LOCUS       NM_001135238            1582 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus twinfilin actin-binding protein 2 (Twf2), mRNA.
ACCESSION   NM_001135238 XM_001070490 XM_001070530
VERSION     NM_001135238.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1582)
  AUTHORS   Guo Z, Neilson LJ, Zhong H, Murray PS, Zanivan S and Zaidel-Bar R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1582)
  AUTHORS   Castello A, Fischer B, Eichelbaum K, Horos R, Beckmann BM, Strein
            C, Davey NE, Humphreys DT, Preiss T, Steinmetz LM, Krijgsveld J and
            Hentze MW.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   3  (bases 1 to 1582)
  AUTHORS   Peng AW, Belyantseva IA, Hsu PD, Friedman TB and Heller S.
  TITLE     Twinfilin 2 regulates actin filament lengths in cochlear
            stereocilia
  JOURNAL   J Neurosci 29 (48), 15083-15088 (2009)
   PUBMED   19955359
REFERENCE   4  (bases 1 to 1582)
  AUTHORS   Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE and
            Yates JR.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   5  (bases 1 to 1582)
  AUTHORS   Nevalainen EM, Skwarek-Maruszewska A, Braun A, Moser M and
            Lappalainen P.
  TITLE     Two biochemically distinct and tissue-specific twinfilin isoforms
            are generated from the mouse Twf2 gene by alternative promoter
            usage
  JOURNAL   Biochem J 417 (2), 593-600 (2009)
   PUBMED   18837697
  REMARK    GeneRIF: like Twf1, mouse Twf2 is a filament barbed-end capping
            protein, and that two tissue-specific and biochemically distinct
            isoforms are generated from the Twf2 gene through alternative
            promoter usage.
REFERENCE   6  (bases 1 to 1582)
  AUTHORS   Yamada S, Uchimura E, Ueda T, Nomura T, Fujita S, Matsumoto K,
            Funeriu DP, Miyake M and Miyake J.
  TITLE     Identification of twinfilin-2 as a factor involved in neurite
            outgrowth by RNAi-based screen
  JOURNAL   Biochem Biophys Res Commun 363 (4), 926-930 (2007)
   PUBMED   17910947
REFERENCE   7  (bases 1 to 1582)
  AUTHORS   Vartiainen MK, Sarkkinen EM, Matilainen T, Salminen M and
            Lappalainen P.
  TITLE     Mammals have two twinfilin isoforms whose subcellular localizations
            and tissue distributions are differentially regulated
  JOURNAL   J Biol Chem 278 (36), 34347-34355 (2003)
   PUBMED   12807912
REFERENCE   8  (bases 1 to 1582)
  AUTHORS   Rohwer A, Kittstein W, Marks F and Gschwendt M.
  TITLE     Cloning, expression and characterization of an A6-related protein
  JOURNAL   Eur J Biochem 263 (2), 518-525 (1999)
   PUBMED   10406962
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473954.2.
            
            On or before Sep 28, 2008 this sequence version replaced
            XM_001070530.1, XM_001070490.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC158614.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132264, SAMD00132266
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1582
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..1582
                     /gene="Twf2"
                     /note="twinfilin actin-binding protein 2"
                     /db_xref="GeneID:684352"
                     /db_xref="RGD:1591460"
     exon            1..177
                     /gene="Twf2"
                     /inference="alignment:Splign:2.1.0"
     CDS             153..1202
                     /gene="Twf2"
                     /codon_start=1
                     /product="twinfilin-2"
                     /protein_id="NP_001128710.1"
                     /db_xref="GeneID:684352"
                     /db_xref="RGD:1591460"
                     /translation="MAHQTGIHATEELKEFFAKARAGSIRLIKVIIEDEQLVLGASQE
                     PVGRWDQDYDRAVLPLLDAQEPCYLLFRLDSQNAQGFEWLFLAWSPDNSPVRLKMLYA
                     ATRATVKKEFGGGHIKDELFGTVKDDLSLAGYQKHLSSCAAPAPLTSAERELQQIRIN
                     EVKTEISVESKHQTLQGLAFPLQPEAQRALQQLKQKTVNYIQLKLDLERETIELVHTE
                     PTNVAQLPSRVPRDAARYHFFLYKHTHEGDSLESVVFIYSMPGYKCSIKERMLYSSCK
                     SRLLDSVEQDFQLEIAKKIEIGDGAELTAEFLYDEVHPKQHAFKQAFAKPKGPGGKRG
                     HKRLIRGPGENGEDS"
     exon            178..255
                     /gene="Twf2"
                     /inference="alignment:Splign:2.1.0"
     exon            256..434
                     /gene="Twf2"
                     /inference="alignment:Splign:2.1.0"
     exon            435..530
                     /gene="Twf2"
                     /inference="alignment:Splign:2.1.0"
     exon            531..635
                     /gene="Twf2"
                     /inference="alignment:Splign:2.1.0"
     exon            636..761
                     /gene="Twf2"
                     /inference="alignment:Splign:2.1.0"
     exon            762..912
                     /gene="Twf2"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1034
                     /gene="Twf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1582
                     /gene="Twf2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggggcgggt cctgcggcac cgcccgggaa gctgcgcgaa gctcggcgcc gtcgccacat
       61 cctccggagc tctgggtcca ggcgagccga gtcgagccgg gccaggacct agcggagagc
      121 tccgacggca cgggcgagcc gaacgctgag ccatggcgca ccagaccggc atccacgcca
      181 ctgaagagct aaaggaattc tttgccaagg cccgggctgg ctccatccga cttatcaaag
      241 tcatcattga ggacgagcag ctcgtgctgg gtgcctcgca ggagccagtg ggacgctggg
      301 accaggacta cgacagggcc gtgctaccgc tgctagatgc ccaagagccc tgctacctcc
      361 tcttccgact tgattcgcag aatgcccagg gtttcgagtg gcttttcctg gcctggtcac
      421 ctgacaattc gcctgtgcgg ctgaagatgc tgtatgcagc cacacgagcc acagttaaga
      481 aggagtttgg aggtggccac atcaaggatg agctcttcgg gacagtaaag gatgacctct
      541 ccttggctgg gtaccagaag cacctgtcat cctgtgctgc accggcccca ctgacttccg
      601 ccgagcgaga gctccagcag atccgaatca atgaggtgaa gactgagatc agtgtggaga
      661 gtaagcacca gaccctgcag ggcctggcct tccccctgca gcctgaggcc cagcgggcac
      721 ttcagcaact caagcagaag acggtcaact atatccagct gaagctggac ctggaacggg
      781 agaccatcga gctggtacac acagaaccca caaatgtggc ccagctgccc tcacgggtac
      841 cccgagatgc tgcccgctac cacttcttcc tgtataagca tacccatgag ggtgactccc
      901 tcgaatctgt ggtgttcatc tactccatgc cggggtacaa gtgcagcatt aaggagcgca
      961 tgctctactc cagctgcaag agccgcctcc ttgactctgt ggagcaggac ttccagctgg
     1021 agatcgctaa gaagattgag atcggcgatg gggcggagct caccgccgag ttcctctatg
     1081 atgaggtgca tcccaagcag cacgccttca agcaggcatt cgccaagccc aaaggccctg
     1141 gaggcaagcg gggccacaag cgcctcatcc ggggccccgg ggagaatggg gaagacagct
     1201 aggtgtctgg cctgggaaca gggcagggca catggactgc agggttgcca cccgtcaccc
     1261 ctgcgcttcc ttcctccccg gcctgggctc taaggaaccg cttcctgtgg gacaggagga
     1321 caggtggctg agcacatttg ctacttctga gggcctctgg accagcactt cgtgacctcg
     1381 ccctgtcact gttcctgact ctcctctgtg tgcacagccc ccctggtgca cacctagcct
     1441 ccagacgatt tcatgctatg gttccagccc agtccaaaag ccgttggcta cagagggtgg
     1501 ggacagttgg caggggccag atatcacagg aagggttggt tgaatgctgt attttgtaaa
     1561 gaataaaata tttttaaatc aa
//
