LOCUS       NM_001004212            1514 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus tumor suppressor candidate 3 (Tusc3), mRNA.
ACCESSION   NM_001004212 XM_214356
VERSION     NM_001004212.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1514)
  AUTHORS   Cherepanova NA and Gilmore R.
  TITLE     Mammalian cells lacking either the cotranslational or
            posttranslocational oligosaccharyltransferase complex display
            substrate-dependent defects in asparagine linked glycosylation
  JOURNAL   Sci Rep 6, 20946 (2016)
   PUBMED   26864433
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1514)
  AUTHORS   Khalid AM, Asano A, Hosaka YZ, Takeuchi T and Yamano Y.
  TITLE     Tumor suppressor candidate TUSC3 expression during rat testis
            maturation
  JOURNAL   Biosci Biotechnol Biochem 77 (10), 2019-2024 (2013)
   PUBMED   24096664
  REMARK    GeneRIF: TUSC3 is deeply involved in spermatogenesis in the testis,
            inducing sperm differentiation and maturation
REFERENCE   3  (bases 1 to 1514)
  AUTHORS   Zhou H and Clapham DE.
  TITLE     Mammalian MagT1 and TUSC3 are required for cellular magnesium
            uptake and vertebrate embryonic development
  JOURNAL   Proc Natl Acad Sci U S A 106 (37), 15750-15755 (2009)
   PUBMED   19717468
REFERENCE   4  (bases 1 to 1514)
  AUTHORS   Molinari F, Foulquier F, Tarpey PS, Morelle W, Boissel S, Teague J,
            Edkins S, Futreal PA, Stratton MR, Turner G, Matthijs G, Gecz J,
            Munnich A and Colleaux L.
  TITLE     Oligosaccharyltransferase-subunit mutations in nonsyndromic mental
            retardation
  JOURNAL   Am J Hum Genet 82 (5), 1150-1157 (2008)
   PUBMED   18455129
REFERENCE   5  (bases 1 to 1514)
  AUTHORS   Shibatani T, David LL, McCormack AL, Frueh K and Skach WR.
  TITLE     Proteomic analysis of mammalian oligosaccharyltransferase reveals
            multiple subcomplexes that contain Sec61, TRAP, and two potential
            new subunits
  JOURNAL   Biochemistry 44 (16), 5982-5992 (2005)
   PUBMED   15835887
REFERENCE   6  (bases 1 to 1514)
  AUTHORS   Mootha VK, Bunkenborg J, Olsen JV, Hjerrild M, Wisniewski JR, Stahl
            E, Bolouri MS, Ray HN, Sihag S, Kamal M, Patterson N, Lander ES and
            Mann M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   7  (bases 1 to 1514)
  AUTHORS   Kelleher DJ, Karaoglu D, Mandon EC and Gilmore R.
  TITLE     Oligosaccharyltransferase isoforms that contain different catalytic
            STT3 subunits have distinct enzymatic properties
  JOURNAL   Mol Cell 12 (1), 101-111 (2003)
   PUBMED   12887896
REFERENCE   8  (bases 1 to 1514)
  AUTHORS   MacGrogan D, Levy A, Bova GS, Isaacs WB and Bookstein R.
  TITLE     Structure and methylation-associated silencing of a gene within a
            homozygously deleted region of human chromosome band 8p22
  JOURNAL   Genomics 35 (1), 55-65 (1996)
   PUBMED   8661104
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079193.1.
            
            On Sep 10, 2004 this sequence version replaced XM_214356.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079193.1, FQ213307.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1514
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.1"
     gene            1..1514
                     /gene="Tusc3"
                     /note="tumor suppressor candidate 3"
                     /db_xref="GeneID:290783"
                     /db_xref="RGD:1303318"
     exon            1..326
                     /gene="Tusc3"
                     /inference="alignment:Splign:2.1.0"
     CDS             189..1232
                     /gene="Tusc3"
                     /codon_start=1
                     /product="tumor suppressor candidate 3 precursor"
                     /protein_id="NP_001004212.1"
                     /db_xref="GeneID:290783"
                     /db_xref="RGD:1303318"
                     /translation="MSARAAPSRRRQAGRRLRYLSTGSFPFLLLLLLLCIQLGGGQKK
                     KENLLAEKVEQLMEWSSRRSIFRMNGDKFRKFVKAPPRNYSMIVMFTALQPQRQCSVC
                     RQANEEYQILANSWRYSSAFCNKLFFGMVDYDEGTDVFQQLNMNSAPTFMHFPSKGRP
                     KRADTFDLQRIGFAAEQLAKWIADRTDVHIRVFRPPNYSGTIALALLVSLVGGLLYLR
                     RNNLEFIYNKTGWAMVSLCIVFAMTSGQMWNHIRGPPYAHKNPHNGQVSYIHGSSQAQ
                     FVAESHIILVLNAAITMGMVLLNEAATSKGDVGKRRIICLVGLGLVVFFFSFLLSIFR
                     SKYHGYPYSFLIK"
     exon            327..496
                     /gene="Tusc3"
                     /inference="alignment:Splign:2.1.0"
     exon            497..614
                     /gene="Tusc3"
                     /inference="alignment:Splign:2.1.0"
     exon            615..755
                     /gene="Tusc3"
                     /inference="alignment:Splign:2.1.0"
     exon            756..896
                     /gene="Tusc3"
                     /inference="alignment:Splign:2.1.0"
     exon            897..986
                     /gene="Tusc3"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1050
                     /gene="Tusc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1125
                     /gene="Tusc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1216
                     /gene="Tusc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1492
                     /gene="Tusc3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtgaaccgg atacgctgtc agtctcctcc tccgcgtcct ttacctccac ccagctccct
       61 ggagaagccg ctgctacccc gaggccttgg ccaagagagg ctgctggcga ctggcccggc
      121 gggcgcgggc agggtaggag ctgggcgcgc acggctaccg cgcgtggagg agacacagcc
      181 ctgcggccat gagtgccagg gccgctcctt cacgccggag acaggcgggc cgcaggttgc
      241 gctacctgtc tactggtagc tttcccttcc tcctcttgtt gctgctgctc tgcatccagc
      301 tcgggggcgg acagaagaaa aaggagaacc ttttggctga aaaggtggag cagctgatgg
      361 aatggagttc caggcgctcg atcttccgaa tgaatggtga caagttccga aagtttgtaa
      421 aagccccacc gcggaactac tccatgatcg tcatgttcac tgctctgcag cctcagaggc
      481 agtgctctgt gtgcaggcag gctaacgaag aatatcaaat cctggctaat tcctggcgtt
      541 attcatctgc tttttgcaac aaactgtttt ttggaatggt ggactatgat gaagggacag
      601 atgtttttca gcagctcaac atgaactctg ctcccacatt catgcatttt ccttcaaaag
      661 gcagacccaa gagagctgat acctttgacc ttcaacgaat tggatttgca gctgaacagc
      721 tagcaaaatg gattgccgac aggacggatg ttcatattcg agttttccgg ccacccaact
      781 actcaggcac cattgctttg gccctcttag tgtcgctggt tggtggcttg ctttatttaa
      841 ggaggaacaa cttggagttc atctataaca agactggttg ggccatggta tctctgtgta
      901 tagtctttgc tatgacgtct ggccagatgt ggaaccatat ccgtggacct ccatatgctc
      961 ataagaaccc acacaatgga caagtgagct acattcatgg cagcagccag gcgcagtttg
     1021 tggcagagtc tcacatcatt ctagtactga atgctgcaat caccatgggg atggttcttc
     1081 taaatgaagc agcaacttcc aaaggggatg tcgggaaaag acggatcatt tgcctcgtgg
     1141 gattgggcct ggtggtcttc ttcttcagtt ttctactttc aatatttcgt tcaaagtacc
     1201 atggctatcc atatagcttt ttaattaaat gaagtcacct cggactatca taaagtgaag
     1261 agaagctgtt cctgacacta tattatttgg aattcttgag gttcactcct tgttgattgt
     1321 gatacattag cttattcttg tataattttt ttaaactgtg gattttccta aaacatttaa
     1381 tttatagaaa tggatgtgta acattctgta atccgcaatg gactatcaaa gtgtttttaa
     1441 atattctcaa tgtatgctac aggagtgaaa taaatgacat tgtaactatg aaaaaaaaaa
     1501 aaaaaaaaaa aaaa
//
