LOCUS       NM_001008521            2875 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus twinfilin actin-binding protein 1 (Twf1), mRNA.
ACCESSION   NM_001008521 XM_235613
VERSION     NM_001008521.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2875)
  AUTHORS   Wang,Y.J., Yu,C., Wu,W.W., Ju,Y.Y., Liu,Y., Xu,C., Long,J.D.,
            Zan,G.Y., Wei,X.Y., Zhang,L.S., Chai,J.R., Chen,Z. and Liu,J.G.
  TITLE     Alteration of twinfilin1 expression underlies opioid
            withdrawal-induced remodeling of actin cytoskeleton at synapses and
            formation of aversive memory
  JOURNAL   Mol Psychiatry 26 (11), 6218-6236 (2021)
   PUBMED   33963280
  REMARK    GeneRIF: Alteration of twinfilin1 expression underlies opioid
            withdrawal-induced remodeling of actin cytoskeleton at synapses and
            formation of aversive memory.
REFERENCE   2  (bases 1 to 2875)
  AUTHORS   Rainger,J., Williamson,K.A., Soares,D.C., Truch,J., Kurian,D.,
            Gillessen-Kaesbach,G., Seawright,A., Prendergast,J., Halachev,M.,
            Wheeler,A., McTeir,L., Gill,A.C., van Heyningen,V., Davey,M.G. and
            FitzPatrick,D.R.
  CONSRTM   UK10K
  TITLE     A recurrent de novo mutation in ACTG1 causes isolated ocular
            coloboma
  JOURNAL   Hum Mutat 38 (8), 942-946 (2017)
   PUBMED   28493397
REFERENCE   3  (bases 1 to 2875)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2875)
  AUTHORS   Kuo,J.C., Han,X., Hsiao,C.T., Yates,J.R. 3rd and Waterman,C.M.
  TITLE     Analysis of the myosin-II-responsive focal adhesion proteome
            reveals a role for beta-Pix in negative regulation of focal
            adhesion maturation
  JOURNAL   Nat Cell Biol 13 (4), 383-393 (2011)
   PUBMED   21423176
REFERENCE   5  (bases 1 to 2875)
  AUTHORS   Li,Q., Song,X.W., Zou,J., Wang,G.K., Kremneva,E., Li,X.Q., Zhu,N.,
            Sun,T., Lappalainen,P., Yuan,W.J., Qin,Y.W. and Jing,Q.
  TITLE     Attenuation of microRNA-1 derepresses the cytoskeleton regulatory
            protein twinfilin-1 to provoke cardiac hypertrophy
  JOURNAL   J Cell Sci 123 (Pt 14), 2444-2452 (2010)
   PUBMED   20571053
  REMARK    Erratum:[J Cell Sci. 2010 Aug 1;123(Pt 15):2680]
REFERENCE   6  (bases 1 to 2875)
  AUTHORS   Vartiainen,M.K., Sarkkinen,E.M., Matilainen,T., Salminen,M. and
            Lappalainen,P.
  TITLE     Mammals have two twinfilin isoforms whose subcellular localizations
            and tissue distributions are differentially regulated
  JOURNAL   J Biol Chem 278 (36), 34347-34355 (2003)
   PUBMED   12807912
REFERENCE   7  (bases 1 to 2875)
  AUTHORS   Palmgren,S., Ojala,P.J., Wear,M.A., Cooper,J.A. and Lappalainen,P.
  TITLE     Interactions with PIP2, ADP-actin monomers, and capping protein
            regulate the activity and localization of yeast twinfilin
  JOURNAL   J Cell Biol 155 (2), 251-260 (2001)
   PUBMED   11604420
REFERENCE   8  (bases 1 to 2875)
  AUTHORS   Vartiainen,M., Ojala,P.J., Auvinen,P., Peranen,J. and
            Lappalainen,P.
  TITLE     Mouse A6/twinfilin is an actin monomer-binding protein that
            localizes to the regions of rapid actin dynamics
  JOURNAL   Mol Cell Biol 20 (5), 1772-1783 (2000)
   PUBMED   10669753
REFERENCE   9  (bases 1 to 2875)
  AUTHORS   Rohwer,A., Kittstein,W., Marks,F. and Gschwendt,M.
  TITLE     Cloning, expression and characterization of an A6-related protein
  JOURNAL   Eur J Biochem 263 (2), 518-525 (1999)
   PUBMED   10406962
REFERENCE   10 (bases 1 to 2875)
  AUTHORS   Beeler,J.F., Patel,B.K., Chedid,M. and LaRochelle,W.J.
  TITLE     Cloning and characterization of the mouse homolog of the human A6
            gene
  JOURNAL   Gene 193 (1), 31-37 (1997)
   PUBMED   9249064
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001008521.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC086536.1, SRR26643429.28537.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                JAXUCZ010000007.1  127607076-127607105 c
            31-108              JAXUCZ010000007.1  127605564-127605641 c
            109-287             JAXUCZ010000007.1  127603715-127603893 c
            288-383             JAXUCZ010000007.1  127602603-127602698 c
            384-488             JAXUCZ010000007.1  127601613-127601717 c
            489-614             JAXUCZ010000007.1  127599984-127600109 c
            615-765             JAXUCZ010000007.1  127598336-127598486 c
            766-887             JAXUCZ010000007.1  127598068-127598189 c
            888-2875            JAXUCZ010000007.1  127595210-127597197 c
FEATURES             Location/Qualifiers
     source          1..2875
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q35"
     gene            1..2875
                     /gene="Twf1"
                     /gene_synonym="Ptk9"
                     /note="twinfilin actin-binding protein 1"
                     /db_xref="GeneID:315265"
                     /db_xref="RGD:1311872"
     exon            1..30
                     /gene="Twf1"
                     /gene_synonym="Ptk9"
                     /inference="alignment:Splign:2.1.0"
     CDS             6..1058
                     /gene="Twf1"
                     /gene_synonym="Ptk9"
                     /note="twinfilin, actin-binding protein, homolog 1;
                     protein tyrosine kinase 9"
                     /codon_start=1
                     /product="twinfilin-1"
                     /protein_id="NP_001008521.1"
                     /db_xref="GeneID:315265"
                     /db_xref="RGD:1311872"
                     /translation="MSHQTGIQASEDVKEIFARARNGKYRLLKISIENEQLVVGSCSP
                     PSDSWEQDYDPFVLPLLEDKQPCYVLFRLDSQNAQGYEWIFIAWSPDHSHVRQKMLYA
                     ATRATLKKEFGGGHIKDEVFGTVKEDVSLHGYRKYLLSQSSPAPLTAAEEELRQIKIS
                     EVQTDVSVDTKHQTLQGVAFPISRDAFQALEKLSKRQLNYVQLEIDIKNETIILANTE
                     NTELKDLPKRIPKDSARYHFFLYKHSHEGDYLESIVFIYSMPGYTCSIRERMLYSSCK
                     SPLLDIVERQLQMDVIRKIEIDNGDELTADFLYDEVHPKQHAHKQSFAKPKGPAGKRG
                     IRRLIRGPAEAEATTD"
     exon            31..108
                     /gene="Twf1"
                     /gene_synonym="Ptk9"
                     /inference="alignment:Splign:2.1.0"
     exon            109..287
                     /gene="Twf1"
                     /gene_synonym="Ptk9"
                     /inference="alignment:Splign:2.1.0"
     exon            288..383
                     /gene="Twf1"
                     /gene_synonym="Ptk9"
                     /inference="alignment:Splign:2.1.0"
     exon            384..488
                     /gene="Twf1"
                     /gene_synonym="Ptk9"
                     /inference="alignment:Splign:2.1.0"
     exon            489..614
                     /gene="Twf1"
                     /gene_synonym="Ptk9"
                     /inference="alignment:Splign:2.1.0"
     exon            615..765
                     /gene="Twf1"
                     /gene_synonym="Ptk9"
                     /inference="alignment:Splign:2.1.0"
     exon            766..887
                     /gene="Twf1"
                     /gene_synonym="Ptk9"
                     /inference="alignment:Splign:2.1.0"
     exon            888..2875
                     /gene="Twf1"
                     /gene_synonym="Ptk9"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcgccatgtc ccaccagacc ggcatccaag caagtgaaga cgtcaaagag atctttgcca
       61 gagccagaaa tgggaaatac cgacttctaa aaatatcgat tgaaaatgag caactggtgg
      121 tcgggtcctg tagtccgcct tcagattcct gggaacagga ttacgatccc tttgtcttgc
      181 ccctgctgga ggacaagcaa ccgtgctatg tgttattcag gttagattct cagaatgccc
      241 agggatatga gtggatattc attgcatggt ctccagatca ttctcatgtt cgtcaaaaaa
      301 tgctgtatgc ggcaacaaga gcaactctga aaaaagaatt tggaggtggc cacattaaag
      361 atgaagtgtt tggaacagta aaggaggacg tatcactaca tggatataga aagtatcttc
      421 tctcccagtc ttctcctgcc cctctgactg cagcagagga agaattaagg cagattaaaa
      481 tcagtgaggt acaaactgac gtgagtgtgg acacaaagca tcagacacta caaggagtag
      541 catttcctat ttctcgagat gccttccagg ctttggaaaa actgagtaag agacagctca
      601 actatgtgca gttggaaata gatataaaaa atgaaacaat aattttggcc aacacagaaa
      661 atacagaact aaaagatttg ccaaagagga ttcccaagga ttcagcacgc taccatttct
      721 ttctgtataa gcattcccac gaaggagact acttagagtc catagttttt atttattcaa
      781 tgcccggata cacatgcagc ataagagagc ggatgctgta ttccagctgc aagagccctc
      841 tgttagatat tgtagaaaga caactgcaga tggatgtgat cagaaagatt gagatagaca
      901 atggggatga actgaccgca gatttcctgt acgatgaagt ccatcccaag cagcatgcac
      961 ataagcagag ttttgctaaa ccaaagggtc ctgcgggaaa gagagggatt agaagattga
     1021 ttaggggtcc agcggaagca gaagccacta ctgattaaaa ttgtcttatt aaatgttgca
     1081 atatagtttt gtaagatttc cagcttttag tacaaggaga actgaaatca ttccatgttg
     1141 atatagttgg gaggaaaatt gtactttttg aaaaatagca cttttcactt ctatgtattt
     1201 tttaaattaa tgctatagaa gactcatggt ttttattttt tagttaaagc tagacaaggt
     1261 ttcaacatag taatgtttgg ttttgtcaca ctgttttcat agcgtgttga ttccacactt
     1321 tcacataatc ttcaacgaaa gcgtaaggac ttgcttttta gaactctgta gtgagttctg
     1381 tttgcctata agggaagtgg aacaaccgag acactcgcac ttctttcgag tgttaaggag
     1441 cctgggagga gcaggcagcc gcttgctttg agcatgctca ggtggggctg tccgccgctg
     1501 tggggaaggc accctgcagc agggcttcct gccccacctc tccattgtag tagtgtccag
     1561 atctcagaaa cgcagcttga acccagcttc aaaggtacca gatgcctcag gctttctcat
     1621 ggcgctggaa gactgcagtc ttgtaaggtc tttgcagagc tctcagttga cgatttccaa
     1681 agggattgtg aaaagactgt gaagccagat gttcaccttc agatggagat tcaagtgtca
     1741 ttaaagagaa acaactaaag gaagtgtctg acctttcaag gttttttggt ttttcttttt
     1801 cttttctttt tttttttttg tatttttttc ttctctttga aaccatgtgt cttaaaggag
     1861 attgtcatat tgcttgggag caagttttca gacctaaaat tattgatttc taatacttag
     1921 taggctagca cagagaatac gtagcctaag gctcttttgt caattaataa tgcctcggaa
     1981 cacgggcttt ctgaagcttg gttactttca gttaaaacct aaagagtttg agcctcaaga
     2041 gttcattgtt acttgaaata gagggagtta gaacacttgg tatttaatct gctaaacctg
     2101 ctgcagagcc ataactcaga agtttggaag cggactgacg tgtccgggat ttggaagacc
     2161 ttgacctgaa cctcatgctg cctgagatgg tgtcagtaac gtacatttca tggaatgaac
     2221 tatgaagcac ccattgcaga gccttattac ctaaggtaat acatgcgcct ttcagaaatt
     2281 cagtgtggac tcacctagat cacagaggaa ttacgagctg atggaagttt ttaaaaatag
     2341 atttgtgtgt tttgtttgtt tacaaatacg tagactttac tacttaaata tgcaggagag
     2401 ttgacagtaa tgttgctctt gtttacgaga ggtaaacttt ttagtcgtgc gtgtgtacac
     2461 gtcatcacac gtgcccatag agtgctgcag cgagagacct ggagctgtga cgcagacctt
     2521 ccagagctgc cgtttcaagc agagggggtg ctttgcgtcc tgggtccaga cccggtgggg
     2581 actgttctga agcagtgtgt gcaatgatgc gctgaagcct gtcacactac agcggtcact
     2641 gacattccac agagatgtga ccttgtaacc tactaataat caaaccaatg attgctgaga
     2701 atcacgtatg catttgtctt agggaataac ccattgttta cagtatgttt taggtgacaa
     2761 tagatgtgaa taacattccc aataaattta tatagcagtg aaaaatgaca tgtcttctgt
     2821 ggacatttta taagtgcatt ttatatcaat aaaatttttc tctttgagtt gtgta
//
