LOCUS       NM_001400921            3249 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus TUB like protein 3 (Tulp3), mRNA.
ACCESSION   NM_001400921 XM_008763338
VERSION     NM_001400921.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3249)
  AUTHORS   Hilgendorf,K.I., Johnson,C.T., Mezger,A., Rice,S.L., Norris,A.M.,
            Demeter,J., Greenleaf,W.J., Reiter,J.F., Kopinke,D. and
            Jackson,P.K.
  TITLE     Omega-3 Fatty Acids Activate Ciliary FFAR4 to Control Adipogenesis
  JOURNAL   Cell 179 (6), 1289-1305 (2019)
   PUBMED   31761534
REFERENCE   2  (bases 1 to 3249)
  AUTHORS   Badgandi,H.B., Hwang,S.H., Shimada,I.S., Loriot,E. and
            Mukhopadhyay,S.
  TITLE     Tubby family proteins are adapters for ciliary trafficking of
            integral membrane proteins
  JOURNAL   J Cell Biol 216 (3), 743-760 (2017)
   PUBMED   28154160
REFERENCE   3  (bases 1 to 3249)
  AUTHORS   Hirano,T., Katoh,Y. and Nakayama,K.
  TITLE     Intraflagellar transport-A complex mediates ciliary entry and
            retrograde trafficking of ciliary G protein-coupled receptors
  JOURNAL   Mol Biol Cell 28 (3), 429-439 (2017)
   PUBMED   27932497
REFERENCE   4  (bases 1 to 3249)
  AUTHORS   Armour,S.M., Bennett,E.J., Braun,C.R., Zhang,X.Y., McMahon,S.B.,
            Gygi,S.P., Harper,J.W. and Sinclair,D.A.
  TITLE     A high-confidence interaction map identifies SIRT1 as a mediator of
            acetylation of USP22 and the SAGA coactivator complex
  JOURNAL   Mol Cell Biol 33 (8), 1487-1502 (2013)
   PUBMED   23382074
REFERENCE   5  (bases 1 to 3249)
  AUTHORS   Qin,J., Lin,Y., Norman,R.X., Ko,H.W. and Eggenschwiler,J.T.
  TITLE     Intraflagellar transport protein 122 antagonizes Sonic Hedgehog
            signaling and controls ciliary localization of pathway components
  JOURNAL   Proc Natl Acad Sci U S A 108 (4), 1456-1461 (2011)
   PUBMED   21209331
REFERENCE   6  (bases 1 to 3249)
  AUTHORS   Mukhopadhyay,S., Wen,X., Chih,B., Nelson,C.D., Lane,W.S.,
            Scales,S.J. and Jackson,P.K.
  TITLE     TULP3 bridges the IFT-A complex and membrane phosphoinositides to
            promote trafficking of G protein-coupled receptors into primary
            cilia
  JOURNAL   Genes Dev 24 (19), 2180-2193 (2010)
   PUBMED   20889716
REFERENCE   7  (bases 1 to 3249)
  AUTHORS   Norman,R.X., Ko,H.W., Huang,V., Eun,C.M., Abler,L.L., Zhang,Z.,
            Sun,X. and Eggenschwiler,J.T.
  TITLE     Tubby-like protein 3 (TULP3) regulates patterning in the mouse
            embryo through inhibition of Hedgehog signaling
  JOURNAL   Hum Mol Genet 18 (10), 1740-1754 (2009)
   PUBMED   19286674
REFERENCE   8  (bases 1 to 3249)
  AUTHORS   Patterson,V.L., Damrau,C., Paudyal,A., Reeve,B., Grimes,D.T.,
            Stewart,M.E., Williams,D.J., Siggers,P., Greenfield,A. and
            Murdoch,J.N.
  TITLE     Mouse hitchhiker mutants have spina bifida, dorso-ventral
            patterning defects and polydactyly: identification of Tulp3 as a
            novel negative regulator of the Sonic hedgehog pathway
  JOURNAL   Hum Mol Genet 18 (10), 1719-1739 (2009)
   PUBMED   19223390
REFERENCE   9  (bases 1 to 3249)
  AUTHORS   Cameron,D.A., Pennimpede,T. and Petkovich,M.
  TITLE     Tulp3 is a critical repressor of mouse hedgehog signaling
  JOURNAL   Dev Dyn 238 (5), 1140-1149 (2009)
   PUBMED   19334287
REFERENCE   10 (bases 1 to 3249)
  AUTHORS   Ikeda,A., Ikeda,S., Gridley,T., Nishina,P.M. and Naggert,J.K.
  TITLE     Neural tube defects and neuroepithelial cell death in Tulp3
            knockout mice
  JOURNAL   Hum Mol Genet 10 (12), 1325-1334 (2001)
   PUBMED   11406614
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Jan 28, 2022 this sequence version replaced XM_008763338.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643290.18134.1,
                                           SRR26360194.985591.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760389,
                                           SAMEA5760475 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-90                JAXUCZ010000004.1  163318165-163318254 c
            91-142              JAXUCZ010000004.1  163298930-163298981 c
            143-302             JAXUCZ010000004.1  163293969-163294128 c
            303-482             JAXUCZ010000004.1  163293265-163293444 c
            483-610             JAXUCZ010000004.1  163283422-163283549 c
            611-808             JAXUCZ010000004.1  163282995-163283192 c
            809-921             JAXUCZ010000004.1  163282081-163282193 c
            922-1036            JAXUCZ010000004.1  163281213-163281327 c
            1037-1135           JAXUCZ010000004.1  163280306-163280404 c
            1136-1307           JAXUCZ010000004.1  163279392-163279563 c
            1308-3249           JAXUCZ010000004.1  163276583-163278524 c
FEATURES             Location/Qualifiers
     source          1..3249
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..3249
                     /gene="Tulp3"
                     /note="TUB like protein 3"
                     /db_xref="GeneID:688749"
                     /db_xref="RGD:1585259"
     exon            1..90
                     /gene="Tulp3"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..1441
                     /gene="Tulp3"
                     /note="rCG29683-like; tubby-like protein 3"
                     /codon_start=1
                     /product="tubby-related protein 3"
                     /protein_id="NP_001387850.1"
                     /db_xref="GeneID:688749"
                     /db_xref="RGD:1585259"
                     /translation="MEAARCAPGSRGDSAFEDETLRLRQLKLDNQRALLEKKQRKKRL
                     EPLMVQPNPEARLRRLKPRGSEEHTPLVDPQTPCSDVILHGIDGPAAFLKPEAQDLES
                     KPQVLSVGSSPTPEEGTEGSADGESPVETASKPDLQEILQKHGILSSVNYDEEPDEEA
                     EDEGENLSSLPAQSEKESAGASQKAASDTGASGMTAQQGDAQLGEVENLEDFAYSPAP
                     RGVTVKCRVTRDKKGMDRGLFPTYYMHLEKEENRKIFLLAGRKRKKSKTSNYLVSTDP
                     TDLSREGESYIGKLRSNLMGTKFTVYDHGVNPVKAQGLVEKAHTRQELAAICYETNVL
                     GFKGPRKMSVIIPGMNMNHERIPFRPRNEHESLLSKWQNKSMENLIELHNKAPVWNDD
                     TQSYVLNFHGRVTQASVKNFQIVHGNDPDYIVMQFGRVADDVFTLDYNYPLCALQAFA
                     IGLSSFDSKLACE"
     exon            91..142
                     /gene="Tulp3"
                     /inference="alignment:Splign:2.1.0"
     exon            143..302
                     /gene="Tulp3"
                     /inference="alignment:Splign:2.1.0"
     exon            303..482
                     /gene="Tulp3"
                     /inference="alignment:Splign:2.1.0"
     exon            483..610
                     /gene="Tulp3"
                     /inference="alignment:Splign:2.1.0"
     exon            611..808
                     /gene="Tulp3"
                     /inference="alignment:Splign:2.1.0"
     exon            809..921
                     /gene="Tulp3"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1036
                     /gene="Tulp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1135
                     /gene="Tulp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1307
                     /gene="Tulp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..3249
                     /gene="Tulp3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcggcggcg tcttggggtc tggacgctga tgccaccggt cgggcgggta tggaggcggc
       61 gcgctgcgca ccgggatccc gcggggacag tgcctttgaa gatgagaccc tgagacttcg
      121 gcaactgaag ctggacaatc agagggcact gctggagaag aagcagagaa agaagcgcct
      181 tgagccactc atggtacagc caaacccaga agccaggctg cgaagattaa agccaagagg
      241 gagtgaggag cacacgcctt tggtggaccc tcagacgccg tgcagcgatg tcatcctaca
      301 tggcatcgat ggtccagctg ctttccttaa gccagaggct caggatttgg aaagcaagcc
      361 tcaagttctc tcagtgggct cctcccctac cccagaagaa ggcaccgaag gaagtgcaga
      421 tggggaaagc cccgtggaga cagcctccaa gccagacctt caggagattc tccaaaaaca
      481 cggcatcttg agtagtgtga actatgacga ggaacctgat gaggaggcag aggatgaagg
      541 ggaaaacctc agctccctac cagctcagtc agagaaggag agtgctggag ccagccagaa
      601 agcagcctcg gacacaggag cttccggtat gacagcccag cagggtgatg cccagcttgg
      661 agaagtggag aatttagagg attttgcata tagtcctgcc cctcggggtg tcacggtgaa
      721 gtgtagagtg accagggata agaaaggcat ggaccgcggc ctcttcccca cctactatat
      781 gcacctggag aaggaggaga accgcaagat atttcttcta gctggtagga agcgaaaaaa
      841 gagcaagaca tccaactacc tggtctccac agacccgaca gatttgtctc gtgaagggga
      901 aagttacatc ggcaaactca gatccaatct catgggaacc aagttcaccg tgtacgacca
      961 tggtgtcaac ccagtgaagg cccagggtct ggtggaaaag gcccacaccc gacaggagct
     1021 ggctgccatc tgctatgaaa caaatgtact tggtttcaaa ggtcccagga aaatgtccgt
     1081 gatcattcca gggatgaata tgaatcacga acgcatccca tttcgaccac gaaacgagca
     1141 cgagagcttg ctttccaaat ggcaaaacaa atccatggag aacctgatcg aactgcacaa
     1201 caaggccccc gtgtggaacg acgacaccca gtcctacgtc ctgaacttcc acggccgagt
     1261 cactcaggcg tctgtgaaga acttccagat agtccacggg aatgatcctg actacatagt
     1321 catgcagttc ggacgcgtgg cggacgacgt gttcacactg gactataact acccactgtg
     1381 tgcacttcaa gccttcgcca tcgggctgtc gagctttgac agcaagctgg cctgtgaatg
     1441 aaaagcagca agagcggggg cgtcttcacc acagagcctt caggagcaga aagctgctgc
     1501 cctcaccccg ccctagcaca agaaaagcag cattctgccc ctctggggaa tgatcgagtg
     1561 tgtgtgtgcg tgcgtgtgtg tgtgtgtgtg tgtgaatgtg cgtgtgtgtg cttatatatg
     1621 cacacgttta tacacacgtg gacgcatgct tccacatact cgttcatgcc ttctctgaac
     1681 ttcagagacc tggtcacaga ttatagcttc tcatgggtga gaggtggttt aaagcacagg
     1741 gaggtagata attcgggcac actggtgtct cctgattgga taacagattc tgtgtggtga
     1801 gtgtagcttt cttgtgctcg ggcacttcca acagaatcag gttctaatga ctaaatactt
     1861 aggcctcctt ttttgaagcc cctttcaaag gggggctatt cctttggatg cctttagccc
     1921 aggagcctgc agacttttct cagccaatgg tctcttgcac tgactccagt tagcttcttt
     1981 agcacaaaac agccataact agttggtgca caaagagtgt agctgtgtcc caataaaatt
     2041 ttatttacaa agtgggcgtt ggcctgagac gctggtctgt ggacctgccc tggatgtgtc
     2101 cgttctccaa ggctggagca ttttccagaa cacaagtgga gagtgggtac agtttagcag
     2161 actgactttt tatttttatt ttttccccgt ggatctctgt gtagccccgg ctgtcctgga
     2221 acttgttctg tagaccagac tggcctcaga gatccacctg cctctgcctc ccaagtgctg
     2281 ggattaaagg cgtgtgctac catgccagca acagactgac tcttaagagg aattcttgcc
     2341 gaatccactc ttggtagctt ttgcctcaag aacattatgg ttgtagagtg tcatctgccg
     2401 tcatggagca tgtgacacta gcttgtgctc tgttgtccca gcctccctct ttcttatcct
     2461 tagagcaggg tggtgggcag ccatctcgag agcatgactg tggccagatc tctggaatcc
     2521 ctgctctcca gcatcttaga ctagtgtctt gtttgaggca ggactgtcat ccacaggcct
     2581 tgcccatccg tcagctttgt cctccagcct cagagcctgg cccacaccag tgcagacact
     2641 gccccgcgta ctcgaggctc tgagatctga gcatctccca gcgaatcatg acaaattcct
     2701 caagttcccc agcctacagt gtacctgaac ttgagaattc aaaaaccctg tgtctacatt
     2761 cagtggtccc agactcgcaa actgcttccc agcgtgggtg aagggtcata ctccatggtt
     2821 ttgcccatat ggaggcggag gaggtccctt catgcctgcg tcctgtgact cccggctcag
     2881 cgtccggtgt gatgctggcg tgagatctgg gaggtgagac ctgtgctgtc ccagtgtctt
     2941 gcctgtccct tcagatgtca gtttctgcct caggcatgct tcccattaag tgccttcttc
     3001 ataaatgtgc tctggaacct gacacacctc tgctacccac tttccccgcc acctttgttg
     3061 agctgaaagt tgctcaattg tccccactta aagagggtgg ggctatgggt caccggctct
     3121 gacctctggc cagctttaaa gagctgtata ctcccatttc acggactctc agcttgagtg
     3181 tgcaggtttt acatgaatcc tatttatacc ttttgtatac catataaata aagataattt
     3241 atataaaga
//
