LOCUS       NM_053530               1513 bp    mRNA    linear   ROD 03-SEP-2024
DEFINITION  Rattus norvegicus twist family bHLH transcription factor 1
            (Twist1), mRNA.
ACCESSION   NM_053530 XM_001076553
VERSION     NM_053530.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1513)
  AUTHORS   Wang,Y., Han,D., Chai,L., Qiu,Y., Liu,J., Li,D., Zhang,Q., Shen,N.,
            Chen,Y., Chen,H., Zhang,J., Wang,Q., Wang,J., Li,S., Xie,X. and
            Li,M.
  TITLE     MFN2-dependent mitochondrial dysfunction contributes to
            Relm-beta-induced pulmonary arterial hypertension via
            USP18/Twist1/miR-214 pathway
  JOURNAL   Eur J Pharmacol 980, 176828 (2024)
   PUBMED   39094924
  REMARK    GeneRIF: MFN2-dependent mitochondrial dysfunction contributes to
            Relm-beta-induced pulmonary arterial hypertension via
            USP18/Twist1/miR-214 pathway.
REFERENCE   2  (bases 1 to 1513)
  AUTHORS   Otsuki,T., Fukuda,N., Chen,L., Ueno,T., Otsuki,M. and Abe,M.
  TITLE     TWIST1 transcriptionally upregulates complement 3 in glomerular
            mesangial cells from spontaneously hypertensive rats
  JOURNAL   Hypertens Res 45 (1), 66-74 (2022)
   PUBMED   34616033
  REMARK    GeneRIF: TWIST1 transcriptionally upregulates complement 3 in
            glomerular mesangial cells from spontaneously hypertensive rats.
REFERENCE   3  (bases 1 to 1513)
  AUTHORS   Qiu,J., Shu,C., Li,X., Ye,C. and Zhang,W.C.
  TITLE     Exosomes from linc00511-overexpressing ADSCs accelerates
            angiogenesis in diabetic foot ulcers healing by suppressing
            PAQR3-induced Twist1 degradation
  JOURNAL   Diabetes Res Clin Pract 180, 109032 (2021)
   PUBMED   34461141
  REMARK    GeneRIF: Exosomes from linc00511-overexpressing ADSCs accelerates
            angiogenesis in diabetic foot ulcers healing by suppressing
            PAQR3-induced Twist1 degradation.
REFERENCE   4  (bases 1 to 1513)
  AUTHORS   Xian,S., Chen,A., Wu,X., Lu,C., Wu,Y., Huang,F. and Zeng,Z.
  TITLE     Activation of activin/Smad2 and 3 signaling pathway and
            the&nbsp;potential involvement of endothelial-mesenchymal
            transition in the valvular damage due to rheumatic heart disease
  JOURNAL   Mol Med Rep 23 (1) (2021)
   PUBMED   33179113
REFERENCE   5  (bases 1 to 1513)
  AUTHORS   Guo,Q., Liu,Y., Sun,R., Yang,F., Qiao,P., Zhang,R., Song,L., E,L.
            and Liu,H.
  TITLE     Mechanical stimulation induced osteogenic differentiation of BMSCs
            through TWIST/E2A/p21 axis
  JOURNAL   Biosci Rep 40 (5) (2020)
   PUBMED   32309849
  REMARK    GeneRIF: Mechanical stimulation induced osteogenic differentiation
            of BMSCs through TWIST/E2A/p21 axis.
REFERENCE   6  (bases 1 to 1513)
  AUTHORS   Howard,T.D., Paznekas,W.A., Green,E.D., Chiang,L.C., Ma,N., Ortiz
            de Luna,R.I., Garcia Delgado,C., Gonzalez-Ramos,M., Kline,A.D. and
            Jabs,E.W.
  TITLE     Mutations in TWIST, a basic helix-loop-helix transcription factor,
            in Saethre-Chotzen syndrome
  JOURNAL   Nat Genet 15 (1), 36-41 (1997)
   PUBMED   8988166
REFERENCE   7  (bases 1 to 1513)
  AUTHORS   Alborzi,A., Mac,K., Glackin,C.A., Murray,S.S. and Zernik,J.H.
  TITLE     Endochondral and intramembranous fetal bone development:
            osteoblastic cell proliferation, and expression of alkaline
            phosphatase, m-twist, and histone H4
  JOURNAL   J Craniofac Genet Dev Biol 16 (2), 94-106 (1996)
   PUBMED   8773900
REFERENCE   8  (bases 1 to 1513)
  AUTHORS   Rohwedel,J., Horak,V., Hebrok,M., Fuchtbauer,E.M. and Wobus,A.M.
  TITLE     M-twist expression inhibits mouse embryonic stem cell-derived
            myogenic differentiation in vitro
  JOURNAL   Exp Cell Res 220 (1), 92-100 (1995)
   PUBMED   7664846
REFERENCE   9  (bases 1 to 1513)
  AUTHORS   Chen,Z.F. and Behringer,R.R.
  TITLE     twist is required in head mesenchyme for cranial neural tube
            morphogenesis
  JOURNAL   Genes Dev 9 (6), 686-699 (1995)
   PUBMED   7729687
REFERENCE   10 (bases 1 to 1513)
  AUTHORS   Hebrok,M., Wertz,K. and Fuchtbauer,E.M.
  TITLE     M-twist is an inhibitor of muscle differentiation
  JOURNAL   Dev Biol 165 (2), 537-544 (1994)
   PUBMED   7958419
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AJ131845.1, BQ206289.1 and BF420349.1.
            
            On or before Jun 25, 2006 this sequence version replaced
            XM_001076553.1, NM_053530.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166412.1, DV714650.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-779               AJ131845.1         57-835
            780-1003            BQ206289.1         493-716             c
            1004-1292           AJ131845.1         1557-1845
            1293-1513           BF420349.1         1-221               c
FEATURES             Location/Qualifiers
     source          1..1513
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q16"
     gene            1..1513
                     /gene="Twist1"
                     /gene_synonym="Twist"
                     /note="twist family bHLH transcription factor 1"
                     /db_xref="GeneID:85489"
                     /db_xref="RGD:621455"
     exon            1..831
                     /gene="Twist1"
                     /gene_synonym="Twist"
                     /inference="alignment:Splign:2.1.0"
     CDS             179..790
                     /gene="Twist1"
                     /gene_synonym="Twist"
                     /note="twist gene homolog 1; twist homolog 1; twist basic
                     helix-loop-helix transcription factor 1"
                     /codon_start=1
                     /product="twist-related protein 1"
                     /protein_id="NP_445982.1"
                     /db_xref="GeneID:85489"
                     /db_xref="RGD:621455"
                     /translation="MMQDVSSSPVSPADDSLSNSEEEPDRQQPASGKRGARKRRSSRR
                     SAGGSAGPGGATGGGIGGGDEPGSPAQGKRGKKSAGGGGGAGGGGGGGGSSSGGGSPQ
                     SYEELQTQRVMANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYIDFL
                     YQVLQSDELDSKMASCSYVAHERLSYAFSVWRMEGAWSMSASH"
     exon            832..1498
                     /gene="Twist1"
                     /gene_synonym="Twist"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgcctccag cgccctcccc gcggaggtcc cccccccatc ccgcctccct gcgtcctccg
       61 ggccgcaccg cccgggccgg cgccgagcgc ggggaagctg gcgggttagg gcgccccgct
      121 cctctgctat tccctccccc gtcccggctc cgcgaggccg caggtcgccg cccgcgagat
      181 gatgcaggac gtgtccagct cgccagtctc gccggccgac gacagcctga gcaacagcga
      241 ggaggagccg gaccggcagc agccggcgag cggcaagcgg ggggctcgca agagacgcag
      301 cagtcggcgc agcgcgggcg gcagcgcggg gcccggcggg gccacgggcg ggggcatcgg
      361 aggcggcgac gagccgggca gcccggccca gggcaagcgc ggcaagaaat ctgcgggcgg
      421 aggcggcggc gcgggcggag gcggcggcgg cggcggcagc agcagcgggg gcgggagccc
      481 gcagtcgtac gaggagctgc agacacagcg ggtcatggcc aacgtgcggg agcgccagcg
      541 cacccagtcg ctgaacgagg catttgccgc cctgcgcaag atcatcccca cgctgccctc
      601 ggacaagctg agcaagattc agaccctcaa actggcggcc aggtacatcg acttcctgta
      661 ccaggtcctg cagagcgacg agctggactc caagatggca agctgcagct atgtggccca
      721 cgagcggctc agctacgcct tctccgtctg gaggatggag ggggcctggt ccatgtccgc
      781 gtcccactag caggcggagc tccccacccc ctcggcaggc cggagaccta gatgtcattg
      841 tttccagaga aggagaacat ggacagtcta gagactctgg agctggataa ctaaaaataa
      901 atctatatga caaagatttt cttggaaatt agaagagcag agaccaaatt tcacaagaat
      961 cagggcgtgg ggcacacttt taaaagagaa agcgagacag gccggtggac agagattccc
     1021 agaggcaacg gcatcaccct cacacctctg cattctgata gaagtctgaa cactcgtttg
     1081 tgtgtccccc ccttttgacg aagaatgttt tatttttatt tttcatgcat gcattctcaa
     1141 gaggtcttgc caatcagtca ctgataggaa agacatcctt gtggactttc tccattttaa
     1201 aatggtaaca atcagaggaa ttttaacaac gcctttagaa ataaaaacgc tgggatcaaa
     1261 ctggcctgca aaatcataag tcagtgaatt ccttaaaaag catacttcct ctgaaggaaa
     1321 agaaaaacac agaatacaaa agacaacatt ctatttattt attgatgacc catggtaaaa
     1381 tgcaaataga tccggtgtct aaatgcattc atatttttat gactgttttg taaatatctt
     1441 ttgtatatta tttttctgca ataaataaat atgattgaaa aattttaaga actttaaaaa
     1501 aaaaaaaaaa aaa
//
