LOCUS       NM_001415067            2054 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus TUB like protein 1 (Tulp1), transcript variant 1,
            mRNA.
ACCESSION   NM_001415067 XM_006256217
VERSION     NM_001415067.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2054)
  AUTHORS   Ebke,L.A., Pauer,G.J., Willard,B. and Hagstrom,S.A.
  TITLE     A Novel Approach to Identify Photoreceptor Compartment-Specific
            Tulp1 Binding Partners
  JOURNAL   Adv Exp Med Biol 854, 605-611 (2016)
   PUBMED   26427465
  REMARK    GeneRIF: Data suggest that photoreceptors-specific protein Tulp1 is
            involved in the trafficking of proteins from the inner segment (IS)
            to the outer segment (OS) and the continuous membrane remodeling
            and vesicle cycling at the synaptic terminal.
REFERENCE   2  (bases 1 to 2054)
  AUTHORS   Grossman,G.H., Beight,C.D., Ebke,L.A., Pauer,G.J. and Hagstrom,S.A.
  TITLE     Interaction of tubby-like protein-1 (Tulp1) and
            microtubule-associated protein (MAP) 1A and MAP1B in the mouse
            retina
  JOURNAL   Adv Exp Med Biol 801, 511-518 (2014)
   PUBMED   24664738
REFERENCE   3  (bases 1 to 2054)
  AUTHORS   Daiger,S.P., Sullivan,L.S. and Bowne,S.J.
  TITLE     Genes and mutations causing retinitis pigmentosa
  JOURNAL   Clin Genet 84 (2), 132-141 (2013)
   PUBMED   23701314
  REMARK    Review article
REFERENCE   4  (bases 1 to 2054)
  AUTHORS   Hagstrom,S.A., Watson,R.F., Pauer,G.J. and Grossman,G.H.
  TITLE     Tulp1 is involved in specific photoreceptor protein transport
            pathways
  JOURNAL   Adv Exp Med Biol 723, 783-789 (2012)
   PUBMED   22183407
REFERENCE   5  (bases 1 to 2054)
  AUTHORS   Won,J., Shi,L.Y., Hicks,W., Wang,J., Naggert,J.K. and Nishina,P.M.
  TITLE     Translational vision research models program
  JOURNAL   Adv Exp Med Biol 723, 391-397 (2012)
   PUBMED   22183357
REFERENCE   6  (bases 1 to 2054)
  AUTHORS   Kondo,H., Qin,M., Mizota,A., Kondo,M., Hayashi,H., Hayashi,K.,
            Oshima,K., Tahira,T. and Hayashi,K.
  TITLE     A homozygosity-based search for mutations in patients with
            autosomal recessive retinitis pigmentosa, using microsatellite
            markers
  JOURNAL   Invest Ophthalmol Vis Sci 45 (12), 4433-4439 (2004)
   PUBMED   15557452
REFERENCE   7  (bases 1 to 2054)
  AUTHORS   Hagstrom,S.A., Adamian,M., Scimeca,M., Pawlyk,B.S., Yue,G. and
            Li,T.
  TITLE     A role for the Tubby-like protein 1 in rhodopsin transport
  JOURNAL   Invest Ophthalmol Vis Sci 42 (9), 1955-1962 (2001)
   PUBMED   11481257
REFERENCE   8  (bases 1 to 2054)
  AUTHORS   Ikeda,S., Shiva,N., Ikeda,A., Smith,R.S., Nusinowitz,S., Yan,G.,
            Lin,T.R., Chu,S., Heckenlively,J.R., North,M.A., Naggert,J.K.,
            Nishina,P.M. and Duyao,M.P.
  TITLE     Retinal degeneration but not obesity is observed in null mutants of
            the tubby-like protein 1 gene
  JOURNAL   Hum Mol Genet 9 (2), 155-163 (2000)
   PUBMED   10607826
REFERENCE   9  (bases 1 to 2054)
  AUTHORS   Hagstrom,S.A., Duyao,M., North,M.A. and Li,T.
  TITLE     Retinal degeneration in tulp1-/- mice: vesicular accumulation in
            the interphotoreceptor matrix
  JOURNAL   Invest Ophthalmol Vis Sci 40 (12), 2795-2802 (1999)
   PUBMED   10549638
REFERENCE   10 (bases 1 to 2054)
  AUTHORS   Hagstrom,S.A., North,M.A., Nishina,P.L., Berson,E.L. and Dryja,T.P.
  TITLE     Recessive mutations in the gene encoding the tubby-like protein
            TULP1 in patients with retinitis pigmentosa
  JOURNAL   Nat Genet 18 (2), 174-176 (1998)
   PUBMED   9462750
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000020.1.
            
            On Dec 21, 2022 this sequence version replaced XM_006256217.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA5760383, SAMEA5760389
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression,
                                         longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-132               JAXUCZ010000020.1  6425702-6425833     c
            133-184             JAXUCZ010000020.1  6425536-6425587     c
            185-269             JAXUCZ010000020.1  6425118-6425202     c
            270-422             JAXUCZ010000020.1  6424860-6425012     c
            423-578             JAXUCZ010000020.1  6424357-6424512     c
            579-674             JAXUCZ010000020.1  6423617-6423712     c
            675-794             JAXUCZ010000020.1  6423409-6423528     c
            795-913             JAXUCZ010000020.1  6423077-6423195     c
            914-919             JAXUCZ010000020.1  6420359-6420364     c
            920-1090            JAXUCZ010000020.1  6420103-6420273     c
            1091-1203           JAXUCZ010000020.1  6419847-6419959     c
            1204-1315           JAXUCZ010000020.1  6417609-6417720     c
            1316-1414           JAXUCZ010000020.1  6417434-6417532     c
            1415-1586           JAXUCZ010000020.1  6415829-6416000     c
            1587-2054           JAXUCZ010000020.1  6413901-6414368     c
FEATURES             Location/Qualifiers
     source          1..2054
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..2054
                     /gene="Tulp1"
                     /note="TUB like protein 1"
                     /db_xref="GeneID:309900"
                     /db_xref="RGD:1311062"
     exon            1..132
                     /gene="Tulp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..1720
                     /gene="Tulp1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     tubby-related protein 1; tubby like protein 1"
                     /codon_start=1
                     /product="tubby-related protein 1 isoform 1"
                     /protein_id="NP_001401996.1"
                     /db_xref="GeneID:309900"
                     /db_xref="RGD:1311062"
                     /translation="MPLQEETLREVWASDSGHEEDWLSPEPPPRPKQRPAQGQKLRKK
                     KPETPESPESKPPRRAGAGRRKHGEPPADPAEPRTEQTVYAKFLRDPEAKKRDPRETF
                     LVARAPDVGGEEDSEEDSDDDDDDDDDDEEKEKKEGKKEKSSLPPKKAPKERERKTKA
                     LGPKGDVGSPDAPQKPLKTKKKEVGEGTKLRKVKKKGAGETDKNPSESPATVRKKIPA
                     SMFLVGEGGTAEKGVKKKGPPKGSEEEKKEEEEEEEEDASPVMRNSNQKGRAKGKGKK
                     KVKEERAPSPPVEVGEPREFVLQPAPQGRAVRCRLTRDKKGMDRGMYPSYFLHLDTEK
                     KVFLLAGRKRKRSKTANYLISSDPTNLSRGGENFIGKLRSNLLGNRFTVFDNGQNPQR
                     GGGGDVESLRQELAAVVYETNVLGFRGPRRMTVIIPGMNSDNERVPIRPRNSSDGLLV
                     RWQNKTLESLIELHNKPPIWNEDSGSYTLNFQGRVTQASVKNFQIVHADDPDYIVLQF
                     GRVAEDAFTLDYRYPLCALQAFAIALSSFDGKLACE"
     exon            133..184
                     /gene="Tulp1"
                     /inference="alignment:Splign:2.1.0"
     exon            185..269
                     /gene="Tulp1"
                     /inference="alignment:Splign:2.1.0"
     exon            270..422
                     /gene="Tulp1"
                     /inference="alignment:Splign:2.1.0"
     exon            423..578
                     /gene="Tulp1"
                     /inference="alignment:Splign:2.1.0"
     exon            579..674
                     /gene="Tulp1"
                     /inference="alignment:Splign:2.1.0"
     exon            675..794
                     /gene="Tulp1"
                     /inference="alignment:Splign:2.1.0"
     exon            795..913
                     /gene="Tulp1"
                     /inference="alignment:Splign:2.1.0"
     exon            914..919
                     /gene="Tulp1"
                     /inference="alignment:Splign:2.1.0"
     exon            920..1090
                     /gene="Tulp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1203
                     /gene="Tulp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..1315
                     /gene="Tulp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..1414
                     /gene="Tulp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..1586
                     /gene="Tulp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1587..2054
                     /gene="Tulp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agctgagctg agattagcta gggagggagg ctgggagctg caagtcacca gagagaggtg
       61 gctgtgaccg gcacacagga acgccatgcc actgcaagag gagacccttc gggaagtgtg
      121 ggcctcagac agtggccacg aagaggactg gctgagcccg gagcctccac cgcgccccaa
      181 acagcgacct gcccagggac agaagttgag gaaaaagaaa cccgagaccc ccgagtcccc
      241 tgaatccaaa ccccctcgta gagctggggc tgggcgcagg aagcacgggg agccgcctgc
      301 agaccccgca gagccgcgca cggagcagac agtctacgcc aagttccttc gggatcctga
      361 ggccaagaag cgggaccccc gggagacctt cctggttgct cgcgccccag atgtgggagg
      421 ggaggaagat tcggaggagg attcagatga cgacgacgac gacgatgacg atgatgaaga
      481 aaaggagaag aaagagggga aaaaagagaa aagctctctg ccccccaaga aagcacccaa
      541 ggagagagag aggaaaacca aggctctggg cccaaaaggg gacgtaggaa gccctgatgc
      601 ccctcagaaa ccgctcaaaa ccaagaagaa ggaggtgggg gagggaacca agctgagaaa
      661 ggtgaagaaa aaaggggctg gggagactga caagaacccc tctgagagcc cagcaaccgt
      721 gaggaagaag attccagcct ccatgttcct ggttggggaa ggtggcacag ctgagaaggg
      781 tgtgaagaag aaagggcccc ccaaaggctc ggaggaagag aagaaggaag aggaggagga
      841 ggaagaggag gatgcatccc cagtgatgag gaacagcaac cagaagggca gagcgaaagg
      901 gaaaggcaaa aagaaagtga aggaggagag agccccatct ccccccgtgg aagtgggtga
      961 accccgggag tttgtgctgc agccagcacc ccagggccgg gcagtacgct gccggctgac
     1021 aagggacaag aagggaatgg accgtggcat gtacccatcc tacttcctgc acctggacac
     1081 cgagaagaag gtgttcctct tggccggcag aaaacgcaag cggagtaaga cggccaatta
     1141 tctcatctcc agcgacccca ccaacctgtc caggggcggg gagaatttca tcgggaagct
     1201 gaggtctaac ctcctgggga accgcttcac ggtctttgac aacgggcaga acccacagcg
     1261 agggggaggt ggtgacgtgg aaagcctgcg ccaggagctg gcagctgtgg tctatgaaac
     1321 caacgtttta ggcttccgag gaccccgccg tatgactgtc atcatccctg gaatgaactc
     1381 ggacaatgag agggtcccta tccggccccg gaattccagc gatggactgt tagtgcgctg
     1441 gcagaacaag accctggaga gcctgatcga gctacacaac aagccaccca tctggaacga
     1501 agacagcggc tcatacaccc tcaacttcca gggccgggtc actcaggcct cggtcaagaa
     1561 cttccagatt gtgcacgctg atgaccccga ctatatagtg ctacaattcg gccgcgtggc
     1621 tgaggacgcc ttcaccctgg attaccggta cccgctgtgc gccctgcagg ccttcgccat
     1681 cgccctctcc agtttcgacg ggaagctggc ctgcgagtga ccccacagtc tctcagcgct
     1741 gagaaagcat tcggttggcg gcggctcggt ccctccccca tagctcccag ggaagggctc
     1801 acccctctgc ctctcggcga cctccgtgca ccctcccagc ctggcacccg gacggactgg
     1861 tggtggggat ggagatgaac atctggtcgc ccaaaaatac ttgcctcgcc ccctcctccc
     1921 cagtcacttc ctgtccagga gaccgagtca gatgttcgag gcccctctgg gcccgcgctg
     1981 tgggggaggg aacgacggtg aagcggagtc agggacccat atccccaata aagtcacgtc
     2041 ctgggctgaa cgca
//
