
     2101 gaagctgtgt agtatgttga ctcctagcct actacagaat tatccagtat tttcttctgt
     2161 agtgtttcca gggagacaga cttcaatact gcaacccttc atagtaataa tatccttacc
     2221 tttaagcatg aatcaaagca aatatttaaa tacacagact caattttata gacttgctat
     2281 tttctctagt gcatatctga attaaaagta actttttagg aataatcttt atatgactac
     2341 atattttagt acataaaata gaaaatgttc tcaaacacat tctgtattct catttgacta
     2401 gctacaagac cgtattataa tggctgtcca tgataatatc cgatagatag caggtgggtg
     2461 cgcaaggtct tccagccttg tacgacgctg acttaggccg tgggtgggtg tgattattaa
     2521 acaccagggt cctcccacct ttaccctcag ggccttgcag actcttcagc tccttccttc
     2581 ttagctccca agggctgtgg tcttcttgaa atcaggagga gttctgaagg accacagccg
     2641 ctgttctcaa gaaagtttgt acatgacgga aggatgttct gatggtttcc cgcagtgtgt
     2701 ctcgtggttg ttgttgttgt tgctattgtg gttctttttt gttgtgagac aggatctctg
     2761 tgcagcctgg ccgacctgga atgtgtcgtg tagaccaagc tggctgtcct cgtgttttct
     2821 ctgcgatggc cataaacatt gttcaaatac gtcaccatct ttttaaaact ttcattatta
     2881 aagtttaaaa tatagtgtgt ctttttttac tgtatacatt ttctgtcaac aatttttaaa
     2941 ccatttgctt taactttttt gttgccctgt tcttcccatt agaaatgatc cccactgaga
     3001 taaattttat attcatattt tgtgtatttc tcctgatttg ccaaggcctt gaagaaatag
     3061 cagccattac ctgagaggtt ttattttcag agccaagggt tgtgtgcata cttgtgctcc
     3121 caccacagag aggctgaaca agacaatgtc caatcagagg atccagcctg gccccgagtc
     3181 cattgtgaga catagcctca gacagctcaa gtcctgtatt caatgttttg agtagtggct
     3241 ttttcctaaa ttgaaattaa agatttcaga agctagcagt agcactaagt ttggactttc
     3301 cacagcattc tagcaattac actccttact gaagagttta taatagttat gtttctttct
     3361 caataaaaaa tgatcttgtt tgtcttatag ccagatccaa aaaaacacta gactttaagg
     3421 tctagaggtg ggactgtcac ctgtcctggt gcagcccctg ttccgccctg agcaccaatg
     3481 agagacaagc actggcttgt ggaccagaaa ttgttattaa acttacacgt atttgcttcc
     3541 tatagcaaga catgggctta tgggcaagtt tttctcataa catttatgag aaaacatttt
     3601 ttccccataa catttaatta gggctgaact tactcataat taaggtgcga aggtgaaaag
     3661 aattggagtg aaatgtactg tttgtttgca caggatgctg tgaatgggtc cacacaccaa
     3721 agtataactt gtaatgtttc agaaaatagc gctgttatta gcatatttga acaaatattt
     3781 acaattttaa aaaagcacca aaatagaaaa aaagaaagta aaaatctgga gaatgagagc
     3841 tgagaatggg ctgcggttta aagggctgta cttagaaagc atcttttaaa gactctaaag
     3901 gctttgttca ttcccaagag tctatgttga ttcatttaac gtgaccgacg acttatatct
     3961 atagttgtga atattttcat tggttgtctc tgtaatcaaa aaaaggtatt ttaataaaaa
     4021 atagaaatga c
//
