LOCUS       NM_001107953            5156 bp    mRNA    linear   ROD 11-APR-2024
DEFINITION  Rattus norvegicus terminal uridylyl transferase 4 (Tut4),
            transcript variant 1, mRNA.
ACCESSION   NM_001107953 XM_001060223 XM_001060286 XM_233345
VERSION     NM_001107953.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5156)
  AUTHORS   Warkocki,Z., Krawczyk,P.S., Adamska,D., Bijata,K.,
            Garcia-Perez,J.L. and Dziembowski,A.
  TITLE     Uridylation by TUT4/7 Restricts Retrotransposition of Human LINE-1s
  JOURNAL   Cell 174 (6), 1537-1548 (2018)
   PUBMED   30122351
REFERENCE   2  (bases 1 to 5156)
  AUTHORS   Morgan,M., Much,C., DiGiacomo,M., Azzi,C., Ivanova,I.,
            Vitsios,D.M., Pistolic,J., Collier,P., Moreira,P.N., Benes,V.,
            Enright,A.J. and O'Carroll,D.
  TITLE     mRNA 3' uridylation and poly(A) tail length sculpt the mammalian
            maternal transcriptome
  JOURNAL   Nature 548 (7667), 347-351 (2017)
   PUBMED   28792939
REFERENCE   3  (bases 1 to 5156)
  AUTHORS   Faehnle,C.R., Walleshauser,J. and Joshua-Tor,L.
  TITLE     Multi-domain utilization by TUT4 and TUT7 in control of let-7
            biogenesis
  JOURNAL   Nat Struct Mol Biol 24 (8), 658-665 (2017)
   PUBMED   28671666
REFERENCE   4  (bases 1 to 5156)
  AUTHORS   Kim,B., Ha,M., Loeff,L., Chang,H., Simanshu,D.K., Li,S., Fareh,M.,
            Patel,D.J., Joo,C. and Kim,V.N.
  TITLE     TUT7 controls the fate of precursor microRNAs by using three
            different uridylation mechanisms
  JOURNAL   EMBO J 34 (13), 1801-1815 (2015)
   PUBMED   25979828
REFERENCE   5  (bases 1 to 5156)
  AUTHORS   Fu,X., Meng,Z., Liang,W., Tian,Y., Wang,X., Han,W., Lou,G.,
            Wang,X., Lou,F., Yen,Y., Yu,H., Jove,R. and Huang,W.
  TITLE     miR-26a enhances miRNA biogenesis by targeting Lin28B and Zcchc11
            to suppress tumor growth and metastasis
  JOURNAL   Oncogene 33 (34), 4296-4306 (2014)
   PUBMED   24056962
REFERENCE   6  (bases 1 to 5156)
  AUTHORS   Jones,M.R., Quinton,L.J., Blahna,M.T., Neilson,J.R., Fu,S.,
            Ivanov,A.R., Wolf,D.A. and Mizgerd,J.P.
  TITLE     Zcchc11-dependent uridylation of microRNA directs cytokine
            expression
  JOURNAL   Nat Cell Biol 11 (9), 1157-1163 (2009)
   PUBMED   19701194
REFERENCE   7  (bases 1 to 5156)
  AUTHORS   Heo,I., Joo,C., Kim,Y.K., Ha,M., Yoon,M.J., Cho,J., Yeom,K.H.,
            Han,J. and Kim,V.N.
  TITLE     TUT4 in concert with Lin28 suppresses microRNA biogenesis through
            pre-microRNA uridylation
  JOURNAL   Cell 138 (4), 696-708 (2009)
   PUBMED   19703396
REFERENCE   8  (bases 1 to 5156)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   9  (bases 1 to 5156)
  AUTHORS   Mullen,T.E. and Marzluff,W.F.
  TITLE     Degradation of histone mRNA requires oligouridylation followed by
            decapping and simultaneous degradation of the mRNA both 5' to 3'
            and 3' to 5'
  JOURNAL   Genes Dev 22 (1), 50-65 (2008)
   PUBMED   18172165
REFERENCE   10 (bases 1 to 5156)
  AUTHORS   Minoda,Y., Saeki,K., Aki,D., Takaki,H., Sanada,T., Koga,K.,
            Kobayashi,T., Takaesu,G. and Yoshimura,A.
  TITLE     A novel Zinc finger protein, ZCCHC11, interacts with TIFA and
            modulates TLR signaling
  JOURNAL   Biochem Biophys Res Commun 344 (3), 1023-1030 (2006)
   PUBMED   16643855
  REMARK    Erratum:[Biochem Biophys Res Commun. 2007 Feb 23;353(4):1121]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474008.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001060223.1, XM_233345.4, XM_001060286.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
FEATURES             Location/Qualifiers
     source          1..5156
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q34"
     gene            1..5156
                     /gene="Tut4"
                     /gene_synonym="Zcchc11"
                     /note="terminal uridylyl transferase 4"
                     /db_xref="GeneID:313481"
                     /db_xref="RGD:1310138"
     exon            1..169
                     /gene="Tut4"
                     /gene_synonym="Zcchc11"
                     /inference="alignment:Splign:2.1.0"
     exon            170..1044
                     /gene="Tut4"
                     /gene_synonym="Zcchc11"
                     /inference="alignment:Splign:2.1.0"
     CDS             261..4640
                     /gene="Tut4"
                     /gene_synonym="Zcchc11"
                     /EC_number="2.7.7.52"
                     /note="isoform 1 is encoded by transcript variant 1;
                     terminal uridylyltransferase 4; zinc finger, CCHC domain
                     containing 11; zinc finger CCHC-type containing 11"
                     /codon_start=1
                     /product="terminal uridylyltransferase 4 isoform 1"
                     /protein_id="NP_001101423.1"
                     /db_xref="GeneID:313481"
                     /db_xref="RGD:1310138"
                     /translation="MEEPKTSKNENHEPKKNIICEESKAVKIITNQTLKPRNDKSMTE
                     IGTSSLNRNSSKKTKQNDICIEKTEAKSCKVNAASVPGPKDLGLVLRDQSHCKVKKLP
                     NSPMKAQKGSSQTKLEKAPSLQAKAEKVPKSPNLPVKVEKTPCTTAAATTEKALNSQR
                     KEENVPTSQMKLQKTPRSPLEPENVPSLLLKENVKQTESQQTGKKLTSSFVSMDKRNS
                     AALQGEKSTLENSSLSQKQQTQADNIADSDDSASGMEDTSDDLSKMKNEESNKENSSE
                     MDYLENATVIDESTLTPEQKLGLKQAEERLERDHIFRLEKRSPEYTNCRYLCKLCLIH
                     IENIQGAHKHIKEKRHKKNILEKQEESELRSLPSPSPAHLAALSVAVVELAKEQGITD
                     DDLRIRQDIVEEMSKVIVTFLPALYVDVESDFHAKVPVVVCKDRKSGLLCRVSAGNDM
                     ACLTTDLLAALGKVEPVFTPLVLAFRYWAKSPLTLEAPNQVPLGQLWLELLKFYTLDF
                     ALEEYVICVRIQDILTRENKNWPKRRIAIEDPFSVKRNVARSLNSQLVYEYVVERFRA
                     AYRYFACPQRKGGNKSTVDLKKKEKGKLSNKKPVKSDCSATNGCVLGESTEKVNMERG
                     QPLKHDEMEFTSQRCIVDNDRLLVNELGLADHGQDSSSLSTGSEGSELQQKSAEKQGD
                     LTPSETSLKKELSQCHCTGTPDGAGSAGTDCRSNLEMESSHQIVCNNISATSCNCKAT
                     EVASDLIDDDNLPSQELYYVFDKFILTSGKPPTIVCSICKKDGHSKNDCPEDFRKIDL
                     KPLPPMTNRFREILDLVCKRCFDELSPPCSEQHNREQILIGLEKFIQKEYDEKARLCL
                     FGSSKNGFGFRDSDLDICMTLEGHENAEKLNCKEIIENLAKILKRHPGLRNILPITTA
                     KVPIVKFEHRRSGLEGDISLYNTLRCDIGDASRGSLSSYAYILMVLYFLQQRKPPVIP
                     VLQEIFDGKQIPQRMVDGWNAFFFDKTEELKKRLPSLGKNTESLGELWLGLLRFYTEE
                     FDFKEYVISIRQKKLLTTFEKQWTSKCIAIEDPFDLNHNLGAGVSRKMTNFIMKAFIN
                     GRKLFGTPFYPLIGREAEYFFDSRVLTDGELAPNDRCCRVCGKIGHYMKDCPKRKRLK
                     KKDSEEEKEGNEEEKDSRDLLDSRDLRCFICGDAGHVRRECPEVKMARQRNSSVAAAQ
                     LVRNLVNAQQVAGSAQQQSDQSIRTRQSSECSDSPSYSPQPQPFPQNSPQPSALPPPP
                     SQPGSQPKLGPPQQGGQPPHQVQMPLYNFPPSPPAHYSPMHGMGLLPMHPLQIPAPSW
                     PIHGPMLHSAPGSTPSNIGLNDPSIIFAQPAARPMAIPSSSHDGHWPRTVAPNSLVNN
                     GAVGNSEPRFRGLNPPIPWEHAPRPHFPLVPASWPYGLHQNFMHQGNPRFQPKPFYAQ
                     AERCATRRSRERCPHPPRGNVSE"
     exon            1045..1208
                     /gene="Tut4"
                     /gene_synonym="Zcchc11"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1325
                     /gene="Tut4"
                     /gene_synonym="Zcchc11"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1503
                     /gene="Tut4"
                     /gene_synonym="Zcchc11"
                     /inference="alignment:Splign:2.1.0"
     exon            1504..1573
                     /gene="Tut4"
                     /gene_synonym="Zcchc11"
                     /inference="alignment:Splign:2.1.0"
     exon            1574..1700
                     /gene="Tut4"
                     /gene_synonym="Zcchc11"
                     /inference="alignment:Splign:2.1.0"
     exon            1701..1875
                     /gene="Tut4"
                     /gene_synonym="Zcchc11"
                     /inference="alignment:Splign:2.1.0"
     exon            1876..2570
                     /gene="Tut4"
                     /gene_synonym="Zcchc11"
                     /inference="alignment:Splign:2.1.0"
     exon            2571..2721
                     /gene="Tut4"
                     /gene_synonym="Zcchc11"
                     /inference="alignment:Splign:2.1.0"
     exon            2722..2808
                     /gene="Tut4"
                     /gene_synonym="Zcchc11"
                     /inference="alignment:Splign:2.1.0"
     exon            2809..2912
                     /gene="Tut4"
                     /gene_synonym="Zcchc11"
                     /inference="alignment:Splign:2.1.0"
     exon            2913..2970
                     /gene="Tut4"
                     /gene_synonym="Zcchc11"
                     /inference="alignment:Splign:2.1.0"
     exon            2971..3074
                     /gene="Tut4"
                     /gene_synonym="Zcchc11"
                     /inference="alignment:Splign:2.1.0"
     exon            3075..3188
                     /gene="Tut4"
                     /gene_synonym="Zcchc11"
                     /inference="alignment:Splign:2.1.0"
     exon            3189..3266
                     /gene="Tut4"
                     /gene_synonym="Zcchc11"
                     /inference="alignment:Splign:2.1.0"
     exon            3267..3444
                     /gene="Tut4"
                     /gene_synonym="Zcchc11"
                     /inference="alignment:Splign:2.1.0"
     exon            3445..3492
                     /gene="Tut4"
                     /gene_synonym="Zcchc11"
                     /inference="alignment:Splign:2.1.0"
     exon            3493..3575
                     /gene="Tut4"
                     /gene_synonym="Zcchc11"
                     /inference="alignment:Splign:2.1.0"
     exon            3576..3691
                     /gene="Tut4"
                     /gene_synonym="Zcchc11"
                     /inference="alignment:Splign:2.1.0"
     exon            3692..3864
                     /gene="Tut4"
                     /gene_synonym="Zcchc11"
                     /inference="alignment:Splign:2.1.0"
     exon            3865..3965
                     /gene="Tut4"
                     /gene_synonym="Zcchc11"
                     /inference="alignment:Splign:2.1.0"
     exon            3966..4413
                     /gene="Tut4"
                     /gene_synonym="Zcchc11"
                     /inference="alignment:Splign:2.1.0"
     exon            4414..4569
                     /gene="Tut4"
                     /gene_synonym="Zcchc11"
                     /inference="alignment:Splign:2.1.0"
     exon            4570..5156
                     /gene="Tut4"
                     /gene_synonym="Zcchc11"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcgcgccgct ccctggcgtc ggcgtgctgg accgcaagac cctctccttg caggctcgct
       61 acagccagca agtcgcgggt agctccgacc ctttccctcc tcgggggccc gcccccagct
      121 cgggcgcaga cgagagcccg cgcgcgctcg ctcgctctcc tcagcgcggt ttgcttgcct
      181 aaactagatt tggaacagtt catatacctg agacctgcca ttttacagta tcaaattggg
      241 aagaatcaga ttttcaaata atggaagagc ccaagacttc taaaaacgaa aatcatgaac
      301 caaagaagaa tattatttgt gaagaaagca aagcagttaa aattataact aatcaaacct
      361 tgaagcctag aaatgataag tccatgacag aaattgggac cagctctctg aatagaaata
      421 gtagtaaaaa aaccaagcaa aatgatattt gtatagaaaa aacagaagct aaatcatgta
      481 aagtaaatgc tgccagtgtt ccaggcccta aagatttggg gttagtactt cgagatcaaa
      541 gtcattgcaa agtgaaaaag ttaccaaatt cacccatgaa agcccagaag ggatcttcac
      601 agacaaaatt agaaaaggca cctagtttac aggcgaaagc agaaaaagta ccaaagtctc
      661 cgaatttacc agtaaaagta gagaaaacgc cctgtacaac agcagcagca acaacagaaa
      721 aagcacttaa ttcacagaga aaagaagaaa acgtacccac ttctcagatg aaattacaga
      781 agacacccag atcaccttta gagccagaaa atgtgcctag tttactgttg aaagaaaatg
      841 tgaaacagac agaatcacaa cagactggga agaaacttac aagctccttt gtttctatgg
      901 ataaaaggaa cagtgcagct ctacaaggag agaagtcaac cctggaaaat tcatcactat
      961 ctcagaagca acagacacag gcagataata ttgctgattc tgatgacagt gcttcaggga
     1021 tggaagatac atcagatgat ttgagtaaaa tgaagaatga agaatctaac aaagaaaatt
     1081 cttccgagat ggactattta gaaaatgcca ctgtgataga tgaatctact ttgacacctg
     1141 agcagaagct aggtttgaaa caagcagaag aacgtctaga aagagatcac atctttcgac
     1201 ttgaaaaacg ctcaccagaa tataccaatt gccgttatct atgcaaactt tgcttaattc
     1261 atattgaaaa catccaagga gcacataaac atataaaaga aaaacgacat aagaagaata
     1321 ttttggaaaa acaagaagag agtgaacttc gatctctccc atctccttcc cctgctcact
     1381 tggctgcttt aagtgttgca gttgttgaat tagcaaaaga acaaggaata acagatgatg
     1441 acctcagaat ccgccaggac attgtggagg aaatgtcaaa ggttatagtg acatttttac
     1501 cagcattata tgtagatgtg gaatctgatt ttcatgctaa agttcctgtt gtggtgtgca
     1561 aagatcggaa aagtggttta ctatgtagag taagtgcagg aaatgatatg gcatgtctca
     1621 caactgactt acttgctgct cttggcaaag tggaaccggt cttcactccc ttagtgttag
     1681 cttttcgcta ttgggctaag tctcctttaa cattggaagc accaaatcag gtaccccttg
     1741 gacagttgtg gttggagctg ctaaaatttt acacactgga ttttgctttg gaggaatatg
     1801 tcatatgtgt acggatacaa gatattttaa ctagagagaa caaaaactgg cctaaaagac
     1861 ggatagcaat tgaagatcca ttttcagtca agaggaatgt tgcacggagc ttaaacagcc
     1921 agcttgtata tgaatatgtt gtggagagat tcagggcagc ttatcgatat tttgcctgtc
     1981 cccaaaggaa gggtggaaat aaatctacag tggatctcaa gaaaaaagag aaagggaagc
     2041 taagcaacaa gaaaccagtg aagtctgatt gctcggcaac caatggttgt gttcttggag
     2101 aaagtacaga aaaagtaaat atggaacgag gccaacctct taaacatgat gaaatggagt
     2161 ttacgtcaca gagatgtatt gttgataatg accgtttatt ggtaaatgaa ctaggtttgg
     2221 ctgaccatgg acaagattct tcatcgcttt ctactggcag tgaaggcagt gaattacagc
     2281 aaaaatcagc tgagaaacaa ggtgatttaa caccttcaga aacttcttta aagaaggaac
     2341 tcagccagtg tcattgcact gggacccctg atggagctgg atctgctgga acagactgta
     2401 gatcaaattt agaaatggag agttcacatc agattgtgtg caacaacata tctgctacct
     2461 cttgcaactg caaagctaca gaagttgctt ctgaccttat tgatgatgat aacctcccct
     2521 cccaggaatt atattatgtg tttgataagt ttattttaac ctctggcaag ccgccaacaa
     2581 tagtatgcag catctgcaaa aaggatggcc attcaaaaaa tgattgccca gaggatttca
     2641 ggaaaattga tctaaaacct ctaccaccaa tgacaaaccg atttcgagaa atacttgatt
     2701 tagtatgcaa aagatgtttt gatgaattat caccgccttg ctctgaacaa cacaacaggg
     2761 aacaaatttt aatcggcttg gaaaagttta ttcaaaaaga atatgatgaa aaagcaagat
     2821 tgtgcttatt tggttcttct aagaatggat ttggattccg tgatagtgat ttggatattt
     2881 gtatgactct ggaaggccat gagaatgcag agaaattaaa ctgtaaggaa ataattgaaa
     2941 atttggcgaa aattcttaag aggcatccag gtttaagaaa cattctgcct ataactactg
     3001 ccaaagtgcc tattgtaaaa tttgaacaca ggagaagtgg actagaaggt gatatcagtt
     3061 tatataacac attgcgctgt gacattggag atgcgtctcg aggaagttta tcttcatatg
     3121 cttatatcct tatggtgctg tactttctgc agcaacgaaa gccaccagtt atcccagttc
     3181 tgcaagagat ctttgatgga aagcagattc cacagagaat ggtggatgga tggaatgcct
     3241 ttttctttga taaaacagaa gaactgaaaa agcgtttacc ttcacttgga aagaacacgg
     3301 aatcactagg agagctttgg ttaggactac ttcgcttcta tactgaagag tttgatttca
     3361 aggaatatgt aatcagtatt cggcagaaaa agctgctcac tacttttgaa aagcagtgga
     3421 cttctaaatg cattgcaatt gaagatcctt ttgacttgaa tcataacctt ggtgctggtg
     3481 tttctagaaa aatgaccaat tttattatga aggcatttat caatggaagg aaactttttg
     3541 gtaccccctt ttatccactc attggcagag aagctgagta cttctttgat tcaagagtat
     3601 taacagatgg agaattggct cctaatgatc ggtgttgtcg tgtgtgtgga aaaataggtc
     3661 actatatgaa agactgtccc aaaaggaaaa gactaaagaa gaaagacagt gaagaagaga
     3721 aagaaggaaa tgaagaagaa aaagactccc gagaccttct tgactcccga gaccttaggt
     3781 gtttcatatg tggagatgcc ggacatgttc gccgggaatg cccagaggtc aagatggccc
     3841 gccagaggaa tagcagtgta gcagcagccc agctggttcg taatcttgtt aatgctcagc
     3901 aggtggctgg ttcagcccag caacagagtg accagtctat aaggactaga cagtcttcag
     3961 agtgttctga ttcaccatct tattctcctc agcctcagcc ttttccacag aattctcccc
     4021 aaccgtctgc tcttccccca cctccatccc agccaggatc ccagcctaag cttggcccac
     4081 cccagcaggg aggccagccc cctcaccagg ttcagatgcc cttgtataac tttcctccat
     4141 cccctccagc tcattactca cccatgcacg gtatgggatt attgccaatg caccccctcc
     4201 agatccctgc cccgtcgtgg cccatccacg gcccaatgct gcactctgca cctggcagta
     4261 cccccagcaa tattggcttg aatgatccca gcatcatctt tgcacagcct gctgccaggc
     4321 cgatggcaat ccctagctct tctcatgatg gacactggcc tcgtaccgtg gctcccaact
     4381 ccctggtgaa caatggtgca gtgggtaatt cggagccacg ttttcgagga ctaaatcctc
     4441 caattccatg ggaacatgca ccacgtcccc atttccccct tgtcccagct tcgtggcctt
     4501 atggtttgca tcaaaacttc atgcatcagg gaaatccaag atttcagccc aaacccttct
     4561 acgctcaagc agagagatgt gccacacgtc gcagtagaga gcgttgtccc cacccaccac
     4621 gaggaaacgt gtcggaataa tgccagccca cagcaaccag ccaatcctga tgtctcaagg
     4681 gtatccgtac ctcagtgtca gttacactca gcagaaaaat tgacatttaa ggaaaggaaa
     4741 acaaatcagg tcctgattta aaattttaac acacgtttag atagcttatt taaattctaa
     4801 gactgttttt aaacactgta ttatttgtat ataaatatga actatagttt ttactggtat
     4861 cactaaattg agtgatacaa atttcatcta ttttattacc ctatttttaa gggaatttta
     4921 tgttttgttt aaccttgatg aattgtataa agagagaatt taaaaaatta cattctttat
     4981 tttctattag ctgtattcat actttggttg cttcagactt tatatatatt gttcttaaga
     5041 attaggaaag gatttcatgt gttttaaatt tgtcacttct attctttaca gaaccttgta
     5101 gtgccaaaaa ctttttaaaa ggttaaaaaa aaaataaaat tacaacataa agattc
//
