LOCUS       NM_173102               2395 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus tubulin, beta 5 class I (Tubb5), mRNA.
ACCESSION   NM_173102
VERSION     NM_173102.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2395)
  AUTHORS   Ngo,L., Haas,M., Qu,Z., Li,S.S., Zenker,J., Teng,K.S.,
            Gunnersen,J.M., Breuss,M., Habgood,M., Keays,D.A. and Heng,J.I.
  TITLE     TUBB5 and its disease-associated mutations influence the terminal
            differentiation and dendritic spine densities of cerebral cortical
            neurons
  JOURNAL   Hum Mol Genet 23 (19), 5147-5158 (2014)
   PUBMED   24833723
REFERENCE   2  (bases 1 to 2395)
  AUTHORS   Milochau,A., Lagree,V., Benassy,M.N., Chaignepain,S., Papin,J.,
            Garcia-Arcos,I., Lajoix,A., Monterrat,C., Coudert,L.,
            Schmitter,J.M., Ochoa,B. and Lang,J.
  TITLE     Synaptotagmin 11 interacts with components of the RNA-induced
            silencing complex RISC in clonal pancreatic beta-cells
  JOURNAL   FEBS Lett 588 (14), 2217-2222 (2014)
   PUBMED   24882364
REFERENCE   3  (bases 1 to 2395)
  AUTHORS   Zanivan,S., Maione,F., Hein,M.Y., Hernandez-Fernaud,J.R.,
            Ostasiewicz,P., Giraudo,E. and Mann,M.
  TITLE     SILAC-based proteomics of human primary endothelial cell
            morphogenesis unveils tumor angiogenic markers
  JOURNAL   Mol Cell Proteomics 12 (12), 3599-3611 (2013)
   PUBMED   23979707
REFERENCE   4  (bases 1 to 2395)
  AUTHORS   Lian,S., Meng,L., Liu,C., Xing,X., Song,Q., Dong,B., Han,Y.,
            Yang,Y., Peng,L., Qu,L. and Shou,C.
  TITLE     PRL-3 activates NF-kappaB signaling pathway by interacting with
            RAP1
  JOURNAL   Biochem Biophys Res Commun 430 (1), 196-201 (2013)
   PUBMED   23178297
REFERENCE   5  (bases 1 to 2395)
  AUTHORS   Huai,J., Zhang,Y., Liu,Q.M., Ge,H.Y., Arendt-Nielsen,L., Jiang,H.
            and Yue,S.W.
  TITLE     Interaction of transient receptor potential vanilloid 4 with
            annexin A2 and tubulin beta 5
  JOURNAL   Neurosci Lett 512 (1), 22-27 (2012)
   PUBMED   22309793
  REMARK    GeneRIF: Coimmunoprecipitation experiments of transfected cells
            revealed that rat TRPV4 and rat tubulin beta 5 associated together
            in a complex.
REFERENCE   6  (bases 1 to 2395)
  AUTHORS   Hurt,P., Walter,L., Sudbrak,R., Klages,S., Muller,I., Shiina,T.,
            Inoko,H., Lehrach,H., Gunther,E., Reinhardt,R. and Himmelbauer,H.
  TITLE     The genomic sequence and comparative analysis of the rat major
            histocompatibility complex
  JOURNAL   Genome Res 14 (4), 631-639 (2004)
   PUBMED   15060004
REFERENCE   7  (bases 1 to 2395)
  AUTHORS   Ledesma,M.D., Da Silva,J.S., Schevchenko,A., Wilm,M. and Dotti,C.G.
  TITLE     Proteomic characterisation of neuronal sphingolipid-cholesterol
            microdomains: role in plasminogen activation
  JOURNAL   Brain Res 987 (1), 107-116 (2003)
   PUBMED   14499952
REFERENCE   8  (bases 1 to 2395)
  AUTHORS   Wubbolts,R., Leckie,R.S., Veenhuizen,P.T., Schwarzmann,G.,
            Mobius,W., Hoernschemeyer,J., Slot,J.W., Geuze,H.J. and
            Stoorvogel,W.
  TITLE     Proteomic and biochemical analyses of human B cell-derived
            exosomes. Potential implications for their function and
            multivesicular body formation
  JOURNAL   J Biol Chem 278 (13), 10963-10972 (2003)
   PUBMED   12519789
REFERENCE   9  (bases 1 to 2395)
  AUTHORS   Tarazona,R., Lopez-Lluch,G., Galiani,M.D., Aguado,E., Barahona,F.,
            Solana,R. and Pena,J.
  TITLE     HLA-B2702 (77-83/83-77) peptide binds to beta-tubulin on human NK
            cells and blocks their cytotoxic capacity
  JOURNAL   J Immunol 165 (12), 6776-6782 (2000)
   PUBMED   11120798
REFERENCE   10 (bases 1 to 2395)
  AUTHORS   Usui,H., Miyazaki,Y., Xin,D., Ichikawa,T. and Kumanishi,T.
  TITLE     Cloning and sequencing of the rat cDNAs encoding class I
            beta-tubulin
  JOURNAL   DNA Seq 9 (5-6), 365-368 (1998)
   PUBMED   10524766
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX883048.1.
            
            On Oct 16, 2009 this sequence version replaced NM_173102.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB011679.1, FQ213253.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-253               BX883048.1         61402-61654         c
            254-362             BX883048.1         60008-60116         c
            363-473             BX883048.1         59558-59668         c
            474-2395            BX883048.1         57505-59426         c
FEATURES             Location/Qualifiers
     source          1..2395
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..2395
                     /gene="Tubb5"
                     /gene_synonym="Tubb"
                     /note="tubulin, beta 5 class I"
                     /db_xref="GeneID:29214"
                     /db_xref="RGD:628596"
     exon            1..253
                     /gene="Tubb5"
                     /gene_synonym="Tubb"
                     /inference="alignment:Splign:2.1.0"
     CDS             197..1531
                     /gene="Tubb5"
                     /gene_synonym="Tubb"
                     /codon_start=1
                     /product="tubulin beta-5 chain"
                     /protein_id="NP_775125.1"
                     /db_xref="GeneID:29214"
                     /db_xref="RGD:628596"
                     /translation="MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGTYHGDSDLQL
                     DRISVYYNEATGGKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWA
                     KGHYTEGAELVDSVLDVVRKEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYP
                     DRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLT
                     TPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSR
                     GSQQYRALTVPELTQQVFDAKNMMAACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQ
                     NKNSSYFVEWIPNNVKTAVCDIPPRGLKMAVTFIGNSTAIQELFKRISEQFTAMFRRK
                     AFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATAEEEEDFGEEAEEEA"
     exon            254..362
                     /gene="Tubb5"
                     /gene_synonym="Tubb"
                     /inference="alignment:Splign:2.1.0"
     exon            363..473
                     /gene="Tubb5"
                     /gene_synonym="Tubb"
                     /inference="alignment:Splign:2.1.0"
     exon            474..2395
                     /gene="Tubb5"
                     /gene_synonym="Tubb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgccggcctc ttctgcctct tagaaccttc ctgcggtcgt gctcgcatct ctctgcagca
       61 gcctccgggg ctacgttcca tcctatcagt ctgagaccag cccagaagaa aaaaaccaaa
      121 aatccttaat tatcttcttt tgctcggtac ctacattggg accatcaaaa aaagattatt
      181 acagtaaacc gtagccatga gggaaatcgt gcacatccag gccggacagt gtggcaacca
      241 gatcggtgct aagttctggg aggtgataag cgatgaacac ggcatcgacc ccaccggcac
      301 ctaccacgga gacagcgact tgcagctgga ccgaatctct gtgtactaca atgaagctac
      361 aggtggcaag tatgtccctc gagctatctt agtggatcta gaacccggga ctatggactc
      421 cgttcgctca ggtccttttg gccagatctt cagaccggac aactttgttt ttggtcagtc
      481 tggggcaggc aacaactggg ctaagggtca ctacacagag ggagctgagc tggttgactc
      541 tgtcttggat gtggtgcgga aggaggcgga gagctgtgac tgcctgcaag gctttcagct
      601 gacccattcg ctgggtggag gcacgggctc tggcatgggc accctgctca tcagcaagat
      661 tcgagaagaa taccccgacc gcatcatgaa cacctttagc gtggtgccct cacccaaagt
      721 gtctgacacc gtggttgagc cctacaacgc caccctgtcc gtccaccagt tggtagagaa
      781 cacagatgag acctactgca ttgacaacga ggccctctac gacatctgct tccgtaccct
      841 taagctcacc acgccaacct acggagacct gaaccatctc gtctctgcca ccatgagcgg
      901 tgtcaccacc tgcctccgtt tcccgggcca gctgaacgcc gaccttcgga agctggctgt
      961 caacatggtg cccttcccgc gtctccactt ctttatgcct ggctttgccc ctctcaccag
     1021 ccgtggaagc cagcagtacc gggccctcac tgtgcctgaa ctcacccagc aggtcttcga
     1081 cgccaagaac atgatggccg cctgtgaccc acgccacggc cggtacctca cggttgcggc
     1141 tgtcttccgt ggacggatgt ccatgaagga ggtagatgag caaatgctca acgtgcagaa
     1201 taagaatagc agctacttcg tggaatggat ccccaacaac gtcaagacgg ctgtctgtga
     1261 catcccaccg cgaggcctca agatggcagt caccttcatc ggaaacagca cggccatcca
     1321 ggagctcttc aagcgcatct ctgagcagtt tacggcaatg ttccgtcgga aggctttcct
     1381 ccactggtac acgggtgagg gcatggacga gatggagttc accgaagctg agagcaacat
     1441 gaatgacctc gtctctgagt atcagcagta ccaggacgcc accgcagaag aggaagagga
     1501 tttcggagag gaggcagaag aagaggccta aggcggaagc cctgcgtcac ctcaggctgc
     1561 ttagttccct tagctttttt ccaactgccc tttgtttctt tctgctgcct ctgtcctgtt
     1621 tttgttccgt tttgttttct cattgggggg taaacggtgc ctggcacgtg gcaggcgctc
     1681 aataaatatt tctttgtgga atgtctcctt tctctttccg atctgacatt ctgagcgtta
     1741 accctgtgct tcctcctggt acccatttct ttattatgac tgtccagtta atattcttcc
     1801 aatatattct ccaggaacca gcgttcggct ccagacccgg ggtagaaccc agcccagttc
     1861 taagaactca agagagtagc caccatctta aagcaaagta gcgggtgggg aaaaggtggg
     1921 tagaggagat gctacttagg gggtgggatt ttccagtcag ggccatttag acacgggaat
     1981 cgctgaggct ttcagtcgat ggggctttct tttttccctg cttcatctct cggcctcagg
     2041 agaggtatta acagtattat caccatttat atcctagctg tcctgagcca aatctgccat
     2101 tggaggtgtc ttccctgtgt tggttctcca agggacgttg catggggatt tgtgggggca
     2161 gggcagcaag gccttgttct ctaaatgtcc agaaacactc taattaccat ttccacctgg
     2221 gtgcctcaca cactccccag aggggaggta acatctctgc cccatttccc tcctgttcct
     2281 tggcttggtc attccctacc tttctatttt gtgttaaact tggctttttt tttttttttt
     2341 ttttcatatt gaaaagatga cattgccccg agagccaaaa ataaatggga attgg
//
