LOCUS       NM_001109297            2060 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus tumor suppressor 2, mitochondrial calcium
            regulator (Tusc2), mRNA.
ACCESSION   NM_001109297 XM_001072836 XM_576468
VERSION     NM_001109297.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2060)
  AUTHORS   Hood MI, Uzhachenko R, Boyd K, Skaar EP and Ivanova AV.
  TITLE     Loss of mitochondrial protein Fus1 augments host resistance to
            Acinetobacter baumannii infection
  JOURNAL   Infect Immun 81 (12), 4461-4469 (2013)
   PUBMED   24042119
REFERENCE   2  (bases 1 to 2060)
  AUTHORS   Uzhachenko R, Issaeva N, Boyd K, Ivanov SV, Carbone DP and Ivanova
            AV.
  TITLE     Tumour suppressor Fus1 provides a molecular link between
            inflammatory response and mitochondrial homeostasis
  JOURNAL   J Pathol 227 (4), 456-469 (2012)
   PUBMED   22513871
REFERENCE   3  (bases 1 to 2060)
  AUTHORS   Ivanova AV, Ivanov SV, Pascal V, Lumsden JM, Ward JM, Morris N,
            Tessarolo L, Anderson SK and Lerman MI.
  TITLE     Autoimmunity, spontaneous tumourigenesis, and IL-15 insufficiency
            in mice with a targeted disruption of the tumour suppressor gene
            Fus1
  JOURNAL   J Pathol 211 (5), 591-601 (2007)
   PUBMED   17318811
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473954.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_576468.2, XM_001072836.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DN934436.1, FQ100277.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2060
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..2060
                     /gene="Tusc2"
                     /note="tumor suppressor 2, mitochondrial calcium
                     regulator"
                     /db_xref="GeneID:501052"
                     /db_xref="RGD:1561664"
     exon            1..691
                     /gene="Tusc2"
                     /inference="alignment:Splign:2.1.0"
     CDS             546..878
                     /gene="Tusc2"
                     /codon_start=1
                     /product="tumor suppressor candidate 2"
                     /protein_id="NP_001102767.1"
                     /db_xref="GeneID:501052"
                     /db_xref="RGD:1561664"
                     /translation="MGASGSKARGLWPFASTTGGGGPEAAGAEQSLVRSRARAVPPFV
                     FTRRGSMFYDEDGDLAHEFYEETIVTKNGQKRAKLRRVHKNLIPQGIVKLDPPRIHVD
                     FPVILYEV"
     exon            692..812
                     /gene="Tusc2"
                     /inference="alignment:Splign:2.1.0"
     exon            813..2060
                     /gene="Tusc2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caagttcttt aatttcttta caagcaaatg tgacaactgc aaagacagtt gtgaaaacaa
       61 gctaactgta ccttagcctg ggcagggcta aggtctcttt ggggatggag gagtgaccta
      121 attgactatt gctactgagc ctgagttttg ggctgcgtca gggacgttgg ggcaattata
      181 ccgggtcaaa ccttaaagtc aacaacaaca cattgcctcc gcctttctgg gagggagctg
      241 tcccagctga cccttgagat ccataggctt ctgggacctg gaggcagcgc atcctggggt
      301 gttcagcctc tgagagtggc cattggttca actccacaga ctgatgagac ctttagccac
      361 tcagaggcgg cagcgtgcag ggcgtgcgga agcggaagta aggtttccgt ggagacagca
      421 gagcctgcgg aaggcggcgg cggcggcggc acctgcgagt ggaagctggg gcagggcatg
      481 gtcgcgcccg cagcgctgtg agagcggagc ggccgctcgg tccgccatgc gccggcggcg
      541 ctgacatggg cgccagcggc tccaaagctc ggggcctctg gccctttgcc tccactacgg
      601 ggggcggcgg cccagaggcg gcaggcgctg agcaatcttt ggtgcggtct cgagcccgag
      661 cagtgcctcc cttcgtattc acgcgccgcg gctccatgtt ctatgatgaa gatggggacc
      721 tggctcacga attctacgag gagacaatcg tcaccaagaa tgggcagaag cgagccaagc
      781 tgaggcgggt acacaagaat ctgattcctc agggcatcgt gaagctggat cccccccgaa
      841 tccacgtgga tttccccgtg atcctctatg aagtatgagc ctgtggcatg gcagacacaa
      901 gcacccactg ccccagcaag aaactcccag gatccaggtg tagcttccat tcaggagtcc
      961 aggctggcgc cacagccctg aataaactaa actccgttgg cccagaacct tcagttgtaa
     1021 gaggggtagt ccctcagtgt taactggtat tggtttatgt ctgaacaata agtggttggt
     1081 ggctggtgag agctaatgac agaattacca gcctgtctcc cccagccact tctacaagaa
     1141 gcatggcagg acacatgccg gtcaggaatg cctggttcct agttacttgt ctgacctgct
     1201 ttcttccaag cttggctagg gcccagccct cctagaagct acagcacttt acaagcagag
     1261 tctgccttct tccggcccct ggcctgtagg ggctctaccc aagtgggaac ttcctttccc
     1321 tcattccctt acctgtagtc agagcatttc agccgtttgc tacctcgatt cctcctgtat
     1381 tggacagact ggagacatgt accagcctcc tccttcctgc ctacctgcca cgtgctccca
     1441 ctctaagacg gacactttgc tggctgttaa cagagaatgg ggaccagtgt gggaggcttc
     1501 tcctttcacc cagccagggc tggactgatc tctcttgatt tcaaccagtc accctcaagt
     1561 cgagagggta caggctacag acgcctgtag ctgtggggtc ttgccccacc ccaccaccgc
     1621 attctgtcgt ctcccttgcc tatgcaccag tcctacaaat ctccagtggt gggggagagg
     1681 cggtccacca cccagtggca agacacaaca actggggctg gtgccagtag ctatgaggag
     1741 cccatcaccc cttctacagc atcttactcc ttcagggtct gttaaggaaa agtaccagag
     1801 ctccttggta aggataggaa ggaaggggaa atacagaaca ggtgtaatta aaatgtgaag
     1861 gtttgtaaat agtctagact atgataatgt tggggcagag tctgatttct atacagagat
     1921 ggcttttaaa aaaaaaaact tatttgtgga agctctgtgc ttctagagtg tgggaaatgg
     1981 cttggggaga gtaaacccca gcataggaag actgttgtgt tctttgttca atttcaataa
     2041 aaattatttg tagaccctgc
//
