LOCUS       NM_145778               1685 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus tubulin, gamma 1 (Tubg1), mRNA.
ACCESSION   NM_145778 XM_001081447 XM_001081448 XM_001081449
VERSION     NM_145778.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1685)
  AUTHORS   Liu,X., Salokas,K., Tamene,F., Jiu,Y., Weldatsadik,R.G., Ohman,T.
            and Varjosalo,M.
  TITLE     An AP-MS- and BioID-compatible MAC-tag enables comprehensive
            mapping of protein interactions and subcellular localizations
  JOURNAL   Nat Commun 9 (1), 1188 (2018)
   PUBMED   29568061
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1685)
  AUTHORS   Hehnly,H. and Doxsey,S.
  TITLE     Rab11 endosomes contribute to mitotic spindle organization and
            orientation
  JOURNAL   Dev Cell 28 (5), 497-507 (2014)
   PUBMED   24561039
REFERENCE   3  (bases 1 to 1685)
  AUTHORS   Chih,B., Liu,P., Chinn,Y., Chalouni,C., Komuves,L.G., Hass,P.E.,
            Sandoval,W. and Peterson,A.S.
  TITLE     A ciliopathy complex at the transition zone protects the cilia as a
            privileged membrane domain
  JOURNAL   Nat Cell Biol 14 (1), 61-72 (2011)
   PUBMED   22179047
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1685)
  AUTHORS   Jakobsen,L., Vanselow,K., Skogs,M., Toyoda,Y., Lundberg,E.,
            Poser,I., Falkenby,L.G., Bennetzen,M., Westendorf,J., Nigg,E.A.,
            Uhlen,M., Hyman,A.A. and Andersen,J.S.
  TITLE     Novel asymmetrically localizing components of human centrosomes
            identified by complementary proteomics methods
  JOURNAL   EMBO J 30 (8), 1520-1535 (2011)
   PUBMED   21399614
REFERENCE   5  (bases 1 to 1685)
  AUTHORS   Vaz Meirelles,G., Ferreira Lanza,D.C., da Silva,J.C., Santana
            Bernachi,J., Paes Leme,A.F. and Kobarg,J.
  TITLE     Characterization of hNek6 interactome reveals an important role for
            its short N-terminal domain and colocalization with proteins at the
            centrosome
  JOURNAL   J Proteome Res 9 (12), 6298-6316 (2010)
   PUBMED   20873783
REFERENCE   6  (bases 1 to 1685)
  AUTHORS   Di Fiore,B., Ciciarello,M., Mangiacasale,R., Palena,A.,
            Tassin,A.M., Cundari,E. and Lavia,P.
  TITLE     Mammalian RanBP1 regulates centrosome cohesion during mitosis
  JOURNAL   J Cell Sci 116 (Pt 16), 3399-3411 (2003)
   PUBMED   12840069
  REMARK    Erratum:[J Cell Sci. 2003 Sep 1;116(Pt 17):3659]
REFERENCE   7  (bases 1 to 1685)
  AUTHORS   Fleming,S.L., Shank,P.R. and Boekelheide,K.
  TITLE     gamma-Tubulin overexpression in Sertoli cells in vivo: I.
            Localization to sites of spermatid head attachment and alterations
            in Sertoli cell microtubule distribution
  JOURNAL   Biol Reprod 69 (1), 310-321 (2003)
   PUBMED   12672673
  REMARK    GeneRIF: gamma-tubulin overexpression caused redistribution of
            Sertoli cell microtubule networks, and a gamma-tubulin-enhanced
            green fluorescent protein fusion protein localized to the site of
            elongate spermatid head attachment to the seminiferous epithelium.
REFERENCE   8  (bases 1 to 1685)
  AUTHORS   Fleming,S.L., Shank,P.R. and Boekelheide,K.
  TITLE     gamma-Tubulin overexpression in Sertoli cells in vivo. II:
            Retention of spermatids, residual bodies, and germ cell apoptosis
  JOURNAL   Biol Reprod 69 (1), 322-330 (2003)
   PUBMED   12672672
  REMARK    GeneRIF: gamma-tubulin overexpression disrupts the Sertoli cell
            microtubule network,leads to gross disorganization of the
            seminiferous epithelium, inducing retention of spermatids and
            residual bodies; and causes germ cell apoptosis.
REFERENCE   9  (bases 1 to 1685)
  AUTHORS   Nakadai,T., Okada,N., Makino,Y. and Tamura,T.
  TITLE     Structure of rat gamma-tubulin and its binding to HP33
  JOURNAL   DNA Res 6 (3), 207-209 (1999)
   PUBMED   10470852
REFERENCE   10 (bases 1 to 1685)
  AUTHORS   Tassin,A.M., Celati,C., Moudjou,M. and Bornens,M.
  TITLE     Characterization of the human homologue of the yeast spc98p and its
            association with gamma-tubulin
  JOURNAL   J Cell Biol 141 (3), 689-701 (1998)
   PUBMED   9566969
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC070957.1.
            
            On or before Jun 25, 2006 this sequence version replaced
            XM_001081448.1, XM_001081449.1, XM_001081447.1, NM_145778.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC070957.1, AB015946.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1685
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q31"
     gene            1..1685
                     /gene="Tubg1"
                     /note="tubulin, gamma 1"
                     /db_xref="GeneID:252921"
                     /db_xref="RGD:628606"
     exon            1..162
                     /gene="Tubg1"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..1469
                     /gene="Tubg1"
                     /note="GCP-1; gamma-1-tubulin; gamma-tubulin complex
                     component 1"
                     /codon_start=1
                     /product="tubulin gamma-1 chain"
                     /protein_id="NP_665721.1"
                     /db_xref="GeneID:252921"
                     /db_xref="RGD:628606"
                     /translation="MPREIITLQLGQCGNQIGFEFWKQLCAEHGISPEGIVEEFATEG
                     TDRKDVFFYQADDEHYIPRAVLLDLEPRVIHSILNSSYAKLYNPENIYLSEHGGGAGN
                     NWASGFSQGEKIHEDIFDIIDREADGSDSLEGFVLCHSIAGGTGSGLGSYLLERLNDR
                     YPKKLVQTYSVFPNQDEMSDVVVQPYNSLLTLKRLTQNADCVVVLDNTALNLIATDRL
                     HIQNPSFSQINQLVSTIMSASTTTLRYPGYMNNDLIGLIASLIPTPRLHFLMTGYTPL
                     TTDQSVASVRKTTVLDVMRRLLQPKNVMVSTGRDRQTNHCYIAILNIIQGEVDPTQVH
                     KSLQRIRERKLANFIPWGPASIQVALSRKSPYLPSAHRVSGLMMANHTSISSLFERTC
                     RQFDKLRKREAFMEQFRKEDIFKDNFDEMDTSREIVQQLIDEYHAATRPDYISWGTQE
                     Q"
     exon            163..275
                     /gene="Tubg1"
                     /inference="alignment:Splign:2.1.0"
     exon            276..443
                     /gene="Tubg1"
                     /inference="alignment:Splign:2.1.0"
     exon            444..512
                     /gene="Tubg1"
                     /inference="alignment:Splign:2.1.0"
     exon            513..592
                     /gene="Tubg1"
                     /inference="alignment:Splign:2.1.0"
     exon            593..719
                     /gene="Tubg1"
                     /inference="alignment:Splign:2.1.0"
     exon            720..806
                     /gene="Tubg1"
                     /inference="alignment:Splign:2.1.0"
     exon            807..956
                     /gene="Tubg1"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1109
                     /gene="Tubg1"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1271
                     /gene="Tubg1"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1658
                     /gene="Tubg1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaaagatca ggggtggagc gcattgccta gcgcctgcgt cttgcgggcg agcgcgctag
       61 cggtcggcgg cgttgctggc gggagagact gcaacgccta tgtctgagga gcgatgccga
      121 gagaaatcat caccctacag ttgggccagt gcggcaatca gattgggttc gagttctgga
      181 aacagctatg tgctgagcat ggcatcagcc ccgagggcat cgtagaggag ttcgccaccg
      241 agggcactga ccgcaaggac gtctttttct accaggcaga cgatgagcat tacatccccc
      301 gggctgtgct gctggacctg gagccccggg tgatccattc catcctcaac tcctcctatg
      361 ccaagctcta caacccagag aacatctacc tgtccgagca tggaggaggg gctggcaaca
      421 actgggccag cggattctcc cagggagaaa aaatccacga ggacattttt gacatcattg
      481 atcgggaggc agatggcagt gacagcctag agggatttgt actgtgtcac tccattgctg
      541 gggggacagg ctctggcttg ggctcctacc tcttggaacg gctaaatgac aggtacccca
      601 aaaaactagt gcagacgtac tccgtgttcc ccaaccagga cgagatgagt gacgtggtgg
      661 tccagcccta caactccctc ctcacgttaa agaggctgac ccagaacgcg gactgtgtgg
      721 tggtgctgga caacacggcc ctgaacctga tcgccacaga ccgcctgcac atccagaacc
      781 catccttctc ccagatcaac cagctggtgt ccaccatcat gtcagccagc accaccaccc
      841 tgcgctaccc cggatacatg aacaacgacc tcatcggcct catcgcctca ctcattccca
      901 cccctcgact acacttcctc atgactggct atacccccct caccacggac cagtcagtgg
      961 ccagtgtgag gaagacaaca gtcctggatg tcatgaggag actgctacag cccaagaacg
     1021 tgatggtgtc cacaggtcgg gatcgtcaga ccaaccactg ctacatcgcc atcctcaaca
     1081 tcatccaggg agaggtggac cccacccagg tccacaagag cctgcagagg atccgggaga
     1141 ggaagttggc caactttatc ccctggggcc cggccagcat ccaggtggcc ctgtcaagga
     1201 agtctcccta cctgccctca gcccaccggg tcagcgggct catgatggcc aaccacacca
     1261 gtatctcctc gctttttgaa aggacctgtc gccagtttga caagctgagg aaacgggagg
     1321 ccttcatgga gcagttccgc aaggaggaca tcttcaagga caattttgac gagatggaca
     1381 cctccaggga gattgtgcag cagctgattg acgagtacca tgcggccaca cggccagact
     1441 acatctcctg gggcacccag gagcaatgag tcgcccgaga cagggaccct catctgcctt
     1501 accggttagc ccaggccctg cctggctgac tacccctcag agcacagatc agggacctca
     1561 tcaatcactc gcatacacat gcactgtctg ttggcttagg ggcgggttta cttctttgag
     1621 agtatttatc tttaataaag cactggatgt aaaccgagaa aaaaaaaaaa aaaaaaaaaa
     1681 aaaaa
//
