LOCUS       NM_001360750            2614 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus tuftelin 1 (Tuft1), mRNA.
ACCESSION   NM_001360750 XM_006232891
VERSION     NM_001360750.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2614)
  AUTHORS   Silhavy,J., Mlejnek,P., Simakova,M., Liska,F., Malinska,H.,
            Markova,I., Huttl,M., Miklankova,D., Musalkova,D., Stranecky,V.,
            Kmoch,S., Sticova,E., Vrbacky,M., Mracek,T. and Pravenec,M.
  TITLE     Spontaneous nonsense mutation in the tuftelin 1 gene is associated
            with abnormal hair appearance and amelioration of glucose and lipid
            metabolism in the rat
  JOURNAL   Physiol Genomics 56 (1), 65-73 (2024)
   PUBMED   37955133
  REMARK    GeneRIF: Spontaneous nonsense mutation in the tuftelin 1 gene is
            associated with abnormal hair appearance and amelioration of
            glucose and lipid metabolism in the rat.
REFERENCE   2  (bases 1 to 2614)
  AUTHORS   Abdel-Hamid,N.M., Zakaria,S.M., Ansary,A.M., El-Senduny,F.F. and
            El-Shishtawy,M.M.
  TITLE     The expression of tuftelin 1 as a new theranostic marker in early
            diagnosis and as a therapeutic target in hepatocellular carcinoma
  JOURNAL   Cell Biochem Funct 41 (7), 788-800 (2023)
   PUBMED   37470499
  REMARK    GeneRIF: The expression of tuftelin 1 as a new theranostic marker
            in early diagnosis and as a therapeutic target in hepatocellular
            carcinoma.
REFERENCE   3  (bases 1 to 2614)
  AUTHORS   Shilo,D., Cohen,G., Blumenfeld,A., Goren,K., Hanhan,S., Sharon,S.,
            Haze,A., Deutsch,D. and Lazarovici,P.
  TITLE     Tuftelin Is Required for NGF-Induced Differentiation of PC12 Cells
  JOURNAL   J Mol Neurosci 68 (1), 135-143 (2019)
   PUBMED   30903486
  REMARK    GeneRIF: Tuftelin is essential for NGF-induced differentiation of
            PC12 cells.
REFERENCE   4  (bases 1 to 2614)
  AUTHORS   Liu,C., Li,C., Deng,Z., Du,E. and Xu,C.
  TITLE     Long Non-coding RNA BC168687 is Involved in TRPV1-mediated Diabetic
            Neuropathic Pain in Rats
  JOURNAL   Neuroscience 374, 214-222 (2018)
   PUBMED   29421435
REFERENCE   5  (bases 1 to 2614)
  AUTHORS   Leiser,Y., Silverstein,N., Blumenfeld,A., Shilo,D., Haze,A.,
            Rosenfeld,E., Shay,B., Tabakman,R., Lecht,S., Lazarovici,P. and
            Deutsch,D.
  TITLE     The induction of tuftelin expression in PC12 cell line during
            hypoxia and NGF-induced differentiation
  JOURNAL   J Cell Physiol 226 (1), 165-172 (2011)
   PUBMED   20658530
  REMARK    GeneRIF: The pathways affecting the expression of tuftelin in PC12
            cells and mice are described.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Feb 13, 2018 this sequence version replaced XM_006232891.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC168687.1, SRR26643287.5948.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760389,
                                           SAMEA5760434 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-70                JAXUCZ010000002.1  184995125-184995194 c
            71-172              JAXUCZ010000002.1  184975328-184975429 c
            173-259             JAXUCZ010000002.1  184971524-184971610 c
            260-349             JAXUCZ010000002.1  184970815-184970904 c
            350-415             JAXUCZ010000002.1  184968471-184968536 c
            416-529             JAXUCZ010000002.1  184963608-184963721 c
            530-658             JAXUCZ010000002.1  184958417-184958545 c
            659-753             JAXUCZ010000002.1  184957778-184957872 c
            754-859             JAXUCZ010000002.1  184953756-184953861 c
            860-943             JAXUCZ010000002.1  184952567-184952650 c
            944-1044            JAXUCZ010000002.1  184951507-184951607 c
            1045-2614           JAXUCZ010000002.1  184949437-184951006 c
FEATURES             Location/Qualifiers
     source          1..2614
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..2614
                     /gene="Tuft1"
                     /note="tuftelin 1"
                     /db_xref="GeneID:365864"
                     /db_xref="RGD:1310373"
     exon            1..70
                     /gene="Tuft1"
                     /inference="alignment:Splign:2.1.0"
     CDS             11..1108
                     /gene="Tuft1"
                     /codon_start=1
                     /product="tuftelin"
                     /protein_id="NP_001347679.1"
                     /db_xref="GeneID:365864"
                     /db_xref="RGD:1310373"
                     /translation="MNGTRSWCTLVDVHPESQTAAGKKTYAMVSGHSSGHSLASELVE
                     SHDGHEEIIKVYLKGRSGDKMIHEKNINQLKSEVQYIQEARNCLQKLREDISSKLDRS
                     PGGPLHQQEIQVVLEKPNGFSQSPMTLYSSPPEVDPSMSEDVESLKKTVQGLLAKLRE
                     AEQRHQSDRVAFEVTLSRYQREAEQSNVALQREEDRVEQKAAEIGELQSRLLGMEAEH
                     QALLVKVREGDMALEELRIKNADCQAEREKSASLEKEVAGFREKIHHLDDMLKSQQRK
                     VRQMIEQLQNSKAVIQSKDATIQELKEKIAYLEAENLEMHDRMEHLIEKQVSHGNFST
                     QTRAKTENLGSVRISKPPSPKPLPLIRVVET"
     exon            71..172
                     /gene="Tuft1"
                     /inference="alignment:Splign:2.1.0"
     exon            173..259
                     /gene="Tuft1"
                     /inference="alignment:Splign:2.1.0"
     exon            260..349
                     /gene="Tuft1"
                     /inference="alignment:Splign:2.1.0"
     exon            350..415
                     /gene="Tuft1"
                     /inference="alignment:Splign:2.1.0"
     exon            416..529
                     /gene="Tuft1"
                     /inference="alignment:Splign:2.1.0"
     exon            530..658
                     /gene="Tuft1"
                     /inference="alignment:Splign:2.1.0"
     exon            659..753
                     /gene="Tuft1"
                     /inference="alignment:Splign:2.1.0"
     exon            754..859
                     /gene="Tuft1"
                     /inference="alignment:Splign:2.1.0"
     exon            860..943
                     /gene="Tuft1"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1044
                     /gene="Tuft1"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..2614
                     /gene="Tuft1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgcgggaag atgaacggga cgcggagctg gtgtaccttg gtggacgtgc acccggagag
       61 ccagaccgcg gcgggcaaga agacctatgc catggtgtct ggccactcct caggtcattc
      121 tctggcttca gaactggtgg agtcccacga tggccatgaa gagattatta aggtgtactt
      181 gaaagggagg tctggggaca agatgatcca cgagaagaac atcaaccagc tgaagagtga
      241 ggtccagtac atccaggagg ccaggaactg cctgcagaag ctccgggagg atataagtag
      301 caagcttgac aggagtccag gaggccccct gcatcagcag gagatacagg tggtactaga
      361 aaagccaaat ggctttagtc agagtcccat gactctctac agcagcccac ctgaggtgga
      421 ccccagcatg agtgaagatg ttgagagctt gaagaagact gtgcaggggt tgcttgccaa
      481 gctgcgggag gctgagcagc gacaccagtc agaccgtgtg gcttttgagg tcacactcag
      541 ccggtatcag cgagaagcag agcagagcaa tgtggccctt cagagagagg aggacagagt
      601 ggaacagaaa gcggcagaaa tcggggagct gcagagccgt ttgttgggga tggaggcgga
      661 gcatcaggcc ttactggtga aagtcaggga aggagacatg gccctagaag agcttcggat
      721 caagaacgct gactgtcaag cagaaagaga aaagtctgct tctctagaaa aggaagtggc
      781 tgggtttcgg gagaagatcc accacctgga tgacatgctg aagagccagc agcggaaagt
      841 tcggcagatg atagagcagc tccagaattc aaaagctgtg atccagtcaa aggatgccac
      901 cattcaagag ctcaaggaga aaattgccta tttggaggct gagaacttag agatgcatga
      961 ccgcatggag catctaatag agaagcaggt cagtcatgga aacttcagta cacagacccg
     1021 ggccaagaca gagaacctgg gcagtgtcag gatatcgaag cctcccagcc ctaagcctct
     1081 gcctctcatc cgcgtggtgg aaacctgagc tgccaggaga tggatgctgc cattgctgtc
     1141 gcctcagtct tgcagagaag ccctccaccc tgagacggtt gatactgact ctgacttcct
     1201 gactaccctg gtggccccag gtctcgggct cctgccccag gctcctctcc actgcttgct
     1261 ggcagacggt caggagcaca gtctccggac actgcagacc ttgggaagac agactcctgc
     1321 tagcaggaac ggagcaatat ccttattctc agttagtgtt tttccatgca acagagcttc
     1381 cctgctgtat gcactggaat ctggctgccc aaaagccagg ccctcatcaa gtccagagaa
     1441 gtgacaaaat tcatctcagc cccaaaagct agaagcacag acgcacagtg attggagcgt
     1501 gtcctggggg aacaaagttc cttctgcaaa cacagctcgg ttcttagcaa caaactgttt
     1561 gcttttccac ttggctccac ccttgtgcca tgctgaccag ggcattttac aggcagccaa
     1621 tggggctaac tggtcttagc cagggaacct tgcctactag atagccttgc cttttggggg
     1681 acaaaggaat gtatactcgg gcagcagttt tagtaggtcg attctctagg gctgtggaag
     1741 ctccccatct gtgggttttc ccctgcggtg tcctgagagg cacacctcag tcttcctaac
     1801 gcagagctga gctctgctac tgtataacgc agagctgaga actgctactg tataacagct
     1861 gagaactgct actgtataac agcagagctg agaactgcta ctatataaca gcagagctga
     1921 gaactgctac tgtataacgc agagctgaga actgctactg tatttatttt gctaagttat
     1981 tgctggtttt gcttacatct tatatttggt ttagagccag tgttcttcag ccttctgcta
     2041 aggtatttgg gtttacctgg acatggggaa agcattctgc ttggcctggt cggtttcaca
     2101 gtgtcatact gattcctcat gccatccctc tagctgctgc ttttcccttc tttctccaga
     2161 gtggacctgg aactcaggag gctcgtgtgc gtgcctggtg tgtgctgttt ggggaatagg
     2221 gcagtcaaga tttgtttggg aggctggttc ttcttctctc tctgaacctt cccaccccta
     2281 acaacctcca tcccagccct gaatgaccct gcagctcgtc gtgttctctg tagtgtggtg
     2341 tggtctagta gcctcgagag tattcacgaa tctgagtgtg ggaccatagg aacaggttca
     2401 gttttagatc tgcttggctc acaaccagaa gccttaagtc tgtgtgtttc tgtgccagga
     2461 ctggacccag agcctggctt tgtctgtaca gttcctgaga cttcaggcgg aatgaggggg
     2521 ttgaacgtaa tctctgtgtc ccttcaaatt ctttccttgt ctgtaacaca cacagtcttt
     2581 gtatgggact ttaataaatt atgctaacat gtct
//
