LOCUS       NM_021691               1200 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus twist family bHLH transcription factor 2
            (Twist2), mRNA.
ACCESSION   NM_021691
VERSION     NM_021691.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1200)
  AUTHORS   Grunz-Borgmann,E.A., Nichols,L.A., Wang,X. and Parrish,A.R.
  TITLE     Twist2 Is Upregulated in Early Stages of Repair Following Acute
            Kidney Injury
  JOURNAL   Int J Mol Sci 18 (2), 368 (2017)
   PUBMED   28208580
  REMARK    GeneRIF: Twist2 gene expression was elevated following injury in
            both young and aged rats, and Twist2 protein expression is elevated
            by mercuric chloride in vitro.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1200)
  AUTHORS   Long,L., Huang,G., Zhu,H., Guo,Y., Liu,Y. and Huo,J.
  TITLE     Down-regulation of miR-138 promotes colorectal cancer metastasis
            via directly targeting TWIST2
  JOURNAL   J Transl Med 11, 275 (2013)
   PUBMED   24171926
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1200)
  AUTHORS   Weaving,L., Mihelec,M., Storen,R., Sosic,D., Grigg,J.R., Tam,P.P.
            and Jamieson,R.V.
  TITLE     Twist2: role in corneal stromal keratocyte proliferation and
            corneal thickness
  JOURNAL   Invest Ophthalmol Vis Sci 51 (11), 5561-5570 (2010)
   PUBMED   20574024
REFERENCE   4  (bases 1 to 1200)
  AUTHORS   Hie,M. and Tsukamoto,I.
  TITLE     Increased expression of the receptor for activation of NF-kappaB
            and decreased runt-related transcription factor 2 expression in
            bone of rats with streptozotocin-induced diabetes
  JOURNAL   Int J Mol Med 26 (4), 611-618 (2010)
   PUBMED   20818503
REFERENCE   5  (bases 1 to 1200)
  AUTHORS   Tukel,T., Sosic,D., Al-Gazali,L.I., Erazo,M., Casasnovas,J.,
            Franco,H.L., Richardson,J.A., Olson,E.N., Cadilla,C.L. and
            Desnick,R.J.
  TITLE     Homozygous nonsense mutations in TWIST2 cause Setleis syndrome
  JOURNAL   Am J Hum Genet 87 (2), 289-296 (2010)
   PUBMED   20691403
REFERENCE   6  (bases 1 to 1200)
  AUTHORS   Bialek,P., Kern,B., Yang,X., Schrock,M., Sosic,D., Hong,N., Wu,H.,
            Yu,K., Ornitz,D.M., Olson,E.N., Justice,M.J. and Karsenty,G.
  TITLE     A twist code determines the onset of osteoblast differentiation
  JOURNAL   Dev Cell 6 (3), 423-435 (2004)
   PUBMED   15030764
REFERENCE   7  (bases 1 to 1200)
  AUTHORS   Lee,Y.S., Lee,H.H., Park,J., Yoo,E.J., Glackin,C.A., Choi,Y.I.,
            Jeon,S.H., Seong,R.H., Park,S.D. and Kim,J.B.
  TITLE     Twist2, a novel ADD1/SREBP1c interacting protein, represses the
            transcriptional activity of ADD1/SREBP1c
  JOURNAL   Nucleic Acids Res 31 (24), 7165-7174 (2003)
   PUBMED   14654692
REFERENCE   8  (bases 1 to 1200)
  AUTHORS   Lee,M.S., Lowe,G., Flanagan,S., Kuchler,K. and Glackin,C.A.
  TITLE     Human Dermo-1 has attributes similar to twist in early bone
            development
  JOURNAL   Bone 27 (5), 591-602 (2000)
   PUBMED   11062344
REFERENCE   9  (bases 1 to 1200)
  AUTHORS   Maestro,R., Dei Tos,A.P., Hamamori,Y., Krasnokutsky,S.,
            Sartorelli,V., Kedes,L., Doglioni,C., Beach,D.H. and Hannon,G.J.
  TITLE     Twist is a potential oncogene that inhibits apoptosis
  JOURNAL   Genes Dev 13 (17), 2207-2217 (1999)
   PUBMED   10485844
REFERENCE   10 (bases 1 to 1200)
  AUTHORS   Li,L., Cserjesi,P. and Olson,E.N.
  TITLE     Dermo-1: a novel twist-related bHLH protein expressed in the
            developing dermis
  JOURNAL   Dev Biol 172 (1), 280-292 (1995)
   PUBMED   7589808
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AI029397.1, BF551124.1, BF550979.1, CB757313.1 and AI030876.1.
            
            On Oct 12, 2007 this sequence version replaced NM_021691.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y08139.1, BF550979.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760384, SAMEA5760434
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-251               AI029397.1         69-319
            252-476             BF551124.1         6-230
            477-783             BF550979.1         170-476
            784-884             CB757313.1         207-307
            885-1200            AI030876.1         1-316               c
FEATURES             Location/Qualifiers
     source          1..1200
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q36"
     gene            1..1200
                     /gene="Twist2"
                     /gene_synonym="Dermo1"
                     /note="twist family bHLH transcription factor 2"
                     /db_xref="GeneID:59327"
                     /db_xref="RGD:621286"
     exon            1..518
                     /gene="Twist2"
                     /gene_synonym="Dermo1"
                     /inference="alignment:Splign:2.1.0"
     CDS             1..483
                     /gene="Twist2"
                     /gene_synonym="Dermo1"
                     /note="dermo-1 protein; twist homolog 2; twist basic
                     helix-loop-helix transcription factor 2"
                     /codon_start=1
                     /product="twist-related protein 2"
                     /protein_id="NP_067723.1"
                     /db_xref="GeneID:59327"
                     /db_xref="RGD:621286"
                     /translation="MEEGSSSPVSPVDSLGTSEEELERQPKRFGRKRRYSKKSSEDGS
                     PTPGKRGKKGSPSAQSFEELQSQRILANVRERQRTQSLNEAFAALRKIIPTLPSDKLS
                     KIQTLKLAARYIDFLYQVLQSDEMDNKMTSCSYVAHERLSYAFSVWRMEGAWSMSASH
                     "
     exon            519..1183
                     /gene="Twist2"
                     /gene_synonym="Dermo1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggaggagg gctccagctc gccggtgtcc cccgtggaca gtctgggcac cagcgaggaa
       61 gagctggagc ggcagcccaa gcgcttcggc cggaagcggc gctacagcaa gaaatcgagc
      121 gaagatggca gcccgacccc gggcaagcgc ggcaagaagg gcagcccgag cgcgcagtcc
      181 ttcgaggagc tgcagagcca gcgcatccta gccaacgtgc gcgagcgcca gcgcacccag
      241 tcgctcaacg aggccttcgc cgcgctgcgc aagatcatcc ccacgctccc ctctgacaag
      301 cttagcaaga tccagacgct caagctggcc gccaggtaca tagacttcct ctaccaggtc
      361 ctgcaaagcg acgagatgga caataagatg accagctgca gctacgtggc tcacgagcgt
      421 ctcagctacg ccttctccgt gtggcgcatg gagggcgcgt ggtccatgtc cgcctcccac
      481 tagcgccgcg ccacccacct ccggagccgc acgccaggac ccacctgcac atctcaggcg
      541 caagaggaac tggatgcgtc cacggctgtg acttttggca cccggacaac cacggctcct
      601 catgacccca acgcccaagt gttcagaggg gacaacagcg gcaggggaca gagagccagg
      661 ttcacatcct tctcagagat acccgtggga tggacaccgg ccttcctgtc agtgacttct
      721 gcgtccttat ctgctcacca ttggattttc ctcctgagct ttagtttggg ggaaactttc
      781 tggaaagttc tagattcagg aatgcatttg taaggatata tattggattg tatttccctc
      841 taagtgcctt tttttttaaa aatgtatatt tttaaataaa acagaagtgc attcttgtag
      901 aacctgttta aactggacca aggctctcag aacaagaacc caagatccct cccaccccag
      961 accttccatg actgtttcga ggaagcctgg aattcttacc cgcacactcc tgttctttac
     1021 ctctccatga tctgctcagc tagccatttt ttatattccc tgttcagtgt atatattgct
     1081 tatttgttta tttattgaga tattttacca gccaagtgac tgccacacgc tgtgtataac
     1141 gctctacacc caggaacaat aaagaggcct gcattgcccc gtgaaaaaaa aaaaaaaaaa
//
