LOCUS       NM_001106295            1884 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus Tu translation elongation factor, mitochondrial
            (Tufm), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001106295 XM_001077188 XM_215069
VERSION     NM_001106295.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1884)
  AUTHORS   Zhang,D.X., Yan,H., Hu,J.Y., Zhang,J.P., Teng,M., Tong,D.L.,
            Xiang,F., Zhang,Q., Fang,Y.D., Liang,G.P. and Huang,Y.S.
  TITLE     Identification of mitochondria translation elongation factor Tu as
            a contributor to oxidative damage of postburn myocardium
  JOURNAL   J Proteomics 77, 469-479 (2012)
   PUBMED   23041468
  REMARK    GeneRIF: the mitochondrial responses to severe burn, and indicate a
            pathway by which decreased EF-Tumt expression mediates oxidative
            damage in postburn myocardium.
REFERENCE   2  (bases 1 to 1884)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   3  (bases 1 to 1884)
  AUTHORS   Weiser,B., Gonye,G., Sykora,P., Crumm,S. and Cahill,A.
  TITLE     Chronic ethanol feeding causes depression of mitochondrial
            elongation factor Tu in the rat liver: implications for the
            mitochondrial ribosome
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 300 (5), G815-G822 (2011)
   PUBMED   21350184
REFERENCE   4  (bases 1 to 1884)
  AUTHORS   Zhao,X., Leon,I.R., Bak,S., Mogensen,M., Wrzesinski,K., Hojlund,K.
            and Jensen,O.N.
  TITLE     Phosphoproteome analysis of functional mitochondria isolated from
            resting human muscle reveals extensive phosphorylation of inner
            membrane protein complexes and enzymes
  JOURNAL   Mol Cell Proteomics 10 (1), M110.000299 (2011)
   PUBMED   20833797
REFERENCE   5  (bases 1 to 1884)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   6  (bases 1 to 1884)
  AUTHORS   Werner,H.B., Kuhlmann,K., Shen,S., Uecker,M., Schardt,A.,
            Dimova,K., Orfaniotou,F., Dhaunchak,A., Brinkmann,B.G., Mobius,W.,
            Guarente,L., Casaccia-Bonnefil,P., Jahn,O. and Nave,K.A.
  TITLE     Proteolipid protein is required for transport of sirtuin 2 into CNS
            myelin
  JOURNAL   J Neurosci 27 (29), 7717-7730 (2007)
   PUBMED   17634366
REFERENCE   7  (bases 1 to 1884)
  AUTHORS   Li,K.W., Hornshaw,M.P., Van Der Schors,R.C., Watson,R., Tate,S.,
            Casetta,B., Jimenez,C.R., Gouwenberg,Y., Gundelfinger,E.D.,
            Smalla,K.H. and Smit,A.B.
  TITLE     Proteomics analysis of rat brain postsynaptic density. Implications
            of the diverse protein functional groups for the integration of
            synaptic physiology
  JOURNAL   J Biol Chem 279 (2), 987-1002 (2004)
   PUBMED   14532281
REFERENCE   8  (bases 1 to 1884)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   9  (bases 1 to 1884)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
REFERENCE   10 (bases 1 to 1884)
  AUTHORS   Ling,M., Merante,F., Chen,H.S., Duff,C., Duncan,A.M. and
            Robinson,B.H.
  TITLE     The human mitochondrial elongation factor tu (EF-Tu) gene: cDNA
            sequence, genomic localization, genomic structure, and
            identification of a pseudogene
  JOURNAL   Gene 197 (1-2), 325-336 (1997)
   PUBMED   9332382
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473956.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001077188.1, XM_215069.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1884
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q36"
     gene            1..1884
                     /gene="Tufm"
                     /note="Tu translation elongation factor, mitochondrial"
                     /db_xref="GeneID:293481"
                     /db_xref="RGD:1305501"
     exon            1..389
                     /gene="Tufm"
                     /inference="alignment:Splign:2.1.0"
     CDS             347..1705
                     /gene="Tufm"
                     /note="elongation factor Tu, mitochondrial"
                     /codon_start=1
                     /product="elongation factor Tu, mitochondrial precursor"
                     /protein_id="NP_001099765.1"
                     /db_xref="GeneID:293481"
                     /db_xref="RGD:1305501"
                     /translation="MAAATLLRATPRFSGLCASPTPFLQGRLRPLKAPASPFLCRGLA
                     VEAKKTYVRDKPHVNVGTIGHVDHGKTTLTAAITKILAEGGGAKFKKYEEIDNAPEER
                     ARGITINAAHVEYSTAARHYAHTDCPGHADYVKNMITGTAPLDGCILVVAANDGPMPQ
                     TREHLLLAKQIGVEHVVVYVNKADAVQDSEMVELVELEIRELLTEFGYKGEETPVIVG
                     SALCALEQRDPELGVKSVQKLLDAVDTYIPVPTRDLEKPFLLPVESVYSIPGRGTVVT
                     GTLERGILKKGDECELLGHNKNIRTVVTGIEMFHKSLERAEAGDNLGALVRGLKREDL
                     RRGLVMVKPGSIQPHQKVEAQVYILSKEEGGRHKPFVSHFMPVMFSLTWDMACRVILP
                     PGKELAMPGEDLKLSLILRQPMILEKGQRFTLRDGNKTIGTGLVTDVPAMTEEDKNIK
                     WS"
     exon            390..584
                     /gene="Tufm"
                     /inference="alignment:Splign:2.1.0"
     exon            585..751
                     /gene="Tufm"
                     /inference="alignment:Splign:2.1.0"
     exon            752..856
                     /gene="Tufm"
                     /inference="alignment:Splign:2.1.0"
     exon            857..1021
                     /gene="Tufm"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1154
                     /gene="Tufm"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1259
                     /gene="Tufm"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1411
                     /gene="Tufm"
                     /inference="alignment:Splign:2.1.0"
     exon            1412..1531
                     /gene="Tufm"
                     /inference="alignment:Splign:2.1.0"
     exon            1532..1884
                     /gene="Tufm"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caaactaacc ctaagcccgc tgccctgaaa actacaacac ccataagcct tcgggagcgc
       61 tcgtgcattg tggggcgctc cgcattttcc tcctaaagtg gcccctcagg ttgaactgtg
      121 aaaattctcc atcatccccc gcgagacacc agaaacctcc ttttccgctc catgcccgga
      181 tataagtggc cgtggccata gaaactttct gctagaggct cccaaagtcg ctgtcccgac
      241 cctcatttcc gccggaagtg atctgctgtt ccaagtgccc gtccttccct acacgcgcgg
      301 gctccgggtc cctagttctc ggtcccggtc gccgagtact accacaatgg cggcagcgac
      361 tctattacga gcgacgcccc gtttcagcgg tctctgcgcc agcccaaccc catttctgca
      421 aggtcggctg cggccgctga aggccccggc atcgcccttc ttgtgtcgcg gcctagcagt
      481 ggaggccaag aagacttacg tacgcgacaa accccatgtg aatgtgggta ccatcgggca
      541 tgtggaccat ggcaagacca ccctgaccgc agccatcacg aaaattctag ccgagggagg
      601 tggagctaag ttcaagaagt acgaggagat agacaatgcc ccagaggagc gagctcgggg
      661 tatcaccatc aatgcagctc atgtggagta tagcactgct gcccgacact atgcccacac
      721 agactgccct ggtcatgcag attatgttaa gaatatgatc acaggcaccg cccctctgga
      781 tggctgcatc ctggtggtgg cagctaatga tggccccatg ccccagaccc gagagcactt
      841 actgctagct aagcagattg gggtagagca tgttgtggtg tatgtgaaca aggcagatgc
      901 tgtccaggac tcggagatgg tggagctggt agagctggag atccgggagc tgctcactga
      961 gtttggctat aaaggagagg aaaccccagt catcgtaggc tcggccctct gtgctcttga
     1021 gcaacgtgat cctgagctag gtgtgaagtc agtgcagaag cttctggatg ctgtggacac
     1081 ttacatccca gtacccaccc gggacctgga gaagcccttt ctgctccctg tagagtcagt
     1141 ttactctatt cctggccgcg gcacagtggt gacaggtaca ctagaacgtg gcattttgaa
     1201 gaaaggagat gagtgtgagt tgctgggaca taacaagaac attcgcactg tggtgacagg
     1261 cattgagatg ttccacaaga gcctggagag ggctgaggca ggggataacc ttggtgctct
     1321 ggtccgaggc ttaaagcgag aggatttgag gcgtggtttg gtcatggtca agccaggatc
     1381 catccaaccc caccagaagg tggaggccca ggtttatatc ctcagcaagg aggagggtgg
     1441 ccgccacaaa ccctttgtat ctcatttcat gcccgtcatg ttctccctga cctgggacat
     1501 ggcctgtcga gtcatcttgc ctccagggaa ggaacttgcc atgcctggag aggacttgaa
     1561 gcttagccta atcttgcggc agcccatgat cttagagaaa ggccaacgtt tcactttgag
     1621 ggatggcaac aagaccattg gcacaggcct tgtcactgat gtaccagcca tgaccgagga
     1681 ggacaagaac atcaaatgga gctgagtctg gacttctgct caggttgttg agcttaaagc
     1741 tgccctggtc agcattccca cttgtggaca caagctgcat ccaaccagag tacacctatg
     1801 gacatttcta atcctgctca caaggagtga gtggcccgcc aagagaggtt ggcaaataaa
     1861 actgttccgt gaataatgca gcct
//
